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145
resultados
Última actualización
24/10/2025 [07:10:00]
Resumen de: AU2024238878A1
A method of modifying a surface of a three-dimensional (3D) article includes immersing at least one part of the 3D article in a buffered solution of functionalized peptides, allowing reaction between the functionalized peptides and reactive groups on the surface of the 3D article; and washing the at least one part of the 3D article to remove unreacted functionalized peptides. The surface-modified 3D article includes a plurality of peptides covalently bonded to the surface of the 3D article via a cysteine bridge. The surface- modified 3D article can be used as a scaffold for the formation of biological tissue or bodily implants.
Resumen de: EP4635526A1
A bio-ink manufacturing device according to the present disclosure is provided. The bio-ink manufacturing device include: a reaction vessel for performing a reaction on tissues of decellularized extracellular matrix and an ink solution; a bio-ink liquefy portion for stirring and compacting the tissues of decellularized extracellular matrix and liquefying the same into bio-ink; and a bio-ink discharge portion discharging the bio-ink whose liquefaction is completed to an outside of the reaction vessel.
Resumen de: EP4635447A1
The invention relates to a method for producing a mesostructural element (3), the mesostructural element (3) being adapted to be fixed to at least one oral implant and to carry at least one suprastructure for prosthetic replacement of a plurality of teeth in an oral cavity, the method comprising:- arranging at least one implant proxy element (17) at a predetermined position in a jawbone model (7),- attaching at least one preform element (19) to the at least one implant proxy element (17),- forming the mesostructural element (3) onto the at least one preform element (19) by laser metal deposition, wherein- the jawbone model (7) and a LMD nozzle (11) are positioned relative to each other by a positioning apparatus (13) comprising at least four axes, and- releasing the at least one preform element (19) from the at least one implant proxy element (17) and obtaining the mesostructural element (3).
Resumen de: EP4635446A1
The invention is a new set of dental aligners (A), wherein each aligner (A) is manufactured joined to one or more aligners (A) intended for the same patient and suitable for progressive use by the same patient. The present patent also concerns the method for making the set of aligners (A) together with the connecting appendages (A) between the aligners (A) making up each set.
Resumen de: WO2024127105A1
Method of making a transfer apparatus includes providing a physical mockup having a shape that corresponds to a positive shape of a patient's dental arch and one or more orthodontic appliances connected to the arch via one or more sprues. A transfer apparatus may be formed over the physical mockup, with the transfer tray representing a negative replica of at least a portion of the mockup. The transfer apparatus may be used to seat the appliance on a patient's dental arch, after which point the appliance can be separated from transfer apparatus and bonded to the associated tooth.
Resumen de: CN120814940A
本发明涉及一种关节假体及其制备方法，包括3D打印关节假体，所述3D打印关节假体包括假体关节和与其相连的假体柄，所述假体关节的表面喷涂有聚醚醚酮。本发明3D打印的关节假体表面达到预热温度后，使用火焰喷涂将聚醚醚酮粉末喷涂在假体关节表面，假体关节面形成牢固、坚硬致密具有晶体结构的聚醚醚酮涂层，有利于骨骼关节面的相互接触，同时未喷涂部位可以利用医用金属的生物相容性。实际使用过程中，接触面是聚醚醚酮与软骨接触，摩擦因数将下降到0.235左右，大幅提高了接触表面的光滑度。同时聚醚醚酮具有水润滑特性，有益于表面有组织液流动，比医用金属表面更具备润滑性，更有益于植入体与原生骨骼组织的表面接触。
