Resumen de: US2025222178A1
Methods for improving the antibacterial and/or bone-forming characteristics of biomedical implants and related implants manufactured according to such methods. In some implementations, a biomedical implant may comprise a composite of a silicon nitride ceramic powder dispersed within a poly-ether-ether-ketone (PEEK) or a poly-ether-ketone-ketone (PEKK) substrate material. In some implementations, the biomedical implant may be 3D printed.
Resumen de: US2025222169A1
The present disclosure relates to a photoinitiator, a bioink including the same, and a method of manufacturing a hydrogel. According to the present disclosure, the photoinitiator of the present disclosure may have water solubility, high molar extinction coefficient, and low cytotoxicity. In addition, the method of manufacturing a hydrogel of the present disclosure may have high cell viability by increasing 3D printing efficiency due to a fast photo-curing rate.
Resumen de: US2025222168A1
Described herein is a method of forming an aligned tissue or tissue construct. The method includes extruding a bioink material through a nozzle onto a support to form a structure of the bioink material, the bioink material comprising anisotropic organ building blocks (aOBBs) comprising extracellular matrix material (ECM) and cellularly aligned cells, wherein the aOBBs align parallel to the direction of the extrude path, and polymerizing the structure of the bioink material, thereby forming the tissue or tissue construct having arbitrarily programmed alignment. Also, described is a tissue or tissue construct produced by the method, as well as bioink material used to produce the same.
Resumen de: US2025222654A1
The method of manufacturing a transparent whitening tray according to the present invention includes 3D printing of the whitening tray using the composition for forming a transparent whitening tray as a raw material (S10), removing uncured resin and liquid from the whitening tray obtained in the above step (S20), post-curing the whitening tray obtained in the above step (S30), post-heat treating the whitening tray obtained in the above step (S40), and washing the whitening tray obtained in the above step (S40).
Resumen de: US2025223568A1
Disclosed herein is a method of extracting extracellular matrix (ECM) from organoids via decellularization and hydrogels formed from methods thereof. The hydrogels can be used in medical devices for regenerative medicine like tissue grafts, and research and development applications to enhance disease modeling utilizing 3D bioprinting or other hydrogel embedding processes. The hydrogels can also be used to enhance tissue culture flasks for cells by offering a softer environment than polystyrene for cell culture. The hydrogels can be used in drug and vaccine delivery as well.
Resumen de: US2025221803A1
Provided herein are methods of making a coated object that include applying a coating composition to a surface of an object that comprises a plurality of entrapment structures thereon, wherein the coating composition is on at least a portion of the plurality of entrapment structures; and curing and/or solidifying the coating composition to form the coated object. Also provided are coated objects formed by such methods. Additionally, provided herein are methods of bonding a first surface to a second surface wherein the first surface and/or the second surface comprises a plurality of entrapment structures thereon. Composite articles are also provided herein.
Resumen de: US2025221824A1
A method of additive manufacturing an object featuring properties of a hard bodily tissue, comprises: dispensing and solidifying a plurality of non-biological material formulations to sequentially form a plurality of hardened layers in a configured pattern corresponding to a shape of the object. The method forms voxel elements containing different material formulations at interlaced locations to provide a three-dimensional textured region spanning over the portion. The material formulations and the interlaced locations are selected such that the textured region exhibits, once hardened, a stress variation of at most ±20% over a strain range of from about 0.1% to about 0.3%.
Resumen de: US2025221826A1
A process for printing a talus implant comprising the steps of scanning a joint for a damaged talus, and scanning a contralateral joint for a healthy talus. Next, the process includes obtaining dimensions for a talus based upon an initial scan and then obtaining dimensions for a talus based upon the scan of the contralateral joint. Next the process includes inverting the dimensions of the talus in the contralateral joint and then comparing the dimensions of the calculated talus with a pre-set of dimensions in a database. Next the process includes exporting a set of dimensions to a printer to print a talus implant.
Resumen de: US2025221814A1
There is provided a device for skin bioprinting and a method of making a device for skin bioprinting, the device comprising: a dispenser module configured to actuate and dispense a bioink from a first chamber, and to actuate and dispense a crosslinker from a second chamber: a storage module coupled to the dispenser module, the storage module comprising the first chamber for storing the bioink and the second chamber for storing the crosslinker; a mixing module coupled to the storage module for mixing the bioink and the crosslinker dispensed from the first and second chambers respectively; and a rotatable applicator coupled to the mixing module for rotatably applying a mixture of the bioink and crosslinker from the mixing module onto a surface of a patient in need of skin regeneration.
Resumen de: AU2023410422A1
The present invention relates to a crosslinkable polymer composition comprising at least one calcium phosphate, at least one biocompatible and biodegradable organic polymer or one of its precursors, and Zn-ZnO core-shell particles, to a biomaterial obtainable by photopolymerization of such a crosslinkable polymer composition, to a process for preparing such a composition and such a biomaterial, and to the use of such a biomaterial for various applications in the field of health.
