3D bioinprimaketa

可3D打印的胶原-磷酸钙复合材料及其制备方法和应用

Resumen de: CN118743786A

本发明属于口腔医学临床应用材料与器械技术领域，涉及一种可3D打印的胶原‑磷酸钙复合材料的制备方法，包括：1)将I型胶原和III型胶原粉碎后，以一定比例混合在一起形成胶原混合物；2)将所述胶原混合物与有机化合物交联剂六亚甲基二异氰酸酯混合在一起形成原料混合物，并加入丙酮和催化剂，进行加热反应以形成交联复合胶原；3)对所述交联复合胶原进行干燥，并在干燥后与磷酸钙材料以一定比例混合，之后加入醋酸溶液溶解制成可3D打印的胶原‑磷酸钙复合材料。其能够提高具备整体力学性能的个性化骨缺损修复体制备的便捷性，保证修复体植入体内后形态与结构的稳定性和引导/诱导骨再生的可靠性，适用不同部位/大小的骨缺损修复。

細胞受容足場を作製するための材料および方法

Resumen de: CN118203703A

A printable composition for preparing a cell receiving scaffold, comprising from about 0.3 wt% to about 3.0 wt% of one or more collagens by weight based on the printable composition; from about 5.0 wt% to about 40.0 wt% of one or more monomers; from about 0.5 wt% to about 2.0 wt% of a photoinitiator; and from 0 wt% to about 75 wt% of a carrier comprising a protic solvent; wherein the composition printable upon printing has a resolution of about 100 microns or less, has a photographic speed (Dp/Ec) of about 0.1-5 mm (Dp) and about 10-100 mJ/cm2 (Ec), and has a green strength of at least about 5 kPa after drying. The technology also includes a method of producing a three-dimensional scaffold that receives cells using the printed composition.

COMPOSITIONS AND METHODS FOR THREE-DIMENSIONAL (3D) BIOPRINTING

Resumen de: WO2024206824A1

As a three-dimensional (3D) bioprinting technique, digital light processing (DLP) has become popular due to its capability to provide high-throughput and high-resolution constructs with precise chemical and biological factor distributions. However, despite the advancements in DLP technology, several hurdles remain, including phototoxicity, extensive printing time, and the limited portfolio of biocompatible/photo-cross-Jinkable materials. Herein, a novel DLP-based 3D-bioprinting technology' called photopolymerization of orderly-extruded multi-materials (POEM) has been developed and fully characterized. The utility of the POEM technique for rapid and high-resolution 3D-printing of multi-material, multi-layer, and cell-laden structures is demonstrated. The printed configurations showed high cell viability (—80%) and metabolic activity' for more than five days. The light-based POEM technique described herein enables the fabrication of 3D-cell-laden structures in a multi -material and multi-layer printing manner in biocompatibie/photo-cross-linkable materials essential to construct complex heterogeneous tissues/organs.

Procedimiento para la fabricación de una prótesis dental utilizando una base de datos digital de filas de dientes, y utilización de dicha base de datos digital de filas de dientes

Resumen de: US2022168078A1

The invention relates to a method for producing a denture, characterized by a) providing a predefined dental arch database, the dental arch database having data on maxilla and mandible arches in occlusion; b) generating the denture on the basis of the dental arch data on the maxilla and mandible arches in occlusion.

PHOTOCURABLE COMPOSITION, THREE-DIMENSIONAL MOLDED OBJECT, AND DENTAL PRODUCT

Resumen de: WO2024204626A1

A photocurable composition according to the present invention includes a photopolymerizable component and a photopolymerization initiator. The photopolymerizable component includes a (meth)acrylate (A) that has at least one carbonate linkage, at least one ether linkage, at least two urethane linkages, and two (meth)acryloyloxy groups.

SYSTEMS AND METHODS FOR ORTHODONTIC APPLIANCE PRODUCTION

Resumen de: WO2024199274A1

The present disclosure provides systems and methods for orthodontic appliance production. The methods may include determining a baseline thickness of an orthodontic appliance for orthodontically treating teeth of a target subject. The methods may include, for each local point on the teeth of the target subject, determining a movement path of the local point from an initial location of the local point to a target location of the local point. The methods may also include, for each local point on the teeth of the target subject, determining, based on the movement path and the baseline thickness, a target thickness of the orthodontic appliance corresponding to the local point. The methods may further include directing a three-dimensional (3D) printer to integrally produce, based on the target thickness of the orthodontic appliance at each local point, the orthodontic appliance.

