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Solicitudes publicadas en los últimos 120 días / Applications published in the last 120 days
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GENETIC TRAITS FOR IMPROVED PHOTOSYNTHESIS AND FOOD PRODUCTION AND PATHOGEN RESISTANCE IN PLANTS

NºPublicación:  WO2025255275A2 11/12/2025
Solicitante: 
UNIV FLORIDA [US]\n
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED
WO_2025255275_PA

Resumen de: WO2025255275A2

By engineering genetic traits associated with photosynthesis in plants, transgenic plants with increased crop yield can be generated, which will ultimately lead to increased food production in the field. To obtain beneficial genetic traits for enhanced photosynthesis, accelerated evolution is applied under salt stress in a cyanobacteria species, Synechococcus elongatus PCC 7942, by conditionally suppressing its mismatch repair system. Through high-throughput screening for biomass accumulation and sucrose production, it is discovered that specific amino acid changes in the pre-Dl protein of Photosystem II (PSII), encoded by the psbA genes, can improve efficiency of photosynthesis under salt stress, as well as pathogen resistance. Next, the same amino acid changes were made in Arabadopsis and proved that photosynthetic efficiency (measured via growth rate) is also increased in this model vascular plant.

CHLORELLA MICROALGAE

NºPublicación:  EP4658753A1 10/12/2025
Solicitante: 
ALGENUITY BV [NL]
Algenuity BV
WO_2024161108_PA

Resumen de: WO2024161108A1

Disclosed is a chlorophyll-deficient strain of Chlorella microalgae having a protein content of at least 50% w/w. Also disclosed is a method of producing a chlorophyll-deficient strain of Chlorella microalgae having a protein content of at least 50% w/w. Also disclosed is a composition comprising an algae biomass derived from the aforementioned chlorophyll-deficient strain of Chlorella microalgae or obtained by performing aforementioned method.

Blue-green algae propagation method

NºPublicación:  CN121086941A 09/12/2025
Solicitante: 
NORTHWEST INSTITUTE ECO ENVIRONMENT & RESOURCES CAS
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CN_121086941_PA

Resumen de: CN121086941A

The invention discloses a blue-green algae propagation method, and relates to the technical field of natural biological soil crust. A porous material which is stable in structure, high in adsorbability and excellent in water-retaining property is used as a core carrier to construct a blue-green algae-carrier synergistic growth system, and system optimization of links such as blue-green algae population attachment propagation, environment control culture and drying treatment is combined, so that efficient attachment, uniform propagation and granulation preparation of blue-green algae are realized on the surface and in pores of the blue-green algae; therefore, the cyanobacteria-based particle product which can be dried, transported, spread and stored is obtained, a three-in-one engineering conversion path of propagation expansion, fixation and application is opened, and the technical requirements of large-scale artificial crust construction in the arid region are met.

Microbubble culture microalgae reactor and coal-fired flue gas treatment system and method

NºPublicación:  CN121086866A 09/12/2025
Solicitante: 
CHN ENERGY NEW ENERGY TECH RESEARCH INSTITUTE CO LTD
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CN_121086866_PA

Resumen de: CN121086866A

The invention discloses a microbubble culture microalgae reactor and a coal-fired flue gas treatment system and method. The microbubble culture microalgae reactor comprises a reaction tank body, an air inlet mechanism, a stirring mechanism and a catalysis mechanism, the air inlet mechanism is connected with the reaction tank body to feed air into the reaction tank body, and the stirring mechanism is connected with the reaction tank body to stir a culture solution in the reaction tank body; the catalysis mechanism is arranged in the reaction tank body so as to widen the light absorption range of the microalgae. According to the device, the gas-liquid contact area can be increased, carbon dioxide and the microalgae species culture solution can be in full contact, the reaction efficiency is improved, the production efficiency per unit area is high, and pure species high-density culture can be realized.

