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3D bioprinting

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LastUpdate Updated on 21/10/2025 [07:09:00]
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Solicitudes publicadas en los últimos 30 días / Applications published in the last 30 days
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数字化3D打印多功能正中颌托盘及其使用方法

Publication No.:  CN120788767A 17/10/2025
Applicant: 
上海陈信医疗器械有限公司
CN_120788767_PA

Absstract of: CN120788767A

本申请实施例提供数字化3D打印多功能正中颌托盘及其使用方法,涉及到口腔用具技术领域。数字化3D打印多功能正中颌托盘及其使用方法,包括:周侧带有半环形边沿的主托体,主托体上表面开设多个浅槽和多个第一通孔,多个浅槽和多个第一通孔错开分布;主托体的弧形中部内侧开设有顶部开口的插槽,插槽内阻尼插接有抬高体,抬高体向主托体中部一侧逐渐凸起,且抬高体的边缘与主托体边缘重合;主托体背侧可拆卸连接有连接块,连接块远离主托体的一侧设置有手柄,本发明通过模块化的设计,实现该正中颌托盘的多功能应用,在不同的使用需求下均能够更精确的获取颌位关系,且调整方便快捷,实际使用效果更佳。

一种基于3D打印的生物牙根支架及其制备方法与应用

Publication No.:  CN120789332A 17/10/2025
Applicant: 
四川大学
CN_120789332_PA

Absstract of: CN120789332A

本发明公开了一种基于3D打印的生物牙根支架及其制备方法与应用,属于生物医用材料技术领域。所述生物牙根支架包括3D打印的生物牙根支架基体和CMC‑BAPE@BMP7纳米颗粒,所述3D打印的生物牙根支架基体表界面具有活化的纳米晶须结构,所述CMC‑BAPE@BMP7纳米颗粒吸附固定在所述3D打印的生物牙根支架基体中。本发明结合了3D打印制备高精度生物陶瓷、高温烧结后优良力学性能、表界面活性改建促进细胞黏附分化以及结合抗炎促细胞分化纳米CMC‑BAPE@BMP7药物,实现了高强度、高精度、免疫调节活性的生物牙根支架的个性化定制,在牙缺失修复领域具有广阔的应用前景。

一种外科钛合金融合器活性涂层的制备方法

Publication No.:  CN120789330A 17/10/2025
Applicant: 
中国人民解放军总医院第四医学中心
CN_120789330_PA

Absstract of: CN120789330A

本发明公开了一种外科钛合金融合器活性涂层的制备方法,包括以下步骤:S1.通过3D打印制备多孔结构的钛合金融合器;S2.在钛合金融合器表面构建聚多巴胺涂层;S3.制备钙磷沉积液,在聚多巴胺涂层上进行羟基磷灰石矿化;S4.在羟基磷灰石矿化涂层表面接枝TBMP2蛋白,即完成钛合金融合器活性涂层的制备。本发明解决现有钛合金融合器生物惰性、骨整合性能差以及BMP2应用中副作用多的问题,并能够适应个性化植入需求。

PATIENT-SPECIFIC GLENOID PROSTHESES FOR PARTIALLY MODIFIED SCAPULA

Publication No.:  WO2025215550A1 16/10/2025
Applicant: 
STRYKER EUROPEAN OPERATIONS LTD [IE]
PENNINGER CHARLES L [US]
GODELU MARINE [FR]
WALCH GILLES [FR]
STRYKER EUROPEAN OPERATIONS LIMITED,
PENNINGER, Charles L,
GODELU, Marine,
WALCH, Gilles
WO_2025215550_PA

Absstract of: WO2025215550A1

A method comprises outputting a user interface of a surgical planning system, wherein the user interface represents a patient-specific glenoid prosthesis at a planned implantation position on a scapula of a patient; and determining a bone-facing surface of the patient-specific glenoid prosthesis having a native-facing portion and a modified-facing portion, wherein the native-facing portion is shaped to conform to an unmodified bone surface of the scapula and the modified-facing portion is shaped to conform to a modified bone surface of the scapula.

