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一种高性能耐磨增强型牙科复合修复材料及其制备方法

Resumen de: CN120093608A

本申请涉及齿科修复用复合材料技术领域，尤其涉及一种高性能耐磨增强型牙科复合修复材料及其制备方法。一种高性能耐磨增强型牙科复合修复材料，包括以下制备原料：树脂45‑55份、改性耐磨填料30‑35份、改性玻璃纤维5‑8份、羟基磷酸钙6‑8份、抗菌剂0.5‑0.8份、偶联剂0.8‑1.2份、着色剂0.01‑0.02份、抗氧化剂0.1‑0.2份，其中，所述树脂，按质量份数计，包括以下制备原料：环氧树脂25‑35份、甲基丙烯酸类化合物60‑75份、固化剂1‑1.5份。本申请的高性能耐磨增强型牙科复合修复材料在力学性能、抗菌性能、生物相容性和应用范围等方面均表现出显著的优势，有望在牙科领域得到广泛应用。

Procédé de fabrication d’une prothèse dentaire partielle amovible et prothèse dentaire partielle amovible

Resumen de: FR3156030A1

Procédé de fabrication d’une prothèse dentaire partielle amovible, comportant des étapes de : a) fabrication d’au moins un bloc monolithique comportant une partie dent artificielle et une partie gencive artificielle, le bloc monolithique comportant au moins un premier organe d’assemblage, b) fabrication d’un châssis configuré pour supporter le bloc monolithique, le châssis comportant au moins un deuxième organe d’assemblage, puis c) assemblage du bloc monolithique avec le châssis par emboîtement du premier organe d’assemblage avec le deuxième organe d’assemblage formant la prothèse dentaire partielle amovible. Figure pour l’abrégé : Fig. 4B

一种具有双触发形状记忆功能的复合PLA/PEG/Mg/Cu抗菌抗肿瘤骨支架及其熔融沉积成型（FDM）制备方法

Resumen de: CN120093989A

本发明公开了一种光驱动/温度驱动双触发形状记忆抗菌抗肿瘤骨支架及其熔融沉积成型（FDM）制备方法，其特征在于：以聚乳酸（PLA）为基体，通过有机溶剂共混法将聚乙二醇（PEG）及纳米氢氧化镁（Mg(OH)2）/氧化铜（CuO）均匀分散，经干燥成膜‑粉碎造粒‑螺杆挤出工艺制备复合丝材，最终通过FDM工艺实现三维多孔支架一体化成型。所述支架通过PLA‑PEG的玻璃化转变调控与纳米金属氧化物颗粒光热效应协同，实现温度和近红外光双触发形状记忆。纳米Mg(OH)2/CuO赋予支架多模态抗菌抗肿瘤功能：1）Mg2+/Cu2+释放破坏微生物膜电位；2）近红外光热响应诱导细菌肿瘤细胞凋亡；3）Mg(OH)2降解形成碱性微环境调控抑制生物膜生成。该支架突破传统植入物形态固定局限，可通过光/热刺激触发形状自适应，精准贴合不规则骨缺损，避免二次手术风险，在微创骨科修复中具有显著优势。

一种表面修饰有序微纳米线的三维生物活性支架及其制备方法和应用

Resumen de: CN120093987A

本发明涉及一种表面修饰有序微纳米线的三维生物活性支架及其制备方法和应用，属于生物材料领域。所述三维生物活性支架包括生物活性支架基体和修饰在所述生物活性支架基体表面的拓扑结构层，其中，所述拓扑结构层由沿固定方向进行有序定向排布的微纳米线构成。本发明成功将有序微纳拓扑结构整合至三维组织工程支架中，可以对多种细胞进行有效的物理干预，同时也可以作为一种灵活的组织工程平台用于复杂组织的再生。另外，本发明将3D打印技术与表面刷涂技术相结合，构建表面具有有序微纳米线的生物活性支架，对组织工程支架的发展具有重要意义。

一种生物打印墨水、生物材料三维支架及制备方法

Resumen de: CN120093986A

本申请提供的生物打印墨水、生物材料三维支架及制备方法，合成水凝胶颗粒前驱体；对所述水凝胶颗粒前驱体进行冷冻干燥得到水凝胶干粉；将细胞悬液载体与细胞悬液混合以形成缝隙胶；将所述缝隙胶与所述水凝胶干粉搅拌分散以得到所述生物打印墨水。本申请提供的生物打印墨水，具有相容性好、易于打印操作的生物材料，可以按需在体外构建人体或动物的组织或器官，提供利于细胞生长的三维支撑材料。该材料可以精确打印高密度的细胞，有效地控制细胞在三维支架中的空间分布(不发生细胞沉降)，提高细胞在三维支架上的粘附率，解决细胞打印的成型性和生物相容性问题。

软骨修复支架

Resumen de: CN222942498U

本实用新型提供了一种软骨修复支架，软骨修复支架的支架本体的内部设有空腔，支架本体的表面设有开口，开口将空腔和支架本体的外部空间连通；支架本体上设有若干微孔，至少部分微孔连通空腔和支架本体的外部空间。本实用新型的软骨修复支架解决了相关技术中的软骨修复支架使用灵活性差的技术问题。

