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150
resultados
Última actualización
23/08/2025 [07:16:00]
Resumen de: EP4602972A1
The present invention provides, inter alia, a method for designing an insole, comprising receiving a measurement of a foot sole associated with pressure, said measurement preferably being obtained by placing a load on a measurement surface; receiving a sole profile; determining, based on said measurement, one or more anatomical zones; determining, based on said anatomical zones, a foot profile comprising a major axis; determining, at least based on said foot profile and said anatomical zones, an interpolating surface; aligning the interpolating surface with the sole profile, to obtain an aligned 3D profile; generating, based on said aligned 3D profile, an instruction for manufacturing the insole; wherein said determining of the interpolating surface is realized according to a 3D characterization according to respective positions (y1, y2) on said major axis; wherein said determining of the interpolating surface comprises calculating, based on said foot profile and said anatomical zones, a plurality of at least two anchor coordinates (d0-d3) each lying in a respective cross-section corresponding to said respective positions (y1, y2), and calculating, based on said at least two anchor coordinates (d0-d3), an interpolating surface.
Resumen de: CN120051256A
A dental appliance for a patient includes a body including a first surface and a second surface opposite the first surface. The second surface defines a channel for receiving a plurality of teeth of the patient. The dental appliance also includes an arrangement of a plurality of features disposed on the first surface of the body. Each feature of the plurality of features includes a protrusion extending from the first surface opposite the second surface; a recess extending partially from the first surface toward the second surface; or a via extending from the first surface to the second surface. The arrangement of the plurality of features encodes feature data representing dental appliance information of the dental appliance or patient information of the patient.
Resumen de: AU2023361612A1
The invention relates to nerve conduits for connecting a lesioned nerve end to a target site. In particular, the invention relates to nerve conduits supporting repair of a nerve lesion and motor control and/or reducing risk of the development of a neuroma at the lesioned nerve end. Accordingly, a nerve conduit (10) for connecting a lesioned nerve end (26) to a target site (28) is suggested, comprising an elongate body (12) formed by a wall (22) and comprising a central portion (14) defining an inner cavity (16) and end portions (18, 19) defining a respective opening (20, 20') to the inner cavity (16) and arranged adjacent to the central portion (14) and at longitudinally opposing ends of the elongate body (12). One end portion (18) is configured as an insertion portion configured for inserting a respective nerve end (26). According to the invention, the other end portion is configured as a nerve end outlet portion (19), wherein an outer diameter of the wall defining the outlet portion (19) is larger than an outer diameter of the wall defining the central portion (14).
Resumen de: EP4603053A1
A removable orthodontic device, suitable to obtain complex orthodontic movements and made with CAD-CAM techniques and 3D printing, comprising an orthodontic member, made from a shape memory polymer, in turn comprising: a restraint portion of a dental arch; a connection portion which is apt to be in contact with a palatal surface and/or a lingual surface; and one or more female members positioned at said connection portion; the orthodontic device further comprises one or more temporary anchorage devices (TADs), acting as orthodontic screw, comprising a shank, a hollow upper end and a protruding head which is attached to said upper end by a respecting connection screw, said head implementing a male connection member and being made from a shape memory polymer as well; said female members of said orthodontic member and said one or more TADs being shaped as to cooperate with each other implementing an automatic pressure connection, whereby a reversible connection mechanism is implemented.
Resumen de: CN120501931A
本发明涉及组织工程生物材料领域，尤其涉及一种角蛋白基复合骨软骨的制备方法和应用，制备方法将软骨层1、钙化软骨层2和软骨下骨层3组合为复合骨软骨。软骨层1为通过静电纺丝法和发泡技术制备的角蛋白基纳米纤维气凝胶，钙化软骨层2为采用静电纺丝法制备的富含钙磷离子的角蛋白纳米纤维膜，软骨下骨层3为利用3D打印技术制备的改性角蛋白基水凝胶材料。三层结构按顺序组合形成角蛋白基复合骨软骨。所制备的角蛋白基支架具有良好的生物相容性，有利于骨细胞的粘附增殖，具有促进骨软骨修复再生的功能。
Resumen de: CN120501945A
本发明涉及一种聚醚醚酮复合材料及其制备方法和在3D打印人工颅骨修复体中的应用，涉及聚醚醚酮材料技术领域，以重量份数计，所述聚醚醚酮复合材料包括以下原料：聚醚醚酮50~60份、改性羟基磷灰石40~50份和壳聚糖4~9份。在现有聚醚醚酮/羟基磷灰石体系基础上，本发明通过采用含羧基的笼型聚倍半硅氧烷对羟基磷灰石改性并引入适宜脱乙酰度的壳聚糖，有效解决了因羟基磷灰石添加量过高导致的拉伸强度下降问题，同时改善了材料的柔韧性，获得了一种兼具高羟基磷灰石含量、优异拉伸强度和良好柔韧性的聚醚醚酮复合材料，可充分满足人工颅骨修复体等骨植入体的应用需求。
Resumen de: WO2024133585A1
The present invention provides a nebuliser (100) comprising one or more inputs (110), and a plurality of droplet ejectors (126) in fluid communication with the one or more inputs (110). Each droplet ejector comprises a nozzle portion and a piezoelectric actuator. The one or more inputs are for receiving one or more liquids. Each nozzle portion defines a nozzle outlet in fluid communication with the one or more inputs. Each piezoelectric actuator is operable to cause ejection of a liquid received by one of the one or more inputs through the respective nozzle outlet as one or more droplets to thereby generate an aerosol comprising the one or more droplets ejected by each droplet ejector.
