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75
results.
Updated on
19/04/2025 [07:25:00]
Absstract of: CN119842745A
本发明公开了鼠伤寒沙门菌毒力基因Ict的鉴定及其减毒疫苗候选株的制备与应用。本发明选择强毒力鼠伤寒沙门菌SL1344株作为亲本株，将其中降解代谢衣康酸的关键毒力基因Ict进行敲除，构建鼠伤寒沙门菌SL1344减毒疫苗候选株。通过小鼠动物毒力实验、免疫保护力实验和安全性实验等证实该疫苗候选株SL1344‑ΔIct缺失株，不仅对动物的致病力显著降低，且提供了良好的免疫原性和免疫保护力。本发明实现对强毒力鼠伤寒沙门氏菌株的减毒，可广泛应用于沙门菌的防控，为研制沙门菌的减毒活疫苗及活载体疫苗奠定基础。
Absstract of: GB2634693A
A duplex fluorescent PCR detection primer probe group of duck Salmonella enteritidis and Salmonella typhimurium, a kit, and the use thereof. Comparative analysis on the whole genomes of Salmonella enteritidis and Salmonella typhimurium is performed to screen out as identification targets a specific fragment Sdf I of lyg D gene of Salmonella enteritidis and a specific gene STM4497 of Salmonella typhimurium, and the present application designs specific primers and probes.
Absstract of: CN119804862A
本发明涉及血清学检测技术领域，特别是涉及SipD重组蛋白在制备检测禽沙门氏菌抗体的间接ELISA检测试剂盒中的应用。本发明通过大量研究，成功筛选出用于检测禽沙门氏菌抗体的特异性抗原‑SipD蛋白。本发明以禽沙门氏菌III型分泌系统SipD亚基(SipD蛋白)为抗原，经蛋白表达纯化后获得包被抗原(SipD重组蛋白)，通过反应条件的摸索与优化，最终建立了灵敏性高、特异性强和重复性好的禽沙门氏菌间接ELISA检测方法。相比于传统的玻片凝集抗原检测方法，该方法极大地提高了检测通量和检测效率。该检测方法的建立对于人类、动物、食品中的沙门氏菌检测具有重要的公共卫生意义。
Absstract of: CN119792228A
本发明公开了一种减毒沙门氏菌来源的细菌外膜囊泡蛋白载药系统及其制备方法和应用，本发明利用细菌外膜囊泡蛋白载药系统可以在细菌外膜囊泡表面实现蛋白药物的“即插即用”。本发明构建了细菌外膜囊泡蛋白载药系统。本发明敲除了减毒鼠伤寒沙门氏菌VNP20009的OmpA，并回补在胞外环结构域中插入SpyTag的重组OmpA，利用SpyTag/SpyCatcher间自发形成异肽键的性质，将SpyCatcher与蛋白药物的融合蛋白展示在细菌外膜囊泡表面，制备方法简单，容易操作，在细菌外膜囊泡表面展示多种蛋白，并高效保护和负载蛋白药物。结合细菌外膜囊泡的免疫刺激特性，实现肿瘤的高效治疗。
Absstract of: WO2023235633A2
A genetically modified Salmonella cell (GMSC) engineered to exhibit specific targeting to cells and regulated delayed lysis in vivo, the GMSC comprising a first heterologous nucleic acid that encodes a first gene product that causes the GMSC to be selectively localized to and/or internalized by a target cell in vivo and a second heterologous nucleic acid that encodes a second gene product that facilitates killing of the target cells following internalization.
Absstract of: WO2023227848A1
The present invention relates to a method for determining the properties of resistance to beta-lactam antibiotics of a strain of enterobacteria present in a biological sample, which method comprises the steps of: a) lysis of the bacteria and hydrolysis of the bacterial proteins in order to obtain a mixture of peptides, b) analysis of this mixture of peptides by targeted mass spectrometry coupled with reverse phase liquid chromatography, detection of at least one specific peptide of an enzyme exhibiting extended spectrum beta-lactamase (ESBL) activity being indicative of the resistance to beta-lactams of the strain of enterobacteria present in the biological sample, the method being characterised in that the analysis step (b) is carried out in the presence of an ion pairing reagent (IPR) added into the chromatography column or into the mixture of peptides.
