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146
resultados
Última actualización
02/11/2025 [07:08:00]
Resumen de: CN120865697A
本发明涉及基于改性木竹纳米纤维素的自修复柔性传感器及其3D打印制备方法与应用，属于柔性传感器技术领域。为解决现有柔性传感器灵敏度低、耐久性差以及无法自修复的问题，本发明提供了基于改性木竹纳米纤维素的自修复柔性传感器的3D打印制备方法：步骤一、制备改性木竹纳米纤维素；步骤二、制备3D打印浆料；步骤三、3D打印制备自修复柔性传感器。本发明柔性传感器具有多尺度导电网络结构，灵敏度和柔性应变响应能力好；动态二硫共价键的引入赋予材料可逆交联特性，受损后2.5小时内即可实现力学性能的高效恢复，具有较好的结构稳定性和抗疲劳性能。本发明以生物基木竹纳米纤维为原料，通过3D打印实现低成本、高精度的定制化制造。
Resumen de: CN120860326A
本发明公开了一种负载锰铁普鲁士蓝类似物的磷酸钙双层结构的组织工程材料，制备方法为：S1、采用基体陶瓷浆料通过光固化3D打印成型，得到具有多孔结构的陶瓷湿坯；S2、对陶瓷湿坯进行梯度烧结，得到多孔陶瓷预制体；S3、将纳米磷酸钙与分散剂充分混合得到纳米磷酸钙悬液，将多孔陶瓷预制体置于纳米磷酸钙悬液中浸泡，烘干，得到双层多孔陶瓷湿坯；S4、将双层多孔陶瓷湿坯快速烧结，得到双层增强生物陶瓷；S5、将双层增强生物陶瓷置于普鲁士蓝类似物‑磷酸钙悬液中浸泡，烘干，得到负载锰铁普鲁士蓝类似物的磷酸钙双层结构的组织工程材料。本发明的组织工程材料兼顾力学性能高，表面粗糙度大以及有效缓解炎症，提高骨诱导性能等多重功效。
Resumen de: CN120860305A
本发明涉及一种3D打印的骨组织工程支架、制备方法及其应用，属于生物材料技术领域。该方法以可生物降解的PCL材料为基体，混合金属氧化物纳米颗粒，得到制备简单、功能性强的3D打印墨水，然后采用FDM技术制备PCL骨组织工程支架。所制备的支架成型性能优，能够保证打印质量和一致性；此外，该支架生物相容性好，展现出显著的促进干细胞增殖分化和抗菌抗氧化等能力。
Resumen de: CN120860308A
本申请提供一种3D打印可吸收骨塞的制备方法，属于生物医用材料技术领域，其制备方法步骤如下：1、对聚己内酯颗粒进行干燥处理，使其含水率不高于0.5%；2、将干燥后的聚己内酯颗粒与羟基磷灰石按配比混合，获得均匀的复合材料混合物；3、将复合材料混合物加入颗粒式3D打印设备中，通过螺杆送料至喷嘴处进行熔融处理；4、按照预设的骨塞三维模型进行逐层堆叠三维打印成型，形成具有连通多孔结构的骨塞坯件；5、对骨塞坯件进行后处理，得到成型的可吸收骨塞。本申请采用聚己内酯这一具备生物降解能力的热塑性高分子材料，结合具备良好骨诱导性的羟基磷灰石，有助于构建可被生理环境逐步吸收替代的植入物基础。
Resumen de: CN120859635A
本发明公开了一种骨再生屏障构件及制备系统，其中，一种骨再生屏障构件，包括：钉体，表面设有自攻螺纹；覆盖件，可拆卸连接在所述钉体上，所述覆盖件的尺寸和形状与患者口腔内的缺损区域形态相适配；所述钉体的内部设置有药物释放通道，所述药物释放通道设置有药物；所述钉体的外壁上设置有多个微孔，所述微孔连通外部与所述药物释放通道，以释放药物。由此，能够与缺损区域完美适配，配合单一的钉体固定，即可完成对覆盖件的安装，固定方式简单，且能够有效减少应力集中现象，同时还能够延长药物的释放时长，保证对患者的治疗效果。
Resumen de: WO2024188844A1
Recombinant bacterial collagen-like protein, preferably with an amino acid sequence that is at least ≥ 60% identical to the amino acid sequence of SEQ ID NO:1 wherein the amino acid sequence comprises a deletion of at least 38 amino acids at the N-terminus of the amino acid sequence of SEQ ID NO:1, wherein the recombinant collagen-like protein is functionalized with at least one non-terminal alkene group. A bioink comprising the functionalized recombinant bacterial collagen-like protein, at least one solvent and at least one photoinitiator, a process for producing a hydrogel by crosslinking the functionalized recombinant bacterial protein or the bioink as well as the hydrogel obtained therefrom. Furthermore, a scaffold for tissue engineering comprising the hydrogel.