SYSTEM FOR CUSTOM IMPLANT DESIGN AND INSTRUMENTATION

Publication No.:  WO2025217154A1 16/10/2025
Applicant: 
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RES [US]
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
WO_2025217154_PA

Absstract of: WO2025217154A1

Systems and methods include a component of a bone implant that includes a patient specific bone contacting surface and, optionally, at least one protrusion adjacent to or extending from the patient specific bone contacting surface. The at least one protrusion is configured for engaging a bone preparation in the bone. To prepare the bone for receiving the component, one or more cutting tool templates may be used. The one or more cutting tool templates may be fabricated to have a patient specific bone contacting surface that engages the bone that is to receive the implant component. A cutting tool is engaged in one or more of one or more slots defined by the cutting tool template(s) to remove surface portions of the bone to create the bone preparation for engaging the protrusion. The patient specific bone contacting surface of the component engages the bone.

VEHICLE FOR NON-ANTIMICROBIAL COMPOSITION

Publication No.:  WO2025215377A1 16/10/2025
Applicant: 
CONVATEC LTD [GB]
CONVATEC LIMITED
WO_2025215377_A1

Absstract of: WO2025215377A1

The present disclosure relates generally to wound care, and more particularly to a wound dressing or debridement tool comprising an absorbent layer at least partially impregnated or coated with a non-antimicrobial composition.

Ink formulation, method of producing the same and uses of the ink formulation

Publication No.:  US2025320367A1 16/10/2025
Applicant: 
AABO AKADEMI [FI]
\u00C5bo Akademi
FI_20225454_PA

Absstract of: US2025320367A1

The present invention relates to ink formulations based on methacrylated cellulose nanofibrils. In particular, the present invention concerns ink formulations for 3D printing, comprising a hydrogel containing methacrylated cellulose nanofibrils and preferably a cross-linking agent, optionally together with biological material, methods of producing such ink formulations, as well as uses thereof for, e.g., preparing 3D hydrogel scaffolds for cell culture and drug screening.

DEVICE AND METHOD FOR PRODUCING A PHARMACEUTICAL PRODUCT

Publication No.:  WO2025214546A1 16/10/2025
Applicant: 
SCHAEFFLER TECH AG & CO KG [DE]
FRIEDRICH ALEXANDER UNIV ERLANGEN NUERNBERG [DE]
SCHAEFFLER TECHNOLOGIES AG & CO. KG,
FRIEDRICH-ALEXANDER-UNIVERSIT\u00C4T ERLANGEN-N\u00DCRNBERG
WO_2025214546_PA

Absstract of: WO2025214546A1

The invention relates to a device (10) and a method for producing a pharmaceutical product for direct dispensing to a patient. The device has a plurality of containers (24) for receiving in each case one pharmaceutical active ingredient, wherein the pharmaceutical active ingredients differ from one another; and at least one dosing device (25) for providing a specific amount of at least one of the pharmaceutical active ingredients from at least one of the containers (24); at least one processing device (28) for shaping the pharmaceutical product from the determined amount of the at least one pharmaceutical active ingredient provided by the at least one dosing device (24); a control unit connected to the dosing device (25) and the processing device (28) for controlling the production of the pharmaceutical product; a control panel (14) connected to the control unit for requesting a dispensing of the pharmaceutical product by the patient; and a dispensing unit (16) for dispensing the pharmaceutical product. By means of the device (10), personalised medicaments or pharmaceutical products can be produced at any time and dispensed directly to a patient.

SYSTEM FOR PROVIDING A BIOINK

Publication No.:  WO2025215103A1 16/10/2025
Applicant: 
UNIV DE GRANADA [ES]
UNIV DE JAEN [ES]
UNIV DA CORUNA [ES]
UNIVERSIDAD DE GRANADA,
UNIVERSIDAD DE JAEN,
UNIVERSIDADE DA CORU\u00D1A
WO_2025215103_A1

Absstract of: WO2025215103A1

The present invention relates to a system for providing a bioink. The system comprises: a) at least two spray configured to receive at least two syringes comprising a nozzle each, each syringe configured to receive one or more components of the bioink; b) a housing, configured to comprise the at least two spray heads and comprising at least two housing nozzles, the housing nozzle comprising a diameter bigger than the diameter of the spray head nozzle; c) a gas inlet connected to the housing configured to receive a gas; and d) a control system.