Absstract of: CN119776251A
本发明公开了一种感应铁镁离子的细菌传感器的构建方法及其应用。本发明属于微生物领域，具体涉及一种感应铁镁离子的细菌传感器的构建方法及其应用。重组大肠杆菌含有超折叠绿色荧光蛋白sfGFP编码基因、感应蛋白PmrB突变体编码基因和响应调节蛋白PmrA突变体编码基因、信号传导蛋白PmrD编码基因和强核糖体结合位点RBS，并含有通过调节蛋白PmrA激活的磷酸化酶PmrG的启动子驱动的T7 RNA聚合酶编码基因和T7启动子驱动的sfGFP编码基因，同时过表达磷酸乙醇胺转移酶EptA编码基因。本发明构建了检测铁离子浓度的细菌传感器，并可通过铁镁离子的诱导改变细菌传感器的脂多糖的修饰，增强细菌的耐药性。
Absstract of: CN119752748A
本发明属于兽医生物制品领域，具体涉及一株驴源马流产沙门菌crp基因缺失株YZUSAL01Δcrp及其构建方法和应用。本发明的基因缺失株已保藏于中国典型培养物保藏中心，保藏号为CCTCC NO:M 20241741。该缺失株是利用λ‑Red同源重组技术，将马流产沙门菌的crp基因敲除后获得的。本发明制备的基因缺失株毒力显著下降，具有良好的安全性。对小鼠的攻毒免疫保护效果良好，为马流产沙门菌减毒活疫苗奠定基础。
Absstract of: US2025109447A1
The present invention relates to a CRISPR-Cas based composition for detecting Salmonella and a method for detecting Salmonella using the same, more specifically, to a composition for detecting Salmonella comprising primers capable of specifically amplifying Salmonella through isothermal amplification, guide RNA, and CRISPR-Cas proteins, and a method for detecting Salmonella using the same.
Absstract of: US2025110128A1
A method for detecting biological objects by means of an SPR imaging detection system comprising an optical measurement device configured to generate plasmon resonance on a functionalized surface when said surface is exposed to a gas; the method comprising: an assimilation step by exposing the functionalized surface to a sample of interest formed of an aqueous carrier liquid containing the biological objects; a step of removing the liquid in contact with the functionalized surface and exposing the surface to a gas not containing the biological objects, said objects remaining bound to the ligands of the sensitive site of the functionalized surface; a step of acquiring an image of the sensitive site; a step of detecting the biological objects from the acquired image.
Absstract of: CN119736221A
本发明公开了一种表达Bcf菌毛的重组菌株，重组菌株由将含有Bcf操纵子基因的表达载体导入惰性载体菌中得到。将Bcf操纵子基因插入到表达载体pBR322中得到重组质粒，将所述重组质粒导入惰性载体菌S9中得到所述重组菌株，惰性载体菌S9的保藏编号为CGMCC No.17340。上述重组菌株在快速、特异性、敏感性、稳定性、简单和价廉等方面表现更好，能够满足畜禽群的沙门氏菌感染现场和大规模、大批量、快速检测的要求，通过靶向检测多种血清型沙门氏菌感染，适用于沙门氏菌的大规模初筛工作。还能够对沙门氏菌疫苗接种后抗体水平进行监测。
Absstract of: WO2025063348A1
The present invention relates to a novel bacteriophage having specific killing ability against Salmonella enterica and an antibacterial composition comprising same, wherein the composition comprising the bacteriophage as an active ingredient can be usefully employed as a composition for preventing or treating infectious diseases caused by Salmonella enterica, feed for livestock, drinking water, a cleaning agent, and a disinfectant.
Absstract of: CN116121203A
The invention discloses a clostridium welchii bacteriophage PM11, a bacteriophage composition and application of the clostridium welchii bacteriophage PM11, the clostridium welchii bacteriophage PM11 is used for preventing and controlling poultry bacterial diarrhea, the preservation number of the clostridium welchii bacteriophage PM11 is CGMCC No.22372, and the clostridium welchii bacteriophage PM11 is preserved in the China General Microbiological Culture Collection Center on April 12, 2021 and has the preservation number of CGMCC The invention also discloses a bacteriophage composition formed by compounding the clostridium welchii bacteriophage PM11, an escherichia coli bacteriophage PD205 and a salmonella bacteriophage PC192, and the clostridium welchii bacteriophage and the bacteriophage composition can be used as active ingredients for effectively preventing and treating avian bacterial diarrhea, and can also be used as an environment disinfectant. And compared with a single lytic bacteriophage, the bacteriophage has the characteristic of wide lysis spectrum, widens the sterilization range and improves the sterilization activity.
Absstract of: WO2025060396A1
A probiotic and prebiotic composition and the use thereof. The composition comprises human milk oligosaccharides, Bifidobacterium bifidum and Bifidobacterium longum subsp. infantis, and has the advantages of improving the resistance of gastrointestinal tracts to pathogenic bacterial infection and reducing colonization of Salmonella.
Absstract of: WO2025063348A1
The present invention relates to a novel bacteriophage having specific killing ability against Salmonella enterica and an antibacterial composition comprising same, wherein the composition comprising the bacteriophage as an active ingredient can be usefully employed as a composition for preventing or treating infectious diseases caused by Salmonella enterica, feed for livestock, drinking water, a cleaning agent, and a disinfectant.