Resumen de: CN120817743A
本发明涉及磷酸镁骨水泥及其3D打印技术领域，公开了一种用于挤压式3D打印的磷酸镁骨水泥及其制备方法和应用，包括固相粉末和固化液，所述固相粉末包括如下质量份数的原料：磷酸钙70~200份、磷酸镁10~90份、三水合磷酸氢镁30~150份、磷酸盐20~90份、锁水剂0.1~2份；所述固化液和固相粉末的液固比为0.45~0.8g/ml。制备时，将固相粉末混合均匀后，加入固化液，搅拌1~5 min完成反应，即得用于挤压式3D打印的磷酸镁骨水泥。本方案制备所得磷酸镁骨水泥在3D打印后，有效提升MPC挤出流动性与挤出后的形状保持能力，增加MPC打印过程中层间结合力，成功实现磷酸镁骨修复支架形状可控化。
Resumen de: CN120818247A
本发明涉及柔性电子材料技术领域，公开了一种丝素蛋白基拓扑结构导电水凝胶及其制备方法与应用，由以下组分构成：以rGO@SilMA为聚合主体，其中所述rGO@SilMA通过将丝素蛋白与氧化石墨烯分散液混合，并在甲基丙烯酸甘油酯存在下反应形成，聚乙二醇二丙烯酸酯为增强相，苯基‑2,4,6‑三甲基苯甲酰基磷酸锂（LAP）为光引发剂，各组分在光固化墨水中的质量占比为：rGO@SilMA20%、PEGDA10%、LAP0.75%。本发明通过构建rGO@SilMA‑PEGDA互穿网络结构并引入TPMS拓扑设计，显著提升了水凝胶的力学性能与传感稳定性，互穿网络使压缩模量提升且断裂伸长率保持高水准，满足高形变场景需求，拓扑结构的负高斯曲率特征让应力分布更均匀，增加有效传感区域。
Resumen de: JP2023159033A
To provide a manufacturing method of orienting a digital dental object so as to be capable of efficient manufacture.SOLUTION: A manufacturing method of dental objects includes: a step which generates a digital dental object in a coordinate system describing a shape of a dental object to be manufactured; a step which rotates a spatial orientation of the digital dental object in the coordinate system on the basis of a digital reference object in the coordinate system; and a step which manufactures the dental object on the basis of the digital dental object having the rotated spatial orientation.SELECTED DRAWING: Figure 1
Resumen de: US2023310704A1
A three-dimensional (3D) biocompatible, degradable soft tissue implant, comprising a bioprinted composite scaffold, the composite scaffold comprising a recombinant human collagen (rhCollagen) and a biocompatible synthetic polymer and features: a porous wall; an inner cavity at least partially enclosed within the porous wall; and at least one injection port that connects the inner cavity with an outer most surface of the scaffold, wherein the injection port has an opening sized to permit insertion of an injection device through the port, processes of preparing same and uses thereof in soft tissue reconstruction are provided. Injectable matrices for use in soft tissue reconstruction, either alone or in combination with the implant are also provided.
Resumen de: CN120789332A
本发明公开了一种基于3D打印的生物牙根支架及其制备方法与应用，属于生物医用材料技术领域。所述生物牙根支架包括3D打印的生物牙根支架基体和CMC‑BAPE@BMP7纳米颗粒，所述3D打印的生物牙根支架基体表界面具有活化的纳米晶须结构，所述CMC‑BAPE@BMP7纳米颗粒吸附固定在所述3D打印的生物牙根支架基体中。本发明结合了3D打印制备高精度生物陶瓷、高温烧结后优良力学性能、表界面活性改建促进细胞黏附分化以及结合抗炎促细胞分化纳米CMC‑BAPE@BMP7药物，实现了高强度、高精度、免疫调节活性的生物牙根支架的个性化定制，在牙缺失修复领域具有广阔的应用前景。
Resumen de: CN120788767A
本申请实施例提供数字化3D打印多功能正中颌托盘及其使用方法，涉及到口腔用具技术领域。数字化3D打印多功能正中颌托盘及其使用方法，包括：周侧带有半环形边沿的主托体，主托体上表面开设多个浅槽和多个第一通孔，多个浅槽和多个第一通孔错开分布；主托体的弧形中部内侧开设有顶部开口的插槽，插槽内阻尼插接有抬高体，抬高体向主托体中部一侧逐渐凸起，且抬高体的边缘与主托体边缘重合；主托体背侧可拆卸连接有连接块，连接块远离主托体的一侧设置有手柄，本发明通过模块化的设计，实现该正中颌托盘的多功能应用，在不同的使用需求下均能够更精确的获取颌位关系，且调整方便快捷，实际使用效果更佳。
Resumen de: CN120789330A
本发明公开了一种外科钛合金融合器活性涂层的制备方法，包括以下步骤：S1.通过3D打印制备多孔结构的钛合金融合器；S2.在钛合金融合器表面构建聚多巴胺涂层；S3.制备钙磷沉积液，在聚多巴胺涂层上进行羟基磷灰石矿化；S4.在羟基磷灰石矿化涂层表面接枝TBMP2蛋白，即完成钛合金融合器活性涂层的制备。本发明解决现有钛合金融合器生物惰性、骨整合性能差以及BMP2应用中副作用多的问题，并能够适应个性化植入需求。
Resumen de: US2025319654A1
