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LastUpdate Última actualización 20/03/2026 [06:51:00]
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CATIONIC LIPIDS AND PREPARATION METHOD THEREOF

NºPublicación:  US20260069542A1 12/03/2026
Solicitante: 
RIBOX THERAPEUTICS HK LTD [CN]
RiboX Therapeutics HK Limited
US_20260069542_PA

Resumen de: US20260069542A1

The present invention provides cationic lipids and lipid nanoparticle formulations comprising these lipids, alone or in combination with other lipids. These lipid nanoparticles may be formulated with nucleic acids to facilitate their intracellular delivery both in vitro and for therapeutic applications. The present invention also provides methods of chemical synthesis of these lipids.

ORAL VACCINE FOR ENHANCING CANCER IMMUNOTHERAPY

NºPublicación:  US20260069669A1 12/03/2026
Solicitante: 
NATIONAL TSING HUA UNIV [TW]
National Tsing Hua University
US_20260069669_PA

Resumen de: US20260069669A1

The disclosure provides an oral vaccine for enhancing cancer immunotherapy, which includes a complex of β-glucan and mRNA and lipid nanoparticles, wherein the mRNA includes a coding region of a tumor antigen, and the lipid nanoparticles encapsulate the complex of β-glucan and mRNA.

COMPOSITIONS AND METHODS FOR THE DELIVERY OF ACTIVE AGENTS INCLUDING NUCLEIC ACIDS

NºPublicación:  US20260069541A1 12/03/2026
Solicitante: 
OHIO STATE INNOVATION FOUND [US]
THE WHITEOAK GROUP INC [US]
Ohio State Innovation Foundation,
THE WHITEOAK GROUP, INC
US_20260069541_PA

Resumen de: US20260069541A1

Disclosed herein are lipid nanoparticles for the delivery of active agents, including nucleic acids, as well as methods of making using thereof.

LIPIDOID COMPOUNDS AND RELATED COMPOSITIONS AND USES

NºPublicación:  US20260069539A1 12/03/2026
Solicitante: 
POSEIDA THERAPEUTICS INC [US]
Poseida Therapeutics, Inc
US_20260069539_PA

Resumen de: US20260069539A1

Compositions comprising lipidoid compounds, methods of preparing such compositions, and the use of these compositions in gene delivery applications are disclosed.

CXCR4 ANTAGONIST LOADED LIPOSOMES AND SILICASOMES

NºPublicación:  US20260069538A1 12/03/2026
Solicitante: 
THE REGENTS OF THE UNIV OF CALIFORNIA [US]
The Regents of the University of California
US_20260069538_PA

Resumen de: US20260069538A1

In various embodiments drug delivery vehicles and uses thereof are provided. In certain embodiments the drug delivery vehicles comprise: 1) a silicasome comprising a mesoporous silica nanoparticle coated with a lipid bilayer and further comprising a CXCR4 antagonist; or 2) a liposome comprising a lipid bilayer comprising where said liposome further comprises a CXCR4 antagonist. In certain embodiments the CXCR4 antagonists are selected from the group consisting of AMD3100, AMD3465, and AMD070.

GENE DELIVERY AGENTS

NºPublicación:  US20260069540A1 12/03/2026
Solicitante: 
TIBA BIOTECH LLC [US]
TIBA Biotech LLC
US_20260069540_A1

Resumen de: US20260069540A1

Nanoparticle compositions for delivery of nucleic acids to subjects including aminoalkyl branched lipid-like molecules as carriers, and therapeutic or immunogenic nucleic acid agents enclosed within the nanoparticle containing are described. Also provided are methods for treating or preventing diseases or conditions in a subject by administering the nanoparticle compositions that provide immune responses and synergistic therapeutic or preventive effects.

COMPOSITIONS, SYSTEMS, AND METHODS FOR DELIVERY OF THERAPEUTICS

NºPublicación:  US20260069536A1 12/03/2026
Solicitante: 
THE JOHNS HOPKINS UNIV [US]
THE US SECRETARY [US]
THE JOHNS HOPKINS UNIVERSITY,
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY,
US_20260069536_PA

Resumen de: US20260069536A1

The present disclosure provides compositions, systems, devices, and methods for the delivery of therapeutics. Particularly, the disclosure provides composition, systems, and devices of the delivery of Janus kinase (JAK) inhibitors and uses thereof, such as for inhibiting allograft rejection or treating autoimmune diseases.