Drug-eluting surgical articles and related methods

Publication No.:  AU2025237992A1 16/10/2025
Applicant: 
BIOSAPIEN INC
BioSapien Inc
AU_2025237992_A1

Absstract of: AU2025237992A1

Disclosed herein is a biomaterial and a method of use thereof for treating a condition. A biomaterial of the disclosure can be, for example, a surgical article. Implantation of a biomaterial disclosed herein into a subject can treat, for example, cancer. Disclosed herein is a biomaterial and a method of use thereof for treating a condition. A biomaterial of the disclosure can be, for example, a surgical article. Implantation of a biomaterial disclosed herein into a subject can treat, for example, cancer. ep e p i s c l o s e d h e r e i n i s a b i o m a t e r i a l a n d a m e t h o d o f u s e t h e r e o f f o r t r e a t i n g a c o n d i t i o n b i o m a t e r i a l o f t h e d i s c l o s u r e c a n b e , f o r e x a m p l e , a s u r g i c a l a r t i c l e m p l a n t a t i o n o f a b i o m a t e r i a l d i s c l o s e d h e r e i n i n t o a s u b j e c t c a n t r e a t , f o r e x a m p l e , c a n c e r

MULTIMATERIAL BIOPRINTING DEVICE

Publication No.:  WO2025215267A1 16/10/2025
Applicant: 
HEALTH BIOLUX S L [ES]
HEALTH BIOLUX, S.L
WO_2025215267_PA

Absstract of: WO2025215267A1

The invention relates to a multimaterial bioprinting device, which comprises a rotary platform (1) on which a plurality of vessels (2) is arranged, the vessels containing different biomaterials for printing, such that the rotary platform (1) is designed to rotate each vessel (2) to a printing area (3); an arm (4) with a support (5) in the printing area, such that the arm (4) is vertically moveable; a digital light processing system designed to direct a light towards the printing area (3); and a processor (11) configured to manage the vertical movement of the arm (4) and to manage the light of the digital light processing system, wherein the printing area (3) is designed such that the light of the digital light processing system makes contact with the extracted biomaterial through the support (5) of the vessels (2).

A METHOD FOR PRODUCING AND USING A COMPLEX FLUID

Publication No.:  AU2023458708A1 16/10/2025
Applicant: 
RAYO 3D BIOTECH OY
RAYO 3D BIOTECH OY
AU_2023458708_PA

Absstract of: AU2023458708A1

Disclosed is a method for producing bubbly liquid material that is suitable for being used as a supporting material in a 3D printing system, the method comprising, producing to liquid material primary bubbles, stabilizing the primary bubbles with cross-linking enhancing compound, producing secondary bubbles to the liquid material, and using the liquid material comprising the primary and secondary bubbles as the supporting material for printing a 3D object, wherein the liquid material comprises a bubble system comprising at least the primary and secondary bubbles.

APPARATUS AND PROCESS FOR MANUFACTURING A MEDICAL DEVICE AT POINT OF CARE

Publication No.:  AU2024231554A1 16/10/2025
Applicant: 
METICULY COMPANY LTD
METICULY COMPANY LIMITED
AU_2024231554_PA

Absstract of: AU2024231554A1

Aspects in accordance with the present invention pertain to an apparatus for manufacturing a medical device, said apparatus comprising at least two production modules, at least one integrating element, and at least one inspection gate, wherein the production module is configured to process the medical device, a medical device part, a medical device accessory, a medical device preform, or a raw material; the integrating element is configured to, between any two of the production modules, move the medical device, the medical device part, the medical device accessory, or the medical device preform; and the inspection gate is configured to, outside the production module, subject the medical device, the medical device part, the medical device accessory, or the medical device preform, to an inspection technique according to a predetermined inspection mode, the operations of said production modules, said integrating element, and said inspection gate, being administered by a controlling software, and said apparatus is constructed as a ready-to-transport compact unit.

