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215
resultados
Última actualización
15/11/2025 [06:59:00]
Resumen de: CN120939222A
本发明提供一种超声激活的铼菁染料配合物纳米制剂，通过共价键将七甲川菁染料(IR‑780)与铼(I)三羰基中心偶联，构建新型配合物Re‑Cy7。该分子设计利用拓展π‑共轭体系实现超声同步触发双重效应——经I型机制高效产生氧非依赖型·OH，并精准释放治疗剂量CO。进一步通过Pluronic F‑127自组装构建纳米制剂(Re‑Cy7NPs)，显著提升水溶性及感染部位靶向蓄积能力。该技术一举突破现有局限：克服缺氧环境对SDT的制约，解除光穿透深度对气体释放的束缚，并在单分子层面实现·OH与CO的高效协同，为根治MDR感染提供全新解决方案。
Resumen de: CN120939138A
本发明公开了复方佛手柑鼻腔洗液及其应用，属于医药技术领域。本发明通过将佛手柑素，丙酮酸钠，金银花提取物与淡竹叶多糖结合，佛手柑素能够抑制病毒刺突蛋白与ACE2结合，丙酮酸钠能够阻断病毒ROS信号通路，金银花提取物能够抗炎抑菌，本发明通过上述物质的组合，实现了“物理冲洗+药物渗透”双重机制，能够降低病毒载量，所得复方佛手柑鼻腔洗液的实现了协同增效的效果，抗病毒和抗炎效果显著优于单一成分洗液。
Resumen de: AU2023368775A1
Provided herein is a lipid nanoparticle comprising an encapsulated oligonucleotide molecule, wherein the oligonucleotide molecule is single-stranded or double-stranded and has a length of between 5 and 500 nucleotides; and 20 to 70 mol% of a neutral lipid content relative to total lipid present in the lipid nanoparticle, an ionizable lipid; a sterol; and optionally a hydrophilic polymer-lipid conjugate.
Resumen de: CN120938907A
本发明属于生物医药技术领域，提出了一种载球姜酮自组装纳米药物、可溶性微针贴片及其制备方法和应用，载球姜酮自组装纳米药物包括质量比为1.5‑5：0.35‑1.4：10‑20的球姜酮、吲哚菁绿和聚合物mPEG‑PLA。本发明还提供了载球姜酮自组装纳米药物的制备方法。本发明还提供了一种可溶性微针贴片，包括上述载球姜酮自组装纳米药物，所述可溶性微针贴片包括贴片基底和设置于所述贴片基底表面的针头；所述针头由载球姜酮自组装纳米药物和可溶性基质材料制备而成。本发明提供的载球姜酮自组装纳米药物，具有抗肿瘤作用，可以用于治疗黑色素瘤，提高了球姜酮的溶解性和生物利用率。
Resumen de: CN120943786A
本发明涉及一种可电离脂质化合物、相应的脂质纳米颗粒及其应用。本发明的可电离脂质化合物含有哌嗪结构和多条烷基链，在兼顾递送效率和靶向性的同时，降低毒副作用，便于大剂量和重复给药。该可电离脂质化合物及其脂质纳米颗粒可应用于递送小分子化药和各种核酸药物（siRNA、DNA、mRNA、miRNA，ASO等等）。
Resumen de: CN120944088A
本发明属于医药技术领域，公开了一种新型结构的聚胆酸‑短链脂肪酸的合成及应用。该聚合物由聚胆酸（作为主链）与一个或多个短链脂肪酸通过共价键连接而成。所述聚胆酸作为聚合物的骨架结构，短链脂肪酸作为侧链基团引入，从而构建出具有生物活性的功能化聚合物。本发明还提供了以该聚合物为载体制备的纳米药物。该纳米药物具有良好的生物相容性和药物负载能力，有效提高了减肥减脂和缓解肝脏炎症方面的效果，且有效缓解肝脏纤维化和衰老，并可以增强治疗脂肪肝效果和进一步降低胰岛素抵抗问题，具有广泛的临床应用前景。
Resumen de: CN118995705A
The invention belongs to the technical field of biological medicine, and particularly relates to a biological switchable siRNA delivery composite material based on RNAi and a preparation method and application thereof. The invention designs a novel biological switchable siRNA delivery system (BiRDS) based on RNAi (Ribonucleic Acid Interference) by combining good endocytosis performance and stability of tetrahedral framework nucleic acid and gene targeting specificity of siRNA, the system consists of three siRNAs (three magic birds) and a nucleic acid core (central sun), and by loading small interfering RNA to target casein kinase 2 interacting protein 1 (siCkip-1), the novel biological switchable siRNA delivery system (BiRDS) based on RNAi is obtained. The siRNA is specifically delivered to the bone formation surface, the loading capacity is improved to the maximum extent, the kip gene is efficiently silenced, cell proliferation and migration are promoted, the good osteogenesis induction effect is achieved, and a new thought is provided for treatment of maxillofacial bone defects.
