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1017
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Updated on
15/11/2026 [08:03:00]
Absstract of: AU2025263109A1
The invention is directed to peptide fragments of FKBP52 that inhibit Tau protein aggregation and ameliorate tauopathies like Alzheimer's Disease (AD). It also involves modifications to these peptides to improve their pharmacokinetic and pharmacodynamic properties.
Absstract of: US20260355128A1
The disclosure relates to a combination of active ingredients/adjuvants for the treatment of neurological disorders and diseases such as Alzheimer's disease and mild cognitive impairment (MCI) and memory and cognitive disorders and conditions. In particular, combinations of scyllo-inositol and treatments for Alzheimer's disease such as lecanemab are disclosed as useful.
Absstract of: AU2025284523A1
Disclosed are compositions and methods for treating Alzheimer's disease or for use in treating Alzheimer's disease. Also disclosed are compositions and methods for treating or for use in treating a neurodegenerative disorder characterized by the presence of tau protein aggregates. Furthermore, disclosed are compositions and methods for reducing tau protein aggregates or for use in reducing tau protein aggregates.
Absstract of: US20260357256A1
Disclosed herein are UNC13A oligonucleotides with one or more spacers or without a spacer. In various embodiments, UNC13A oligonucleotides with spacer(s) reduce mis-spliced UNC13A transcripts and increase full length UNC13A transcripts, thereby imparting therapeutic efficacy against neurological diseases such as amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), or Alzheimer's disease (AD).
Absstract of: WO2025151884A1
The present invention is directed to methods and compositions for the administration of sodium pentosan polysulfate and related glycosaminoglycans, particularly by oral administration, particularly in combination with administration of an intestinal penetration agent. The methods and compositions are suitable for treatment of neurodegenerative diseases such as, but not limited to, Alzheimer's disease. Methods and compositions according to the present invention can be used together with other agents suitable for treatment of neurodegenerative diseases such as, but not limited to, Alzheimer's disease.
Absstract of: AU2025206055A1
The present invention relates to compounds of formula (I) useful for modulating Triggering Receptor Expressed on Myeloid Cells-2 ("TREM2"). The invention also relates to the compounds for use in treatment of conditions related to loss of function of TREM2, such as e.g. neurodegenerative diseases, and to pharmaceutical compositions comprising the compounds.
Absstract of: WO2025146476A1
The present invention relates to compounds of formula (I) useful for modulating Triggering Receptor Expressed on Myeloid Cells-2 ("TREM2"). The invention also relates to the compounds for use in treatment of conditions related to loss of function of TREM2, such as e.g. neurodegenerative diseases, and to pharmaceutical compositions comprising the compounds.
Absstract of: WO2025155789A1
The present invention relates to novel chemical compounds of indane-, indene-, azaindane-, and azaindene-amines that act as 5-HT2A receptor agonists. These compounds are designed to offer improved therapeutic profiles for the treatment of a variety of neuropsychiatric, neurological, and neurodegenerative disorders. Also disclosed are methods for the synthesis and pharmaceutical use of these compounds.
Absstract of: US20260347407A1
The present invention relates to a peptide capable of directly binding to amyloid beta protein Aβ42, which is known to be a causative agent of Alzheimer's disease, and a composition for the treatment and prevention of Alzheimer's disease, comprising the peptide. When peptide SMA_04088-2 of the present invention is used, the fibrilization and oligomerization of amyloid beta can be prevented, and thus, the peptide SMA_04088-2 can be used in the treatment and prevention of amyloid diseases such as Alzheimer's disease. In addition, the peptide SMA_04088-2 can be used to detect amyloid beta, and thus can be used in the diagnosis of amyloid diseases such as Alzheimer's disease.
Absstract of: US20260347408A1
The present invention relates to a peptide capable of directly binding to amyloid beta protein Aβ42, known to be a causative agent of Alzheimer's disease, and a composition for treating and preventing Alzheimer's disease, comprising the peptide. The peptide of the present invention can be used to prevent fibrosis and oligomerization of amyloid beta, and thus can be used for the treatment and prevention of amyloidogenic disease such as Alzheimer's disease. In addition, the peptide of the present invention can be used to detect amyloid beta, and thus can be used for the diagnosis of amyloidogenic diseases such as Alzheimer's disease.