Cathepsin B-reduction double-response type biological self-degradation cationic lipid as well as preparation and application of lipid nanoparticles of cathepsin B-reduction double-response type biological self-degradation cationic lipid

NºPublicación:  CN121085994A 09/12/2025
Solicitante: 
UNIV SHENYANG PHARMACEUTICAL
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CN_121085994_PA

Resumen de: CN121085994A

The invention discloses cathepsin B-reduction dual-response type biological self-degradation cationic lipid and preparation and application of lipid nanoparticles thereof, belongs to the technical field of new auxiliary materials and new dosage forms of pharmaceutical preparations, and relates to a preparation method of cathepsin B and reduction dual-response type self-degradation cationic lipid and construction of siRNA lipid nanoparticles of the cathepsin B and reduction dual-response type self-degradation cationic lipid. The invention discloses colonizable inulin-spirulina composite gel for colon targeted delivery and application of the colonizable inulin-spirulina composite gel in nucleic acid drug delivery. According to the invention, a colon-specific modular hydrogel platform is designed by integrating a microalgae biotechnology and a nano-drug, and a new strategy and choice are provided for solving the toxic and side effects of lipid nanoparticles and oral delivery of RNA (Ribonucleic Acid).

Method for preparing concrete super-hydrophobic surface through microorganisms

NºPublicación:  CN121085658A 09/12/2025
Solicitante: 
UNIV SHANDONG TECHNOLOGY
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CN_121085658_PA

Resumen de: CN121085658A

The invention belongs to the technical field of preparation of concrete through microorganisms, and particularly relates to a method for preparing a concrete super-hydrophobic surface through microorganisms. The invention provides a method for preparing a concrete super-hydrophobic surface by microorganisms, which comprises the following steps: smearing a cyanobacteria culture solution on the surface of concrete, and mixing to obtain cyanobacteria concrete; and the cyanobacteria concrete surface is subjected to smoothing treatment and mineralization treatment, and the concrete super-hydrophobic surface is obtained. The cyanobacteria disclosed by the invention are wide in distribution, easy to culture and extremely low in cost. The concrete is in contact with cyanobacteria, the cyanobacteria secretes a large amount of acid compounds, cement in the concrete is decomposed, the content of calcification compounds in the concrete is increased, a mineralization layer is conveniently formed on the surface of the concrete, and the hydrophobic effect is guaranteed. Meanwhile, the concrete surface is smoothed, so that the concrete surface is smooth, and the hydrophobic effect of the concrete is improved. And through mineralization treatment, drying of the surface of the concrete is accelerated, and a super-hydrophobic structure is formed.

Flue gas absorption microalgae culture device

NºPublicación:  CN121086870A 09/12/2025
Solicitante: 
RIZHAO POLYTECHNIC
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CN_121086870_PA

Resumen de: CN121086870A

The invention discloses a flue gas absorption microalgae culture device, which comprises a culture system, the culture system comprises a culture room, the culture room comprises: a plurality of groups of carriers uniformly arranged in the culture room and used for carrying microalgae; a plurality of groups of liquid storage tanks are uniformly arranged at the bottom in the culture room, are used for providing a culture medium solution for the microalgae, and are uniformly distributed below the plurality of groups of carriers; the driving mechanism is located on one side of the culture room and used for pushing the liquid storage tank to reciprocate left and right; the liquid storage tank is arranged in the culture room, the opening is formed in one side of the liquid storage tank in the culture room, a side door is arranged in the opening, and a fixing mechanism is arranged between the side door and the opening. Nutrient substances are transferred by utilizing the principle of capillary action, a carrier is cultured in a vertical space, and a fixed culture medium which is relatively low in water content and is sufficiently wet is provided for microalgae cells to provide nutrition; a double-sided light source is combined with a technology for recycling carbon dioxide in flue gas and a microalgae culture technology, so that energy conservation and emission reduction are facilitated.

