Alerta

一种极小曲面结构多孔钽的制备方法及其医疗应用

Resumen de: CN120133543A

本发明涉及一种基于极小曲面结构的多孔钽材料的制备方法及其医疗应用，尤其应用于椎间融合器、人工椎体、髋关节臼杯、关节填充块和牙种植体等医疗植入物。材料为纯钽或含钽合金（如钽钛、钽铌、钽锆、钽钛铌锆，钽含量大于1%），采用增材制造技术构建，孔隙率30~90%，其相比于桁架孔道结构（如菱形十二面体）无明显的应力集中点，在强度、模量、抗疲劳性能等方面均有显著提升，特别适合用于大面积和承重骨缺损的结构和功能重建。

一种兼具抗菌与促成骨性能的钛基植入物及其制备方法和应用

Resumen de: CN120132042A

本发明公开了一种兼具抗菌与促成骨性能的钛基植入物及其制备方法和应用，属于生物医用材料与生物医学交叉技术领域。本发明以选区激光熔化多孔钛合金为基体，利用微弧氧化和水热处理，在其表面构建兼顾抗菌及促成骨的多功能复合涂层；并通过掺杂功能性元素对涂层的微观结构及生物学性能进行调控，从而对涂层的抗菌性能和促成骨性能进行优化。

钛合金粉末材料、钛合金及其制备方法、应用

Resumen de: CN120133517A

本申请属于合金材料技术领域，尤其涉及钛合金粉末材料、钛合金及其制备方法、应用。该钛合金粉末材料包括纳米Fe颗粒、纳米TiO2颗粒和Ti颗粒，其中纳米Fe颗粒、纳米TiO2颗粒分布在Ti颗粒的表面。该钛合金粉末材料中的Fe和TiO2以纳米颗粒的形式存在，并分布在Ti颗粒的表面，这样的分布有利于提高Fe元素和O元素的分布均匀性，缓解元素偏析形成有害力学性能的β‑fleck问题，进而改善钛合金的力学性能均匀性。

一种3D打印超材料压电型骨缺损修复支架及其制备方法

Resumen de: CN120132062A

本发明属于生物医学工程与增材制造交叉领域，具体涉及一种3D打印超材料压电型骨缺损修复支架，所述支架的孔隙结构由数学表达式定义的Gyroid、SchwarzP和Diamond三种极小曲面单元复合构成；所述支架的孔隙率为30％‑70％，孔径范围为0.1‑1mm；所述支架的材料为由聚偏氟乙烯、聚乳酸及钛酸钡组成的压电复合材料，所述压电复合材料按质量百分比如下：聚偏氟乙烯(PVDF)30％‑55％，聚乳酸(PLA)20％‑45％，钛酸钡(BaTiO3)10％‑25％，且各组分的质量百分比之和为100％。该发明通过多材料3D打印技术实现宏观结构及微观结构的精准调控，具有力学适配性、降解可控性和主动促进骨再生功能，适用于颅颌面、四肢长骨等大段骨缺损修复场景。

一种有支撑富弹性和防逆流功能的组织工程泪道

Resumen de: CN120131256A

本发明公开了组织工程与再生医学技术领域的一种有支撑富弹性和防逆流功能的组织工程泪道，包括由脱细胞气管基质材料构成的泪道管主体，泪道管主体外表面外覆有外螺旋加固层，外螺旋加固层表面包裹有生物羊膜，泪道管主体的中部设有若干特斯拉阀结构，底部设有防逆流瓣膜。本发明采用脱细胞气管、生物羊膜、3D打印聚氨酯为支架构建组织工程泪道，并将特斯拉阀结构和防逆流瓣膜应用到组织工程泪道，从而保持泪管弹性且防止泪液和鼻腔分泌物及气体逆流。

骨性Ⅱ类错颌畸形正颌手术辅助器械组件及其制备方法

Resumen de: CN120131133A

本发明提供一种骨性Ⅱ类错颌畸形正颌手术辅助器械组件及其制备方法，截骨辅助部件包括固定支持夹板与第一定位导板，第一定位导板中设有截骨定位槽、钛钉定位孔与髁突位置指示孔，固定支持夹板与第一定位导板通过第一连接杆保持固定姿态连接；定位辅助部件包括咬合夹板、髁突定位板与第二定位导板，髁突定位板贴合于患者的近心段下颌支表面，与患者的下颌支固定连接，第二定位导板中设有钛板定位框，咬合夹板分别与髁突定位板及第二定位导板通过第二连接杆及第三连接杆保持固定姿态连接。通过本发明，可建立与患者颌骨精准适配的截骨辅助部件与定位辅助部件，实现对颌骨的定位与固定功能。

HYDROGEL-EXTRACELLLAR MATRIX GRANULAR COMPOSITES WITH VISCOUS INTERSTITIUM

Resumen de: WO2025122495A1

Composite matrix materials including a plurality of microgel particles having a mean particle size in a range of about 1 μm to about 100 μpm, and an interstitial matrix, where the composite matrix is characterized by reversible yield-stress behavior at 4°C; methods of preparation of the composite matrix materials; and methods of preparing organoids from the composite matrix materials are disclosed.