Resumen de: CN120939068A
本申请提供一种沙棘籽油脂质纳米囊滴眼剂，其中，包括沙棘籽油1～20gw/v、乳化剂I 0.1～5g w/v、乳化剂II 0.1～5g w/v、金属螯合剂0.02～0.2g w/v、渗透压调节剂1～5g w/v和pH调节剂0.2～5mL v/v。本申请将油脂制成脂质纳米囊形式，不仅加速了药物的吸收，更能提高患者的使用感受。
Resumen de: WO2024218166A1
The present disclosure is directed to the use of reconstituted mRNA dry powder particles for parenteral administration. The present disclosure is also directed to a method of generating dry powder particles supplemented with appropriate excipients for optimal thermostability and in vivo expression.
Resumen de: AU2024254989A1
The present disclosure relates to a synthetic circuit that can be used to selectively express a payload in a target cell. In some aspects, a synthetic circuit comprises a payload sequence comprising a sensor and a regulator sequence comprising a sensor. Also provided herein are methods of using such synthetic circuits to treat a wide range of disease or disorders.
Resumen de: CN120938962A
本发明公开一种聚合物载药纳米粒制备方法。该方法在乳化法基础上，利用超声微流控技术，实现了聚合物载药纳米粒的可控化连续制备。方法具体为，将药物和聚合物溶解于与水不相溶的有机溶剂中，作为有机相，将表面活性剂水溶液作为水相，两相以一定流速比例引入超声微流控设备中，在超声作用下发生乳化，得到均匀液滴。通过搅拌、旋转蒸发、真空离心、超滤等方法除去有机溶剂，得到固化的聚合物载药纳米粒。本方法制备的纳米粒粒径均一、药物包封率高，可连续生产。
Resumen de: CN120939212A
本发明公开了一种PDADMAC修饰的二氧化硅矿化口蹄疫病毒样颗粒及其制备方法和应用。所述的PDADMAC修饰的二氧化硅矿化口蹄疫病毒样颗粒(VLPs‑SiO2)是在聚二甲基二烯丙基氯化铵(PDADMAC)作用下形成二氧化硅矿化的口蹄疫病毒样颗粒，然后进一步用PDADMAC修饰后得到的矿化颗粒，FMDV VLPs的SiO2矿化率达到90％以上。透射电镜和扫描电镜观察表明VLPs‑SiO2为80～100nm的类球形纳米颗粒。SiO2矿化提升了DC2.4细胞摄取FMDVVLPs的水平，滴鼻免疫小鼠后，VLPs‑SiO2免疫组血清中特异性抗体水平及肺脏、盲肠和粪便中的分泌型IgA水平均高于FMDVVLPs免疫组，Tfh、Th1、Th2、记忆B细胞和记忆T细胞的水平也得到了提升。本发明的提出为增强VLPs疫苗黏膜免疫保护提供了有效的技术手段。
Resumen de: CN120943970A
本发明提供FcRn靶向的布鲁氏菌多表位纳米疫苗，该疫苗可实现长期保护：展现出持续的免疫记忆，具有高频生发中心B细胞(GCB)、滤泡辅助性T细胞(TFH)和中央记忆T细胞(TCM)，确保长期免疫监视；即使在免疫后6个月，血清IgG滴度仍显著高于对照组；能够高效抗原递送：采用壳聚糖基纳米颗粒系统，并通过FcRn靶向配体修饰，增强抗原保护和肠上皮摄取；可10倍递送效率提升，克服胃肠道黏膜屏障；并且可快速免疫启动：在最终免疫后14天内诱导多维度免疫反应，为对抗布鲁氏菌感染提供快速保护。
Resumen de: CN120943900A
本发明公开了一种多肽修饰靶向呼吸系统的脂质体纳米颗粒及其应用，所述多肽修饰靶向呼吸系统的脂质体纳米颗粒包括多肽和脂质体，所述多肽与脂质体的质量比为（0.01~30）：100，所述多肽为多肽1或多肽2。本发明的多肽修饰靶向呼吸系统的脂质体纳米颗粒，能够靶向呼吸系统，尤其是鼻黏膜、呼吸道和肺部，从而提高了靶向药物在鼻黏膜、呼吸道细胞及肺黏膜细胞的摄取率。
Resumen de: CN120939190A
本发明涉及中药组合物技术领域，提供了一种超级纳米包裹技术治疗男性勃起障碍的组合物及其制备方法，制备步骤如下：将刺蒺藜提取物、南非醉茄提取物、L‑精氨酸、东革阿里提取物、喜来芝提取物、葛缕子提取物、葛根提取物、牛蒡根提取物、火麻仁肽和超纯水、乙醇混合，得到混合物；将明胶和壳聚糖用超纯水溶解，得到壁材溶液；将混合物和壁材溶液混合，加入表面活性剂，搅拌，干燥，得到纳米包裹颗粒；将纳米包裹颗粒用胶囊填充机填充，得到组合物。本发明通过纳米包裹技术制备的组合物能够提高药物的稳定性和生物利用度；同时组合物中的各中药成分相互配伍，提升了精子活力和肾脏动力，增强了机体的抗疲劳能力，进而起到治疗性功能障碍的作用。
Resumen de: WO2024203660A1