POROUS CERAMIC FRAMEWORK AND PREPARATION METHOD THEREFOR, AND DOUBLE-BIONIC RESIN CERAMIC COMPOSITE MATERIAL

Resumen de: WO2024198488A1

A porous ceramic framework and a preparation method therefor, and a double-bionic resin ceramic composite material. The porous ceramic framework is of a three-dimensional structure formed by a plurality of unit cell structures arranged in an array; the unit cell structure is a cube provided with a through hole; the through hole is of a chamfered three-cylinder structure, the sizes of three cylinders in the three-cylinder structure are the same, and the length of the cylinders in the three-cylinder structure is the same as the side length of the cube. The porosity of hole units is controlled by changing a parameter D, a porous ceramic framework the porosity of which gradually changes from the bottom to the top is constructed, and bionics of a resin-infiltrated ceramic material and human teeth are achieved to the maximum extent in terms of physical performance; the porosity, pore diameter and pore distribution of the provided porous ceramic framework are highly controllable, a three-dimensional through structure can be realized, and the bionics of a resin-infiltrated ceramic material and human teeth is realized to the greatest extent in terms of structure.

DEVICE AND METHOD FOR COATING SURFACES

Resumen de: AU2024219654A1

- 67 The present invention relates to devices and methods for coating surfaces including surfaces of medical devices, in particular the coating of microprojections on microprojection arrays. The present invention also relates to print head devices and their manufacture and to methods of using the print head devices for manufacturing articles such as microprojection arrays as well as to coating the surfaces of microprojection arrays. The present invention also relates to high throughput printing devices that utilize the print heads of the present invention. Fig. 11 Fig. 11 Fig. 12

CONTINUOUS FIBER SUPPORT BARRIER FOR ENGINEERED VASCULAR NETWORKS

Resumen de: AU2023255504A1

Disclosed herein are apparatuses comprising one or more channels defining a luminal space, wherein the luminal space is defined by an inner wall of fibrous basement membrane material, as well as methods of their manufacture and use.

Breakaway Endplate Portions For Implant Revision

Resumen de: US2024325165A1

An interbody spinal cage comprising: a body portion comprising a superior side, an inferior side and at least one lateral side connecting the superior side and the inferior side; and at least one endplate portion coupled to the superior side or the inferior side of the body portion, the at least one endplate portion comprising a unibody structure and operable to be fixedly coupled to an anatomical structure of a patient and decoupled from the superior side or the inferior side of the body portion.

METHOD FOR THE ADDITIVE MANUFACTURING OF CASTING MOLDS

Resumen de: US2024326119A1

A method for manufacturing a photopolymerizable slurry comprises the steps of: providing a plurality of particles of an inorganic salt in the form of a powder; wherein at atmospheric pressure the inorganic salt has a melting point of above 250° C.; and wherein at room temperature the inorganic salt has a solubility in water above 9% w/w; providing at least one radiation curable monomer; the at least one radiation curable monomer being in the liquid phase; and adding the inorganic salt particles to the liquid composition and mixing the inorganic salt particles with the liquid composition; obtaining a photopolymerizable slurry, selectively curing the photopolymerizable slurry to obtain a green body article; debinding the green body article to obtain a binderless body article; and sintering the binderless body article to obtain a sintered ceramic article; providing a first template mold (1); wherein the first template mold comprises the sintered ceramic article; providing a second mold (2, 2′, 2″); wherein the second mold comprises a compartment into which said first template mold can be placed; mounting the first template mold into the compartment of the second mold, thereby obtaining an operative mold (1, 2, 2′, 2″); casting a fluid casting material (3, 3′, 3″) into said operative mold to obtain after solidification of said casting material an infiltrated template mold (8) comprising a solid article (9) that is at least partially located within the first template

METHOD OF PRODUCING A MICRONEEDLE ARRAY, MICRONEEDLE ARRAY AND USE THEREOF

Resumen de: US2024325701A1

Disclosed is a method of forming a microneedle array having a predefined microneedle pattern. The method comprises transforming digital information in a digital input pattern/image into a desired microneedle pattern, such that locations of microneedles in the microneedle pattern correspond to pixels in at least a portion of the digital input pattern or image; and forming a microneedle array having the desired microneedle pattern. Also disclosed is a method of forming a microneedle array having the predefined microneedle pattern using a master microneedle mold. The method comprises masking one or more holes in the master mold at predefined locations to create an array of unmasked holes corresponding to a desired microneedle pattern; and forming a microneedle array having the desired microneedle pattern using the masked master mold.

