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322
resultados
Última actualización
30/04/2026 [07:15:00]
Resumen de: WO2025079951A1
The present invention relates to a method for designing, using a computer, an orthodontic device on the basis of partial designation of teeth, the method being characterized by comprising the steps of: displaying the arrangement of teeth of a patient (S01); setting up and displaying all the teeth in the arrangement of teeth in the state after orthodontics (S02); designating teeth in the teeth arrangement (S03); designating specific portions in the designated teeth (S04); and inputting the thickness of the orthodontic device in contact with the specific designated portions in the designated teeth (S05).
Resumen de: CN121910496A
本发明提供了一种数字化定制的推磨牙矫治器及其制作方法，涉及医疗器械领域。该方法包括：获取患者口腔三维数据建立数字牙列模型；基于模型设计包括定制式带环和横腭杆的一体式结构，并在横腭杆上设计微种植钉孔；采用增材制造工艺制作该一体式结构；最后将一体式结构与一螺旋扩弓器连接。本申请提供的矫治器包括：与磨牙固定的定制式带环、横跨上腭的横腭杆、以及设置在横腭杆上用于植入微种植钉的微种植钉孔，其中带环与横腭杆为一体式结构，并与一螺旋扩弓器连接。本申请解决了现有推磨牙矫治器磨牙远中移动效率不高、支抗不足、舒适度差及个性化精度低的问题，通过数字化流程和骨性支抗，实现了高效精确的矫治，同时提升了佩戴舒适度。
Resumen de: CN121910946A
本申请提供了一种具有取向排列的生物材料基水凝胶及其制备方法，所述生物材料基水凝胶通过包含下述步骤的方法制备得到：将修饰的生物材料溶于培养基中，并加入交联剂和引发剂得到混合物；将混合物进行3D打印，并进行交联得到所述生物材料基水凝胶，其中3D打印的喷嘴直径为200‑350μm，所述的生物材料基水凝胶具有优异的取向排列，用于损伤修复场景时无二次损伤，高水合条件匹配体内组织的理化特性，所述的方法支持一体化成型，无需支撑浴、助剂或纤维加入，且成胶可在1min之内完成，具有高细胞活性；无需额外准备纤维或支持浴，溶解迅速，便于多场景使用，并且实现载多细胞打印构建取向性组织，操作简便，可满足多动物类型、不同尺寸移植需求。
Resumen de: CN121913779A
本发明提供一种氧化锆陶瓷牙周夹板的制备方法，包括以下步骤：制备具有氧化锆粉与醚类有机溶剂的陶瓷浆料；根据患者口内扫描数据，设计贴合患者牙齿舌侧形态的牙周夹板三维数字模型；将陶瓷浆料置入喷墨3D打印设备，将陶瓷浆料与支撑材料同步喷射，逐层打印出牙周夹板的生胚，并在逐层打印过程中，于牙周夹板内部生成若干微腔；对生胚进行高温烧结，得到氧化锆陶瓷牙周夹板成品，将微胶囊分散于溶剂中，通过真空浸渍使微胶囊溶液渗入微腔内部，然后干燥去除溶剂，以使微胶囊置入微腔中；本发明提高牙周夹板的生物相容性，适配不同患者的具体牙周轮廓，固定松动牙，保持牙列固定，并可实现抗菌剂的持续稳定释放，预防牙周感染。
Resumen de: CN224155791U
本实用新型公开了一种个性化根型种植体；包括种植本体，所述种植本体的上端开设有中央螺丝孔，所述中央螺丝孔的上部开设有莫氏锥度孔，所述莫氏锥度孔的上端开设有内六角基座孔；本实用新型采用Ti‑Ta合金的种植体，接近人体骨组织，有效降低应力屏蔽效应；同时，钽元素的引入提高了材料的耐腐蚀性和骨结合能力；采用3D打印技术实现种植体完全匹配拔牙窝形态，骨内部分表面构建仿生骨小梁多孔结构的骨孔和凸块，使得种植体便于在牙窝中进行安装；并且在种植体上端设计中央螺丝孔和莫氏锥度孔，便于对假牙进行安装连接，以及在上端设有内六角基座孔，便于提高假牙的连接稳定性，防止假牙旋转脱落。
Resumen de: CN121311220A
In some aspects, the present disclosure relates to oral pharmaceutical dosage forms configured to release a drug at a desired location in the colon of an individual. As provided in certain aspects, the oral pharmaceutical dosage forms include a pharmaceutical component containing an erodible material mixed with the drug and a delay component not mixed with the drug, where the delay component is configured to prevent release of the drug from the pharmaceutical component until the oral pharmaceutical dosage form reaches the colon of the individual after administration. In other aspects, the present disclosure relates to methods of design, methods of preparation, such as the use of three-dimensional printing, and methods of treatment related to the oral pharmaceutical dosage forms described herein.
