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108
resultados
Última actualización
23/08/2025 [07:17:00]
Resultados 50 a 75 de 108
Resumen de: US2025197951A1
This disclosure relates to methods of isolating rare or non-dominant serotypes of Salmonella species from a sample. The disclosure further relates to the isolation of non-dominant serotypes of Salmonella in a sample related to one or more products for human or animal consumption.
Resumen de: AU2023323947A1
The invention is directed to immunogenic compositions and method of treatment comprising a peptide or nucleic acid that encodes the peptide that induces an immune response in a mammal that is protective against infection by one or more pathogens. The peptide sequence contains multiple epitopes, wherein at least one epitope is a composite epitope which is a combination of two or more conserved epitopes of the pathogen wherein the amino acid sequence of the composite is not an amino acid sequence of the pathogen. In addition, the invention is directed to vaccines comprising the peptide or nucleic acid that encodes the peptide for treating and preventing an infection in mammals such as animals and humans.
Resumen de: CN120158403A
The invention provides lactobacillus pentosus YN-02, a product prepared from the lactobacillus pentosus YN-02 and application of the lactobacillus pentosus YN-02, and belongs to the technical field of biological medicine, the lactobacillus pentosus YN-02 is preserved in China Center for Type Culture Collection on October 22, 2024, and the preservation number is CCTCC NO.M20242300; the gene sequence of 16srRNA (Ribonucleic Acid) of the lactobacillus pentosus YN-02 is as shown in SEQ ID NO. 1. According to the lactobacillus pentosus YN-02, the product prepared from the lactobacillus pentosus YN-02 and the application of the lactobacillus pentosus YN-02, the lactobacillus pentosus YN-02 and the product, the lactobacillus pentosus YN-02, the product and the application have a remarkable effect in the aspect of resisting infection of listeria monocytogenes, salmonella enteritidis, escherichia coli, staphylococcus aureus and salmonella typhimurium.
Resumen de: CN120158533A
The invention provides a method for detecting salmonella enteritidis, which comprises the following steps of: 1, expressing a nano antibody for resisting salmonella enteritidis FliC by using escherichia coli, and verifying the nano antibody; step 2, preparing immunomagnetic beads for resisting FliC protein, and verifying the immunomagnetic beads; step 3, carrying out specific enrichment on the target bacteria; 4, performing rapid splitting decomposition to release nucleic acid; step 5, carrying out isothermal amplification on the target DNA fragment; and step 6, CRISPR/Cas12a mediated signal amplification and detection are carried out. The kit has the effects of ultra-fast detection, high sensitivity, high specificity, portability, easiness in operation, no need of bacterial culture and the like.
Resumen de: CN120157916A
The invention relates to the technical field of hydrogel, in particular to a preparation method and application of EGCG-mediated hydrogel, a lysozyme solution is heated under the acidic condition to form lysozyme amyloid fibrils LAFs, EGCG is dissolved in a buffer solution and mixed with the LAFs solution obtained in the step 1 in proportion to form an LAFs-EGCG compound, and the EGCG-mediated hydrogel is prepared. The chitosan CS is dissolved in an acetic acid buffer solution, glutaraldehyde is added to serve as a cross-linking agent, the mixture is mixed with the LAFs-EGCG compound obtained in the step 2 and stirred, the composite hydrogel is formed, the concentration of EGCG is 0.2-1.0 wt%, the concentration of LAFs is 5 wt%, the concentration of chitosan is 2 wt%, the pH value of the lysozyme solution in the step 1 is 2.0, the heating temperature is 77 DEG C, the heating time is 10 hours, the concentration of EGCG in the step 2 is 0.4-0.8 wt%, and the pH value of the lysozyme solution in the step 2 is 1.5-2.5. In the step 3, the concentration of glutaraldehyde is 2%, the storage modulus G'of the hydrogel is 325-480 Pa, the hardness is 2176.71 g, and the bacteriostasis rate on staphylococcus aureus and salmonella exceeds 95%.