Resumen de: CN120860329A
本发明公开了一种心肌修复材料及其制备方法和应用。该心肌修复材料包含多个层叠的纤维层，纤维层由若干个交错的微米级纤维组成，并具有微米级孔隙；微米级纤维的表面粗糙度Ra不低于130 nm。该心肌修复材料利用自身结构特点促进M2型巨噬细胞极化并增强血管生成，无需负载外源性活性成分即可促进心肌修复，避免了使用外源性活性成分引发免疫排斥反应的问题。
Resumen de: WO2025223804A1
The invention relates to a surgical shaft instrument (1) with at least one jaw part (30) which is movable in at least one axis (X) and by means of which a preferably pliers-like or scissors-like tool is formed in a distal end region (9), comprising a first part (10) having a first shaft portion (20) along a shaft axis (L); a second part (40) having a second shaft portion (50) along the shaft axis (L) and a second guiding means (42) in the distal end region (9); and at least one jaw part (30) which is provided on the first part (10) in the distal end region (9), said at least one jaw part (30) having a first guiding means (32) and being provided as a single piece. The first part (10) and the second part (40) are combined such that the first guiding means (32) and the second guiding means (42) interact in such a way that when the first shaft portion (20) and the second shaft portion (50) are mutually displaced, the at least one jaw part (30) is deflected about the at least one axis (X). The invention also relates to a method for producing the surgical shaft instrument (1).
Resumen de: WO2025223689A1
The aim of the invention is to devise a method for providing a connection between a number of inserted dental implants and a prosthetic body, which makes it particularly simple to establish a reliable and secure connection between the prosthetic body and the inserted implants. For this purpose, according to the invention, the prosthetic body is provided with a recess for each dental implant, said recess being associated with the dental implant and being suitable for accommodating a connecting element of the particular dental implant. Following the insertion of the dental implants into the jawbone of the patient, the intraoral data characteristic of the oral situation of the patient including the inserted dental implants is captured. Using this intraoral data, the geometric data defining the intermediate space formed by the connecting element and the associated recess when the prosthetic body is correctly placed is determined for the connecting element of the dental implant, and, using this data, an intermediate body is produced that fills the intermediate space.
Resumen de: WO2025223664A1
The aim of the invention is to devise a method for providing a connection between an inserted dental implant and a crown, which makes it particularly simple to establish a reliable and secure connection between the crown and the inserted implant. For this purpose, according to the invention, the crown is provided with an associated recess suitable for accommodating a connecting element of the dental implant. Following the insertion of the dental implant into the jawbone of the patient, the intraoral data characteristic of the oral situation of the patient including the inserted dental implant is captured. Using this intraoral data, the geometric data defining the intermediate space formed by the connecting element and the associated recess when the crown is correctly placed is determined, and, using this data, an intermediate body is produced that fills the intermediate space.
Resumen de: WO2025223663A1
The aim of the invention is to devise a method for providing a connection between a number of inserted dental implants and a prosthetic body, which makes it particularly simple to establish a reliable and secure connection between the prosthetic body and the inserted implants. For this purpose, according to the invention, the prosthetic body is provided with a recess for each dental implant, said recess being associated with the dental implant and being suitable for accommodating a connecting element of the particular dental implant. Following the insertion of the dental implants into the jawbone of the patient, the intraoral data characteristic of the oral situation of the patient including the inserted dental implants is captured. Using this intraoral data, the geometric data defining the intermediate space formed by the connecting element and the associated recess when the prosthetic body is correctly placed is determined for the connecting element of the dental implant, and, using this data, an intermediate body is produced that fills the intermediate space.
Resumen de: US2025334162A1
There is disclosed a compliant support mechanism including a first support surface; a second support surface; and one or more flexure prongs arranged in a configuration therebetween, each flexure prong having a plurality of bends or curves along its length so as to allow the configuration of one or more flexure prongs to be resiliently compliant when subjected to external forces on the support surfaces. The one or more flexure prongs have a compliance profile dependent upon the application.