一种基于复合陶瓷修复材料的3D打印梯度仿生牙体结构的方法

Resumen de: CN120093463A

本发明涉及仿生牙技术领域，具体涉及一种基于复合陶瓷修复材料的3D打印梯度仿生牙体结构的方法，步骤S1,采用硅酸锂铝系生物陶瓷作为基础材料，经等离子体球磨处理得到均匀的粉末，将粉末与含3wt%光引发剂的聚乙二醇二丙烯酸酯树脂按42%‑46%粉水比配制浆料；步骤S2，将浆料进行真空脱泡机组三级处理；步骤S3，基于CT扫描数据，构建梯度应力分布模型，划分釉质层、牙本质层和牙髓腔过渡层；步骤S4，通过压电微滴喷射系统以50±5mm/s速度将浆料进行层积成型；步骤S5，将打印完成的仿生牙体结构采用梯度烧结工艺烧结成型。解决传统的修复材料往往难以精确模仿牙齿的这种梯度结构，导致修复体与周围组织之间的界面不稳定，容易出现炎症反应和排斥反应的问题。

3D打印的陶瓷组合物和使用方法

Resumen de: AU2023330160A1

The present disclosure provides devices comprising a therapeutic agent bound to a printed three-dimensional structure. Ink formulations for three-dimensional printing are also disclosed. Additionally, provided herein are methods for manufacturing devices and uses thereof,

3D PRINTED CONDUCTIVE BIOPOLYMER FOR CARDIAC TISSUE ENGINEERING

Resumen de: US2025177607A1

An engineered material includes a conductive biopolymer including a plurality of layers, each of which includes methacrylated hyaluronic acid conjugated with at least one of 3-thiophene acetic acid and with poly(3-thiophene) acetic acid; and myocytes. The myocytes can include iPSC-derived cardiomyocytes. The myocytes can be substantially aligned in single lines. The single lines can be approximately parallel to one another and approximately normal to planes defined by the plurality of layers. A method of 3D printing the layers is also described.

DRUG-ELUTING SURGICAL ARTICLES AND METHODS OF USE THEREOF

Resumen de: US2025177290A1

Disclosed herein is a biomaterial and a method of use thereof for treating a condition. A biomaterial of the disclosure can be, for example, a surgical article. Implantation of a biomaterial disclosed herein into a subject can treat, for example, cancer.

POLYETHER-CONTAINING POLYMERIZABLE COMPOUNDS AND USE IN CURABLE RESIN COMPOSITIONS

Resumen de: US2025179236A1

This disclosure provides polymerizable resin compositions comprising a hydrophobic polyether-containing polymerizable polyurethane compound to impart improved stain resistance to polymeric materials formed from the polymerizable resin compositions. Further provided herein are methods of producing the compositions and using the same for the fabrication of dental devices, such as orthodontic appliances.

LASER MARKABLE RESIN COMPOSITIONS FOR ORTHODONTIC APPLIANCES

Resumen de: US2025179305A1

This disclosure provides laser markable polymerizable resin compositions comprising infrared absorbing marking additives to achieve improved laser markability of 3-D printed objects obtained from these polymerizable resin composition, and methods for marking the cured resin compositions using an infrared laser.

ADDITIVELY MANUFACTURED DENTURE BASE WITH BRACING BODY

Resumen de: US2025177102A1

The invention relates to additively manufactured dental devices comprised of a denture base and at least one removable bracing body joined at specific locations to the denture base. The invention also relates to methods of using these additively manufactured dental devices in the fabrication of dental prostheses.

MIXING AND COLORING DEVICE FOR DENTAL RESINS

Resumen de: US2025177090A1

A mixing and dyeing device for dental resins for 3D printing and is arranged for contactless dyeing by mixing fluid ingredients. The device includes a housing with a stabilizing means, a mixing means which is arranged for mixing resin housed within a container, the container provided within the housing, positioned concentrically with the mixing means, at least two pigment tanks, at least two dispensing means, a colour sensor which based on a template colour is arranged for determining proper amounts of the resin pigments fed from the pigment tanks, a scales positioned under the container, a device closing sensor, a temperature sensor, a control panel, and includes at least one heating means, which heating means is arranged for heating resin within the container, and a mixing arm has a tip enabling coupling replaceable mixing tips, and the colour sensor is arranged for scanning the patient's dentition.

STABLENEC STANDALONE INTERBODY

Resumen de: US2025177160A1

Implants include one or more pieces that are designed to replace joint motion from the implant-bone interface to an interface within the implant. Because the motion occurs within the implant instead of at the implant-bone interface, the implants relieve pain, reduce fibrous tissue formation, and alleviate pscudoarthrosis. Implants can have tailored stiffnesses by modifying the geometry of the contact surfaces within the implant and or by modifying flexures of the implant. Primary fixation of the implant to the bone using screws, blades, or other fixation devices decreases motion at the bone-implant interface. The flexibility of the implant itself decreases motion between the bone and the implant at the bone-implant interface. Additionally, porous and/or roughened surfaces and/or volumes of the implant facilitate boney attachment of the bone to the implant, further reducing the likelihood of movement at the bone-implant interface.

