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59
results.
Updated on
19/04/2025 [07:37:00]
Absstract of: US2025123296A1
A level of mouse Aβ1-40 and a level of mouse APP669-711 in a biological sample derived from an AD model mouse are measured by detection of markers including mouse Aβ1-40 and mouse APP669-711; an APP669-711/Aβ1-40 ratio which is a ratio of the level of mouse APP669-711 to the level of mouse Aβ1-40 is calculated; and when the ratio in the AD model mouse is higher than the same ratio in a reference mouse in which cerebral Aβ deposition is absent, it is judged that an amount of cerebral Aβ deposition in the AD model mouse is higher than an amount of cerebral Aβ deposition in the reference mouse.
Absstract of: US2025122570A1
Methods are provided for identifying Alzheimer's disease cells or subjects, based on the methylation status of multiple methylation markers in genomic DNA. Also provided are methods for identifying therapeutic agents for treating Alzheimer's disease by monitoring changes in the methylation status of multiple methylation markers.
Absstract of: AU2023294616A1
Described herein are detecting methods for conformational disease, aging and proteinopathies, by measuring the presence of b-isox-precipitates and the levels of b-isox-captured proteins in biofluids of healthy individuals and patients. Research identified additional biomarkers, which made it possible to detect, diagnose or treat, a human disease in a human subject by, with or without adding an isoxazole to an obtained biofluid sample, detecting the biomarker. Use of b-iso and/or biomarkers for diagnosing the disease are made possible.
Absstract of: US2025116035A1
In the field of aptamers, closed sequence solution space libraries for aptamer selection. Also, methods for selecting aptamers for binding to target molecules in which biological samples derived from individuals that differ by phenotype are contacted with the library of aptamers and the aptamer oligonucleotides that bound to the target molecules are covered. Further, methods of treating a disorder or a disease of a subject in which the disorder or disease is diagnosed using the library of aptamers and the subject is treated.
Absstract of: US2023349925A1
The present invention addresses the problem of providing: a determination method that can determine, early and with ease, whether or not a disease caused by synaptic dysfunction or a disease accompanied by synaptic dysfunction has occurred, and the severity level of the disease; and a screening method for a therapeutic agent and a prophylactic agent for a disease caused by synaptic dysfunction or a disease accompanied by synaptic dysfunction. The present invention provides a determination method that can determine disease caused by synaptic dysfunction or a disease accompanied by synaptic dysfunction early and with ease and also can contribute to drug discovery research for these diseases, with a determination method for determining whether or not a disease caused by synaptic dysfunction or a disease accompanied by synaptic dysfunction has occurred, where drebrin A-related proteins (DARPs) serve as indices, and with a screening method for screening a therapeutic agent and prophylactic agent for a disease caused by synaptic dysfunction or a disease accompanied by synaptic dysfunction, where drebrin A-related proteins (DARPs) serve as indices.
Absstract of: WO2025076222A1
Human tau protein phosphorylated at the amino acid, serine 413 (pS413 tau), can serve as a biomarker for tauopathies such as Alzheimer's disease. Detection and quantitation of pS413 tau in a biological sample such as cerebrospinal fluid can be useful in developing therapeutics for certain tauopathies. However, pS413 tau is present in biological samples at very low levels. Thus, the invention provides a highly sensitive assay for the detection and quantitation of pS413 tau in a biological sample comprising a series of steps as described herein.
Absstract of: AU2023356443A1
Provided is a protein marker Nell-1, which is present in a person's blood sample in an amount that is correlated with neurodegenerative disorders such as Alzheimer's Disease (AD), Mild Cognitive Impairment (MCI), and Parkinson's Disease (PD). Corresponding diagnostic and treatment methods for these neurodegenerative disorders as well as kits for diagnosing or treating the neurodegenerative disorders are also provided.
Absstract of: US2025115952A1
In the field of aptamers, closed sequence solution space libraries for aptamer selection and related methods for selecting aptamers for binding to target molecules. Also, a method of treating a disease or disorder in a subject, including diagnosing, monitoring, or predicting a using at least one aptamer obtained by the closed sequence solution space libraries, and treating the diagnosed subject. Further a specific set of aptamers, which may be used for detection and/or quantification of a target molecule.