The present invention provides a method for producing nucleic acid-encapsulated lipid nanoparticles, the method comprising the following steps (a) and (b): (a) a step for mixing an alcohol solution containing an ionic lipid having a tertiary amino group, a sterol and a PEG lipid with a citrate buffer solution, in which a nucleic acid is dispersed and which has a pH of 3-6.5, to prepare a suspension of nucleic acid-encapsulated lipid nanoparticles; and (b) a step for concentrating the suspension of the nucleic acid-encapsulated lipid nanoparticles by ultrafiltration and diluting the suspension with a tris buffer solution having a pH of 5.2-9.0 to thereby replace the dispersion medium of the suspension with the tris buffer solution.
Resumen de: WO2024205076A1
The present invention relates to a device useful for manufacturing nanoparticles that contain hydrophobic and hydrophilic substances. Specifically, the device according to the present invention is characterized by comprising: a plurality of inlet channels through which the hydrophobic and hydrophilic substances respectively flow; a mixing channel in which the substances are mixed to manufacture the nanoparticles; and an outlet channel through which the manufactured nanoparticles flow out, wherein the mixing channel includes micro-pillars that can increase the mixing efficiency of the substances. Therefore, the nanoparticles manufactured using the device according to the present invention exhibit excellent particle uniformity and can be useful as drugs or drug delivery carriers.
Resumen de: WO2024220043A1
The present disclosure relates to a composition for prohibiting cross-species infection of malaria caused by P. vivax in a subject. Preferably, the disclosed composition is prepared in the form of a vaccine, which comprises a plurality of polynucleotides each comprising a sequence as setting forth in SEQ ID No. 1 or SEQ ID No. 2, the polynucleotides being expressed in a body of the subject for inducing an immune response reactive against the infection of malaria thereof; a liquid phase of lipid nanoparticles configured to form a protective layer encapsulating the pluralities of polynucleotides within the protective layer; and a pharmaceutically acceptable adjuvant.
Resumen de: WO2024026029A2
Disclosed are compositions and methods related to lipid nanoparticles (LNPs) comprising ionizable lipids. The LNPs can comprise nucleic acid sequences encoding therapeutic peptides for immunotherapy, for example, bispecific antibodies or antigen binding fragments thereof.