OVERCURE REGIONS FOR 3D PRINTED OBJECTS IN DENTISTRY

Resumen de: US2025178276A1

A method of manufacturing a three-dimensional (3D) object comprises: fabricating one or more support structures; fabricating the 3D object on the one or more support structures, wherein the one or more support structures contact the 3D object at one or more support regions of the 3D object; and overcuring the 3D object at one or more overcure regions of the 3D object, wherein the one or more overcure regions are distinct from the one or more support regions. The 3D object is configured such that after removal of the one or more support structures from the 3D object, one or more support marks remain on the 3D object where the one or more support structures had contacted the 3D object, wherein the one or more overcure regions of the 3D object are configured to project past the one or more support marks.

Customized Urinary Catheters and Methods for Making

Resumen de: US2025177695A1

A method of making a customized catheter for an end user, comprising: capturing images of an end user's urethra; creating a 3D image of the end user's urethra; identifying areas of interest of the end user's urethra; generating a software or computerized model of a customized catheter using the 3D image, wherein the software or computerized model is modified based on the areas of interest; and 3D printing at least a portion of the customized catheter from the model and catheter made by this method

SYSTEM FOR MANUFACTURING COVERINGS FOR ANATOMICAL SURFACES

Resumen de: US2025182869A1

A system for manufacturing an artificial covering includes a 3D surface scanning module and a 3D printing module where an anatomical surface is imaged and the image is processed for manufacturing and embedding a sensor or device in the covering which can be used for diagnosis or sensing medical issues in the user.

SYSTEMS AND METHODS FOR ORTHOPEDIC IMPLANTS

Resumen de: US2025177149A1

A system and computer-implemented method for manufacturing an orthopedic implant involves segmenting features in an image of anatomy. Anatomic elements can be isolated. Spatial relationships between the isolated anatomic elements can be manipulated. Negative space between anatomic elements is mapped before and/or after manipulating the spatial relationships. At least a portion of the negative space can be filled with a virtual implant. The virtual implant can be used to design and manufacture a physical implant.

METHOD OF MANUFACTURING A MEDICAL DEVICE USING 3D PRINTING AND ELECTROSPINNING

Resumen de: US2025177145A1

A method of manufacturing a medical device made of polylactic acid (PLA) and hydroxyapatite (HA) aimed at the repair of fractures or considerable bone injuries, using 3D printing and electrospinning techniques.

LASER MARKABLE RESIN COMPOSITIONS FOR ORTHODONTIC APPLIANCES

Resumen de: WO2025117572A1

This disclosure provides laser markable polymerizable resin compositions comprising infrared absorbing marking additives to achieve improved laser markability of 3-D printed objects obtained from these polymerizable resin composition, and methods for marking the cured resin compositions using an infrared laser.

Wide-Field Dynamic Aberrometer Measurements for Myopia Control with Customized Contact Lenses

Resumen de: US2025176824A1

This invention relates to optical methods and optical systems for making both on-axis and wide-field, peripheral off-axis wavefront measurements of an eye; and for designing and manufacturing wavefront-guided customized contact lens useful for myopia control. The wide-field optical instrument can comprise either (1) a multi-axis optical configuration using multiple off-axis beamlets, or (2) an instrument comprising a rotatable scanning mirror that generates off-axis probe beams.

BONE STABILIZING IMPLANTS AND METHODS OF PLACEMENT ACROSS SI JOINTS

Resumen de: US2025177011A1

Threaded sacro-iliac joint stabilization (e.g., fusion, fixation) implants and methods of implantation and manufacture. Some implants include a threaded distal region, an optionally threaded central region, and an optionally threaded proximal region. The distal, central, and proximal regions have lengths such that when the implant is laterally implanted across a SI joint, the distal region can be positioned in a sacrum, the central region can be positioned across an SI-joint, and the proximal region can be positioned in an ilium.

Customized Knee Replacement Implant Based on Average Geometry of the Knee

Resumen de: US2025177151A1

A total knee replacement implant having an anatomically representative femoral component that is based on an average knee geometry model determined from scans of multiple people. The implant can be customized for a given patient by scaling the average knee geometry according to one or more measurements (e.g. AP and ML) of the patient's knee. The implant can be formed by 3D printing or any suitable fabrication technique.

BONE STABILIZING IMPLANTS AND METHODS OF PLACEMENT ACROSS SI JOINTS

Nº publicación: AU2025203235A1 05/06/2025

Solicitante:

SI BONE INC
SI-BONE, Inc

Resumen de: AU2025203235A1

Abstract Threaded sacro-iliac joint stabilization (e.g., fusion, fixation) implants and methods of implantation and manufacture. Some implants include a threaded distal region, an optionally threaded central region, and an optionally threaded proximal region. The distal, central, and proximal regions have lengths such that when the implant is laterally implanted across a SI joint.The distal region can be positioned in a sacrum, the central region can he positioned across an SI-joint, and the proximal region can be positioned in an ilium. WO 2021/108590 PCT/US2020/062275 Nlhb Rtn Rt Ni