Resumen de: US2025332067A1
A magnetic cup includes a first cup portion including a first magnet and a second cup portion including a second magnet. A target capsule is placed between the first cup portion and the second cup portion. The target capsule is sealed with a first seal. The magnetic cup provides a second seal formed from a magnetic force between the first magnet and the second magnet. Further provided is a tool designed to assist a user for opening the magnetic cup. The tool includes a first arm including a third magnet designed to attract the first magnet through a second magnetic force greater than the first magnetic force, and a second arm including a fourth magnet designed to attract the second magnet through a third magnetic force greater than the first magnetic force.
Resumen de: US2025332412A1
A method for treating tumor cells around a resection cavity comprises positioning a nonconductive material within a resection cavity that is adjacent to a target region. At least a first electrode and a second electrode are positioned relative to the tumor resection cavity so that electric fields between the at least one first electrode and the at least one second electrode travel through the target region. Tumor-treating electric fields are the generated between the at least one first electrode and the at least one second electrode.
Resumen de: US2025332406A1
Implantable apparatus includes two or more alignable marker elements, and systems and methods for manufacturing such implantable apparatus, and methods to utilize such implantable apparatus. For example, the implantable apparatus may include a first alignable marker element and a second alignable marker element that may be used to ensure proper alignment with a target site.
Resumen de: US2025331850A1
An apparatus includes a staple, a body, a staple driver, and an alignment feature. The alignment feature is coupled to or formed with at least one of the staple driver or an inner surface of the staple aperture of the body. The alignment feature is configured to minimize rotation of the staple driver. The alignment feature includes at least one of a first contact feature, an alignment member, an alignment member, or an inwardly tapering portion. The first contact feature projects beyond a first lateral side of the staple driver. The alignment member extends through at least a portion of the staple driver. The first connecting portion rigidly connects the inner surface of the staple aperture with the staple driver in a connected state. The inwardly tapering portion of the inner surface or the staple driver is configured to guide the staple driver.
Resumen de: US2025331954A1
A method of fabricating a dental appliance includes receiving a 3D model of a mold for a dental arch of a patient, the digital three-dimensional model of the mold comprising one or more features associated with one or more coordinate system reference marks, and fabricating the mold by a rapid prototyping machine using the digital three-dimensional model, the mold having the one or more features. The method further includes thermoforming the dental appliance over the mold, wherein the one or more features cause the dental appliance to have the one or more coordinate system reference marks. The method further includes orienting, by a trimming machine, a coordinate system of the trimming machine with a coordinate system of the dental appliance using the one or more coordinate system reference marks, trimming, by the trimming machine, the dental appliance along a cut line according to a digital file comprising trimming instructions.
Resumen de: US2025331953A1
Methods for determining appliance geometry are provided. In some embodiments, a method includes determining a geometry for an attachment placement appliance. The attachment placement appliance can include an appliance body including a support formed in a tooth-receiving cavity for a tooth of a patient, one or more coupling structures connected to the support, and an aligner attachment connected to the one or more coupling structures. The aligner attachment can be configured to be mounted on the tooth and shaped to engage with an attachment well of a shell aligner and exert forces on the tooth when the aligner attachment is coupled to the attachment well. The appliance body can be configured to align an aligner attachment to a predetermined location on the tooth. The method can further include generating instructions for direct fabrication of the attachment placement appliance via an additive manufacturing process, based on the determined geometry.
Resumen de: US2025331960A1
An orthodontic device includes an alignment body, a support member, and a positioning mechanism connecting the support member to the alignment body. The support member includes a bracket receiving structure and is actuatable between a bonding position and a non-bonding position. A process of manufacturing an orthodontic device includes constructing an orthodontic device from data including a three-dimensional model obtained from a patient's dentition, an orthodontic prescription, and a structure of an orthodontic bracket including a bonding surface.