Circulating culture system for hatching grouper fries

NºPublicación:  CN223639958U 09/12/2025
Solicitante: 
ZHONGFA GUOXIN SHANGHAI AGRICULTURAL TECH DEVELOPMENT CO LTD
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CN_223639958_U

Resumen de: CN223639958U

The utility model provides a circulating culture system for hatching grouper fries. The circulating culture system comprises a hatching culture barrel, a temperature control device, a physical filtering device, a protein separator, a microorganism filtering device and a PEM ozone device. The marine fish inland breeding device can achieve marine fish inland breeding, solves the pain point of outdoor grouper fry hatching, and accumulates organic waste generated by microalgae, live bait and fry in the water body in the grouper fry hatching process, ammonia nitrogen (NH3/NH4) generated by ammoniation and nitrite (NO2) generated by nitration when the grouper fry hatching operation is carried out indoors. Huge injury is caused to the fish fries.

Hulong hybrid spot seedling raising method capable of improving survival rate

NºPublicación:  CN121086887A 09/12/2025
Solicitante: 
LINGSHUI CHENHAI SEED IND CO LTD
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CN_121086887_A

Resumen de: CN121086887A

The invention belongs to the technical field of aquaculture, and particularly relates to a Hulong hybrid spot seedling raising method capable of improving the survival rate. The invention firstly provides a special microalgae solution combination for Hulong hybrid spots, different microalgae solutions are specifically mixed, and microalgae is rich in nutritional ingredients such as protein, polyunsaturated fatty acid, vitamins and minerals, so that the microalgae solution combination can be used as a high-quality feed, the growth performance of the Hulong hybrid spots is remarkably improved, and the yield of the Hulong hybrid spots is improved; the breeding environment can be improved to meet different breeding conditions; in addition, the invention further provides application of the microalgae solution combination in improving the survival rate of Hulong hybrid spot seedlings and/or improving the immune performance of Hulong hybrid spots, a nursery pond is disinfected by using a disinfectant containing a moringa oleifera extract and lactobacillus plantarum, and the microalgae solution combination is inoculated at different culture stages, so that the survival rate of the Hulong hybrid spot seedlings is increased, and the immune performance of the Hulong hybrid spots is improved. The survival rate and the immunity of the Hulong hybrid spotted fish are improved.

Rice soil improver and method for improving gleying rice soil

NºPublicación:  CN121063997A 05/12/2025
Solicitante: 
BEIJING GOLDENWAY BIO TECH CO LTD
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CN_121063997_A

Resumen de: CN121063997A

The invention relates to the technical field of soil improvement, and particularly discloses a rice soil improver and a method for improving gleying rice soil. The rice soil improver provided by the invention comprises a component A and a component B, the component A is an organic-inorganic compound and comprises the following raw materials in parts by weight: 100-200 parts of kitchen waste fermentation products, 1-5 parts of slow-release calcium peroxide and 5-10 parts of a microbial agent I; wherein the slow-release calcium peroxide is prepared from the following raw materials in parts by weight: 100 parts of calcium peroxide, 70 to 80 parts of sepiolite and 10 to 15 parts of binder; the component B is microalgae gel beads and comprises the following raw materials: a microbial agent II, algae species and 2-5wt% of a sodium alginate solution. The rice soil improver provided by the invention can significantly improve the hardening and long-term oxygen deficit problems of gleying rice field soil, increase the effective fertility of the soil, promote the improvement of rice root activity and nutrient absorption, and finally increase the rice yield.

Method for treating micro-plastic wastewater

NºPublicación:  CN121063719A 05/12/2025
Solicitante: 
JIANGXI BROTHER PHARMACEUTICAL CO LTD
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CN_121063719_A

Resumen de: CN121063719A

The invention discloses a micro-plastic wastewater treatment method, and relates to the technical field of wastewater treatment.The micro-plastic wastewater treatment method comprises the steps that micro-plastic wastewater is subjected to aging treatment, and then micro-plastic wastewater is treated with microalgae granular sludge; the preparation method of the microalgae granular sludge comprises the following steps: adding an algae solution and a sodium alginate solution into dewatered sludge, then dropwise adding a calcium chloride solution, preparing granular sludge after the reaction is finished, and then circularly operating according to the sequence of water feeding, anaerobic stirring, aeration, sedimentation, drainage and idling in sequence to prepare the microalgae granular sludge. By preparing the microalgae granular sludge and constructing a bacteria-algae symbiotic system, extracellular polymeric substances are synergistically and adaptively generated in the wastewater with high-concentration polypropylene micro-plastic concentration, the hydrophobicity of the micro-plastic promotes aggregation of the microalgae granular sludge and the bacteria-algae symbiotic system, and the purification capacity is improved.