A process for producing a three-dimensional structure involves providing a light source, coupling the light source to a proximal end of an optical fibre to propagate a light generated by the light source through the optical fibre and produce, at a distal end of the optical fibre, a predetermined incident optical field, providing a photo-crosslinkable polymeric material coated with a transparent material having a first surface in contact with the photo-crosslinkable polymeric material and a second surface not in contact with the photo-crosslinkable polymeric material and opposite to the first surface, placing the distal end of the optical fibre at a distance D from the second surface of the transparent material, and irradiating the second surface of the transparent material with the light propagated and exiting the distal end of the optical fibre, obtaining propagation of the light through the transparent material and photo-crosslinking, by irradiation, of the polymeric material.
Resumen de: US2025320367A1
The present invention relates to ink formulations based on methacrylated cellulose nanofibrils. In particular, the present invention concerns ink formulations for 3D printing, comprising a hydrogel containing methacrylated cellulose nanofibrils and preferably a cross-linking agent, optionally together with biological material, methods of producing such ink formulations, as well as uses thereof for, e.g., preparing 3D hydrogel scaffolds for cell culture and drug screening.
Resumen de: US2025318907A1
Processes for producing dental aligners and/or appliances and dental aligners and/or appliances produced by the processes are provided, wherein the processes comprise making a scan of teeth of a patient and developing a treatment plan for moving at least one tooth of the teeth from an original or first position to a new, final, or second position. The processes further comprise developing a force vector matrix, wherein the force vector matrix comprises all variables that are known to contribute to force generation of an orthodontic appliance on a patient's tooth, and 3D printing the dental aligner or appliance based on the developed treatment plan, the developed force vector matrix, and/or the scan of the teeth of the patient.
Resumen de: AU2024231554A1
Aspects in accordance with the present invention pertain to an apparatus for manufacturing a medical device, said apparatus comprising at least two production modules, at least one integrating element, and at least one inspection gate, wherein the production module is configured to process the medical device, a medical device part, a medical device accessory, a medical device preform, or a raw material; the integrating element is configured to, between any two of the production modules, move the medical device, the medical device part, the medical device accessory, or the medical device preform; and the inspection gate is configured to, outside the production module, subject the medical device, the medical device part, the medical device accessory, or the medical device preform, to an inspection technique according to a predetermined inspection mode, the operations of said production modules, said integrating element, and said inspection gate, being administered by a controlling software, and said apparatus is constructed as a ready-to-transport compact unit.
Resumen de: AU2023458708A1
Disclosed is a method for producing bubbly liquid material that is suitable for being used as a supporting material in a 3D printing system, the method comprising, producing to liquid material primary bubbles, stabilizing the primary bubbles with cross-linking enhancing compound, producing secondary bubbles to the liquid material, and using the liquid material comprising the primary and secondary bubbles as the supporting material for printing a 3D object, wherein the liquid material comprises a bubble system comprising at least the primary and secondary bubbles.