3D PRINTING DEVICE, 3D PRINTING METHOD AND 3D TUBULAR OBJECTS OBTAINED BY SAID METHOD

Resumen de: US2024326324A1

3D printing device and 3D printing method. The device (1) comprising: —a build platform having an external surface; —means for providing a polymerizable fluid resin (4) on said surface; —a radiation source (5), to emit a radiation beam (7) to said surface; —beam positioning means (8), to variably position an impinging point of said beam (7); and —means for controlling said source (5) and said positioning means (8) to manufacture a 3D tubular object (100) according to a model: wherein the build platform comprises a stem (3) forming a tubular shaped surface (2) around a longitudinal axis (9), so that said external surface of said build platform is comprised in said tubular shaped surface (2), and said positioning means (8) is configured to variably position said impinging point of said beam (7) on different points of said fluid resin (4) provided on said tubular shaped surface (2).

PHOTOPOLYMERIZABLE COMPOSITION FOR 3D PRINTER CONTAINING POLYMERIZABLE MONOMER HAVING ALLOPHANATE BOND

Resumen de: US2024325256A1

ProblemTo provide a photopolymerizable composition that has excellent formability in 3D printer and can prepare a three-dimensional modeled object with excellent toughness by using optical stereolithography (stereolithography).SolutionTo provide a dental photopolymerizable composition for 3D printer, comprising (a) (meth)acrylic polymerizable compound having an allophanate group, (b) (meth)acrylic polymer having one or two (meth)acryloyloxy groups, and (c) photoinitiator.

PERSONALIZED IMPLANT

Resumen de: US2024325151A1

A personalized implant for bone replacement comprises an implant body as a reconstruction of a bone portion. The implant body comprises a closed cavity and a solid impervious layer of material defining an outside surface of the implant body exposed to an exterior of the implant. The solid impervious layer fully encloses the closed cavity inside the implant body. The closed hollow interior can comprise an open support structure to reinforce the solid outside layer.

GROWTH FACTOR TRANSDUCED CELL-LOADED CERAMIC SCAFFOLD FOR BONE REGENERATION AND REPAIR

Resumen de: US2024325157A1

A method for repairing a bone defect of a patient includes providing a ceramic scaffold configured for filling the bone defect, loading the scaffold with growth factor transduced cells incorporating a gene that encodes a growth factor essential for bone formation, placing the ceramic scaffold with the growth factor transduced cells in or across the bone defect, and stabilizing the ceramic scaffold with the growth factor transduced cells in the patient until the bone defect is healed. An assembly for repairing a bone defect includes a ceramic scaffold configured for spanning the bone defect and a culture of live growth factor transduced cells incorporating a gene that encodes a growth factor essential for bone formation loaded onto the ceramic scaffold.

Tissue Scaffold with Patterned Microstructure

Resumen de: US2024325605A1

Provided herein is a tissue scaffold that may include microstructure patterns on one or more surfaces that can modify the physical properties of the tissue scaffold. The microstructure patterns may be cell-directing across a larger spatial range than the prior art which uses chemically modified substrates. The present disclosure further includes tissue scaffold configured such that cells may infiltrate the tissue scaffold by responding to patterns of surface energy gradients on the tissue scaffold and the cells may not be constrained into patterns by physical means. As the cells proliferate, they associate and orient in response to long-range patterns to form confluent monolayers of cells while constructing functional macro-structure across the tissue scaffold surface.

ACOUSTIC LEVITATION-ASSISTED CONTACTLESS DROPLET PRINTING

Resumen de: US2024326322A1

A method for universal contactless printing comprises depositing a first droplet into a sound field, curing the droplet to form a cured droplet, depositing a second droplet, and securing the second droplet to previously cured droplet by curing the second droplet. The method of contactless printing can be repeated to form a complex three-dimensional structure. The first droplet that is deposited can be secured to a moveable structure by curing the first droplet to the moveable structure. The moveable structure can be moved to place a next droplet to be deposited and cured.