BONE REPAIR MATERIAL, PREPARATION METHOD THEREFOR, AND USE THEREOF

Resumen de: WO2025118246A1

Provided are a bone repair material, a preparation method therefor, and use thereof. The bone repair material is prepared by printing with a material slurry by means of a photocuring 3D printing method and then sintering. The material slurry comprises the following components: 55-65% by mass of bioactive glass, 30-40% by mass of photosensitive resin, 1-5% by mass of a dispersing agent, and 0.1-1% by mass of a photoinitiator. The bone repair material has excellent biocompatibility and relatively high porosity, with the hemolysis rate lower than 5% and the cytotoxicity less than 30%. In addition, the bone repair material has relatively good morphology and relatively superior mechanical properties, and thus can be used as a bone repair scaffold material.

BIODEGRADABLE 3D PRINTED STRUCTURE FOR BONE AUGMENTATION

Resumen de: WO2025120338A1

Biodegradable 3D printed structure for bone augmentation (1) comprises an outer structure (100) and an inner structure (200) that are printed from polylactide (PLA), wherein the inner structure (200) is filled with a chitosan and hydroxyapatite gel and the outer structure (100) is coated with a chitosan and hydroxyapatite composite. The outer structure (100) has a tunnel-like shape resembling an elongated projection of the letter "U" rotated 180 degrees in depth. Implants made in the form of a biodegradable 3D-printed structure for bone augmentation as disclosed in the present invention can be adapted to each individual patient and each individual situation, which will optimize the dentist's time required for the procedure and treatment, and will also facilitate the recovery of the patient due to the reduction of the invasiveness of the procedure. This makes the entire procedure faster, simpler, and painless, but also financially acceptable for patients.

METHOD OF MANUFACTURING PROSTHETIC SOCKET INTERFACE

Resumen de: US2025190637A1

A method of manufacturing an interface for a body part is described. The method includes the step of selecting an inner radial dimension of the interface to have a plurality of compression areas that extend along the long axis of the interface. The method also includes the step of spacing the plurality of compression areas circumferentially around the long axis of the interface to create a compression pattern. The compression pattern is sized and dimensioned to reduce motion of the skeletal structure towards a wall of the interface when the interface is worn on the body part by compressing soft tissue of the body part against the skeletal structure.

A LENTICULE, METHOD OF PREPARATION AND IMPLEMENTATIONS THEREOF

Resumen de: WO2025120669A1

The present disclosure provides a three-dimensional hydrogel prepared using a bioink composition comprising methacrylated hyaluronic acid, methacrylated gelatin, a photoinitiator and a photoabsorber; and a method for preparing the three- dimensional hydrogel or lenticule. The present disclosure further provides a method of treating corneal tissue repair in a subject in need thereof using the three- dimensional hydrogel or lenticule.

METHOD FOR MANUFACTURING A REMOVABLE PARTIAL DENTAL PROSTHESIS, AND REMOVABLE PARTIAL DENTAL PROSTHESIS

Resumen de: WO2025120283A1

The invention relates to a method for manufacturing a removable partial dental prosthesis, the method comprising the steps of: a) manufacturing at least one monolithic block comprising an artificial tooth part and an artificial gum part, the monolithic block comprising at least one first joining member; b) manufacturing a frame that is configured to support the monolithic block, the frame comprising at least one second joining member; then c) joining the monolithic block to the frame by interlocking the first joining member with the second joining member to form the removable partial dental prosthesis.

SHAPE MORPHING HYDROGEL ACTUATORS AND CONSTRUCTS

Resumen de: US2025186656A1

A construct includes a biocompatible polymer-based shape morphing hydrogel or cell condensate that is configured to undergo multiple, reversible, and/or controllable different shape transformations over time via either pre-programmed design or user-controlled environmental condition alterations, wherein the hydrogel is cytocompatible and, upon degradation, produces substantially non-toxic products.