Resumen de: US2025025552A1
The present invention provides methods and compositions for specific activation of inflammatory responses in dendritic cells (DCs). 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine (PAPC) and its oxidized variant (oxPAPC) were identified to promote DC-mediated immunity, and are provided as adjuvants in immunostimulatory compositions, including vaccines.
Resumen de: CN120137852A
The invention relates to a bifidobacterium animalis subsp. Lactis YYSJ001 with a blood sugar reducing effect and application of the bifidobacterium animalis subsp. Lactis YYSJ001. The classification name of the strain is bifidobacterium animalis subsp. Lactis, and the preservation number is CGMCC (China General Microbiological Culture Collection Center) No.33471. The invention further relates to a preparation method of the bifidobacterium animalis subsp. Lactis YYSJ001. The bacterial strain has good artificial gastric juice resistance, artificial intestinal juice resistance and intestinal tract adhesion ability, has an inhibition effect on numerous pathogenic bacteria such as escherichia coli, staphylococcus aureus, salmonella, klebsiella pneumoniae and quail chicken enterococcus, and can stimulate intestinal cells to generate glucagon-like peptide-1, so that the bacterial strain can be applied to preparation of various pathogenic bacteria. Diseases of diabetic mice can be effectively improved, and the compound can be used for preparing products for preventing and treating diabetes or assisting in reducing blood sugar.
Resumen de: CN120137051A
The invention discloses a fusion antibacterial peptide BMAP18-BSN37 and application thereof, and belongs to the technical field of gene engineering. The nucleotide sequence of the fusion antibacterial peptide BMAP18-BSN37 is as shown in SEQ ID NO. 1, and the amino acid sequence of the fusion antibacterial peptide BMAP18-BSN37 is as shown in SEQ ID NO. 2. The fusion antibacterial peptide BMAP18-BSN37 gene is inserted into a pNZ8148 expression vector to construct a recombinant expression vector pUBB, so that protein aggregation or degradation in cells can be avoided, and the survival rate of strains and the stability of protein expression are improved. The method comprises the following steps: transferring a plasmid pUBB into a lactic acid bacteria NZ9000 strain through electrotransformation, and screening a recombinant lactic acid bacteria strain capable of expressing a fusion protein BMAP18-BSN37 to obtain a recombinant strain NZ-BB; the recombinant lactic acid bacteria NZ-BB strain shows a remarkable prevention effect in an animal infection model, and can effectively reduce bacterial colonization and relieve pathological injury; the Salmonella strain has the potential of being used as an animal feed additive, can reduce the use of antibiotics and chemicals, slow down the development of bacterial drug resistance, improve animal immunity and slow down intestinal inflammation caused by salmonella, and provides support for effectively preventing the health of livestock and poult
Resumen de: CN120137870A
The invention discloses a sifA gene knockout attenuated salmonella recombinant engineering bacterium as well as a preparation method and application thereof, and belongs to the technical field of microbial biology. An intracellular vesicle (SCV) of the attenuated salmonella VNP20009 of the engineering bacterium forms a related gene sifA, and the related gene sifA is seamlessly knocked out. The engineering bacterium is named as VNP20009 delta sifA. The invention also discloses a preparation method of the engineering bacterium. The engineering bacterium has the characteristic of keeping the characteristic of specific colonization of a female parent strain VNP20009 in a tumor hypoxic region, and meanwhile, the biotoxicity of the strain is further reduced; meanwhile, the strain has a potential value of becoming a chassis strain for combined synthesis of biological tumor therapy due to relatively weak killing performance and higher intracellular load on immune cells. The invention also provides a construction method of the strain and application of the strain in treatment of mouse entity subcutaneous melanoma.
