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202
resultados
Última actualización
27/12/2025 [07:17:00]
Resumen de: CN121197551A
本发明公开了一种3D打印光固化骨修复膜及其制备方法，骨修复膜由光固化树脂组合物通过光固化3D打印成型，其厚度为0.1‑0.3mm，具有三维连通的孔隙结构；所述光固化树脂组合物包括高分子树脂、活性稀释剂和光引发剂，其中，高分子树脂与活性稀释剂的质量比为0.5‑3:1，光引发剂的质量为高分子树脂质量的0.1%~10%。本发明3D打印光固化骨修复膜与骨创面填充作用的骨粉相匹配使用，能紧密贴合于骨粉填充的骨创面表面，无需缝合固定，简化临床操作流程，以实现屏障作用，降低创面二次损伤风险；且该骨修复膜兼具良好生物相容性、可控降解性与三维连通孔隙结构，能匹配骨组织再生速率，且工艺可控性强，可精准调控结构与性能，满足骨组织修复需求。
Resumen de: CN121196807A
本发明涉及制备数据处理技术领域，尤其涉及一种用于微创植入的3D打印假体及其制备方法，包括物理结构装置和集成控制模块，物理结构装置由多个通过3D打印制造的PEEK材料分块模块组成，每个分块模块包括榫卯结构的拼接接口和装配标识；集成控制模块包括数据获取单元、分块优化单元和制造控制单元。制备方法获取患者特定解剖结构的医学影像数据构建三维数字模型，生成可打印三维模型数据驱动3D打印设备制造分块模块，最终在微创手术中依据装配标识引导模块植入和拼合。本发明实现从医学影像到假体植入的全流程自动化处理，有效解决复杂解剖结构假体在微创条件下力学性能与拼接可靠性协同优化的技术问题。
Resumen de: CN121197512A
本发明公开一种静电纺丝‑3D打印联用制备仿生骨支架复合材料及其制备方法，涉及到仿生骨支架复合材料技术领域。一种静电纺丝‑3D打印联用制备仿生骨支架复合材料，其特征在于，生物可降解高分子聚合物80‑100份、生物活性无机陶瓷材料5‑30份、溶剂200‑500份、生物活性因子0.01‑5份、抑菌活性化合物0.1‑0.5份、柚皮苷0.01‑5份。本发明以甲硝唑衍生物提供抑菌能力，搭配柚皮苷实现抗炎与促成骨协同作用，规避传统抗菌手段的耐药性或药物释放不均问题，同时增强支架对骨再生的诱导效果，降低修复过程中的感染风险。
Resumen de: CN121197510A
本发明公开了一种协同效用的3D打印金属植入物及其制备方法。该植入物是由3D打印多孔金属植入物基体通过微弧氧化处理和表面刻蚀，表面形成纳米锥型针结构后，再依次通过含抗菌离子的溶液浸渍、热处理、含有复合功能物的悬浊液浸渍和热处理制得。本发明制备的3D打印金属植入物具有稳定长效抗菌性能以及优异的生物相容性和促进骨整合效果。制备方法简单，成本低廉，适合工业化生产。
Resumen de: CN121197515A
本发明适用于生物医用材料技术领域，提供了基于木犀草素化学接枝的复合支架及其制备方法和应用。将聚己内酯二醇、聚乙二醇、木犀草素通过化学接枝法形成高分子聚合物，经3D打印制成支架形态。本发明合成过程简单且成本低廉，通过氨基甲酸酯键构建木犀草素化学接枝的聚己内酯二醇/聚乙二醇高分子聚合物复合支架，既实现了木犀草素在支架中的均匀分散与缓释，解决了木犀草素水溶性差、代谢速度快及物理共混易团聚的问题，又借助木犀草素调控巨噬细胞M2型极化的功能实现免疫调节性骨再生，同时改善了高分子复合支架表面亲水性；该复合支架可应用于免疫微环境异常状态下的骨缺损等生物医学领域，通过上述作用共同促进骨缺损区域的修复。
Resumen de: MX2025011659A
The present disclosure discusses techniques for marking a dental appliance. A dental model and dental appliance are positioned onto a conveyor tray, which is transported to a scan station. The dental model and conveyor tray each include an identifying code. The scan station includes a camera and barcode reader to read the identifying codes on the dental model and conveyor tray, and these codes are associated with one another. The conveyor tray then moves to a marking station where a barcode reader reads the code on the conveyor tray, and then marks the dental appliance with the appropriate marking.