Resumen de: WO2026085159A1
Disclosed are methods and compositions to enable bioprinting of energy-responsive bioinks. The embodiments of the present disclosure relate to ultrasound-controlled gene delivery to a target cell in a three-dimensional bioprinted cell construct. The compositions include, for example, a hydrogel scaffold with a plurality of filament structures printed on a substrate; and a collagen cast gel that encases the hydrogel scaffold; wherein the compositions are configured to receive a population of microparticle-coupled cargo for controlled delivery to one or more target cells by application of ultrasound energy. Also disclosed are methods of creating transgenic target cells using the disclosed compositions.
Resumen de: US20260108198A1
Techniques are disclosed for using both feature delineation and machine learning to detect cardiac arrhythmia. A computing device receives cardiac electrogram data of a patient sensed by a medical device. The computing device obtains, via feature-based delineation of the cardiac electrogram data, a first classification of arrhythmia in the patient. The computing device applies a machine learning model to the received cardiac electrogram data to obtain a second classification of arrhythmia in the patient. As one example, the computing device uses the first and second classifications to determine whether an episode of arrhythmia has occurred in the patient. As another example, the computing device uses the second classification to verify the first classification of arrhythmia in the patient. The computing device outputs a report indicating that the episode of arrhythmia has occurred and one or more cardiac features that coincide with the episode of arrhythmia.
Resumen de: AU2026202533A1
22549546_1 (GHMatters) P117197.AU.1 Provided herein are systems for modeling a patient’s cardiac electrical activity data, including at least one diagnostic catheter for insertion into the heart of the patient and a processing unit. The at least one diagnostic catheter includes at least one recording element to record patient data over multiple cardiac cycles. The patient data includes biopotential data and localization data of the at least one recording element. The processing unit includes a clustering routine that: receives the recorded patient data; segments the recorded patient data by cardiac cycle to produce segmented patient data; groups the segments based on one or more characteristics of the segments to produce segmented data groups; and combines the segmented patient data within each segmented data group to produce one or more composite recordings. The systems create one or more models of cardiac electrical activity of the patient based on the one or more composite recordings. pr p r
Resumen de: US20260108468A1
0000 A product of additive manufacturing with a silicone-based ink having core-shell microspheres, where the product has a plurality of continuous filaments. The product includes a plurality of core-shell microspheres. Each core-shell microsphere includes a polyorganosiloxane shell and one or more cores inside the shell, at least one of the cores having a carrier and at least one component configured to be released post processing. An average diameter of the cores of the plurality of core-shell microspheres is in a range of greater than 2 μm to less than about 100 μm.
Resumen de: US20260108739A1
0000 A system and method for applying stimulation therapy to a patient, the system including a first stimulation strip that includes a first elongated portion configured to be placed on the upper eyelid of the first eye of the patient and a second elongated portion configured to be placed on the lower eyelid of the first eye of the patient, wherein the first stimulation strip includes: a first plurality of individually controlled electrodes configured to deliver a microcurrent stimulation therapy to the patient, a first plurality of individually controlled light emitters configured to deliver light stimulation therapy to the patient, and a first plurality of individually controlled heat sources configured to deliver heat therapy to the patient; and a controller operatively coupled to the first stimulation strip and configured to control delivery of the microcurrent stimulation therapy, the light stimulation therapy, and the heat therapy.