Resumen de: CN120138182A
The invention discloses a detection method for salmonella based on RPA-CRISPR/Cas12a regulation and control of fluorescence polarization enhancement. The detection method comprises the following steps: performing DNA extraction on a to-be-detected sample, and then mixing the to-be-detected sample with an RPA reagent, a dissolving agent, ddH2O, an upstream primer, a downstream primer and an activating agent to obtain an amplification product; the amplification product is mixed with Exo I enzyme, Exo I buffer and ddH2O for incubation, and a cutting product is obtained; mixing and incubating the cleavage product with water, LbaCas12a, a target sequence crRNA and an r2.1 buffer, so as to obtain a solution to be detected; and detecting the salmonella in the to-be-detected sample according to the fluorescence polarization value of the to-be-detected solution. The salmonella detection method provided by the invention has the advantages of rapidness, simplicity and convenience in operation, high sensitivity and strong specificity, and can efficiently detect salmonella.
Resumen de: CN120137814A
The invention belongs to the technical field of biology, and particularly relates to lactobacillus gasseri LTG1323 and application thereof. The lactobacillus gasseri provided by the invention has relatively strong enrichment ability and acid production ability, has relatively strong inhibition ability on escherichia coli, staphylococcus aureus, bacillus cereus, shigella flexneri and salmonella typhimurium, has strong colonization ability in human intestinal tracts, can regulate and optimize a microenvironment, is sensitive to six common antibiotics, and can be used for preparing a feed additive. And the prepared freeze-dried powder has the characteristics of high viable count, long shelf life and the like.
Resumen de: CN120131712A
The invention belongs to the field of biological medicines, and provides a composition and a method for treating tumors by using attenuated salmonella and an immune checkpoint inhibitor. The anti-tumor immune response is activated in a mode of combining the attenuated salmonella and the immune checkpoint inhibitor, and the inhibition effect on tumor cells is synergistically improved. The medicine shows an excellent treatment effect on malignant tumors lacking an effective control means at present, and has a wide application prospect.
Resumen de: WO2025122955A1
Provided herein are methods and compositions for treating cancer. One composition includes an engineered bacterial cell comprising: a) a lysis gene or lysis cassette operably linked to an intracellularly induced Salmonella promoter; b) one or more of the bacterial cell genes selected from the group consisting of recA, recB, recF, sbcB, sbcCD, red, sseJ or any combination thereof are knocked out; and c) a nucleic acid sequence coding for an oncolytic virus genome.
Resumen de: WO2024155027A1
The present invention relates to an attenuated Salmonella gallinarum expressing FliC or FliC-hiL2 and use thereof. The Salmonella strain according to the present invention has excellent immune activity and exhibits excellent anti-cancer efficacy, and thus can be used as a therapeutic agent for cancer together with or independently of existing anti-cancer drugs.
Resumen de: CN120119015A
The invention belongs to the technical field of microbiological detection, and discloses an RPA (recombinase polymerase amplification) primer pair, a real-time fluorescent RPA primer group and a kit for detecting salmonella typhimurium. The primer pair for detecting the salmonella typhimurium based on the RPA comprises an upstream primer RPA-F with a sequence as shown in SEQ ID NO: 1 and a downstream primer RPA-R with a sequence as shown in SEQ ID NO: 2, and the primer group for detecting the salmonella typhimurium based on the real-time fluorescence RPA comprises the upstream primer RPA-F, the downstream primer RPA-R and a probe RPA-P with a sequence as shown in SEQ ID NO: 3. The primer group and the primer pair can be used for rapidly detecting salmonella typhimurium, and are high in specificity and sensitivity and low in minimum detection limit.
Resumen de: CN120119014A
The invention belongs to the technical field of bacterial detection, and discloses a liquid-phase gene chip method for simultaneously detecting Listeria monocytogenes, Staphylococcus aureus, Salmonella and Escherichia coli, which comprises the following specific steps: step 1, designing primers; the method comprises the following steps: downloading an H ly gene sequence of listeria monocytogenes, an FemA gene of staphylococcus aureus, an i nvA gene of salmonella and an rfbE gene of escherichia coli O157: H7; after preparation work of primer design, bacterial DNA extraction and plasmid construction, simultaneous and high-throughput detection of Listeria monocytogenes, Staphylococcus aureus, Salmonella and Escherichia coli can be realized through the detection method established in the step 4, so that the detection time is effectively shortened, the operation is simpler, and the detection efficiency is improved. Meanwhile, a specificity test, a sensitivity test, a repeatability test and a clinical sample detection result show that the detection method disclosed by the invention is higher in sensitivity and lower in specificity and cost, and meets the requirements of rapid on-site real-time detection of the food-borne pathogenic bacteria.