Resumen de: AU2025237992A1
Disclosed herein is a biomaterial and a method of use thereof for treating a condition. A biomaterial of the disclosure can be, for example, a surgical article. Implantation of a biomaterial disclosed herein into a subject can treat, for example, cancer. Disclosed herein is a biomaterial and a method of use thereof for treating a condition. A biomaterial of the disclosure can be, for example, a surgical article. Implantation of a biomaterial disclosed herein into a subject can treat, for example, cancer. ep e p i s c l o s e d h e r e i n i s a b i o m a t e r i a l a n d a m e t h o d o f u s e t h e r e o f f o r t r e a t i n g a c o n d i t i o n b i o m a t e r i a l o f t h e d i s c l o s u r e c a n b e , f o r e x a m p l e , a s u r g i c a l a r t i c l e m p l a n t a t i o n o f a b i o m a t e r i a l d i s c l o s e d h e r e i n i n t o a s u b j e c t c a n t r e a t , f o r e x a m p l e , c a n c e r
Resumen de: WO2025215377A1
The present disclosure relates generally to wound care, and more particularly to a wound dressing or debridement tool comprising an absorbent layer at least partially impregnated or coated with a non-antimicrobial composition.
Resumen de: WO2025215550A1
A method comprises outputting a user interface of a surgical planning system, wherein the user interface represents a patient-specific glenoid prosthesis at a planned implantation position on a scapula of a patient; and determining a bone-facing surface of the patient-specific glenoid prosthesis having a native-facing portion and a modified-facing portion, wherein the native-facing portion is shaped to conform to an unmodified bone surface of the scapula and the modified-facing portion is shaped to conform to a modified bone surface of the scapula.
Resumen de: WO2025214546A1
The invention relates to a device (10) and a method for producing a pharmaceutical product for direct dispensing to a patient. The device has a plurality of containers (24) for receiving in each case one pharmaceutical active ingredient, wherein the pharmaceutical active ingredients differ from one another; and at least one dosing device (25) for providing a specific amount of at least one of the pharmaceutical active ingredients from at least one of the containers (24); at least one processing device (28) for shaping the pharmaceutical product from the determined amount of the at least one pharmaceutical active ingredient provided by the at least one dosing device (24); a control unit connected to the dosing device (25) and the processing device (28) for controlling the production of the pharmaceutical product; a control panel (14) connected to the control unit for requesting a dispensing of the pharmaceutical product by the patient; and a dispensing unit (16) for dispensing the pharmaceutical product. By means of the device (10), personalised medicaments or pharmaceutical products can be produced at any time and dispensed directly to a patient.
Resumen de: WO2025215103A1
The present invention relates to a system for providing a bioink. The system comprises: a) at least two spray configured to receive at least two syringes comprising a nozzle each, each syringe configured to receive one or more components of the bioink; b) a housing, configured to comprise the at least two spray heads and comprising at least two housing nozzles, the housing nozzle comprising a diameter bigger than the diameter of the spray head nozzle; c) a gas inlet connected to the housing configured to receive a gas; and d) a control system.
Resumen de: WO2025215084A1
The present invention relates to a bioink formulation comprising fibrinogen and a glycosaminoglycans (GAGs)/collagen (Col) matrix, preferably comprising human cells, preferably human mesenchymal stem cells (hMSCs), keratinocytes and/or human dermal fibroblasts (hDFs), and its use in the treatment of tissue or bone injuries or damages, specifically skin tissue injuries or damages.
Nº publicación: WO2025214921A1 16/10/2025
Solicitante:
MERCK PATENT GMBH [DE]
MERCK PATENT GMBH
Resumen de: WO2025214921A1
The invention relates to a method and an apparatus (1) for additive manufacturing of a 3D item (2) by means of fused deposition modeling of a composite material, whereby the composite material is fed through a heated printer extruder head (4) and deposited on a printer bed (3) as a layer arrangement that form the 3D item (2). The composite material is provided as at least one rigid rod (10) that is conveyed out of a rod magazine (9) that is capable of storing at least one rigid rod (10). The rigid rod (10) is then conveyed through a guide tube (15) that is arranged within the printer extruder head (4), whereby the rigid rod (10) is heated during the conveyance through the guide tube (15), and whereby the heated and viscous composite material is discharged through a discharge nozzle (16) at one end of the guide tube (15) and deposited as the layer arrangement onto the printer bed (3) to generate the 3D item (2).
BOPI
Sede Electrónica