Absstract of: US20260345717A1
0000 Alzheimer's disease is treated with a composition including grapevine stem extract or a compound isolated therefrom as an effective component. As the grapevine stem extract and vitisin A as an effective component exhibit an excellent effect of inhibiting infection with the herpes simplex virus and inhibiting Alzheimer-causing factors in the brain tissue of animal models infected with the herpes simplex virus, the composition can be advantageously used as an agent for treating Alzheimer's disease or a functional health food or an animal feed additive for preventing or ameliorating Alzheimer's disease.
Absstract of: US20260345565A1
The present disclosure provides methods, compositions and kits for prophylactic treating or preventing a degenerative disease related to amyloid. The compositions and kits comprise Sigma-1 receptor agonist, an allosteric sigma agonist, and/or a dual agonist of Sigma-1 and M1. The compositions and kits elicit effects of delaying the onset, deterring the progress, and/or diminish the likelihood of the degenerative disease, such as deterring the memory loss and/or cognition decline in Alzheimer's disease.
Absstract of: CA3330167A1
The present invention relates to a series of compounds with an indazole structural core, which are capable of inhibiting the SGK1 enzyme. Accordingly, the invention also relates to the use of these compounds to treat neurodegenerative and/or cardiovascular diseases involving this enzyme, such as Parkinson's disease, Alzheimer's disease, myocardial infarction or high blood pressure.
Absstract of: US20260347847A1
The invention relates to the field of human genetics, more specifically neurological disorders. The invention in particular relates to the use of the antisense oligonucleotide AON1 with improved characteristics enhancing clinical applicability for treating Huntington as further defined herein.
Absstract of: US20260347941A1
0000 Presented herein are methods, systems, and a model useful in identifying a subject who has, or is at risk of developing Alzheimer's Disease (AD) and/or Mild Cognitive Impairment (MCI), or identifying a subject who has or is at risk of progressing from MCI to AD, or increasing in the severity of AD symptoms that includes determining a presence or amount of two or more micro-RNAs (miRNAs) selected from 151a-3p, 151a-5p, 146a-5p, 4454, 10b-5p, 199a-3p, 199a-5p, 29b-3p, 126-5p, 150-5p, 107, let-7g-5p, 1290, 95-3p, 375-3p, 99a-5p, 125b-5p, 642a-5p, 92a-1-5p, 362-5p, 342-3p, 196a-5p, 155-5p, 409-3p, 744-5p, 223-3p, 584-5p, 340-5p, 421, 486-5p, 126-3p, 320c, 320b, let-7d-3p, 27b-3p, 148b-3p, 143-3p, 326, 335-5p, 25-3p, 153-3p, 19b-3p, let-7c-5p, 652-3p, 376c-3p, 154-5p, 376a-3p, 30d-5p, and 381-3p in a subject's circulating blood, without determining a presence or amount of the miRNAs from neural-derived exosomes. Also presented herein are methods of preventing, treating, or delaying the onset of AD and/or MCI.
Absstract of: US20260347760A1
0000 Summary 0000 The present invention relates to a new B. subtilis strain with positive influence on Alzheimer's disease.
Absstract of: US20260345527A1
0000 The present disclosure relates to a therapeutic composition for treating, preventing, inhibiting, improving, or slowing down a neurodegenerative disease, in particular a disease related to aggregate formation of TAR DNA-binding protein 43(TDP-43) such as amyotrophic lateral sclerosis, or the onset or development of such condition, by using a combination agent containing colchicine or a pharmaceutically acceptable salt thereof and metformin or a pharmaceutically acceptable salt thereof as active ingredients. The inventors of the present disclosure have confirmed that neurodegenerative diseases as described above may be treated or prevented by using a combination agent in which colchicine and metformin, which are drugs not used in the related art, are mixed as a therapeutic agent for conditions as described above.
Absstract of: US20260345604A1
The disclosure relates to lemborexant, a dual orexin receptor antagonist, and compositions and methods for use in treatment of Alzheimer's disease (AD), e.g., in a subject who has AD or who is at risk for developing AD.
Absstract of: US20260345504A1
0000 The present invention relates to a composition and a method for treating Alzheimer's disease in a patient in need thereof. The method comprises administration to the patient of the composition comprising a therapeutically effective amount of extracellular vesicles, wherein the extracellular vesicles are isolated from culture medium of cells. In some embodiments, the extracellular vesicles comprise one or more of following miRNAs: let-7, miR-9, miR-21, miR-34a, and miR-10b.