Chlorella QDHP-04 and application thereof

NºPublicación:  CN121064963A 05/12/2025
Solicitante: 
QINGDAO HELP BIOSCIENCE CO LTD
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CN_121064963_A

Resumen de: CN121064963A

The invention relates to the technical field of microalgae biology, and particularly discloses chlorella QDHP-04 and application thereof. The invention relates to chlorella QDHP-04, which is named as Chlorellasp.QDHP-04, and is preserved in the China Center for Type Culture Collection on March 9, 2023, the preservation number is CCTCC NO: M2023272, and the address is Wuhan University, Wuhan, China. The chlorella QDHP-04 disclosed by the invention can be used for preparing a biocontrol agent, and can be used for effectively inhibiting wheat sharp eyespot, promoting the growth and development of wheat and remarkably increasing the yield and quality of wheat planting.

Method for increasing fucoxanthine accumulation amount by using microcystis subjected to depolymerization treatment to feed palmarthria formosana

NºPublicación:  CN121064964A 05/12/2025
Solicitante: 
HUBEI ZAOLAN BIOTECHNOLOGY CO LTD
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CN_121064964_PA

Resumen de: CN121064964A

The invention belongs to the technical field of biology, and particularly relates to a method for increasing the fucoxanthine accumulation amount by using microcystis subjected to depolymerization treatment to feed palmarthria formosana. According to the method, microcystis subjected to depolymerization treatment are added in the culture process of the palmitothecium for heterotrophic culture, meanwhile, continuous inflation is conducted, the microcystis subjected to depolymerization treatment are swallowed by the palmitothecium, and the higher fucoxanthine accumulation amount in the palmitothecium is obtained by means of the culture mode. The experiment proves that after the microcystis is subjected to pretreatment and depolymerization, the removal efficiency of the microcystis is higher by the brown algae, the limitation of treatment of harmful cyanobacteria and ingestion of protozoa is made up, and meanwhile, an integrated solution is provided for biological treatment of cyanobacterial bloom and resource utilization of the microalgae; meanwhile, a new way is provided for obtaining fucoxanthine with higher accumulation amount.

Fish feed composition and production method thereof

NºPublicación:  CN121058813A 05/12/2025
Solicitante: 
UNIV HONG KONG
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CN_121058813_PA

Resumen de: CN121058813A

A fish feed composition for supplementing the diet of fish comprises a microalgae biomass produced using food waste leachate and harvested by flocculation, and wherein the fish feed composition promotes the growth and immunity of fish.

Method for improving selenium tolerance of euglena gracilis and preparation method of selenium-rich microalgae

NºPublicación:  CN121065061A 05/12/2025
Solicitante: 
UNIV SHENZHEN
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CN_121065061_PA

Resumen de: CN121065061A

The invention provides a method for improving selenium tolerance of euglena gracilis and a preparation method of selenium-rich microalgae, and belongs to the technical field of microalgae application. The invention provides a method for improving selenium tolerance of euglena gracilis. The method comprises the following steps: culturing euglena gracilis in a culture medium added with sodium selenite; the adding mode of the sodium selenite comprises the step of adding the sodium selenite once a day from the beginning of inoculating the euglena gracilis; or sodium selenite is added once after the euglena gracilis is cultured for 48 hours or two days; or, starting from inoculation of the euglena gracilis, after the euglena gracilis is cultured for 48 hours or 2 days, sodium selenite is added once a day; the addition amount of the sodium selenite in each time is 1-10 mg/L. The method can prolong the growth cycle of the euglena gracilis, improve the movement ability of the euglena gracilis, promote the accumulation of parastarch, improve the maximum photosynthetic rate of the euglena gracilis, promote the chlorophyll synthesis of the euglena gracilis and improve the catalase activity of the euglena gracilis, and is beneficial to improving the selenium tolerance of the euglena gracilis.