Resumen de: CN120118856A
The invention provides a freeze-drying protective agent and a penicillin bottle freeze-drying method of salmonella bacteriophage, and belongs to the technical field of biology. The freeze-drying protective agent comprises the following components in percentage by mass: 5%-10% of trehalose, 1%-3% of mannitol, 1%-3% of lactose, 1%-3% of sodium citrate, 0.5%-2% of linseed oil, 10%-20% of skim milk powder, 1%-3% of sodium sulfate and 1%-3% of succinic acid. According to the penicillin bottle freeze-drying method of the salmonella bacteriophage, the freeze-drying recovery rate of the salmonella bacteriophage can be remarkably improved; the freeze-dried bacteriophage preparation is small in size, light in weight, easy to transport and store and capable of keeping activity for a long time at normal temperature.
Resumen de: CN120118818A
The invention provides a controllable self-destruction engineering bacterium and a preparation method thereof, attenuated salmonella typhimurium is taken as a carrier, plasmid containing PD-1 gene is introduced into the body of the bacterium, and the engineering bacterium VNP-mPD-1 is obtained; the preparation method comprises the following steps: preparing engineering bacteria VNP-mPD-1-N3, enabling the surface of the engineering bacteria to contain an azide group through a glycometabolism method to obtain the engineering bacteria VNP-mPD-1-N3 with the surface containing the azide group, and covalently linking a DBCO modified photosensitizer with the azide group on the surface of the engineering bacteria through a click chemistry method to prepare the controllable self-destruction engineering bacteria VNP-mPD-1-(at) IN. The controllable self-destruction engineering bacterium prepared by the invention is good in biological safety, can generate active oxygen under laser irradiation, and has anti-tumor performance.
Resumen de: CN120118166A
本发明通过筛选、实验验证获得一段能够代表沙门氏菌作为抗原的特异性蛋白片段，以这一段特异性蛋白片段作为抗原免疫小鼠，利用细胞融合技术得到可以稳定分泌单克隆抗体的杂交瘤细胞，最终制备了效价高、特异性好的抗沙门氏菌单克隆抗体。同样以该特异性蛋白片段免疫兔子，获得了抗沙门氏菌多克隆抗体。基于鼠单克隆抗体和兔多克隆抗体，建立沙门氏菌胶体金免疫层析检测方法，该检测方法特异性良好，为食品中沙门氏菌的检测提供了快速、简便的检测手段。
Resumen de: CN120121832A
The invention relates to a double-probe detection reagent for detecting salmonella typhimurium and a preparation method of the double-probe detection reagent, and belongs to the technical field of food safety. The double-probe detection reagent is formed by respectively packaging a magnetic separation probe reagent solution and a fluorescent nano-enzyme probe reagent solution; the magnetic separation probe reagent liquid is used for specifically binding salmonella typhimurium and carrying out separation and enrichment treatment on a detection sample; the red fluorescent nano-enzyme probe reagent solution is used for specifically combining the salmonella typhimurium subjected to separation and enrichment treatment and generating a salmonella typhimurium concentration dependent colorimetric signal and a fluorescent signal. The double-probe detection reagent disclosed by the invention is short in detection time and high in detection sensitivity when being used for detecting salmonella typhimurium, and has relatively good specificity on common type strains. According to the invention, the specific surface area is high, the peroxidase-like activity is excellent, and the high-sensitivity capture efficiency is enhanced; according to the invention, mutual verification is carried out between the dual-mode signals, an internal proofreading effect is achieved, and the detection result is accurate.