3D PRINTED PROSTHETIC LINERS AND SOCKETS

Resumen de: US2024325174A1

A prosthetic device includes a polymer lattice structure. The lattice structure includes a first surface arranged to face toward a residual limb, a second surface arranged to face away from the residual limb, a thickness between the first and second surfaces, and a variable lattice density across the thickness.

ORTHODONTIC APPLIANCE SYSTEMS AND METHODS OF MAKING SAME

Resumen de: WO2024206597A1

An orthodontic appliance system for orthodontic treatment of teeth. The system includes a template with a cavity. An attachment is removably received in the receptacle and has a surface including a bonding surface. A method of manufacturing includes constructing a scaffold assembly including a base and placing a template in contact with the scaffold assembly. The method includes inserting the attachment into the receptacle. During separating, the attachment remains coupled to the template in the receptacle. A method of manufacturing includes providing a mold of the patient's teeth. The mold including at least one projection and a through-passage. The method includes placing a container of dental composite in fluid communication with the through-passage, placing a template over the at least one projection, injecting dental composite from the container through the through-passage and into the receptacle, and removing the template from the at least one projection with the filled receptacle.

NOVEL PROCESS

Resumen de: WO2024201321A1

The present invention relates to a process for obtaining a dental prosthesis comprising a crown and tooth root. Said process comprises at least one step of directing undifferentiated cells or keratinocytes and at least one three-dimensional printing step, preferably 3D bioprinting of the dental prosthesis. Furthermore, the invention regards the dental prosthesis obtained with the process and a bioink suitable for three-dimensional printing (3D), preferably suitable for 3D bioprinting.

METHOD FOR PREPARING A PRINTABLE THREE-DIMENSIONAL REPRESENTATION OF THE DENTITION OF A PATIENT FOR THE ADDITIVE MANUFACTURING OF A DENTAL MODEL REPLICATING THE DENTITION OF THE PATIENT

Resumen de: WO2024200944A1

The present invention relates to a method for preparing a printable three-dimensional representation of the dentition of a patient for the additive manufacturing of a dental model replicating the dentition of the patient, the method being characterised in that it comprises the implementation of the following steps: (a) obtaining a raw three-dimensional representation of the surface of the dentition of the patient, referred to as a digital dental impression; (b) selecting a portion of interest of the digital dental impression by applying a binary classification algorithm to the digital dental impression; (c) positioning the portion of interest of the raw digital dental impression in space such that an occlusal plane of the portion of interest of the digital dental impression is substantially parallel to a reference plane; (d) constructing a printable three-dimensional representation of the dentition of the patient by fusing the positioned portion of interest of the digital dental impression and a support block.

METAL-REINFORCED POLYMER FEMORAL COMPONENT OF AN ORTHOPAEDIC KNEE PROSTHESIS AND ASSOCIATED METHOD OF MAKING THE SAME

Resumen de: US2024325160A1

An orthopaedic knee prosthesis includes a femoral component having a metal base with a polymer articular layer molded thereto. A method for making a metal-reinforced femoral component of an orthopaedic knee prosthesis is also disclosed.

DEVICE FOR THE DIGITIZATION AND MANUFACTURING OF DENTAL MODELS

Resumen de: US2024325120A1

Device for the digitization and manufacturing of dental models, for replicating the cavity and position of the implant connection in plaster and digital 3D models, having an analog, a fixing element and a multipurpose accessory, as a reference when digitizing and as an aid when inserting the analog in and removing it from the model. The analog, the fixing element and the accessory are adapted for fixing the analog on the 3D printing model and/or connecting the analog to the accessory. The external surface of the analog combines cylindrical portions and flat vertical and horizontal faces, which define positioning surfaces, for use as a scan analog. And, for plaster models, the device includes a protective cover for the analog.

Direct-Snap Dental Abutment Systems

Nº publicación: US2024325123A1 03/10/2024

Solicitante:

BELL PATRICK C [US]
MATHEWS MICHAEL A [US]
ARENDT THOMAS J [US]
MALIN LEO J [US]
Bell Patrick C,
Mathews Michael A,
Arendt Thomas J,
Malin Leo J