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ＳＡＬＭＯＮＥＬＬＡ ＥＮＴＥＲＩＣＡを制御するためのバクテリオシン

Resumen de: US2023406892A1

The present invention relates to bacteriocins for control of Salmonella enterica (salmocins). The bacteriocins are derived from Salmonella. The salmocins can be expressed in plants and can be used in a method of preventing or reducing infection or contamination of an object with Salmonella.

Method for analyzing composition of human microbiota based on blood and uses thereof

Resumen de: KR20250073901A

본 발명은 혈액 기반 인체 마이크로바이오타 조성 검사 방법 및 이의 용도에 관한 것으로, 보다 구체적으로는 환자 유래 단리된 생물학적 시료를 384종의 인체 장내미생물 항원으로 이루어진 마이크로어레이에 처리하는 단계를 포함하는 질환 관련 치료제 후보 장내미생물의 스크리닝 방법 및 상기 스크리닝 방법을 통해 선발된 질환 관련 치료제 후보 장내미생물에 관한 것이다.

细菌转染

Resumen de: AU2023361317A1

The present invention relates to a modified live attenuated Gram-negative bacteria, wherein said bacteria has been modified in such a way that RNA molecules can be safely and efficiently delivered to target eukaryotic cells. As such, the present invention relates a to a bacterial delivery system and various uses and methods thereof.

METHODS FOR TREATING INFECTIVE DISEASES

Resumen de: CN120051271A

The present invention provides a method of treating an infectious disease. The method comprises the step of administering to a subject in need thereof an effective amount of (i) a polymer-flavonoid conjugate, (ii) a flavonoid oligomer, or (iii) a micelle having a shell formed from one or more polymer-flavonoid conjugates or one or more flavonoid oligomers, or a combination thereof and having an agent encapsulated within the shell. The methods of the present invention can effectively treat viral infections, such as, for example; severe acute respiratory syndrome coronavirus (SARS-CoV), enterovirus, HIV, hepatitis B virus, MERS-CoV, influenza virus, dengue fever virus, respiratory syncytial virus, hepatitis C virus, monkey pox virus, human papilloma virus, methicillin-resistant staphylococcus aureus, pseudomonas, tuberculosis, bacillus anthracis, tetanus, streptococcus pneumoniae, meningococcus, escherichia coli, bacillus subtilis, bacillus subtilis, bacillus subtilis, bacillus subtilis, bacillus subtilis, bacillus subtilis, bacillus subtilis, bacillus subtilis, bacillus subtilis, bacillus subtilis, bacillus subtilis, bacillus subtilis, bacillus subtilis, bacillus subtilis, bacillus subtilis, bacillus subtilis, bacillus subtilis, bacillus subtilis, bacillus subtilis, bacillus subtilis, bacillus subtilis, bacillus subtilis, bacillus subtilis, bacillus subtilis, bacillus subtilis, , Legionella genus, Neisseria gonorrhoeae, Neisseria meningitidis, and Salmonella genus.

Monoclonal antibody for resisting pathogenic campylobacter and application thereof

Resumen de: CN120040584A

The invention discloses a monoclonal antibody CJ116 for resisting pathogenic campylobacter and an application of the monoclonal antibody CJ116. In the monoclonal antibody CJ116, the amino acid sequence of a heavy chain variable region is as shown in SEQ ID NO.1, and the amino acid sequence of a light chain variable region is as shown in SEQ ID NO.5. The CJ116 monoclonal antibody has high affinity and high specificity, the detection sensitivity of the CJ116 monoclonal antibody to campylobacter jejuni and campylobacter colons can reach 10 < 2 > CFU/mL, and the detection sensitivity of the CJ116 monoclonal antibody to campylobacter fetus, campylobacter upsackii and campylobacter seagull is 10 < 3 > CFU/mL. However, the enteropathogenic bacteria have no cross reaction with other common enteropathogenic bacteria such as pathogenic Escherichia coli, salmonella enteritidis, yersinia enterocolitica, Shigella flexneri, Shigella baumannii and Staphylococcus aureus.