Resumen de: CN120938870A
本发明属于化妆品原料技术领域，尤其涉及一种积雪草发酵微囊及其制备方法与应用。本发明将药用植物积雪草用多元醇溶解进行发酵，且发酵前后不进行高压蒸汽灭菌，保留更多活性成分，提高原料中具有舒缓修复功效的羟基积雪草苷等活性成分的溶解度，同时通过微射流对羟基积雪草苷等活性成分进行包裹并形成微囊，增加活性成分的水溶性和稳定性，确保活性成分能被皮肤有效吸收。本发明的微囊中包裹了积雪草中具有舒缓修复功效的活性成分形成纳米粒，实现高效舒缓修复功效的同时，更加稳定、安全无刺激；且微囊成分简单，不含有致敏性成分，安全性高。
Resumen de: CN120943972A
本发明涉及分子生物学技术领域，公开了一种新型自包封MVP‑INT纳米蛋白颗粒及其应用。本发明一种新型自包封MVP‑INT纳米蛋白颗粒，其是由MVP基因、自切割内含体基因和INT基因串联而成。本发明提供的一种新型自包封MVP‑INT纳米蛋白颗粒，通过自切割内含肽将MVP纳米颗粒与INT蛋白设计在一起，制备出可以自我封装药物的蛋白纳米颗粒，降低使用纳米颗粒进行封装药物的繁琐过程，优化MVP作为纳米载体的使用问题和挑战，提高纳米载体的包封药物的效率，为通用性纳米颗粒载体的研发提供市场价值。
Resumen de: CN120939067A
本发明公开了一种灵芝孢子油复合真菌多糖抗肿瘤口服制剂及其应用，按重量百分比计包括：灵芝孢子油：15％‑25％；复合真菌多糖：10％‑15％；辅酶Q10：1％‑3％；纳米包封载体：1％‑2％；辅料：包括磷脂：3％‑6％、维生素E：0.3％‑0.8％；余量为无菌水；本发明通过灰树花多糖激活巨噬细胞、裂褶菌多糖增强NK细胞毒性、姬松茸多糖抑制血管生成、冬虫夏草多糖调节免疫平衡，形成"直接杀伤+免疫激活+血管阻断"的三重协同网络；采用酪蛋白酸钠‑壳聚糖复合载体的膜乳化技术，解决了脂溶性与水溶性成分共递送难题；壳聚糖的正电荷特性实现靶向递送；本发明通过成分创新、工艺优化和机制突破，克服了现有真菌类抗肿瘤制剂的固有缺陷，为高效、低毒的肿瘤辅助治疗提供了全新解决方案。
Resumen de: US2025345481A1
Nanocomposite hydrogels suitable for bone tissue regeneration may include (i) a scaffold comprising serum albumin and a cell adhesion promoter crosslinked with polyethylene glycol and (ii) a nanoparticle dispersed in the scaffold. Said nanocomposite hydrogels may formed from an injectable composition that includes: a nanocomposite hydrogel precursor A comprising that comprises a polyethylene glycol with two or more N-hydroxysuccinimide-terminal groups (PEG-NHS); and a nanocomposite hydrogel precursor B comprising a serum albumin, a nanoparticle, and a cell adhesion promoter; wherein the nanocomposite hydrogel precursor A and the nanocomposite hydrogel precursor B are physically separated.
Resumen de: AU2024276494A1
This invention relates to a process of preparing an oil-in-water emulsion comprising testosterone for use in a pump-action dispensing device. It further relates to the oil-in-water emulsion produced by the process of the invention, and the combination of the emulsion with a pump-action dispensing device.
Nº publicación: US2025345442A1 13/11/2025
Solicitante:
SAN DIEGO STATE UNIV SDSU FOUNDATION DBA SAN DIEGO STATE UNIV RESEARCH FOUNDATION [US]
San Diego State University (SDSU) Foundation, dba San Diego State University Research Foundation
Resumen de: US2025345442A1
Provided are compositions, kits, and methods for delivering a proteinaceous cargo, or a protein or a peptide, or a drug or a marker, to or into a cell or to an individual in need thereof. In alternative embodiments, products of manufacture as provided herein comprise: (a) a recombinant bacterial Contractile Injection System (CIS) or a Metamorphosis Associated Contractile structure (MAC) formed or configured to comprise a tube having an inner core, (b) a Metamorphosis-Inducing Factor 1 (Mif1) protein positioned in the inner core of the tube of the CIS or MAC, (c) a chaperone 605 protein non-covalently associated with the Mif1 protein positioned in the inner core of the tube of the CIS or MAC, and (d) a proteinaceous cargo, or a heterologous protein or peptide, or compound, non-covalently associated or covalently associated or linked to the Mif1.
BOPI
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