ALGAL BIOFILM HARVESTING METHOD CAPABLE OF REDUCING RELEASE OF PLANKTONIC MICROALGAE

NºPublicación:  US2025368946A1 04/12/2025
Solicitante: 
NANJING UNIV [CN]
Nanjing University
CN_118289943_PA

Resumen de: US2025368946A1

An algal biofilm harvesting method capable of reducing release of planktonic microalgae includes the following steps: S1: constructing an algal biofilm treatment system; S2: calculating a cutting area; S3: harvesting microalgae biomass; and S4: cyclic harvesting. By constructing an algal biofilm treatment system, a surface of an algal biofilm can be regularly cut to harvest microalgae biomass, thereby keeping activity of the biofilm in a best state all the time. In addition, the harvested microalgae biomass can be used as a high-quality substrate for subsequent fermentation, which can achieve resource saving. Quality attainment of effluent from a sewage tank with planktonic microalgae as a suspended solid indicator can be achieved, the treated effluent can be prevented from deteriorating due to an increase of the planktonic microalgae, and a risk that the planktonic microalgae in the effluent of the algal biofilm affects a subsequent treatment process is reduced.

METHOD FOR CONVERTING CARBON SOURCE INTO ETHYLENE GLYCOL

NºPublicación:  US2025369023A1 04/12/2025
Solicitante: 
NAN YA PLASTICS CORP [TW]
NAN YA PLASTICS CORPORATION
CN_121046471_PA

Resumen de: US2025369023A1

A method for converting a carbon source into ethylene glycol includes: providing a plasmid, in which the plasmid includes gene sequences of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, and SEQ ID NO: 6; implanting the plasmid into cyanobacteria through an electroporation treatment, so that modified cyanobacteria are obtained; and providing the carbon source to the modified cyanobacteria, so that the modified cyanobacteria convert the carbon source into the ethylene glycol.

Chlamydomonas reinhardtii source organism iron steady state regulator and application thereof

NºPublicación:  CN121041408A 02/12/2025
Solicitante: 
SHANXI TOUYUN BIOTECHNOLOGY CO LTD
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CN_121041408_PA

Resumen de: CN121041408A

The invention discloses a chlamydomonas reinhardtii source organism iron steady state regulator and application thereof, and belongs to the technical field of biology. The chlamydomonas reinhardtii hydroxyproline-rich glycoprotein or the protein component thereof disclosed by the invention can activate low-oxygen inducible factor signal channels of intestinal tracts, livers and kidneys, and up-regulate the expression of iron absorption transporters such as a divalent metal ion carrier 1, duodenum cytochrome b, membrane iron transporters and ferrous oxidase in intestinal epithelial cells; according to the present invention, the liver hepcidin overexpression caused by inflammation can be inhibited, the generation of erythropoietin in the liver and the kidney can be promoted so as to stimulate the absorption of the body on the iron nutrient, and the compound can be used in the anemia improving health food and the anemia improving drug. The organism iron homeostasis regulator adopted by the invention is derived from microalgae food, so that compared with a conventional artificially synthesized organism iron homeostasis regulator drug, the organism iron homeostasis regulator has the advantage of no toxic or side effect.