Immunochromatography test strip for rapidly detecting escherichia coli O157: H7 through AIE double labeling and high sensitivity and application of immunochromatography test strip

Resumen de: CN120044235A

The invention discloses an AIE double-labeled high-sensitivity immunochromatographic test strip for rapidly detecting escherichia coli O157: H7 and application thereof, and belongs to the technical field of escherichia coli detection. The immunochromatography test strip consists of a sample pad, a combination pad, a nitrocellulose membrane and an absorption pad which are sequentially connected and fixed on a bottom plate; an escherichia coli O157: H7 detection antibody marked by TCBPE is coated on the combination pad; the nitrocellulose membrane is sequentially coated with a detection line T and a quality control line C which are separated from each other; the detection line T is coated with an escherichia coli O157: H7 capture antibody; and the quality control line C is coated with a goat anti-mouse antibody. The immunochromatography test strip has the advantages of high sensitivity and accuracy, strong stability and convenience in operation. The invention provides a new method for detecting escherichia coli O157: H7.

Wide-splitting-spectrum salmonella typhimurium bacteriophage, bacteriophage composition thereof and application of bacteriophage composition

Resumen de: CN120041399A

The invention discloses a wide-splitting-spectrum salmonella typhimurium bacteriophage, a bacteriophage composition and application thereof, the bacteriophage is named as salmonella bacteriophage PC817 which is preserved in China General Microbiological Culture Collection Center on August 16, 2024, the preservation address is No.3, Yard 1, Beichen West Road, Chaoyang District, Beijing, and the preservation number is CGMCC NO.9687. The invention further discloses a preparation method of the wide-splitting-spectrum salmonella typhimurium bacteriophage. The preservation number of the strain is CGMCC (China General Microbiological Culture Collection The bacteriophage PC817 is a salmonella typhimurium bacteriophage with a wide lysis spectrum, has the characteristic of high lysis rate for different types of salmonella, and can be used for preparing drugs for treating or preventing salmonellosis, environment disinfectants, feed additives, drinking water additives, food preservatives, detection kits and the like. While salmonella typhimurium infection is solved, the problems of antibiotic residues and pathogen drug resistance caused by use of antibiotics are avoided. The bacteriophage and the composition thereof can provide a more effective scheme for prevention and control of pigeon salmonellosis.

Aptamer functionalized DNA (deoxyribonucleic acid) nanosphere for detecting bacteria as well as preparation method and application of aptamer functionalized DNA nanosphere

Nº publicación: CN120041456A 27/05/2025

Solicitante:

UNIV NINGXIA MEDICAL
UNIV SOUTHERN MEDICAL
\u5B81\u590F\u533B\u79D1\u5927\u5B66,
\u5357\u65B9\u533B\u79D1\u5927\u5B66

Resumen de: CN120041456A

The invention discloses an aptamer functionalized DNA (deoxyribonucleic acid) nanosphere, which is formed by self-assembling long-chain DNA serving as a carrier, short-chain DNA and an aptamer, and is loaded with an electrochemical luminescence signal molecule, the short-chain DNA is composed of 166 pieces of fixed short-chain DNA and 5 pieces of variable short-chain DNA. The method comprises the following steps: gradually annealing by utilizing a PCR (Polymerase Chain Reaction) instrument, synthesizing aptamer functionalized DNA (Deoxyribonucleic Acid) nanospheres, carrying out incubation reaction on the aptamer functionalized DNA nanospheres and a bacterial sample, and detecting a solution after reaction by utilizing an electrochemical luminescence instrument so as to confirm whether target bacteria exist or not. The detection method is simple, the nucleic acid aptamer is adopted to specifically recognize the specific antigen on the surface of the bacteria, washing is not needed, the detection time is only 40 minutes, and the method has the advantages of being rapid, simple, high in universality and the like.