Resumen de: CN121197516A
本发明公开了超亲水抗污的3D打印硅橡胶瓣膜复合材料及其制备方法和应用，涉及高分子复合材料技术领域。该超亲水抗污的3D打印硅橡胶瓣膜复合材料包括3D打印硅橡胶瓣膜复合本体材料和超亲水改性涂层，3D打印硅橡胶瓣膜复合本体材料包括以下重量份组分：硅橡胶预聚物40‑85份、交联剂40‑85份、无机纳米填料10‑55份和催化剂0.5‑5份，超亲水改性涂层包括以下重量份组分：去离子水5‑96份、聚乙烯醇5‑80份、柠檬酸0.1‑30份和抗菌剂0.1‑10份。本发明还提供了超亲水抗污的3D打印硅橡胶瓣膜复合材料的制备方法和应用。本发明复合材料具有优异的超亲水和抗污功效，有效解决了传统硅橡胶瓣膜易引发血栓和钙化的问题。
Resumen de: CN121197521A
一种适用于富氢键聚合物的3D打印快速固化方法、富氢键聚合物的生物支架，包括步骤：步骤01：制备含有富氢键聚合物与溶剂的直写式打印墨水；步骤02：将墨水通过直写式三维打印构建预定结构；步骤03：将步骤02中所构建的预定结构置于与所述溶剂互溶但不溶解聚合物的替代溶剂中，实现聚合物沉淀固化。本发明打印完成后，立即将预定结构浸泡于高极性替代溶剂中（如水），利用氢键重配原理，使原打印溶剂迅速释放，从而促使聚合物快速沉淀成型。本发明所提供的纳米颗粒能促进溶剂扩散：在墨水中引入羟基磷灰石纳米粒子，构建内部微湍流与扩散通道，显著提升溶剂挥发速率，同时提升支架强度、生物活性及成骨性能。
Resumen de: CN121196669A
本发明涉及一种可定制化可调扩张及振动辅助的3D打印鼻腔支撑装置，一个由生物相容性材料通过3D打印制成的中空管状支撑主体，其前端为圆钝形；多段扩张机构，其包括沿所述支撑主体周侧设置的至少一个扩张单元；所述扩张单元为环状结构，其内锚固有由形状记忆材料制成的功能元件，所述扩张单元配置为在激活时能够发生径向扩张；一个振动与正压辅助模块，其设置在所述支撑主体的尾端，用于产生振动和/或呼气正压。本发明将多段可调扩张与振动/正压辅助结合，并运用个性化3D打印与形状记忆材料技术，能够解决严重鼻塞，使患者在鼻炎发作时仍能顺畅用鼻呼气。
Resumen de: CN121197508A
本发明提供了一种负载马奶来源外泌体的促炎和抗氧化3D打印水凝胶及其制备方法和应用，属于创面敷料技术领域。本发明马奶来源外泌体（M‑Exo）具有良好的促炎作用，能够促进细胞的促炎因子IL‑12p40和TNF‑α的高表达，可以有效杀灭感染性伤创面的微生物。本发明利用蚕丝蛋白肽将M‑Exo包裹起来，所得纳米纤维载药微晶可以作为M‑Exo的ROS响应的纳米载药缓释系统，当感染性创面微环境高表达ROS的时候，蚕丝蛋白肽纳米纤维微晶被溶解，释放M‑Exo，提高T淋巴细胞转化率，快速杀死创面微生物，加速感染性创面愈合。
Resumen de: CN121197220A
本发明提供了一种负载酸马奶来源外泌体的ROS调控水凝胶及其制备方法和在制备烧伤药物中的应用，属于烧伤药物技术领域。本发明利用丝素肽将酸马奶来源外泌体（K‑Exo）包裹起来，所得纳米载药纤维微晶可以作为K‑Exo的ROS响应的纳米载药缓释系统，当烧伤处微环境高表达ROS时候，丝素肽纳米纤维微晶被溶解，释放K‑Exo，有效降低损伤处ROS含量和炎症细胞浸润，加速烧伤处皮肤快速愈合。本发明将K‑Exo负载到GelMa水凝胶中，所得水凝胶表现出具有广谱抗氧化和抗炎生物学效应，以及主动调控免疫系统、ROS响应的控释作用、促进细胞迁移能力、神经再生和血管再生的能力，从而可以提高大面积烧伤难愈性创面的修复。
Resumen de: AU2024241734A1
This invention relates to an implant (10), including a support arrangement (12) manufactured from a form of a porous material, for receiving and supporting stem cells (14) in a supported condition, for receiving a medium in the form of a neural basal and neural induction medium mixture (20) and the support arrangement (12) being shaped and sized to conform to and be received complementally by an implant zone (16). The implant zone (16) being a space defined by an excised portion of a subject's spinal cord (18). The neural basal and neural induction medium mixture (20) provides nutrients for the development of the stem cells (14) and the growth factors, in form of neurotrophin 3, neurotrophin 4 and brain-derived neurotrophic factor (BDNF) encourage and control development of the stem cells (14), the growth factors typically being constituents of the medium mixture (20).