Absstract of: EP4535003A1
Provided is a method for analyzing a neurogranin-related peptide capable of suppressing variations in analysis results, and a method for preparing a biological sample containing a neurogranin-related peptide used therein. A method for preparing a sample solution containing a neurogranin-related peptide, the method includes mixing a biological sample containing a neurogranin-related peptide with an organic solvent having a relative polarity of 0.200 or more and 0.700 or less to prepare a sample solution having a final concentration of the organic solvent of 5.0 (v/v)% or more.
Absstract of: CN117589996A
The invention relates to a diagnostic use of highly toxic amyloid oligomers. Specifically, the present invention relates to the use of a novel highly toxic amyloid oligomer A beta o * 3F, specifically bound by a 3F antibody, in the cerebrospinal fluid (CSF), blood and/or brain tissue of AD patients and AD-derived MCI patients, as a target for the diagnosis of early and mid-advanced Alzheimer's disease (AD) and AD-derived mild cognitive impairment (MCI), the Abeta oligomers have the advantages that the Abeta oligomers are high-toxicity oligomers, the levels of the Abeta oligomers are remarkably different in CSF, blood and/or brain tissues of AD patients, MCI patients and healthy old people, and the Abeta oligomers are super-toxicity oligomers, are the most major toxic components in A beta oligomer mixtures, have strong pathogenic effects and play a key role in occurrence and development of AD.
Absstract of: WO2025068747A1
The present invention relates to the field of neurodegenerative diseases detection and diagnosis, in particular to a delivery system comprising bodipy markers, said delivery system consisting of a modified humanized ferritin from Archaeoglobus fulgidus (HumAfFt) and a bodipy fluorescent marker that selectively binds the TAU protein, compositions comprising said delivery system and methods ad uses thereof.
Absstract of: WO2025068791A1
The present invention relates to the field of neurodegenerative diseases detection and diagnosis, in particular to a delivery system comprising bodipy markers, said delivery system consisting of a modified humanized ferritin from Archaeoglobus fulgidus (HumAfFt) and a bodipy fluorescent marker that selectively binds the TAU protein, compositions comprising said delivery system and methods ad uses thereof.
Absstract of: AU2023329330A1
Provided herein are antibodies, or fragments thereof, that specifically bind to a microtubule-binding region (MTBR) of tau, and uses thereof. Further provided are methods of detecting species of MTBR in blood or cerebral spinal fluid, and the use of such detection for diagnosing, prognosing, or staging pathological features and/or clinical symptoms of tauopathies, and to choose treatments appropriate for a given disease stage.
Absstract of: AU2023329158A1
The invention relates to methods of detecting, diagnosing or monitoring an inflammatory condition of the central nervous system, in particular by detecting or measuring neutrophil extracellular traps, extracellular traps and/or cell free nucleosomes.
Absstract of: US2025101491A1
Method for diagnosing Alzheimer's disease in an individual, comprising the steps of providing at least one serum sample derived from the individual, providing at least one preparation of phage clones expressing peptides that mimic conformational epitopes of the Aβ-42 peptide, reacting said at least one serum sample with said at least one preparation of phage clones expressing peptides that mimic conformational epitopes of Aβ-42, so that antibodies that may be present in said serum and are directed against the Aβ-42 peptide bind to the peptides expressed by phage clones of said preparation of phage clones, detecting, by real-time PCR technique, the quantity of phage clones of said preparation to which said antibodies have bound, and determining, based on the quantity of phage clones of said preparation to which said antibodies have bound, whether the individual from whom said serum sample was derived suffers from Alzheimer's disease.
Absstract of: WO2025064229A1
The disclosure pertains to treating a cognitive impairment, for example, an aging-associated cognitive impairment. In certain aspects, the disclosure describes methods of assaying a sample obtained from a subject having or suspected of having a cognitive impairment for one or more proteins selected from: DLL1, VNN2, VAV3, and SUMF1. In certain embodiments, the cognitive impairment is caused by a neurodegenerative disease, such as Alzheimer's disease. The methods further comprise identifying a subject as likely or not likely to respond positively to the plasma exchange therapy. In even further aspects, the disclosure describes methods for treating a cognitive impairment in the subject by a plasma exchange therapy, wherein based on the specific protein expression data, the subject is identified as likely or not likely to respond positively to the plasma exchange therapy. The plasma exchange therapy can be full and/or low volume plasma exchange. Also provided are kits suitable for performing the methods disclosed herein.