Absstract of: US20260348984A1
0000 Provided herein is a method for diagnosing and treating Alzheimer's disease comprising: (a) providing a biological sample obtained from the subject; (b) measuring concentration levels from the obtained sample, at least one, at least two, at least three, at least four or at least five Alzheimer's-related metabolites described herein and/or at least one, at least two, at least three, at least four or at least five Alzheimer's-related proteins described herein; (c) comparing the concentration levels of the Alzheimer's-related metabolites and/or proteins from the obtained sample to the concentration levels of corresponding reference Alzheimer's-related metabolites and/or proteins from an Alzheimer's-negative sample; (d) identifying the subject as having Alzheimer's if the concentration levels of the Alzheimer's-related metabolites and/or proteins from the obtained sample are different relative to the concentration levels of the reference Alzheimer's-related metabolites and/or proteins from the Alzheimer's-negative sample; and (e) treating or causing treatment of the subject.
Absstract of: US20260345495A1
The present invention relates to a pharmaceutical composition comprising crisdesalazine or a salt thereof, which has improved stability by reducing the content of related substances of crisdesalazine, and has an increased dissolution rate by improving the intrinsic solubility thereof. The composition of the present invention secures stability and bioavailability, and thus is more effective in treating neurodegenerative diseases (Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, epilepsy accompanied by free radical neurotoxicity, cerebral trauma, spinal injury, and the like), inflammatory diseases (gastritis, colitis, pancreatitis, arthritis, diabetic inflammation, inflammatory bowel disease, nephritis, hepatitis, arteriosclerosis inflammation, and the like), stress disorders (anxiety disorder, depression, and the like), and the like.
Absstract of: WO2026227150A1
The present document describes compounds of formula (I) or a pharmaceutically acceptable salt thereof, or stereoisomers thereof, pharmaceutical compositions comprising a therapeutically effective amount of the compounds, and method, and/or use of the compounds for the treatment or prevention of neurodegenerative diseases including Alzheimer's disease, myastenic disease, mild dementia, or early dementia.
Absstract of: WO2026230982A1
Disclosed is a pharmaceutical composition for preventing or treating degenerative brain diseases, the pharmaceutical composition comprising lipid nanoparticles (LNPs) encapsulating mRNA expressing a chimeric antigen receptor (CAR) that specifically binds to amyloid-beta (Aβ), and mRNA expressing anti-inflammatory cytokine interleukin-10 (IL-10). The lipid nanoparticles are absorbed by peripheral monocytes or macrophages after intravenous administration in vivo, pass through the blood-brain barrier (BBB), move to brain tissue, and express Aβ-CAR and IL-10 in immune cells. Accordingly, an anti-inflammatory environment is induced at the same time as the selective removal of Aβ plaques, thereby inhibiting the pathological activation of microglia and promoting conversion to a homeostasis state. The present invention provides an in vivo gene therapy platform based on bifunctional immune cells, which simultaneously achieves Aβ removal and neuroinflammation inhibition, and is useful for the fundamental treatment of degenerative brain diseases including Alzheimer's disease.
Absstract of: WO2026231057A1
The present disclosure provides a method of generating midbrain organoid comprising at least one culturing step performed under an oxygen concentration of 1% to 10%. In one embodiment, the culturing steps comprising (a) culturing pluripotent stem cells in a first culture medium to obtain embryoid bodies, (b) culturing the embryoid bodies in a second culture medium comprising a TGF-0 inhibitor, a BMP signaling inhibitor, a hedgehog signaling activator, and a Wnt signaling activator to obtain midbrain floor plate progenitor cells, (c) culturing the midbrain floor plate progenitor cells in a third culture medium comprising a fibroblast growth factor, and (d) culturing the midbrain floor plate progenitor cells in a fourth culture medium to obtain the midbrain organoid. The present disclosure further provides an isolated midbrain organoid obtained from the method, and uses of the cells isolated from said midbrain organoid in treating neurodegenerative diseases including Parkinson's disease.
Nº publicación: WO2026231767A1 05/11/2026
Applicant:
THE REGENTS OF THE UNIV OF CALIFORNIA [US]
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Absstract of: WO2026231767A1
The present disclosure relates to compositions and methods for treating neurodegenerative diseases and disorders, e.g., Alzheimer's disease. The compositions of the present disclosure may comprise live bacterial cultures and/or prebiotic carbohydrates.
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