Resumen de: CA3203310A1
A biocompatible scaffold construct may include a biocompatible hydrogel and at least one biomaterial microfiber strand wound to form a plurality of microfiber segments in proximity to one another and arranged in an organized configuration.
Resumen de: CN119403514A
The invention discloses a method for manufacturing a transparent correction device based on a 3D printer, namely a method for executing the transparent correction device through a computer, and the method comprises the following steps: (A) scanning an oral cavity structure of a patient, and generating and storing data related to the shape of the oral cavity structure; (B) displaying the oral cavity structure of the patient on the basis of the data stored in the step (A); (C) setting detailed correction information on the oral cavity structure of the patient displayed in the step (B), the step (C) comprising: selecting a tooth to be corrected in a state where the oral cavity structure of the patient is displayed, and inputting correction values of the rotation amount and the movement amount of the selected tooth; a step for inputting the scale of the transparent correction device on the basis of the input correction value; and a step of inputting the thicknesses of the portion where the transparent orthodontic device is in contact with the orthodontic teeth and the portion where the transparent orthodontic device is not in contact with the orthodontic teeth, respectively, so that the thicknesses of the transparent orthodontic device are partially differentiated.
Resumen de: US2025222166A1
The present invention relates to a method of providing a graft scaffold for cartilage repair, particularly in a human patient. The method of the invention comprising the steps of providing particles and/or fibres; providing an aqueous solution of a gelling polysaccharide; providing mammalian cells; mixing said particles and/or fibres, said aqueous solution of a gelling polysaccharide and said mammalian cells to obtain a printing mix; and depositing said printing mix in a three-dimensional form. The invention further relates to graft scaffolds and grafts obtained by the method of the invention.
Resumen de: JP2025103477A
【課題】より簡単に作製することができる変形部材を提供する。【解決手段】変形部材10は、液体を膨潤させることにより膨潤する膨潤性ゲルからなる板状の変形部材であって、一方の表面に複数の溝11が並列に延びている。【選択図】図1
Resumen de: WO2024047045A1
The present invention provides methods for the preparation of synthetic bone grafts which are made of a composition comprising two matrixes, one ceramic including interlocked CDHA crystals, and another of one or more binder(s), the two matrixes being admixture. The method comprises the preparing of an ink composition, the 3D-printing, and the hardening of the binder and ceramic components, in this order. The resulting bone grafts, which are characterized by including the two matrixes in admixture, shows improved mechanical properties as well as excellent biological properties.
Resumen de: WO2024047098A1
The present invention relates to guidance in spatial setups of a room in a medical facility. In order to provide improvements for a facilitated work procedure in medical interventions, a device (10) for guidance in spatial setups of a room in a medical facility is provided that comprises a data input (12), a data processor (14) and an output interface (16). The data input is configured to provide procedure data (18) about a current executed medical procedure. The data input is also configured to provide spatial data (20) of at least one of the group of staff and equipment relating to the currently executed medical procedure. The data processor is configured to calculate upcoming physical movement of at least one of the group of the staff and the equipment based on the procedure data and the spatial data procedure data. The data processor is also configured to determine, based on the calculated upcoming physical movement, at least one of the group of equipment movement instructions (22) and staff spatial guidance (24). Further, the output interface is configured to provide at least one of the group of the equipment movement instructions and the staff spatial guidance.
Resumen de: WO2024047419A1
The present disclosure provides a microstructured article including a thermoplastic polymer shaped to have a curve. At least a portion of the curve includes a microstructured surface of utilitarian discontinuities and the microstructured surface includes peak structures and adjacent valleys. The peak structures and the curve are formed of a single piece of the thermoplastic polymer. A method of making the microstructured articles is also provided including a) obtaining a tool shaped to include at least one of a protrusion or a concavity; b) disposing a microstructured film on at least a portion of the tool including the protrusion and/or the concavity; and c) thermoforming a single piece of thermoplastic polymer onto the tool to form a microstructured article shaped to include a curve. The curve is an inverse of the protrusion or the concavity of the tool.
Resumen de: WO2024047317A1
The present invention relates to a surgical insert (1) comprising a first layer (11) and a second layer (12), wherein the first layer and the second layer comprise openings (111, 112) having a figure-of-eight shape. The invention also relates to a bone cement comprising a pulverulent solid phase that comprises natural polysaccharides and a ceramic filler, a liquid acrylate, and a polymerising agent.