Resumen de: CN120119010A
The invention discloses an LMTIA primer combination for detecting salmonella and application, and relates to the technical field of microbiological detection.The LMTIA primer combination comprises a first primer and a second primer, the sequence of the first primer is shown as SEQ.ID.No.1, and the sequence of the second primer is shown as SEQ.ID.No.2. The invention further discloses a kit for detecting salmonella. Amplification of the target gene of the to-be-detected sample can be completed within 30 min through the first primer, the second primer and a constant-temperature environment, expensive equipment such as a PCR instrument is not needed, the specificity is high, the false positive rate is low, the sensitivity is not worse than that of PCR, and the kit can be used for rapidly detecting salmonella on site.
Resumen de: CN120098102A
The invention relates to the technical field of biology, in particular to an antibacterial peptide Clavanin A-1, a coding gene and application of the antibacterial peptide Clavanin A-1. The invention provides an antibacterial peptide Clavanin A-1 which has good thermal stability, acid-base stability and endogenous protease degradation resistance, can obviously inhibit the growth of escherichia coli, salmonella and staphylococcus aureus, and has good application prospects in the fields of food, hygienic products, cosmetics, biopesticide, biological feed additives or natural food preservatives and the like. Wide application prospects are realized.
Resumen de: CN120098782A
The invention relates to the technical field of microbiological detection, and particularly discloses a microfluidic device for detecting salmonella and a detection method.The microfluidic device comprises a top cover, a functional plate and a heating base which are detachably connected in sequence from top to bottom; an observation window, a first sample adding opening and a second sample adding opening are formed in the top cover; a detection bin is formed in a position, corresponding to the observation window, on the function plate; an amplification bin communicated with the second sample adding opening is formed in the functional plate; a buffer bin communicated with the first sample adding opening is formed in the functional plate; the amplification bin is communicated with the buffer bin, the buffer bin is communicated with the detection bin, and a space for placing a test strip is reserved in the detection bin; a ventilation channel is further formed in the function plate and communicates with the amplification bin. The micro-fluidic device provided by the invention is simple in structure, convenient to carry, easy to interpret a detection result and simple in operation mode, and meanwhile, in combination with the design of the micro-fluidic device, the nucleic acid detection does not need additional equipment and complicated manual intervention.
Resumen de: CN120098081A
The invention belongs to the technical field of biology, and relates to a narrow-spectrum antibacterial peptide XMK-8 and application thereof. The amino acid sequence of the narrow-spectrum antibacterial peptide XMK-8 is as shown in SEQ ID NO: 1, and the narrow-spectrum antibacterial peptide XMK-8 has no bacteriostatic activity on escherichia coli, salmonella, staphylococcus aureus and aeromonas hydrophila and only has bacteriostatic activity on pasteurella multocida and haemophilus parasuis. The antibacterial activity of the narrow-spectrum antibacterial peptide XMK-8 can still be detected after treatment with salt ions (sodium ions and potassium ions, 50-200 mmol/L), acid-base (pH 4-10) and protease K (20-100 mu g/mL) at the temperature of 0-100 DEG C, and the narrow-spectrum antibacterial peptide XMK-8 has low hemolytic activity on red blood cells of mice. The antibacterial peptide XMK-8 disclosed by the invention is expected to become a novel antibiotic substitute and has a good application prospect in prevention, treatment, diagnosis and identification of pasteurella multocida, haemophilus parasuis and infection thereof.
Nº publicación: CN120093643A 06/06/2025
Solicitante:
WUHAN XINYAHUI BIOTECHNOLOGY CO LTD
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Resumen de: CN120093643A
The invention discloses multi-effect talcum powder for animals as well as a preparation method and application of the multi-effect talcum powder. The multi-effect talcum powder comprises the following components in percentage by mass: 1-3% of sodium benzoate, 1-3% of glycerol monolaurate, 0.5-1.5% of tea polyphenol, 7-13% of citric acid, 15-25% of corn fiber powder and 54.5-75.5% of diatomite. The talcum powder does not stick to the body, is easy to fall off, has good moisture absorption and drying effects, can improve a humid environment and adsorb odor, is good in acidic stability, has an inactivation effect on escherichia coli, salmonella, staphylococcus aureus and porcine rotavirus, and is safe, non-toxic, free of drug resistance, low in cost and stable in performance when being applied to a livestock and poultry breeding environment.
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