Resumen de: WO2024170549A1
The present invention relates a bioprinted three-dimensional tumor model which is able to reproduce the cellular heterogeneity, the spatial architecture, and the tissue-specific ECM of the tumor microenvironment. In addition, the invention refers to a process for preparing such three-dimensional tumor model, to methods for testing anticancer drugs as well as to the use of the tumor model in developing personalized medicine and developing new therapies based on the understanding of the in vitro tumor progression.
Resumen de: US2024268938A1
Disclosed is a computer-implemented method for closing one or more holes in a bottom section of a three-dimensional digital preparation model of a preparation of a tooth. The tooth is prepared for receiving a dental restoration element with a lower limit of the bottom section of the preparation being prepared in form of a stepless edge. The method comprises receiving the three-dimensional digital preparation model of the prepared tooth. One or more holes of the three-dimensional digital preparation model to be closed are detected within the bottom section. A preparation angle used for preparing the bottom section is determined and the detected one or more holes are closed. The closing comprises an extrapolation of the bottom section into the holes using the determined preparation angle.
Resumen de: WO2024170473A1
The invention provides an excipient composition for the preparation of an amorphous solid dispersion or amorphous solid solution suitable for, i.a., 3D printing of immediate release tablets. The excipient composition comprises: a) 8-20 % by weight of the excipient composition of sugar alcohol, and b) 80-92 % by weight of the excipient composition of a polymer blend, the polymer blend comprising a first polymer component and a second polymer component in a weight ratio of 1:0.55 - 1:1.75, the first polymer component being a copolymer of 1-vinyl-2 -pyrrolidone and vinyl acetate, and the second polymer component being polyethylene glycol-polyvinyl alcohol graft copolymer.
Resumen de: DE102024117454A1
Die Erfindung betrifft eine Kniegelenkendoprothese mit einer Femurkomponente zum Verankern an einem distalen Ende eines Femurs und einer Tibiakomponente zum Verankern an einem proximalen Ende einer Tibia, wobei die Femurkomponente und die Tibiakomponente jeweils eine poröse und/oder Erhebungen und Vertiefungen aufweisende Oberfläche aufweisen.Weiter betrifft die Erfindung ein chirurgisches Kit für den Kniegelenkersatz.
Resumen de: DE102024117508A1
Beschrieben werden ein Knochenimplantat (1), ein Verfahren zur Herstellung eines Knochenimplantats (1) sowie ein Computerprogrammprodukt. Das Knochenimplantat verfügt über eine Manschette (2), die wenigstens bereichsweise einen Innenraum (7) umgibt, und über eine Elektrodenanordnung (3), die zumindest bereichsweise auf einer dem Innenraum (7) zugewandten Innenseite (10) der Manschette (2) angeordnet ist, wobei der Innenraum (7) geeignet ist, ein Knochenersatzmaterial (6) zur Herstellung einer elektrisch leitfähigen Verbindung mit der Elektrodenanordnung (3) aufzunehmen. Die beschriebene technische Lösung zeichnet sich dadurch aus, dass die Manschette (2) auf der Grundlage von Daten, die patientenspezifische Informationen enthalten, mit einem additiven Herstellungsverfahren hergestellt ist, an dem den Defekt (8) umgebenden Knochen (9) befestigbar ist und dass die Elektrodenanordnung (3) mittels einer Stimulationseinheit (5) und eines elektrischen Energiespeichers (11), die zumindest mittelbar an der Manschette (2) befestigt sind, mit elektrischer Energie zur Einleitung eines elektrischen Stroms in das im Innenraum (7) angeordnete Knochenersatzmaterial (8) versorgbar ist.