Resumen de: US20260108329A1
A method for creating a digital 3D model of a patient's dentition, according to the invention, provides that in a computing unit for a plurality of dentition variants, each comprising a combination of a digital 3D model of the upper jaw and a digital 3D model of the lower jaw of the patient, which differ from each other in the relative positioning of the upper and lower jaws, respectively: the digital 3D model of the upper jaw is combined with the digital 3D model of the patient's lower jaw in such a way that the upper and lower jaws rest on each other at a number of contact points without any spatial overlap of parts of the upper and lower jaws, andthe contact surface between the upper and lower jaw is determined, whereby an optimized denture variant is selected as a 3D model of the denture, taking into account the contact surface.
Resumen de: WO2026080955A1
The invention relates to a method for producing a template for a bone plate for treating a fracture of a bone of a human or animal, in particular for a bone plate for treating a pelvic fracture of a human. According to the invention, in order to produce the template in a patient-specific manner with high practical applicability, a digital data set of an image of bone fragments of the fracture is obtained using an imaging method, in particular an MRI or CT or X-ray method, wherein the method comprises the following steps: a) creating a digital, in particular virtual, three-dimensional bone model of the bone fracture fragments on the basis of the data set; b) determining a digital template design adapted to the bone model; c) producing, in particular 3D printing, the template on the basis of the determined template design. The invention also relates to a data processing device, to a system for producing the template, and to a computer program product.
Resumen de: US20260108326A1
Systems and methods for identifying teeth in a patient image are provided. For example, a computer-implemented method can include, by one or more processors, accessing a 2D image including a depiction of a patient's teeth, where a plurality of the depicted patient's teeth are annotated with tooth identifiers according to a first tooth identification scheme. The computer-implemented method can further include transmitting, to a server computing device, the 2D image, and receiving from the server computing device, a second tooth identification scheme for the patient's teeth in the 2D image. The second tooth identification scheme can be generated by accessing a 3D model of the patient's teeth, projecting the 3D model onto the 2D image, comparing the projection to the 2D image to determine a probability parameter for each of one or more teeth in the 2D image, and determining, based on the probability parameters, the second tooth identification scheme.
Resumen de: US20260108304A1
A modified digital library and an algorithm able to make six functions for the improvement of most implant planning software used for the design of the custom surgical guide are provided. The prior art implant planning software available on the market, improved by the modified digital library and algorithm presented here, is essential to guide the digital design of both the custom surgical guide and the CAD-CAM cemented prosthesis onto straight or angled prefabricated abutments, through preliminary determination of abutment position with respect to an appropriate system of reference planes in correspondence with digital crown design. Furthermore, in a future perspective, the improved implant planning software presented here could be usefully employed in robot-assisted dental implant surgery.
Resumen de: US20260108215A1
0000 The present invention relates to a method for predicting the prognosis of intravitreal injection treatment, comprising the steps of: receiving OCT images and clinical information of a plurality of diabetic macular edema patients; extracting one or more major lesion information from the OCT images; training a multi-modal deep learning model by inputting the OCT images, the clinical information, and the one or more major lesion features, and outputting the intravitreal injection treatment prognosis of the diabetic macular edema patients; and predicting the prognosis of intravitreal injection treatment by inputting the OCT images, the clinical information, and the major lesion features of a specific diabetic macular edema patient to the trained multi-modal deep learning model.
Resumen de: US20260108172A1
0000 Disclosed is a bioimpedance measurement system: A stabilized high frequency current generator is connected to padset electrodes via a patient cable. Electrodes are connected to an adaptive circuit that conditions the resulting voltage signal and converts it to digital form. Firmware performs signal acquisition and relays data to the device.
Resumen de: US20260108275A1
A spatial frame apparatus for positioning on a patient to treat an injury. The apparatus includes a frame having one or more motorized struts. One or more motorized struts include one or more motors configured to cause movement of one or more motorized struts in one or more directions in accordance with one or more treatment plans. The apparatus includes one or more processing 2024/102351 components communicatively coupled to one or more motorized struts and/or one or more motors. One or more processing components determine one or more loading parameters on the one or more motorized struts. The loading parameters define loading on the one or more motorized struts resulting from the frame being positioned and/or adjusted on the patient. The processing components execute at least one adjustment of one or more motorized struts based on the determined loading parameters.