PROCESSES FOR MAKING CLEAR DENTAL ALIGNERS AND CLEAR DENTAL ALIGNERS PRODUCED BY THE PROCESSES

Publication No.:  US2025318907A1 16/10/2025
Applicant: 
PDR/ORCHESTRATE LLC [US]
PDR/ORCHESTRATE LLC
WO_2023225149_PA

Absstract of: US2025318907A1

Processes for producing dental aligners and/or appliances and dental aligners and/or appliances produced by the processes are provided, wherein the processes comprise making a scan of teeth of a patient and developing a treatment plan for moving at least one tooth of the teeth from an original or first position to a new, final, or second position. The processes further comprise developing a force vector matrix, wherein the force vector matrix comprises all variables that are known to contribute to force generation of an orthodontic appliance on a patient's tooth, and 3D printing the dental aligner or appliance based on the developed treatment plan, the developed force vector matrix, and/or the scan of the teeth of the patient.

PORTABLE PRINTER

Publication No.:  US2025319710A1 16/10/2025
Applicant: 
LG HOUSEHOLD & HEALTH CARE LTD [KR]
LG HOUSEHOLD & HEALTH CARE LTD
JP_2024544478_PA

Absstract of: US2025319710A1

A portable printer including a body accommodating a cartridge including a printing material, a nozzle configured to deliver the printing material to a target, a seating part facing a surface of the target, a roller on a lower portion of the body such that the body is moved on the surface of the target, and a printing adjustment part configured to maintain a height difference between the nozzle and the roller in a first height or a second height, wherein the printing adjustment part is configured to preset a height difference between the nozzle and the roller.

PROCESS FOR PRODUCING A THREE-DIMENSIONAL STRUCTURE

Publication No.:  US2025319654A1 16/10/2025
Applicant: 
MATERIAS S R L [IT]
MATERIAS S.R.L
WO_2023214362_PA

Absstract of: US2025319654A1

A process for producing a three-dimensional structure involves providing a light source, coupling the light source to a proximal end of an optical fibre to propagate a light generated by the light source through the optical fibre and produce, at a distal end of the optical fibre, a predetermined incident optical field, providing a photo-crosslinkable polymeric material coated with a transparent material having a first surface in contact with the photo-crosslinkable polymeric material and a second surface not in contact with the photo-crosslinkable polymeric material and opposite to the first surface, placing the distal end of the optical fibre at a distance D from the second surface of the transparent material, and irradiating the second surface of the transparent material with the light propagated and exiting the distal end of the optical fibre, obtaining propagation of the light through the transparent material and photo-crosslinking, by irradiation, of the polymeric material.

METHOD FOR ADDITIVE MANUFACTURING OF A 3D ITEM BY MEANS OF FUSED DEPOSITION MODELING AND ADDITIVE MANUFACTURING APPARATUS

Publication No.:  WO2025214921A1 16/10/2025
Applicant: 
MERCK PATENT GMBH [DE]
MERCK PATENT GMBH
WO_2025214921_PA

Absstract of: WO2025214921A1

The invention relates to a method and an apparatus (1) for additive manufacturing of a 3D item (2) by means of fused deposition modeling of a composite material, whereby the composite material is fed through a heated printer extruder head (4) and deposited on a printer bed (3) as a layer arrangement that form the 3D item (2). The composite material is provided as at least one rigid rod (10) that is conveyed out of a rod magazine (9) that is capable of storing at least one rigid rod (10). The rigid rod (10) is then conveyed through a guide tube (15) that is arranged within the printer extruder head (4), whereby the rigid rod (10) is heated during the conveyance through the guide tube (15), and whereby the heated and viscous composite material is discharged through a discharge nozzle (16) at one end of the guide tube (15) and deposited as the layer arrangement onto the printer bed (3) to generate the 3D item (2).