Resumen de: CN120501942A
本发明属于组织工程支架材料技术领域，具体涉及一种磁力辅助制备成分梯度型熔体电写支架的方法。本发明将含核壳结构磁性羟基磷灰石(Fe3O4纳米颗粒和包覆在其表面的羟基磷灰石壳层)、聚己内酯和二氯甲烷的分散液干燥，得到的mHA‑PCL复合原料加热至熔融状态形成的复合熔体经线性梯度磁场处理后，进行熔体电写打印，得到成分梯度型熔体电写支架。该方法通过核壳结构磁性羟基磷灰石在线性梯度磁场中的定向迁移，实现熔体电写支架中羟基磷灰石(HA)含量呈连续线性梯度分布，模拟骨软骨组织内部存在的自然的钙化梯度结构，提升支架的仿生性能，解决传统熔体电写方法制备的支架中HA浓度突变，无法实现梯度渐变的问题。
Resumen de: CN120501928A
本发明涉及一种双向强化高稳定浆料3D打印羟基磷灰石支架的制备方法，首先根据Furnas理论计算纳米球HA和微米球HA的最佳级配比例并进行级配，其次将光固化树脂单体和稀释剂单体按照不同比例混合，加入第一分散剂和光引发剂，避光搅拌，之后将粉体与树脂进行球磨并加入第二分散剂，混合均匀得到羟基磷灰石浆料，最后将羟基磷灰石浆料使用3D打印机打印支架，对打印支架进行清洗、脱脂烧结，得到双向强化高稳定浆料3D打印羟基磷灰石支架；本发明所制备的多孔支架孔隙率为62％，抗压强度可达到14.2MPa，同时通过双重分散剂结合球形粉体协同增强浆料稳定性，能有效提高浆料的流动性和固含量，提高打印支架质量和稳定一致性。
Resumen de: CN120504796A
本发明属于生物医学工程及医用材料领域，公开了一种水凝胶组合试剂，基于水凝胶组合试剂可制备一种强韧水凝胶，所述强韧水凝胶基于全新的双网络水凝胶，其网络由PEGMA/GelNB的共价交联网络和PEGMA自交联网络组成，降冰片烯作为一种刚性结构，在凝胶网络中可以起到一种类似弹簧的作用，可以显著提升水凝胶的拉伸和压缩性能，水凝胶组合试剂制备的强韧水凝胶具有良好的生物活性和优异的力学性能，可在温和条件下快速凝胶化。
Resumen de: CN120501924A
本发明涉及一种自发电的椎间融合器及其制备方法，椎间融合器包括多孔钽支架和设置在多孔钽支架上的生物活性压电陶瓷，所述生物活性压电陶瓷包含羟基磷灰石和钛酸钡；制备方法包括以下步骤：通过3D打印制得多孔钽支架，并在多孔钽支架的上下表面预留生物活性压电陶瓷的组装位，将生物活性压电陶瓷嵌入多孔钽支架上下表面的组装位，钛酸钡和羟基磷灰石的重量比为(92～98)：(2～8)。与现有技术相比，本发明具有利用人体内机械力自发电促进椎体融合、融合器接触面力学性能匹配、提供骨生成相关离子、界面结合较好等优点。
Resumen de: AU2023361612A1
The invention relates to nerve conduits for connecting a lesioned nerve end to a target site. In particular, the invention relates to nerve conduits supporting repair of a nerve lesion and motor control and/or reducing risk of the development of a neuroma at the lesioned nerve end. Accordingly, a nerve conduit (10) for connecting a lesioned nerve end (26) to a target site (28) is suggested, comprising an elongate body (12) formed by a wall (22) and comprising a central portion (14) defining an inner cavity (16) and end portions (18, 19) defining a respective opening (20, 20') to the inner cavity (16) and arranged adjacent to the central portion (14) and at longitudinally opposing ends of the elongate body (12). One end portion (18) is configured as an insertion portion configured for inserting a respective nerve end (26). According to the invention, the other end portion is configured as a nerve end outlet portion (19), wherein an outer diameter of the wall defining the outlet portion (19) is larger than an outer diameter of the wall defining the central portion (14).
