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60
results.
Updated on
23/12/2025 [07:24:00]
Results 25 to 50 of 60
Absstract of: CN120457337A
The present disclosure provides a method of preparing a biosensor for detecting Alzheimer's disease biomarkers, comprising depositing an alumina film on a Si substrate by an atomic layer deposition system to form an Al2O3/Si substrate; depositing an electric contact part Cr/Au on the Al2O3/Si substrate through a thermal evaporator, and forming a source electrode, a drain electrode and a planar grid electrode on the Al2O3/Si substrate; providing double-layer graphene on the Al2O3/Si substrate through thermal annealing in a vacuum environment; performing low-damage plasma treatment (LDPT) on the double-layer graphene with a mixture of oxygen and hydrogen to form a graphene oxide/graphene (GO/G) layered composite material on the Al2O3/Si substrate; an antibody is immobilized on the surface of a GO/G layered composite material by a reaction between an amine group of the antibody and a carboxyl group of GO of the GO/G layered composite material, where the antibody is specific for p-tau217 protein.
Absstract of: US2025191903A1
Provided are methods for determining the apolipoprotein E (ApoE) phenotype in a sample by mass spectrometry; wherein the ApoE allele(s) present in the sample is determined from the identity of the ions detected by mass spectrometry. In another aspect, provided herein are methods for diagnosis or prognosis of Alzheimer's disease or dementia.
Absstract of: WO2025240658A1
Neprilysin inhibitors are used for the treatment of patients with Alzheimer's disease or other proteinopenic diseases of the CNS. The patients selected for therapy may be selected based on confirmed biomarker diagnosis of disease, along with a reduced Aβ level.
Absstract of: US2025355001A1
The invention relates to an in vitro method for detecting a tau protein fragment in a sample from a patient wherein the amino acid sequence of the fragment consists of amino acid residues within residues 113 to 379 of SEO ID NO: 1. The method may use a specific binding molecule, such as an antibody, directed to key epitopes of tau. The invention may find applications in diagnostics of tauopathics.
Absstract of: US2025355002A1
The invention provides antibodies and binding fragments thereof that specifically binds to TDP-43 cryptic exon-encoded neoepitopes, and methods of use thereof. The methods of use include methods of detecting TDP-43 loss of function, methods of detection and/or diagnosing TDP-43 associated diseases, and methods of monitoring disease progression and/or response to therapy. The invention also provides a kit including the antibodies and binding fragments thereof.
Absstract of: US2024310389A1
This document provides methods and materials related to screening for and treating Alzheimer's disease (AD), including late-onset Alzheimer's disease (LOAD).
Absstract of: WO2024148357A2
U-p53 peptide P1 is useful in the determination of the rate of progression of Alzheimer's disease (AD). By quantitating the level of U-p53 peptides in a subject's biological sample, the rate of progression of Alzheimer's disease at the pre-clinical and prodromal stages of the disease in a subject can be determined.
Absstract of: ES3041857A1
Screening for the diagnosis of Alzheimer's disease based on the detection of β-amyloid by FRET in plasma. Alzheimer's disease (AD) is the leading cause of dementia worldwide. Therefore, the search for biomarkers and the development of methodologies that allow for its early detection constitute a health and economic challenge. The concentrations of beta-amyloid Aβ 40 and AβThe presence of 42 Aβ oligomers in the cerebrospinal fluid and blood of Alzheimer's patients constitutes a good prognostic biomarker. Currently, Aβ oligomers with abnormal conformation can be detected using an ELISA-type immunoassay, or early detection of Aβ oligomerization can be achieved using an infrared immunosensor. A method based on fluorescence energy transfer resonance is proposed, employing a FRET (fluorescence energy transfer) pair consisting of compound A with general formula I and compound B CRANAD-2. (Machine-translation by Google Translate, not legally binding)
Absstract of: JP2025094219A
To provide TDP-43-specific binding molecules for diagnosing, preventing, ameliorating, and/or treating diseases, disorders, and/or abnormalities associated with TDP-43 aggregates, or TDP-43 proteinopathies.SOLUTION: Provided is a TDP-43 binding molecule that is an antibody or an antigen-binding fragment thereof, which binds misfolded aggregated TDP-43 and non-aggregated physiological TDP-43, or a humanized variant thereof.SELECTED DRAWING: None
Absstract of: US2025346956A1
In some aspects, the present disclosure provides a method for determining a risk or state of a neurodegenerative disease of a subject. In some embodiments, the method compriseses detecting a presence of a biomarker in a biological sample from the subject, wherein the biomarker comprises at least one of: E7EUF1, O94812, P02549, P02730, P05019, P05154, P05546, P13497, P16157, P16452, P17936, P24593, P27918, P35858, P41218, Q12797, Q13214, Q13822, Q8NI99, Q96IY4, Q99715, Q9BXN1, Q9H0B8, or a proteoform thereof. In some embodiments, the method comprises detecting a presence of a biomarker in a biological sample from the subject, wherein the biomarker comprises at least one of: P54803, P14625, P30043, P00742, A0A0D9SG88, Q5TFM2, P54803, P54803-3, P54803-4, P04196, or a proteoform thereof. In some embodiments, the method comprises determining the risk or state of the neurodegenerative disease of the subject based on the presence of the biomarker in the biological sample.