Pretreatment device for synchronously and intensively preparing biodiesel by utilizing microalgae to generate electricity

NºPublicación:  CN121046186A 02/12/2025
Solicitante: 
UNIV HARBIN ENG
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CN_121046186_PA

Resumen de: CN121046186A

The invention aims to provide a pretreatment device for synchronously and intensively preparing biodiesel by utilizing microalgae to generate electricity, and belongs to the field of biomass energy production. The invention belongs to a microbial electrochemical coupling system, and adopts a microbial fuel cell (MFC) and a microbial electrolytic cell (MEC) as main structures. Anode microorganisms in the microbial fuel cell MFC take microalgae as a substrate, generate electricity through metabolism, and synchronously transmit electric energy to the microbial electrolytic cell MEC through a series lead to serve as an external power supply of the microbial electrolytic cell MEC; during continuous operation, algae liquid is fed into the MEC under the rate control of the pump, the MEC realizes microalgae wall breaking pretreatment through electric fermentation, and grease extraction is enhanced. According to the invention, the dependence of the traditional MEC process on external energy is broken through, the self-production and self-use of the capacity of the device are realized, the manual requirement for replacing the anolyte can be effectively reduced, and the microalgae biodiesel preparation pretreatment under continuous operation is realized.

Process for converting carbon source to ethylene glycol

NºPublicación:  CN121046471A 02/12/2025
Solicitante: 
NAN YA PLASTICS CORP
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CN_121046471_PA

Resumen de: CN121046471A

The invention discloses a method for converting a carbon source into ethylene glycol. The method comprises the following steps: providing a plastid, wherein the plastid comprises gene sequences of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5 and SEQ ID NO: 6; implanting the plastid into blue-green bacteria by means of electroporation treatment to obtain modified blue-green bacteria; and providing the carbon source to the modified cyanobacteria, so that the modified cyanobacteria converts the carbon source into ethylene glycol, thereby producing chemicals with high economic value while treating the carbon-containing waste gas.

n2 co2 Carbon-free energy supply system for carbon neutrality with renewable energy from microalgae culture due to n2 and co2 inhalation in the atmosphere

NºPublicación:  KR20250167386A 01/12/2025
Solicitante: 
윤승균

Resumen de: KR20250167386A

본 발명은 미세조류가 배양되는 배양부 외부의 펌프 라인의 이젝터 벤투리 내부의 스크류 발전 ; 상기 배양부 외 부에 위치하여 펌프가 설치되고, 이 젝터 벤 투리 내부의 설치된 제1파이프 라인; 및 상기 제1파이프 라인이 적 어도 하나의 접목부를 포함하며, 상기 접목부는 상기 배양 부 외부에 위치하는 이산화탄소공급부와 연결되는 제2 파이프 라인; 을 포함하는 것을 특징으로 하는 미세조류 배 양 시스템에 관한 것이다.

Microalgae cultivation photoreactor using wavelength controller

NºPublicación:  KR20250167316A 01/12/2025
Solicitante: 
한국해양과학기술원

Resumen de: KR20250167316A

본 발명은 상단에 개구를 포함하고 내부에 배양 수조의 설치 공간부를 갖는 메인바디, 상기 메인 바디 내에 소정 간격 이격되어 수용되는 배양 수조 및 상기 개구를 통해 배양 수조의 상부를 커버할 수 있는 수조 덮개를 포함하는 미세 조류 배양 장치로서, 메인 바디의 전원부로부터 전원을 공급받아, 미세 조류의 종류, 생육 상태 및 관심 있는 표적 물질에 맞추어 빛을 조사하도록 배치된 복수개의 LED 소자를 포함하는 LED 모듈을 구비하고, 상기 메인 바디의 중앙부에 위치하여 개폐 가능하도록 구성되며, 교체 가능한 형태의 LED 기판, 및 제어기를 포함하는 것을 특징으로 하는 미세 조류 배양 장치를 제공한다. 상기 제어기는 상기 LED 소자의 광도를 조절하는 제1 조절기, 상기 LED 소자의 광 조사 시간을 조절하는 제2 조절기, 및 상기 LED 소자의 광 조사 순서를 조절하는 제3 조절기를 포함한다. 본 발명의 미세 조류 배양을 위한 배양 장치는 특정 파장의 조사 시간을 자동적으로 조절함으로써 특정 물질의 최대 함량을 유도한 특정 미세 조류를 최대 밀도로 배양한 후, 높은 농도의 원하는 물질을 추출할 수 있도록 할 수 있다.