SINGLE DOMAIN ANTIBODIES TARGETING HPV E6/E7 ONCOGENIC PEPTIDE/MHC COMPLEXES

NºPublicación:  US20260070960A1 12/03/2026
Solicitante: 
THE U S A AS REPRESENTED BY THE SEC DEP OF HEALTH AND HUMAN SERVICES [US]
The U.S.A., as represented by the Secretary, Department of Health and Human Services
US_20260070960_PA

Resumen de: US20260070960A1

Single-domain antibodies that specifically bind human papillomavirus (HPV) E6 or E7 oncogenic peptides in complex with human major histocompatibility complex (MHC) proteins are described. The E6-MHC-specific and E7-MHC-specific single-domain antibodies were isolated from dromedary camel (VHH) antibody libraries by panning the library with an E6- or E7-derived peptide in complex with HLA-A*02:01. Use of the single-domain antibodies for the detection and treatment of HPV-associated cancers and pre-cancerous lesions is also described.

ENHANCED IMMUNE CHECKPOINT BLOCKADES FORMULATION FOR IMAGE GUIDED LOCAL IMMUNOTHERAPY

NºPublicación:  US20260070985A1 12/03/2026
Solicitante: 
NORTHWESTERN UNIV [US]
Northwestern University
US_20260070985_PA

Resumen de: US20260070985A1

Disclosed are nanoparticles comprising directionally attached antibodies and compositions for use in locoregional delivery, including intra-tumoral and transarterial chemoembolization (TACE), and methods of making the nanoparticles. Also disclosed are methods for treating a subject in need thereof the compositions described.

BISPHOSPHONATE LIPIDS, LIPID NANOPARTICLE COMPOSITIONS COMPRISING THE SAME, MINERAL TISSUE-ADSORBED COMPOSITIONS THEREOF, AND METHODS OF USE THEREOF

NºPublicación:  US20260070935A1 12/03/2026
Solicitante: 
THE TRUSTEES OF THE UNIV OF PENNSYLVANIA [US]
The Trustees of the University of Pennsylvania
US_20260070935_PA

Resumen de: US20260070935A1

Described herein, in part, are bisphosphonate lipid compounds, lipid nanoparticles (LNPs) thereof, and methods of use thereof. In various embodiments, the LNP selectively targets a cell of interest (e.g., a bone cell and/or bone marrow cell, such as a stem cell, stroma cell, osteoblast, osteocyte, osteoclast, bone lining cell, local mesenchymal cell, progenitor cell, mononuclear blood-borne precursor cell, B cell, endothelial cell, granulocytes, T cell, monocytic lineage, B cell lineage, monocytes, cancer cell, tumor cell, tumor cell that metastasize to bone, blood cancer cell, and multiple myeloma cell, inter alia). In other aspects, the present disclosure relates to methods for in vivo delivery of therapeutic agents to prevent or treat diseases, disorders, or conditions using the LNP compositions of the disclosure.

IL-12 GENE THERAPY AND ANTI-VEGF COMBINATION FOR TREATING CANCER

NºPublicación:  US20260070964A1 12/03/2026
Solicitante: 
IMUNON INC [US]
IMUNON, INC
US_20260070964_PA

Resumen de: US20260070964A1

The present disclosure relates to a combination therapy comprising an anti-VEGF antibody, a nanoparticle formulated plasmid comprising an IL-12 coding nucleic acid, and, optionally, at least one adjunctive chemotherapeutic drug, and methods of treatment using such combination therapies and/or compositions.

Nanocapsule for Delivery of Lipophilic Compound and Process of Preparation Thereof

NºPublicación:  AU2026201122A1 12/03/2026
Solicitante: 
CHDE POLSKA S A
CHDE POLSKA S.A
AU_2026201122_A1

Resumen de: AU2026201122A1

Abstract The invention relates to biocompatible polysaccharide-based nanocapsule templated on oil core of diameter not exceeding 1 μm, stabilized without low molecular weight surfactants. The nanocapsule shows long-term stability in an aqueous suspension and is able to highly efficient encapsulation of hydrophobic compounds. Abstract eb b s t r a c t e b

IONIZABLE LIPIDS AND USES THEREOF

NºPublicación:  AU2024367887A1 12/03/2026
Solicitante: 
GREEN CROSS CORP
GREEN CROSS CORPORATION
AU_2024367887_PA

Resumen de: AU2024367887A1

The present invention relates to a novel ionizable lipid compound represented by Formula (I) or a salt thereof, and a lipid nanoparticle containing the same. The lipid nanoparticle containing the novel ionizable lipid compound according to the present invention has an excellent nucleic acid encapsulation efficiency and has a high efficiency of cellular delivery of nucleic acid.