Absstract of: WO2025235473A2
The presently described and claimed technology relates to high-throughput automated methods for the investigation of ApoE isoforms the subsequent prediction of a likelihood of developing a neurodegenerative disease.
Absstract of: WO2025235476A2
The presently described and claimed technology relates to high-throughput automated methods for the investigation of ApoE isoforms the subsequent prediction of a likelihood of developing a neurodegenerative disease.
Absstract of: US2025347684A1
Provided herein is a method for treating a human subject with Alzheimer's Disease (AD) having an AD metabolomic phenotype, the method comprising: obtaining or having obtained a blood sample from the human subject with Alzheimer's disease; measuring the levels of metabolites in the blood sample; applying an algorithm to the measured metabolite levels, the algorithm generating a metabolomic score based on a comparison of the measured metabolites levels to reference metabolites levels; identifying the human subject with Alzheimer's Disease as having an AD metabolomic phenotype based on the metabolomic score; wherein the algorithm is selected from a machine learning algorithm, a clustering algorithm, a random forest algorithm, a support vector machines algorithm, a radial basis function algorithm and a combination thereof.
Absstract of: CA3242558A1
Aspects of the application relate to methods and systems for obtaining information regarding multiple amino acids in a polypeptide based on binding interactions between the polypeptide and one or more amino acid recognizers. Kinetic signature information may be obtained from a series of signal pulses indicative of a series of binding events between one or more amino acid recognizers and an amino acid of a polypeptide (e.g., a terminal amino acid, an internal amino acid). The kinetic signature information (e.g., pulse duration, interpulse duration, recognition segment (RS) duration, intersegment duration) may be used to determine one or more chemical characteristics (e.g., identity, modification) of multiple amino acids of the polypeptide.
Absstract of: MX2024001835A
Compositions and kits for diagnosing and prognosing Alzheimer's Disease (AD) in a human patient include a binding agent such as a monoclonal antibody for a biomarker conjugated to a detectable moiety such as a fluorophore, wherein the biomarker is chosen from CD 163, CD91, CD59, MerTK and other phagocytosis-related molecules. Further compositions and kits employ panels of fluorophore-conjugated monoclonal antibodies for biomarkers including scavenger receptors. Methods for determining the relative expression of biomarkers, diagnosing AD, and determining the efficacy of AD therapeutic candidates such as phagocytosis-promoting agents and scavenger receptor agonists also appear.
Absstract of: KR20250158875A
본 발명은 NOX4(NADPH oxidase 4), RBP4(Retinol binding protein 4) 및 CXCL10(C-X-C motif chemokine ligand 10)으로 이루어진 군에서 선택된 어느 하나 이상의 유전자 또는 상기 유전자로부터 암호화되는 단백질을 포함하는 동물의 퇴행성 신경 질환 진단용 바이오마커 조성물에 관한 것으로, 퇴행성 신경 질환 동물 모델에서 상기 바이오마커의 수준이 정상 그룹 대비 감소함을 확인하였고, 머신 러닝을 활용하여 최적의 바이오마커 조합을 확인함으로써, 기존의 신경 퇴행성 질환 진단 방법 대비 높은 정확도를 가지는 바이오마커를 제공할 수 있다.
Absstract of: WO2025231348A1
Provided are methods of phospho-tau aggregation-based biomarker discovery, and new utilities for discovered biomarkers in Alzheimer's disease (AD) diagnosis, differentiation, treatment, and identification of the presence of pretangles in a subject. Novel p-tau sites, p-tau198, p-tauS356, p-tau396, and p-tau422, identified through such methods showed comparable or superior characteristics with established p-tau biomarkers, and identified biomarkers were capable of differentiating AD or mild cognitive impairment (MCI) from cognitively normal controls.