Absstract of: US2025101018A1
Described herein are compounds of formula (I), and pharmaceutically acceptable salts, solvates, hydrates, isotopically labeled derivatives and radiolabeled derivative thereof, and pharmaceutical compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for detecting and imaging Tau aggregates in the brain for detection of Alzheimer's disease (AD) in a subject.
Absstract of: AU2023329330A1
Provided herein are antibodies, or fragments thereof, that specifically bind to a microtubule-binding region (MTBR) of tau, and uses thereof. Further provided are methods of detecting species of MTBR in blood or cerebral spinal fluid, and the use of such detection for diagnosing, prognosing, or staging pathological features and/or clinical symptoms of tauopathies, and to choose treatments appropriate for a given disease stage.
Absstract of: JP2024037794A
To provide a method for measuring an amount of singly or multiply phosphorylated p217+tau protein in a sample, regarding compositions and methods for detecting neurodegeneration.SOLUTION: A method for measuring a p217+ tau peptide in a sample, comprises: (i) contacting the sample with a capture antibody against a p217+ tau epitope to capture the p217+ tau peptide in the sample; and (ii) contacting the captured p217+ tau peptide with at least one of a first detection antibody against an epitope comprising amino acid residues 119 to 126 of a tau protein and a second detection antibody against an epitope comprising amino acid residues 7 to 20 of the tau protein, and measuring at least one of an amount of the p217+ tau peptide and an amount of a long p217+ tau peptide, where amino acid numbering refers to a specific amino acid sequence.SELECTED DRAWING: None
Absstract of: EP4528281A2
The present invention relates to a method for assessing atrial fibrillation in a subject, said method comprising the steps of determining the amount of BMP10 in a sample from the subject, and comparing the amount of BMP10 to a reference amount, whereby atrial fibrillation is to be assessed. Moreover, the present invention relates to a method for diagnosing heart failure based on the determination of BMP10 in a sample from a subject. Further, the present invention relates to a method for predicting the risk of a subject of hospitalization due to heart failure based on the determination of a BMP10-type peptide in a sample from a subject. The present invention further pertains to antibodies which bind to one or more BMP10-type peptides such as NT-proBMP10.
Absstract of: EP4528274A2
The invention relates to the use of biomarkers of TrkB-FL, TrkB-ICD, TrkB-T', the TrkB-T':TrkB-FL ratio, or the TrkB-ICD:TrkB-FL ratio in the in vitro diagnosis of Alzheimer Disease (AD) or for determining the stage of AD, methods for their use, methods of diagnosis, methods of monitoring disease progression, in neuropathological diseases, in particular for Alzheimer's disease.
Absstract of: EP4527944A1
The present invention relates to a Gram-positive, anaerobic and non-spore-forming bacterium in the stool that can serve as a biomarker for diagnosing, assessing and predicting the development of dementia related diseases induced by high fat diet consumption. This was done by analyzing bacterial metagenome using cecum samples derived from AD mice models and to investigate the increase of a specific bacterium's relative abundance and its association with the disease. By using the strategy in this invention, it is possible to diagnose and predict AD at an early stage, so that it is possible to delay the onset of the disease or to prevent the onset of the disease through proper management thereby lowering the incidence of AD and improving the therapeutic effect.
Absstract of: AU2023329158A1
The invention relates to methods of detecting, diagnosing or monitoring an inflammatory condition of the central nervous system, in particular by detecting or measuring neutrophil extracellular traps, extracellular traps and/or cell free nucleosomes.
Absstract of: AU2023334129A1
The invention relates to identification of an intron-retaining Tau splicing isoform as a novel Alzheimer's disease biomarker. Provided herein are polypeptides to generate binding molecules, such as antibodies specific for the Tau11i isoform, oligonucleotides and antibodies for use in methods for detecting the Tau11i isoform in a sample and methods for use in diagnosis for Alzheimer's disease.
Nº publicación: US2025092361A1 20/03/2025
Applicant:
CASSAVA SCIENCES INC [US]
Cassava Sciences, Inc
Absstract of: US2025092361A1
A method of inhibiting phosphorylation of the tau protein and/or a TLR4-mediated immune response is disclosed. The method contemplates administering to cells in recognized need thereof such as cells of the central nervous system an effective amount of a of a compound or a pharmaceutically acceptable salt thereof that binds to a pentapeptide of filamin A (FLNA) of SEQ ID NO: 1, and contains at least four of the six pharmacophores of FIGS. 35-40.
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