A NANOFORMULATION FOR THERAPEUTIC USE

NºPublicación:  AU2025308132A1 12/03/2026
Solicitante: 
COUNCIL OF SCIENT AND INDUSTRIAL RESEARCH
COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH
AU_2025308132_A1

Resumen de: AU2025308132A1

The present invention relates to a nanoformulation comprising L-leucyl-L-leucine methyl ester (LLOMe) and a polymer for wound healing, which promotes multiple molecular signaling pathways essential for faster wound healing. The nanoformulation offers faster and improved wound and tissue healing, axon regeneration, antiviral immunity, stem cell proliferation, embryonic development, and anti-aging effects.

IONIZABLE LIPID AND USE THEREOF

NºPublicación:  AU2024366071A1 12/03/2026
Solicitante: 
GREEN CROSS CORP
GREEN CROSS CORPORATION
AU_2024366071_PA

Resumen de: AU2024366071A1

The present invention relates to a novel ionizable lipid compound represented by formula (I), or a salt thereof, and lipid nanoparticles comprising same. The lipid nanoparticles comprising the novel ionizable lipid compound, according to the present invention, have excellent nucleic acid encapsulation efficiency and high nucleic acid cell delivery efficiency.

POLYGLYCEROL STABILIZING AGENTS, COMPOSITIONS, USES, AND MANUFACTURING METHODS THEREOF

NºPublicación:  AU2024341673A1 12/03/2026
Solicitante: 
GLOBAL LIFE SCIENCES SOLUTIONS CANADA ULC
GLOBAL LIFE SCIENCES SOLUTIONS CANADA ULC
AU_2024341673_PA

Resumen de: AU2024341673A1

The invention provides stabilizing agents, compositions, methods of manufacturing, and uses thereof. In one aspect, a lipid nanoparticle composition includes: (a) an ionizable lipid; (b) two or more lipids; and (c) a stabilizing agent of formula (I) or formula (II) and methods for preparing the stabilizing agents and the lipid nanoparticle are provided.

POLYVINYLPYRROLIDONE STABILIZING AGENTS, COMPOSITIONS, USES, AND MANUFACTURING METHODS THEREOF

NºPublicación:  AU2024342034A1 12/03/2026
Solicitante: 
GLOBAL LIFE SCIENCES SOLUTIONS CANADA ULC
GLOBAL LIFE SCIENCES SOLUTIONS CANADA ULC
AU_2024342034_PA

Resumen de: AU2024342034A1

The invention provides stabilizing agents, compositions, methods of manufacturing, and uses thereof. In one aspect, a lipid nanoparticle composition includes: (a) an ionizable lipid; (b) two or more lipids; and (c) a stabilizing agent of formula (I) and a method for preparing the stabilizing agent and the lipid nanoparticle are provided.

POLYPHOSPHOESTER STABILIZING AGENTS, COMPOSITIONS, USES, AND MANUFACTURING METHODS THEREOF

NºPublicación:  AU2024340379A1 12/03/2026
Solicitante: 
GLOBAL LIFE SCIENCES SOLUTIONS CANADA ULC
GLOBAL LIFE SCIENCES SOLUTIONS CANADA ULC
AU_2024340379_PA

Resumen de: AU2024340379A1

The invention provides stabilizing agents, compositions, methods of manufacturing, and uses thereof. In one aspect, a lipid nanoparticle composition including: (a) an ionizable lipid; (b) two or more lipids; and (c) a stabilizing agent of formula (I) and a method for preparing the stabilizing agent and the lipid nanoparticle are provided.

NANOPORE

NºPublicación:  AU2024326546A1 12/03/2026
Solicitante: 
OXFORD UNIV INNOVATION LIMITED
OXFORD UNIVERSITY INNOVATION LIMITED
AU_2024326546_PA

Resumen de: AU2024326546A1

Described is a nanopore that is selectively convertible between an open form and a closed form using light, a method for producing such a nanopore, a method of modulating the flow of one or more substances through the nanopore, the use of the nanopore in modulating ionic flow across an amphiphilic membrane, a device comprising the nanopore, use of the nanopore as an ionotronic component, use of the nanopore in bio-computation and/or bioionotronics, a method of transmitting information using the nanopore, and method of receiving information comprising the nanopore, and an ionotronic component comprising the nanopore.