Resumen de: EP4454601A2
The invention relates to a custom tool for forming a dental restoration in a mouth of a patient including an occlusal plane. The custom tool comprising a facial mold body for a patient-specific, customized fit with the facial side of at least one tooth of the patient, wherein the facial mold body includes a restorative portion and a first engagement portion extending away from the restorative portion, a lingual mold body for a patient-specific, customized fit with the lingual side of the tooth of the patient, wherein the lingual mold body includes a restorative portion and a first engagement portion extending away from the restorative portion. The first engagement portion of the facial mold body interlocks with the first engagement portion of the lingual mold body. The facial mold body and lingual mold body are configured to combine with the tooth of the patient to form a mold cavity encompassing missing tooth structure of at least one tooth to be restored. The first engagement portion of the facial mold body and the first engagement portion of the lingual mold body extend generally perpendicular to the occlusal plane, and wherein either (i) the first engagement portions are sized and shaped to be adjacent the posterior teeth of the patient, and the restorative portions are sized and shaped to mate with the anterior teeth; or (ii) the first engagement portions are sized and shaped to be adjacent the anterior teeth of the patient, and the restorative portions are sized and sha
Resumen de: US2025129138A1
The present application provides a preparation method for biosynthesis of a human body structural material. A polypeptide has the amino acid sequence of SEQ ID NO. 4, 5 or 6. Recombinant type-VII humanized collagen prepared in the present application has high activity of promoting cell proliferation and does not produce an immune response when applied to a human body, and the preparation method therefor is novel and can obtain the recombinant type-VII humanized collagen on a large scale, and is widely applied in the preparation of human body structural materials.
Resumen de: US2024374359A1
A computer-implemented method for generating a color 3D model for a dental restoration. The method receives color information, a color distribution map. and shape for a tooth. The color information is assigned to the color distribution map. The color information and the color distribution map are then combined with the shape to generate a digital color 3D model. The resulting 3D model includes volumes for different color materials for the restoration to provide for color transition zones, which can be 3D printed from the 3D model to made a corresponding restoration.
Resumen de: CN119654116A
The present invention relates to a step (S01) for generating and storing, by a computer, a plurality of tooth images that are provided so as to be moved step by step in the order of orthodontic stages, a step (S02) for displaying any one of the plurality of tooth images, in which in the tooth images displayed in step S02, in order to determine the overall shape of a transparent orthodontic appliance, first a transverse reference line is provided for each tooth, and then a transverse reference line is provided for each tooth. S03, displaying the reference line, setting a cutting line of the orthodontic appliance in the tooth image displayed in the step S02 and displaying the cutting line, and displaying the semitransparent state of the transparent orthodontic appliance covering the upper tooth and the lower tooth according to the cutting line set in the step S04, and displaying the transparent orthodontic appliance according to the semitransparent state of the transparent orthodontic appliance covering the upper tooth and the lower tooth. And a step (S05) of displaying the first treatment image.
Resumen de: CN120485595A
本申请涉及金属材料增材制造技术领域，尤其涉及一种通过纳米铁粉均匀掺杂抑制β‑fleck缺陷的钛合金及其制备方法与应用。提供的钛合金材料以微米球形钛粉为基材，基材的内部均匀分布纳米铁粉；其中，以钛合金材料的总质量为100％计，纳米铁粉为0.5‑2.0wt％、微米球形钛粉为98～99.5wt％。由于纳米铁粉尺寸小、比表面积大，在激光粉末床熔融过程中快速溶解并均匀扩散至钛基体，避免了微米铁粉因扩散不充分导致的局部铁元素偏析的问题，同时纳米铁粉扩散速度快，并且避免了局部铁富集，确保无出现β相富集区(β‑fleck)和脆性TiFe析出相，有利于钛合金材料的广泛应用。
Resumen de: CN120478726A
本发明涉及材料制备技术领域，特别涉及一种用于3D打印构建组织工程皮肤的复合生物墨水及其制备方法和应用，复合生物墨水包括氧化海藻酸钠‑明胶生物墨水和AgNPs胶体溶液，氧化海藻酸钠‑明胶生物墨水通过氧化海藻酸钠与明胶构成席夫碱网络完成凝胶化。通过聚多巴胺原位还原#imgabs0#溶液，得到AgNPs胶体溶液。本发明提供的复合生物墨水具有良好的可打印性、机械性能，可用于3D生物打印；不仅拥有优秀的生物相容性还兼具自愈、抗菌、促进皮肤成纤维细胞增殖、分化的功能，可用于组织工程皮肤支架的制备，促进皮肤组织伤口愈合与功能重建，有较高的应用前景。
Resumen de: CN120478195A
本发明公开一种微藻光合治疗水凝胶面膜及其制备方法，利用悬浮浴3D打印技术与面部扫描技术，使用微藻生物墨水定制化生产3D贴合的面膜，使之在使用过程中利用光合作用产生氧气并释放有效成分，起到产氧消炎、促进细胞迁移和清除自由基来促进皮肤修复的作用，在二次交联的过程中引入小分子胶原和Se元素，促进细胞增殖与迁移，起着支撑、修复、保护的三重抗衰老作用。本发明可持续和环境友好，配方简单、设计科学，直接利用微藻、以可再生、可降解材料为原料，制备和使用过程无污染排放，原料可回收，与传统的面膜制备方式相比更加低碳环保。
Resumen de: US2024099816A1
Methods and systems are provided for diagnosing and generating a treatment plan for temporomandibular joint dysfunction where a polymeric shell appliance is utilized to generate one or more activation forces that facilitate tooth movement. The polymeric shell appliances may comprise one or more tooth receiving cavities, in which each of the plurality of tooth receiving cavities is shaped and arranged to provide a counter moment of each of the plurality of teeth.