Resumen de: EP4667037A2
The present invention discloses a patient interface for sealed delivery of a flow of air at a continuously positive pressure with respect to ambient air pressure to an entrance to a patient's airways including at least entrance of a patient's nares, wherein the patient interface is configured to maintain a therapy pressure in a range of about 4 cmH2O to about 30 cmH2O above ambient air pressure in use, throughout a patient's respiratory cycle, while the patient is sleeping, to ameliorate sleep disordered breathing; said patient interface comprising: a plenum chamber at least partially forming a cavity pressurisable to a therapeutic pressure of at least 6 cmH<sub>2</sub>O above ambient air pressure, said plenum chamber including a plenum chamber inlet port sized and structured to receive a flow of air at the therapeutic pressure for breathing by a patient; and a seal-forming structure having a textile membrane constructed and arranged to form a seal with a region of the patient's face surrounding an entrance to the patient's airways, said textile membrane having at least one hole formed therein such that the flow of air at said therapeutic pressure is delivered to at least an entrance to the patient's nares, the seal-forming structure constructed and arranged to maintain said therapeutic pressure in the cavity throughout the patient's respiratory cycle in use, wherein the seal-forming structure includes a flexible support structure to support the textile membrane,
Resumen de: US2024425704A1
The present disclosure provides compounds capable of producing biradical photoinitiators (e.g., cyclic photoinitiators), photo-curable resins produced using one or more biradical photoinitiators, as well as polymeric materials formed using the biradical photoinitiators. Further provided herein are methods of producing the compositions and using the same for the fabrication (e.g., via 3D printing) of medical devices, such as orthodontic appliances.
Resumen de: CN120693184A
Techniques for in vivo printing of deep tissue are described. Some embodiments of the present disclosure relate to a method comprising: obtaining a biopolymer mixture comprising a prepolymer material and a crosslinking agent encapsulated in a carrier particle; delivering the biopolymer mixture to a subcutaneous or deep tissue target location of the subject; and transferring radiation to the subcutaneous or deep tissue target site by transdermal administration using the bioprinting device, the radiation configured to cause the carrier particles to release at least some of the cross-linking agent, the released cross-linking agent configured to cause the prepolymer material to form a gel or polymer matrix.
Resumen de: AU2024221303A1
A method and apparatus enabling additive manufacturing of individualized oral therapeutic capsule forms containing multiple medicinal ingredients, also referred to as a personalized polypill process. A process and supporting apparatus to fulfil the formulated therapy prescribed by a physician to address the medical conditions of an individual patient, furthering the practice of personalized medicine. The methods and apparatus apply to the powder forms of active pharmaceuticals, dietary supplements, and specialized chemicals, such as diagnostic inks and dyes. The methods teach the deposition of computer-controlled amounts of high-potency powder forms of active ingredients deposited in sequential layers into a single delivery form. Each active ingredient layer is sequentially deposited to a programmable dosage accurately controlled with closed-loop gravimetric sensing, enabling sub-milligram mass deposition accuracy. Cumulative doses are compacted into segregated layers of programmable density with the optional addition of an inert barrier film between each chemical entity to minimize interactions.
Resumen de: US2025367348A1
A method for reinforcing a cellularized retinal construct fabricated from (i) endothelial cells; (ii) retinal pigment epithelial cells and/or photoreceptors; and (iii) an extracellular matrix (ECM) hydrogel is disclosed. The method comprises contacting the construct with a biocompatible small-molecule reinforcing agent that is capable of chemically interacting with the ECM hydrogel under conditions that maintain viability of the cells, to thereby increase a compressive modulus of the ECM hydrogel by at least 10%.
Resumen de: EP4667002A1
A method for manufacturing a tablet, preferably a 3D printable pharmaceutical product (100). The method as described herein comprises repeated steps of: providing a layer of a homogeneous powder formulation (1), the formulation comprising a first excipient (2) and an active pharmaceutical ingredient (3). The tablet comprising a core and an enteric coating. Preferably the core comprises an active pharmaceutical ingredient (API).
Resumen de: US2024376039A1
The present disclosure provides monomer compounds that can produce desirable polymeric materials and photo-curable resins. Further provided herein are methods of producing compounds, compositions, resins, devices, and polymeric materials. Also provided herein are methods of using compounds, resins, and polymeric materials for the fabrication (e.g., via 3D printing) of medical devices, such as orthodontic appliances.
Nº publicación: GB2641942A 24/12/2025
Solicitante:
PRAKASH CRJ NAIDU [GB]
Prakash CRJ Naidu
Resumen de: GB2641942A
A bite fork or bite tray device with channels to facilitate flow of impression material through the substrate while held inside a patient's oral cavity to obtain bite registration or impression consisting of full or partial teeth impression or full or partial gum impression or alveolar bone or alveolar process or alveolar ridge or a combination of these. A process for use of the system for prescription or design or manufacture of an appliance by providing the necessary steps.
BOPI
Sede Electrónica