Resumen de: DE102024111699A1
Die vorliegende Erfindung betrifft ein chirurgisches Schaftinstrument (1) mit mindestens einem in mindestens einer Achse (X) beweglichen Maulteil (30) durch welches ein bevorzugt zangen- oder scherenartiges Werkzeug in einem distalen Endbereich (9) gebildet wird, aufweisend ein erstes Teil (10) mit einem entlang einer Schaftachse (L) angeordneten ersten Schaftabschnitt (20), ein zweites Teil (40) mit einem entlang der Schaftachse (L) angeordneten zweiten Schaftabschnitt (50) und einem im distalen Endbereich (9) angeordneten zweiten Führungsmittel (42) und mindestens ein im distalen Endbereich (9) an dem ersten Teil (10) angeordnetes Maulteil (30), wobei das mindestens eine Maulteil (30) ein erstes Führungsmittel (32) aufweist und einstückig ist, wobei das erste Teil (10) und das zweite Teil (40) derart zusammengesetzt werden können, dass das erste Führungsmittel (32) und das zweite Führungsmittel (42) derart zusammenwirken, dass bei einem gegenseitigen Verschieben des ersten Schaftabschnitts (20) und des zweiten Schaftabschnitts (50), das mindestens eine Maulteil (30) um die mindestens eine Achse (X) ausgelenkt wird. Weiterhin betrifft die vorliegende Erfindung ein Verfahren zum Herstellen des chirurgischen Schaftinstruments (1).
Resumen de: US2025332794A1
To provide simple yet accurate stent graft fenestration, a patient-specific fenestration template is used as a guide for graft fenestration. To generate the fenestration template, a patient's medical imaging data such as CT scan data may be used to generate a 3-D digital model of an aorta lumen of the patient. The aorta lumen may encompass one or more branch vessels, which may be indicated on the 3-D digital model. Based on the 3-D digital model or a segment thereof, the fenestration template may be generated, for example, using 3-D printing technology. The fenestration template may include one or more holes or openings that correspond to the one or more branch vessels. To fenestrate a stent graft, the fenestration template is coupled to the stent graft so that the holes or openings on the fenestration template indicate the fenestration locations.
Resumen de: US2023310704A1
A three-dimensional (3D) biocompatible, degradable soft tissue implant, comprising a bioprinted composite scaffold, the composite scaffold comprising a recombinant human collagen (rhCollagen) and a biocompatible synthetic polymer and features: a porous wall; an inner cavity at least partially enclosed within the porous wall; and at least one injection port that connects the inner cavity with an outer most surface of the scaffold, wherein the injection port has an opening sized to permit insertion of an injection device through the port, processes of preparing same and uses thereof in soft tissue reconstruction are provided. Injectable matrices for use in soft tissue reconstruction, either alone or in combination with the implant are also provided.
Resumen de: WO2025226761A1
The present invention relates to a method and system for fabricating customized orthodontic brackets using 3D printing technologies with ultra-fine resolution to produce the orthodontic bracket with multiple layer thicknesses, and each layer thickness ranges from 0.05 micrometers to 100 micrometers. The process involves accessing data related to a 3D CAD bracket structure model for the customized orthodontic bracket. The 3D printing technologies with adaptive slicing dynamically adjust layer thickness based on geometric complexity and surface roughness, ensuring the variable layer ranges from 0.05 micrometers to 100 micrometers. By applying variable layer thickness, the method optimizes surface roughness.
Resumen de: WO2025226727A1
This disclosure relates to systems, methods, and devices for plaque analysis, vessel and fluid flow analysis, and/or risk determination or prediction thereof. Some embodiments relate to determining fractional flow reserve (FFR) values. Some embodiments relate to determining FFR values using 3D-printed models. Some embodiments relate to identifying thin cap fibroatheroma based on analysis of computed tomography (CT) imaging. Some embodiments relate adjusting calcified plaque thresholds for CT images to address effects of calcium blooming.
Nº publicación: WO2025226163A1 30/10/2025
Solicitante:
UNIV DE INGENIERIA Y TECNOLOGIA [PE]
UNIV NACIONAL DE TRUJILLO [PE]
INSTITUTO NAC DE SALUD DEL NINO SAN BORJA [PE]
UNIVERSIDAD DE INGENIER\u00CDA Y TECNOLOG\u00CDA,
UNIVERSIDAD NACIONAL DE TRUJILLO,
INSTITUTO NACIONAL DE SALUD DEL NI\u00D1O SAN BORJA
Resumen de: WO2025226163A1
The present invention relates to a flexible exoskeleton having a suit with one or more pneumatic artificial muscles, wherein the pneumatic artificial muscle comprises: a flexible membrane; internal rings spaced apart from one another and wrapped inside the flexible membrane; and external rings that are coupled to the internal rings from the outside of the flexible membrane. The rings and the clips may be manufactured, for example, by means of 3D printing and the membrane may be a thin plastic film or a fabric.
BOPI
Sede Electrónica