Resumen de: CN120484471A
本发明属于生物医用材料技术领域，提供了一种聚L‑丙交酯‑己内酯复合材料及其制备方法和应用、血管支架。本发明的复合材料以聚L‑丙交酯‑己内酯（PLCL）和金属氧化物（三氧化二铁、氧化镁、氧化锌和二氧化钛中的一种或多种）为制备原料。相比PLLA，本发明的复合材料具有更好的强度和韧性；金属氧化物可以提高聚合物PLCL的降解速度。所以，本发明的复合材料兼具优异的韧性、强度和降解速度。进一步地，尤其是当金属氧化物为三氧化二铁时，所得复合材料的断裂伸长率和拉伸强度都有显著提升；且体外降解速率也有显著提升；同时，具有优异的生物相容性。
Resumen de: CN120478739A
本发明公开了一种可体温回复的形状记忆血管支架及制备方法，其制备方法包括：将聚乳酸粒料烘干后，加入PEG增韧，熔融共混，再加入聚乳酸纤维作为增强相，螺杆挤出得到复合材料，该材料相对于纯聚乳酸材料而言，提高了形状记忆材料的韧性，降低了形状记忆材料的形状回复温度，实现“人体体温”下形状回复。通过3D打印制备血管支架，本发明制得的形状记忆血管支架具有较好的回复率、固定率、更低的回复温度以及良好的生物相容性。
Resumen de: CN120478721A
本发明涉及生物医用材料技术领域，公开了一种改性聚己内酯支架及其制备方法和应用。所述改性聚己内酯支架包括由以下原料制备得到：聚己内酯、羟基磷灰石、纳米粘土和溶剂；其中，所述纳米粘土选自蒙脱石、层状双氢氧化物、凹凸棒石、海泡石、高岭土和合成型纳米粘土中的至少一种。本发明提供的改性聚己内酯支架，基于羟基磷灰石和纳米粘土的协同作用，实现了力学性能、生物活性和免疫调控功能的协同优化，支架具有接近松质骨的抗压强度，通过多级孔道结构和亲水性表面显著促进细胞粘附与迁移，羟基磷灰石与纳米粘土的协同作用不仅诱导干细胞成骨分化，还调控巨噬细胞向促修复的M2型极化，创造了利于骨再生的微环境。
Resumen de: WO2025168626A1
The invention relates to a device for producing three-dimensional screen-printed workpieces, in particular a 3D screen-printing system, comprising a printing device having a printing screen for producing at least one screen-printed workpiece layer by layer in a plurality of printing processes and comprising a metering device (18) for metering a pasty printing compound onto the printing screen, wherein the metering device has at least one container (20) for storing the pasty printing compound, a dispensing device (24) for dispensing the printing compound onto the printing screen, and a supply line (26) extending between the container and the dispensing device and supplying the printing compound from the container to the dispensing device.
Nº publicación: WO2025166443A1 14/08/2025
Solicitante:
VOXCELL BIOINNOVATION INC [CA]
VOXCELL BIOINNOVATION INC
Resumen de: WO2025166443A1
One aspect described herein is a method of 3D printing a tissue model in a contained volume of photocrosslinkable bioink located on a print surface. The bioink may contain living cells. The method may comprise maintaining, with the print surface, a cell viability temperature of the contained volume; locating an objective lens vertically in a bottom working plane within the contained volume and successive working planes located above the bottom working plane by moving the lens vertically relative to the surface; and in the bottom working plane and each successive working plane, moving the voxel horizontally by directing the laser beam into the objective lens at different angles at different times; focusing, with the objective lens, at each different angle and time, the laser beam into a voxel; polymerizing, with the voxel, a portion of the contained volume at each horizontal location; and moving the contained volume horizontally.
BOPI
Sede Electrónica