Aerobic granular sludge based on functional flora-microalgae-pyrite composite system reinforced synergy and preparation method thereof

NºPublicación:  CN121020844A 28/11/2025
Solicitante: 
TONGJI UNIV
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CN_121020844_PA

Resumen de: CN121020844A

The invention relates to the technical field of biological sewage treatment, and provides aerobic granular sludge based on functional flora-microalgae-pyrite composite system reinforced synergy and a preparation method of the aerobic granular sludge. The method is characterized by comprising the four steps of pyrite pretreatment, bacteria-algae synergistic domestication and inoculation, aerobic granular sludge induction formation and aerobic granular sludge maturation and stabilization. According to the invention, a'pyrite-functional flora-microalgae 'three-in-one system is constructed, so that the pyrite, the functional flora and the microalgae form a physicochemical-biochemical collaborative network. The aerobic granular sludge prepared by the functional flora-microalgae-pyrite composite system in a reinforced and synergistic manner not only has higher COD (Chemical Oxygen Demand), TN (Total Nitrogen) and TP (Total Phosphorus) removal efficiency and good impact resistance and load resistance when being used for deeply treating the mariculture tail water, but also can regularly collect the microalgae in the system as an aquatic feed additive, so that the conversion from pollutants to resources is realized.

Extracellular vesicles from microalgae, their biodistribution upon intranasal administration and uses thereof

NºPublicación:  CN121038801A 28/11/2025
Solicitante: 
AGS THERAPEUTICS SAS
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CN_121038801_PA

Resumen de: CN121038801A

Compositions comprising microalgal extracellular vesicles (MEVs) formulated for intranasal delivery are provided whereby, after intranasal administration, the MEVs are transported by a specific route, via olfactory nerves to specific regions in the brain after intranasal administration, and through lateral olfactory beams (LOTs) to interconnected brain regions. The MEV is transported via neuronal axons. The MEV has the ability to traverse synapses including: (i) a synapse between an olfactory sensory neuron (OSN) and a monk cap/clustered neuron; (ii) synapses between monk cap/cluster neurons and local neurons in a plurality of brain regions colonized by a lateral olfactory beam (LOT); and (iii) synapses between neurons in the brain region colonized by LOT and neurons from the frontal cortex, hippocampus, thalamus and hypothalamus. The compositions contain extracellular vesicles (MEVs) from microalgae loaded with biologically active cargo for use in treating, detecting, diagnosing or monitoring a disease, disorder or condition of the brain or involving the brain, in particular to provide neuronal delivery of cargo. The compositions and methods have various applications as therapeutic and diagnostic agents for treating, diagnosing, and monitoring the brain or a disease, disorder, or condition involving the brain. The compositions are useful in methods and uses for the treatment of cancers involving the brain, and are useful, for example, for the delivery of therapeutic agents f

Method for comprehensively extracting eicosanoic acid containing EPA and ARA from phaeodactylum tricornutum and application of eicosanoic acid

Nº publicación: CN121021291A 28/11/2025

Solicitante:

HUBEI ZAOLAN BIOTECHNOLOGY CO LTD
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CN_121021291_PA

Resumen de: CN121021291A

The invention provides a method for comprehensively extracting eicosanoic acid containing EPA and ARA from phaeodactylum tricornutum and application of eicosanoic acid, a complete process chain of algae culture, algae mud acquisition, rapid ASE extraction of microalgae oil, SPE enrichment and semi-preparative HPLC purification is established, the anti-inflammatory medium is definite in composition proportion, and the structure is identified through high performance liquid chromatography; existing literatures and patents do not disclose a combination of the algal strain capable of enriching the multiple anti-inflammatory media at the same time. The raw material of the phaeodactylum tricornutum is from marine diatom which can be cultured on a large scale, the risk of pesticide residue of terrestrial plants is avoided, an organic chlorine solvent is avoided in the production process, and the requirement of FDA/EFSA on natural marine source functional ingredients is met; the compound can be used for anti-inflammatory prescription medicines, postoperative inflammation relieving foods and relieving and repairing cosmetics at the same time, and the market application range is wide.

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