Absstract of: US2025340941A1
Disclosed herein are methods for assaying a potential drug candidate for the treatment, prevention, reduction or amelioration of neurodegenerative diseases and disorders. Some aspects pertain to stimulating a cell to induce a phenotype characteristic of a neurodegenerative disease or disorder and contacting the cell with a potential drug candidate and determining a responsive change, wherein a decrease or loss in the phenotype is indicative that the drug candidate is capable of treating, preventing, reducing or ameliorating neurodegenerative diseases or disorders.
Absstract of: US2025341530A1
The present disclosure relates to immunoassays for NF-L performed on liquid samples derived from physiological fluids such as venous blood to detect the presence or absence of a physiological condition by quantifying one or a combination of NF-L determinations at concentrations indicative of the condition.
Absstract of: AU2024274218A1
The present invention refers to the use of a biomarker for measuring the efficacy or effectiveness of treatments for neurodegenerative diseases, in particular, for Alzheimer's disease.
Absstract of: US2025339434A1
A process for treating a human subject with a neurologic disorder comprises obtaining a sample of the human subject. The sample is contacted with an assay for detecting a presence of soluble folate binding protein (sFBP), one or more single nucleotide polymorphism (SNP) in folate or related one-carbon metabolism genes, or both. Based on the whether there is a presence of sFBP, a presence of SNPs, an amount of folate receptor alpha autoantibody (FRAA) (i.e., FRAA titer), or a combination thereof in the sample, a treatment including a folate is created. The treatment is then administered to the human subject.
Absstract of: KR20250158282A
본 발명은 퇴행성 뇌질환 조기 진단용 조성물 및 이를 이용한 진단 키트에 관한 것이다. 본 발명은 BDNF 단백질 및 GAP43 단백질과, Netrin-1 단백질 또는 Netrin-4 단백질을 포함하는, 퇴행성 뇌질환 조기 진단용 바이오마커 조성물을 제공한다.
Absstract of: EP4644569A2
The present disclosure provides methods and systems for mapping gene and protein expression in a cell (i.e., mapping gene and protein expression within the same cell simultaneously). The present disclosure also provides methods for diagnosing a disease or disorder (e.g., a neurological disorder such as Alzheimer's disease) in a subject. Methods of screening for a candidate agent capable of modulating gene and/or protein expression are also provided by the present disclosure. The present disclosure also provides methods for treating a disease or disorder, such as Alzheimer's disease, in a subject in need thereof. A plurality of oligonucleotide probes, which may be useful for performing the methods described herein, are also described by the present disclosure, as well as kits comprising any of the oligonucleotide probes described herein. Additionally, the present disclosure provides methods, apparatuses, and non-transitory computer-readable storage media for identifying spatial variations of cell types in at least one image.
Absstract of: MX2025011654A
The present invention relates to anti-a-synuclein antibodies, which preferentially recognize a-synuclein aggregates, and uses for detection, diagnosis, and/or treatment or prevention of a variety of diseases or disease symptoms related thereto due to accumulation of a-synuclein aggregates by using the anti-a-synuclein antibodies.
Nº publicación: MX2025011444A 03/11/2025
Applicant:
CITRYLL B V [NL]
CITRYLL B.V
Absstract of: MX2025011444A
The invention provides antibodies or binding fragments thereof directed against citrulline-containing epitopes for use in treating or preventing diseases associated with extracellular trap release from cells, such as Neutrophil Extracellular Trap (NET)- associated pathologies (NET associated pathology) or Eosinophil Extracellular Trap (EET) -associated pathologies (EET-associated pathology), wherein the methods comprising administering at least one dose of the antibody at a specific concentration. The invention also provides the methods themselves. The NET-associated pathologies include systemic lupus erythematosus (SLE), lupus, sepsis, vasculitis, inflammatory arthritis, rheumatoid arthritis and osteoarthritis, psoriasis, Alzheimer's disease, autoimmune hepatitis, juvenile idiopathic arthritis, myositis (polymyositis and dermatomyositis), Sjögren's disease, Anti-phospholipid Syndrome, Bechet's disease, spondylitis, spondyloarthropathy, multiple system atrophy, Parkinson's disease, Lewy body dementia, asthma, allergic rhinovirus exacerbated asthma, allergic asthma, acute respiratory distress syndrome, cystic fibrosis, fibrosis and idiopathic pulmonary fibrosis, heart failure, atherosclerosis, dry eye disease, uveitis, nongranulomatous uveitis, granulomatous uveitis, dermatitis, atopic dermatitis, COPD, bronchitis, or other NET-associated pathologies such as wound healing in diabetes, cancer, cancer metastasis, and transplant organ health in vivo or ex vivo. The invention a
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