System and Methods for Preparation of Adipose-Derived Stem Cells

Resumen de: US2025186502A1

A device that allows for either fat graft preparation or cell fraction harvest is disclosed. The device includes a first centrifuge tube configured to receive and process a biological substance, the first centrifuge tube comprising an upper cylindrical portion and a lower conical portion, a sterile tissue inlet fitting, at least one sterile processing fluid inlet fitting, a sterile suction fitting, and at least one sterile extraction port connected to a first extraction tube. The first centrifuge tube further includes an internal space including a screen being positioned therein, the screen being configured to divide the internal space in half, and a filter positioned therein, the filter being positioned below the screen in the lower conical portion of the first centrifuge tube. The device may further include a second centrifuge tube configured to receive and further process the biological substance from the first centrifuge tube. The second centrifuge tube has at least one sterile fitting, wherein the second centrifuge tube is releasably connected via the at least one sterile fitting to one of the at least one sterile extraction ports of the first centrifuge tube.

Photocurable Materials for the Production of Dental Prostheses and Devices

Resumen de: US2025187262A1

A resin based material whose composition includes a light-curable mixture of monomers of no more than 35 wt. % of an ethoxylated difunctional bisphenol A dimethacrylate; of no more than 10 wt. % of a methacrylate monomer; of no more than 10 wt. % of a difunctional urethane acrylate; of no more than 0.1 wt. % of an optical brightener; of no more than 5 wt. % of silica particles having methacrylate functionalization layers and having an average particle size of less than about 200 nm; of having more than 40 wt. % of an inert glass; of no more than 15 wt. % of a heavy metal oxide; of no more than 2.5 wt. % of an ultraviolet/visible (UV/Vis) light-photo-polymerization initiator; a colorant; and a stabilizer.

PRINTING MECHANISM FOR MEDICAL MONITORING DEVICE AND MEDICAL MONITORING DEVICE

Resumen de: US2025187357A1

The present invention provides a printing mechanism for a medical monitoring device and a medical monitoring device. The printing mechanism comprises a support plate, a movable frame assembly disposed movably on the support plate. the movable frame assembly comprising a frame, and a print paper drawer for holding the print papers, the print paper drawer being mounted on the frame to move along with the movable frame assembly. The printing mechanism further comprises at least one set of spaced sleeves provided on a top surface of a body of the support plate in a movement direction of the movable frame assembly. and a guide rod passing through holes defined by each set of the spaced sleeves and secured to a bottom of the frame at two ends. the guide rod guiding the movable frame assembly and moving along with the movable frame assembly, wherein a damping bracket is provided between adjacent sleeves of each set of the spaced sleeves, the damping bracket contacts the guide rod and exerts an upward force onto the guide rod perpendicularly to a movement direction of the guide rod. The printing mechanism for the medical monitoring device according to the present invention may ensure that the print paper drawer is positioned with high accuracy and is opened and closed smoothly when the printing mechanism operates in the horizontally arranged state or the vertically hung state.

THREE-DIMENSIONAL CELL-LADEN BIOINK SCAFFOLDS AND METHODS OF MAKING THE SAME UNDER CRYOGENIC CONDITIONS FOR TISSUE ENGINEERING

Resumen de: US2025188298A1

The present invention provides three-dimensional, cell-laden bioink scaffolds, methods of making and using the same.

PATIENT SPECIFIC SURGICAL GUIDE LOCATOR AND MOUNT

Resumen de: US2025186062A1

A resection guide locator includes a bone engagement portion with surfaces that are complementary to the surface topographies of a bone to be resected during surgery. A housing includes a socket defined by a resilient annular wall that is sized and arranged so to accept a resection guide by press-fit to thereby position and hold the resection guide within the socket. The resection guide is maintained in a predetermined, preferred position while the surfaces are releasably locked in position on the bone. A method is disclosed for forming and using the resection guide locator.

BIODEGRADABLE 3D PRINTED STRUCTURE FOR BONE AUGMENTATION

Resumen de: EP4566637A1

Biodegradable 3D printed structure for bone augmentation (1) comprises an outer structure (100) and an inner structure (200) that are printed from polylactide (PLA), wherein the inner structure (200) is filled with a chitosan and hydroxyapatite gel and the outer structure (100) is coated with a chitosan and hydroxyapatite composite. The outer structure (100) has a tunnel-like shape resembling an elongated projection of the letter "U" rotated 180 degrees in depth. Implants made in the form of a biodegradable 3D-printed structure for bone augmentation as disclosed in the present invention can be adapted to each individual patient and each individual situation, which will optimize the dentist's time required for the procedure and treatment, and will also facilitate the recovery of the patient due to the reduction of the invasiveness of the procedure. This makes the entire procedure faster, simpler, and painless, but also financially acceptable for patients.