Resumen de: US20260108182A1
0000 Systems and methods are directed to screening a subject for motor and cognitive impairment. A method for screening motor and cognitive impairment comprises administering a spiral tracing assessment to a subject, and receiving a response thereto; assessing the subject's performance based on the response; collecting performance parameters based on the subject's performance on the spiral tracing assessment; providing the performance parameters and the response to a pretrained machine learning model; predicting, using the pretrained machine learning model, a likelihood of the patient having a cognitive impairment; determining a motor and cognitive impairment status of the patient based on the prediction; and outputting the motor and cognitive impairment status.
Resumen de: WO2026083104A1
This invention relates to a method of manufacturing a membrane for lateral flow assay or rapid diagnostic assay, a device comprising a membrane for detecting an analyte in a sample and the use of the device for detecting an analyte in a sample, wherein a two-dimensional barcode of a plurality of reagent dots comprising bioreceptors is patterned or printed on the membrane, the plurality of reagent dots being arranged in form of a two-dimensional barcode visible after the completion of the test and in which a certain information associated with the analyte is embedded, and to the use of said device.
Resumen de: WO2026083418A1
The present invention provides a photopolymerisable composition for 4D printing, comprising an acrylated polyol (AOPO) derived from a natural oil, such as olive oil, and acrylic acid as a comonomer. The composition is used in a solvent-free digital light processing (DLR) method to fabricate high-resolution, multifunctional objects. The resulting 4D printed objects are biocompatible, hemocompatible, and cytocompatible. They exhibit excellent temperature- responsive shape memory properties activated near body temperature, inherent antimicrobial activity against both gram-negative and gram-positive bacteria, and tuneable mechanical properties suitable for soft tissue engineering. Furthermore, the composition can be loaded with therapeutic agents, such as progesterone, to form biodegradable objects capable of sustained, controlled drug release. These properties make the material ideal for medical implants, cardiovascular stents, and drug delivery devices.
Resumen de: US20260108339A1
0000 A drug delivery device may include a component with a bonding location to be bonded to a surface of one or more teeth. A cavity may hold a formulation that includes a compound, and an orifice may release the compound outside the component.
Resumen de: WO2026085208A1
An ink composition for a tattoo stencil and methods of making the same are disclosed herein. The ink composition comprises a plurality of cationic violet dyes in combination with a humectant, optionally along with surfactants and/or alcohol. It exhibits enhanced color vibrancy and color reproduction of the transferred tattoo design. The disclosed ink composition also exhibits excellent stability under thermal conditions and is suitable for long-term storage.
Resumen de: US20260108673A1
A vision-enabled fluid flow rate detection system is disclosed. The system includes an image sensing device that images an infusion container supplying a fluid to an infusion pump and a pattern of markings associated with a surface of the container, and identifies a visual difference in the pattern from a default state of the pattern to determine a volume of fluid infused from the infusion container, and used to calculate a volume of fluid in the container and a flow rate of the fluid. When the amount of fluid, as determined by the vision system, differs from the amount reported by the pump, the pump's motor may be adjusted to correct the expected volume or flow rate, as needed. When a severe infusion inaccuracy is detected, an alarm or other indication may be provided, or the infusion terminated.
Nº publicación: US20260108889A1 23/04/2026
Solicitante:
UNIV OF FLORIDA RESEARCH FOUNDATION INCORPORATED [US]
Resumen de: US20260108889A1
Described herein is microfluidic droplet generation device for producing multicellular collagen encapsulated spheroids. The multicellular collagen encapsulated spheroids can be used as bio-ink comprising multicellular collagen encapsulated spheroids and a scaffold which can be used to 3D bio-print in vivo-like 3D tumor models. When combined together the 3D multicellular collagen encapsulated spheroid generation platform is adjustable, can be used for high-throughput generation of 3D multicellular collagen encapsulated spheroids and 3D tumor models, and can be used to produce 3D multicellular collagen encapsulated spheroids and 3D tumor models at large scale.
BOPI
Sede Electrónica