NOVEL FIBRINOGEN-BASED BIOINKS FOR WOUND HEALING AND TISSUE REGENERATION

Publication No.:  WO2025215084A1 16/10/2025
Applicant: 
UNIV DE GRANADA [ES]
UNIV DE JAEN [ES]
UNIV DA CORUNA [ES]
UNIVERSIDAD DE GRANADA,
UNIVERSIDAD DE JAEN,
UNIVERSIDADE DA CORU\u00D1A
WO_2025215084_PA

Absstract of: WO2025215084A1

The present invention relates to a bioink formulation comprising fibrinogen and a glycosaminoglycans (GAGs)/collagen (Col) matrix, preferably comprising human cells, preferably human mesenchymal stem cells (hMSCs), keratinocytes and/or human dermal fibroblasts (hDFs), and its use in the treatment of tissue or bone injuries or damages, specifically skin tissue injuries or damages.

Patient-specific humeral head guide device and systems and method for manufacturing same

Publication No.:  GB2640326A 15/10/2025
Applicant: 
3D LIFEPRINTS UK LTD [GB]
3D Lifeprints UK Ltd
GB_2640326_PA

Absstract of: GB2640326A

A patient-specific humeral head guide device may be designed and manufactured to contour the shape of a patient’s humeral head from medical images. A humeral shaft is identified and two or more points along the shaft used to define a humeral axis along with a colinear point based on a centre of lesser tuberosity. A humeral sagittal plane is identified, as is a coplanar anterior axis. A resection plane is also identified based on the sagittal plane and an angle of inclination from the longitudinal axis. Computer aided manufacturing (CAM) printing instructions are generated to print a resection channel for a cutting device. The humeral head contouring body may be of loop style and may have an extended footprint to contour a portion of lesser tuberosity. There may be fixation wire channels, at least one of which permits visual confirmation that a patient forearm aligns with an anterior axis. There may be a channel for receiving an intermedullary reamer aligned to a humeral canal centre. The CAM instructions may include G-code that causes a three-dimensional (3D) printer to manufacture a patient-specific humeral head guide device and for other various portions of the device.

3D FAT TISSUE STRUCTURE, PRODUCED USING LIGHT-BASED STRUCTURING CURING, FOR USE AS A BREAST IMPLANT

Publication No.:  EP4630067A1 15/10/2025
Applicant: 
CELLBRICKS GMBH [DE]
Cellbricks GmbH
CN_120322257_PA

Absstract of: CN120322257A

The present invention relates to a 3D adipose tissue scaffold for use as a breast implant for surgical, therapeutic, prophylactic or aesthetic recovery, construction or replacement of human breast tissue, in which the 3D adipose tissue scaffold has a matrix consisting of a biocompatible polymer, the matrix being colonized with a plurality of biological cell types, wherein the colonization of the plurality of cell types is carried out during the formation of a matrix made of a biocompatible polymer, accompanying the formation of a network of vascular structures within the 3D adipose tissue scaffold. Light-based structured curing of a photo-polymerizable or photo-crosslinkable liquid is used to build a matrix composed of a biocompatible polymer. The invention also relates to the use of a 3D adipose tissue scaffold as a human breast implant, the 3D adipose tissue scaffold having a matrix consisting of a biocompatible polymer, the matrix being colonized with a plurality of cell types, the colonization of the plurality of cell types being carried out in the process of forming the matrix consisting of a biocompatible polymer, the present invention relates to a 3D adipose tissue scaffold, in which a network of vascular structures is formed within the 3D adipose tissue scaffold, characterized in that a matrix consisting of a biocompatible polymer is constructed by means of light-based structured curing of a photopolymerizable or photocrosslinkable liquid.