DRUG DELIVERY MATERIAL AND APPLICATION THEREOF

NºPublicación:  AU2024325184A1 12/03/2026
Solicitante: 
DSCILAB CO LTD
DSCILAB.CO., LTD
AU_2024325184_A1

Resumen de: AU2024325184A1

The present invention relates to a drug delivery material and an application thereof. Specifically provided is a nanoparticle composition comprising a lipid component, the lipid component comprising a compound represented by formula (I). The nanoparticle composition of the present invention is delivered only at the site of administration.

USE OF MIR-342 ENRICHED, TAMOXIFEN LOADED, MESENCHYMAL STEM CELL DERIVED EXOSOMES FOR OVERCOMING TAMOXIFEN RESISTANCE IN BREAST CANCER

NºPublicación:  WO2026054725A1 12/03/2026
Solicitante: 
BURSA ULUDAG UENIVERSITESI [TR]
BURSA ULUDA\u011E \u00DCN\u0130VERS\u0130TES\u0130
WO_2026054725_A1

Resumen de: WO2026054725A1

The invention relates to a pharmaceutical composition comprising tamoxifen-loaded mesenchymal stem cell-derived exosomes enriched with miR-342 for use in the pharmaceutical and vaccine industry, in the treatment of cancer, in the treatment of breast cancer, in overcoming tamoxifen resistance in the treatment of estrogen receptor positive breast cancer using tamoxifen.

3-COMPONENT LIPID NANOPARTICLE COMPOSITIONS, USES, AND MANUFACTURING METHODS THEREOF

NºPublicación:  WO2026052854A1 12/03/2026
Solicitante: 
GLOBAL LIFE SCIENCES SOLUTIONS CANADA ULC [CA]
GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD [GB]
GLOBAL LIFE SCIENCES SOLUTIONS CANADA ULC,
GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LIMITED
WO_2026052854_PA

Resumen de: WO2026052854A1

The disclosure provides nanoparticle lipid compositions, methods of manufacturing, and uses thereof. In one aspect, a lipid nanoparticle composition includes: (a) an ionizable lipid; (b) a sterol; and (c) a stabilizer. The disclosure provides methods for preparing the lipid nanoparticle compositions and uses of the lipid nanoparticle or the pharmaceutical composition for preventing, treating, or ameliorating conditions or diseases.

3-COMPONENT LIPID NANOPARTICLE COMPOSITIONS, USES, AND MANUFACTURING METHODS THEREOF

NºPublicación:  WO2026052844A1 12/03/2026
Solicitante: 
GLOBAL LIFE SCIENCES SOLUTIONS CANADA ULC [CA]
GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LTD [GB]
GLOBAL LIFE SCIENCES SOLUTIONS CANADA ULC,
GLOBAL LIFE SCIENCES SOLUTIONS OPERATIONS UK LIMITED
WO_2026052844_PA

Resumen de: WO2026052844A1

P2023-0430-WO 84 ABSTRACT The disclosure provides nanoparticle lipid compositions, methods of manufacturing, and uses thereof. In one aspect, a lipid nanoparticle composition includes: (a) an ionizable lipid; (b) a sterol; and (c) a stabilizer. The disclosure provides methods for preparing the lipid nanoparticle compositions and uses of the lipid nanoparticle or the pharmaceutical composition for preventing, treating, or ameliorating conditions or diseases.

TARGETING FUSION PROTEINS

NºPublicación:  WO2026052839A1 12/03/2026
Solicitante: 
HONE BIO LTD [GB]
HONE BIO LIMITED
WO_2026052839_PA

Resumen de: WO2026052839A1

This invention relates to targeting fusion proteins based on molecules which bind serum proteins, such as serum protein receptors. The invention also relates to amphipathic structures linked to the targeting fusion proteins. The invention also relates to methods of targeting and therapeutic methods using the fusion proteins and/or amphipathic structures.

NANOSCOPIC VECTORS FOR DELIVERING THERAPEUTIC AGENTS FOR TREATING PANCREATIC DISORDERS

Nº publicación: WO2026052938A1 12/03/2026

Solicitante:

SWANSEA UNIV [GB]
SWANSEA UNIVERSITY

WO_2026052938_PA

Resumen de: WO2026052938A1

Pancreatic Disorders The invention relates to a nanoparticle that is suitable for use as a nanoscopic vector for delivering therapeutic agents for use in treating a pancreatic disorder; a pharmaceutical or veterinary composition for use in treating a pancreatic disorder comprising said vectors; and the use of said vectors for treatment of a pancreatic disorder. The invention further relates to a method of treating a pancreatic disorder employing the use of said vectors or pharmaceutical compositions.

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