Resumen de: WO2024120583A1
The invention relates to a tool for use as a micromanipulator and to a method for producing the tool. The tool consists of a plurality of parts in the form of - a frame (1) which is oriented along a longitudinal axis (L) and which is arranged as a hollow body around an interior, - at least one manipulator element (2) arranged on a first end face (1.1) of the frame (1), and - at least one actuation element (3) which is arranged on a second end face (1.2) opposite the first end face (1.1) and which is mounted slidably and axially movably in the interior of the frame (1), said parts being connected interlockingly and movably to one another by means of necessary connecting and bearing elements, and the tool being entirely generated by additive manufacture, including all the necessary gaps between the parts movably connected to one another. According to the method, the tool with all its parts and with the gaps between the movable parts is manufactured entirely by additive manufacture in one processing operation.
Resumen de: EP4582433A1
The present disclosure relates to a photoinitiator, a bioink including the same, and a method of manufacturing a hydrogel. According to the present disclosure, the photoinitiator of the present disclosure may have water solubility, high molar extinction coefficient, and low cytotoxicity. In addition, the method of manufacturing a hydrogel of the present disclosure may have high cell viability by increasing 3D printing efficiency due to a fast photo-curing rate.
Resumen de: EP4582433A1
The present disclosure relates to a photoinitiator, a bioink including the same, and a method of manufacturing a hydrogel. According to the present disclosure, the photoinitiator of the present disclosure may have water solubility, high molar extinction coefficient, and low cytotoxicity. In addition, the method of manufacturing a hydrogel of the present disclosure may have high cell viability by increasing 3D printing efficiency due to a fast photo-curing rate.
Resumen de: CN120267444A
本发明公开了一种金属增材制造高耐磨异构股骨髁假体及其制造方法,假体包括:第一平面、第二平面、第三平面以及第四平面,各平面沿着根据患者的股骨远端的骨性解剖特征排列并一体化成型;每个平面包括细晶层、强韧基体层和力学匹配多孔接触层,所述力学匹配多孔接触层与股骨远端的创面接触,所述强韧基体层与力学匹配多孔接触层呈一体化,所述细晶层设置在最外层,所述力学匹配多孔接触层具有多孔结构;所述第二平面设有用于第二平面上固定假体的固定钉。本发明通过利用激光原位重熔技术对假体运动曲面进行作用,假体表面金属组织快速凝结形成晶粒细化,从而实现膝关节假体表面性能的提高。
Resumen de: CN120267891A
本发明公开了一种骨再生多重仿生支架材料及其制备方法,涉及仿生骨技术领域;本发明的一种骨再生多重仿生支架材料及其制备方法,是先以聚乳酸嵌段共聚物为原料采用3D打印技术制得符合骨缺损形貌的基底支架,再将基底支架在胶原蛋白混合溶液和改性层状双氢氧化合物溶液中进行交替浸渍多次,在基底支架表面形成由胶原蛋白/层状双氢氧化合物组成的仿生基质层,最后将表面附着有仿生基质层的基底支架依次在磷酸氢二钾和氯化钙溶液进行多次交替浸泡,在表面附着有仿生基质层的基底支架上原位矿化形成钙磷酸盐纳米粒子,最后进行清洗、干燥得到;本发明制得的骨再生多重仿生支架材料的生物相容性较好,力学性能较好。
Resumen de: CN120267892A
本申请公开了一种骨软骨修复支架及其制备方法,其中,骨软骨修复支架包括依次连接的软骨下骨层、钙化软骨层以及软骨层,钙化软骨层包括钙化软骨上层、钙化软骨中层、钙化软骨下层,以及镶嵌在钙化软骨上层、钙化软骨中层内的多孔凝胶,本申请实施例中,采用上述的一种骨软骨修复支架及其制备方法,采用分层结构模拟人体生理软骨,通过钙化软骨层的分层及梯度孔隙率设计,不仅提升了支架的柔韧性,改善支架的使用性能,而且能够确保支架在植入到骨软骨缺损部位后能够快速招募患者的自体血液,从而引导骨髓间充质干细胞在软骨层分化为软骨细胞,促进软骨组织生成。
Nº publicación: CN120269016A 08/07/2025
Solicitante:
浙江大学医学院附属口腔医院
Resumen de: CN120269016A
本发明公开了一种具有光敏抗菌性的钙‑钛八面体骨缺损修复复合材料及其制备方法。本发明通过抑制病源微生物活性,重建骨内微观‑宏观结构,纠正微环境离子‑结构紊乱,促进感染性骨缺损再生。钙‑钛八面体复合材料具有独特的光催化效应,在420‑460nm波长的蓝光催化下能有效抑制细菌生长。此外,在微酸性环境下,八面体离子笼内的Ca2+与H+自发进行离子交换,升高微环境pH,释放Ca2+辅助骨修复。钙‑钛八面体与胶原类支架交联构成的复合支架材料具备良好的力学性能,可以基于应力匹配,模拟各种骨质类型,恢复骨宏观结构完整性。