ELECTROSURGICAL INSTRUMENT WITH MONOPOLAR AND BIPOLAR ENERGY CAPABILITIES

Resumen de: EP4567142A2

An electrosurgical instrument comprising an end effector including a first jaw, a second jaw, and an electrical circuit is disclosed. The first jaw comprises a first conductive skeleton, a first insulative coating selectively covering portions of the first conductive skeleton, and first-jaw electrodes comprising exposed portions of the first conductive skeleton. The second jaw comprises a second conductive skeleton, a second insulative coating selectively covering portions of the second conductive skeleton, and second-jaw electrodes comprising exposed portions of the second conductive skeleton. The circuit is configured to transmit a bipolar RF energy and a monopolar RF energy to the tissue through the first-jaw electrodes and the second-jaw electrodes. The monopolar RF energy shares a first electrical pathway and a second electrical pathway defined by the electrical circuit for transmission of the bipolar RF energy.

PHARMACEUTICAL FORMULATION PRINTING DEVICE

Resumen de: US2019276239A1

Provided is a pharmaceutical formulation transporting device capable of easily ensuring a large exposed area of a solid pharmaceutical formulation during transport. A pharmaceutical formulation transporting device 10 comprises a first pulley 11, a second pulley 12, and a plurality of endless transport belts 13, 14 wound around the first pulley 11 and the second pulley 12, wherein the plurality of transport belts 13, 14 are disposed so as to be capable of holding a solid pharmaceutical formulation between respective first side surfaces.

METHOD FOR PRODUCING A DENTAL RESTORATION

Resumen de: US2024299144A1

A method of producing a dental restoration (100), including the steps of calculating (S101) a pressure distribution (101) on the oral mucosa (105) through the dental restoration (100) based on a three-dimensional data set (103-DS) of the dental restoration (100) and a three-dimensional data set (103-MS) of the oral mucosa (105); and determining (S102) a spatial region (107) for an elastic production material (109) within the dental restoration (100) based on the calculated pressure distribution (101).

Dental and skeletal training aid and method for producing same

Resumen de: GB2636068A

The present invention relates to an artificial tooth 10 or bone formed from a unitary 3D printable material. An artificial tooth comprises an outer enamel-like portion 12 and an inner dentine-like portion (14) having voids therein. The outer layer offers a high resistance to drilling and may be of stereolithography (SLA) resin comprising three parts: Urethane Dimethacrylate (UDMA), Isobornyl Methacrylate (IBMA) and a reinforcing agent, such as glass filler, ceramic powder, carbon or graphene. The dentine layer has foam or sponge-like properties with voids or channels 16 and is of lower resistance to drilling. A pulp layer 18 of e.g., a wax-type material, 3D printing resin, silicone or rubber may be provided to mimic tooth pulp. The printing method may be e.g., a resin-vat stereolithography or a material extrusion method. Simulated bone may be produced in a similar manner. A tooth may be implanted in a phantom head for training purposes.

一种3D打印的、具有多功能梯度的仿生压电支架、制备方法及应用

Resumen de: CN120114649A

本发明涉及生物医学工程领域，具体涉及一种3D打印的、具有多功能梯度的仿生压电支架，包括3层支架层和1层仿生结构层，仿生结构层置于支架层上，仿生结构层由PDMS阴模翻制为仿生结构，浸泡三氯十八烷基硅烷溶液后得到；支架层在仿生结构层表面，由不同组成的生物墨水经墨水书写式3D打印技术逐层打印得到，生物墨水是将聚(3‑羟基丁酸酯‑co‑3‑羟基戊酸酯)、海藻酸钠和丙烯酰胺加入水、DMF和CH2Cl2配制成的溶剂，再加入光引发剂和交联剂制备得到，仿生压电支架，具有良好的生物相容性、促进肌腱修复、抗炎和抗菌的功能环境，可以有效促进肌腱干细胞增殖与迁移，促进肌腱干细胞诱导分化，为缺损肌腱的修复再生提供物理屏障，具有广阔的应用前景。

3D打印的下颌前移阻鼾器

Nº publicación: CN120114246A 10/06/2025

Solicitante:

中国医科大学附属第一医院中国科学院沈阳自动化研究所

Resumen de: CN120114246A

本发明公开了3D打印的下颌前移阻鼾器，本发明涉及阻鼾技术领域，包括上牙槽和下牙槽，所述上牙槽和下牙槽均通过3D打印而成；所述上牙槽和下牙槽的周边处均匀设置有安装块；所述下牙槽的两端后侧均设置有支撑块，所述安装块和支撑块均通过3D打印而成；通过放在用户周围的噪音传感器检测用户的鼾声，当用户打鼾时，通过控制器和信号发射器控制电动伸缩杆工作，使得输出杆推动导杆移动，进而通过销轴一和销轴二，使得下牙槽向前移动，推动下颌前移，扩大呼吸通道，以阻止打鼾，从而可以在睡着后打鼾时再进行调节，避免用户在初期使用时，出现带着调节好后的阻鼾器往往难以进入睡眠状态的问题。