Absstract of: US2025099564A1
A vaccine for treating Salmonella enteriditis that includes an immunogenically effective amount of a Salmonella enteritidis protein InvG, and optionally a pharmaceutically acceptable carrier is described. Methods of using compositions that include the Salmonella Enteritidis protein InvG or a delivery vector that expresses Salmonella Enteritidis protein InvG for immunizing poultry against Salmonella Enteritidis are also described.
Absstract of: AU2023361317A1
The present invention relates to a modified live attenuated Gram-negative bacteria, wherein said bacteria has been modified in such a way that RNA molecules can be safely and efficiently delivered to target eukaryotic cells. As such, the present invention relates a to a bacterial delivery system and various uses and methods thereof.
Absstract of: AU2023346467A1
The present invention relates to a modified live attenuated strain of Salmonella, said strain comprising at least one chromosomally integrated synthetic polynucleotide sequence inserted into a pre-determined pseudogenomic location, said sequence comprising at least one defined recombination site for the introduction of a heterologous polynucleotide sequence encoding a polypeptide, wherein said chromosomally integrated synthetic polynucleotide sequence is located within at least one genomic locus as defined by any one of SEQ ID NOs: 1-30, or a sequence comprising at least 70% identity to any one of SEQ ID NOs: 1-30. The present invention also relates to a vaccine composition comprising the modified strain and various uses and methods thereof.
Absstract of: KR20250041982A
본 발명은 비장티푸스성 살모넬라 2가 백신의 면역원성 동시 측정용 혈청사멸분석법에 관한 것이다.
Absstract of: WO2023223331A1
The present invention relates to diagnostic platform. More specifically, the invention relates to a dual platform composed of a detection and quantification unit and a characterization unit, systems, kits, methods and uses thereof in detection, quantification and characterization of pathogens, the system comprising monoclonal-antibody-based biosensor chips, for detection and/or quantification of pathogens in a sample, and substrate-based biosensor chips for enzymatically profiling the pathogen in the sample.
Absstract of: US2025092355A1
The invention relates to compositions and methods, including polynucleotide sequences, amino acid sequences, and engineered host cells for producing fatty acids and derivates of fatty acids such as acyl-CoA, terminal olefins, fatty aldehydes, fatty alcohols, alkanes, alkenes, wax esters, ketones and internal olefins through altered expression of the transcription factor, fadR.
Absstract of: US2025093348A1
A nucleic acid testing device and method are provided. A base plate that is turned during nucleic acid testing is included, wherein the base plate includes the following chambers: a sample chamber for adding and containing a nucleic acid sample solution, the nucleic acid sample solution is placed in the chamber, and an upper port of the sample chamber communicates with the outside atmosphere; a reaction chamber for nucleic acid amplification reaction and located below the sample chamber, a nucleic acid amplification reagent for nucleic acid amplification reaction is pre-placed in the chamber, and an upper end of the reaction chamber communicates with a bottom end of the sample chamber though a longitudinal liquid channel; a test strip chamber for lateral flow test strip testing, a nucleic acid test strip is pre-placed in the chamber, and the test strip chamber communicates with the reaction chamber through a bent channel.
Absstract of: AU2023338191A1
The present invention provides compositions and methods for inducing an immune response in a subject in need thereof, comprising administering to the subject an immunologically-effective amount of a live
Absstract of: AU2022480516A1
Provided is a method against Salmonella typhimurium infection using a composition containing cultures of Lactobacillus rhamnosus LRH10 which is deposited at the Deutsche Sammlung Von Mikroorganismen und Zellkulturen (DSMZ) GmbH under an accession number DSM 32786, Lactobacillus paracasei LPC12 which is deposited at the DSMZ GmbH under an accession number DSM 32785, Lactobacillus fermentum LF26 which is deposited at the DSMZ GmbH under an accession number DSM 32784，Streptococcus thermophilus ST30 which is deposited at the DSMZ GmbH under an accession number DSM 32788, and Lactobacillus helveticus LH43 which is deposited at the DSMZ GmbH under an accession number DSM 32787.
Nº publicación: CN119633101A 18/03/2025
Applicant:
扬州大学
Absstract of: CN119633101A
本发明公开了SseB蛋白在制备交叉免疫同源或异源血清型肠炎沙门菌的疫苗中的应用。本发明使用动物实验评估其免疫保护力，结果发现肠炎沙门菌SseB蛋白具有良好的免疫反应性，可以显著减轻肠炎沙门菌同源或异源血清型野生菌株引起的临床症状。本发明涉及的具有交叉免疫保护作用的肠炎沙门菌SseB蛋白，具有作为研制肠炎沙门菌亚单位疫苗的潜力。
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