NOVEL FIBRINOGEN-BASED BIOINKS FOR WOUND HEALING AND TISSUE REGENERATION

Publication No.:  EP4631538A1 15/10/2025
Applicant: 
UNIV GRANADA [ES]
UNIV JAEN [ES]
UNIV CORUNA [ES]
Universidad de Granada,
Universidad De Jaen,
Universidade da Coru\u00F1a
EP_4631538_PA

Absstract of: EP4631538A1

The present invention relates to a bioink formulation comprising fibrinogen and a glycosaminoglycans (GAGs)/collagen (Col) matrix, preferably comprising human cells, preferably human mesenchymal stem cells (hMSCs), keratinocytes and/or human dermal fibroblasts (hDFs), and its use in the treatment of tissue or bone injuries or damages, specifically skin tissue injuries or damages.

SYSTEM FOR EDGE CASE PATHOLOGY IDENTIFICATION AND IMPLANT MANUFACTURING

Publication No.:  EP4629937A1 15/10/2025
Applicant: 
CARLSMED INC [US]
CASEY NIALL PATRICK [US]
NICOLAU RODRIGO JUNQUEIRA [US]
Carlsmed, Inc,
Casey, Niall, Patrick,
Nicolau, Rodrigo, Junqueira
WO_2024151669_PA

Absstract of: WO2024151669A1

Systems and methods for identifying edge case pathologies for inspection in a patient-specific orthopedic implant procedure are disclosed. A system can analyze patient data, such as implant data, pre-operative data, post-operative data, or implant manufactured data to identify edge case pathologies in the patient data that can affect installing an implant in the patient. Based on the type of edge case pathology, the system sends a notification for a human, such as a healthcare provider, to review the patient data prior to installing the patient-specific orthopedic implant in the patient.

一种牙齿3D打印机用可调式操作平台

Publication No.:  CN223431997U 14/10/2025
Applicant: 
北京极数增材医疗科技有限公司
CN_223431997_U

Absstract of: CN223431997U

本实用新型涉及3D打印设备技术领域,提供了一种牙齿3D打印机用可调式操作平台,包括:安装板,驱动电机,通过架体设置在所述安装板的表面上;还包括:两个槽口,开设在所述安装板表面的对称处,其中一个所述槽口的内部设置有螺纹杆一,所述螺纹杆一的一端设置在驱动电机的输出端表面上。本实用新型,通过旋转滑槽内部的螺纹杆二,带动滑块在滑槽的内部进行移动,使得连接板表面的安装架进行横向移动,带动放置板对准打印机本体,通过驱动电机工作,带动输出端螺纹杆一表面的U型架沿着导向杆进行横向移动,使得打印的牙齿对准打印机本体的输出端,配合电动推杆工作,带动移动板表面的安装座进行纵向移动,完成打印机本体的打印工作。

三维自组装支架

Publication No.:  CN120771293A 14/10/2025
Applicant: 
徕卡显微系统有限公司
CN_120771293_PA

Absstract of: US2025313799A1

A three-dimensional scaffold includes a plurality of scaffold elements. Each scaffold element includes at least one peptide component, which comprises a stretch of amino acids, and at least two nucleic acid components. The at least two nucleic acid components of the plurality of scaffold elements are configured to mediate self-assembly of the three-dimensional scaffold.

假肢打印方法、装置、电子设备、存储介质及计算机程序产品

Nº publicación: CN120770988A 14/10/2025

Applicant:

德索拉科技公司

CN_120770988_PA

Absstract of: CN120770988A

本申请公开了一种假肢打印方法、装置、电子设备、存储介质及计算机程序产品,其中,方法包括:获取第一用户的第一生理数据组;调用第一人工智能模型对第一生理数据组进行处理,得到第一约束参数组;第一人工智能模型用于基于输入的生理数据组推荐约束参数组;约束参数组表征该输入的生理数据组对应的机械性能要求相关的约束;以第一约束参数组作为约束,调用生成式设计算法对第一生理数据组进行处理,得到第一设计参数组;生成式设计算法用于基于输入的生理数据组生成满足对应的舒适度要求的设计参数组,且设计参数组中包含假肢的多个设计参数;基于第一设计参数组与切片参数组,生成第一文件,并输出第一文件至三维打印装置。

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