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181
results.
Updated on
23/12/2025 [07:09:00]
Absstract of: CN121154924A
本发明提供了一种复合骨修复支架及其制备方法和在制备治疗放射性骨髓炎产品中的应用，属于生物医用材料技术领域。所述复合骨修复支架包括三维多孔支架基体、抑菌剂和功能化微球；所述三维多孔支架基体为明胶‑氧化海藻酸钠双网络水凝胶；所述功能化微球为包载有杜仲提取物和牛膝提取物的微球。本发明提供的复合骨修复支架具有良好的孔径、孔隙率和力学性能，且降解性能、吸水性能、抑菌性能好，具有良好的生物相容性，可用于制备治疗放射性骨髓炎的产品，具有广阔的应用前景。
Absstract of: AU2024238878A1
A method of modifying a surface of a three-dimensional (3D) article includes immersing at least one part of the 3D article in a buffered solution of functionalized peptides, allowing reaction between the functionalized peptides and reactive groups on the surface of the 3D article; and washing the at least one part of the 3D article to remove unreacted functionalized peptides. The surface-modified 3D article includes a plurality of peptides covalently bonded to the surface of the 3D article via a cysteine bridge. The surface- modified 3D article can be used as a scaffold for the formation of biological tissue or bodily implants.
Absstract of: CN121154898A
本发明公开了一种基于静电场电流体喷射水母胶原蛋白水凝胶敷料及其制备方法，包括如下步骤：(1)将水母原料预处理后，采用超声辅助酸‑酶复合提取胶原蛋白，制得水母胶原蛋白；(2)通过紫外线活化笼状胶原模拟肽CMP与水母胶原蛋白结合，制备胶原蛋白杂交肽；(3)通过高压微射流均质机将水母胶原蛋白、胶原蛋白杂交肽和透明质酸均匀混合，制得多组分蛋白复合体系，作为天然生物墨水；(4)在无菌真空的条件下，采用静电场电流体喷射3D打印制得所述水母胶原蛋白水凝胶敷料。本发明采用天然海洋提取物，在低致敏性的同时兼顾了高吸湿性、高渗透性和生物相容性，实现了抗菌止血性能与促进新组织的生长。
Absstract of: CN121154909A
本发明公开了一种基于增材制造的超弹性微创人工骨支架及其制备方法，所述超弹性微创人工骨支架基于TPMS G型互穿晶格超材料，并由基础胞元排列构成，所述基础胞元在XYZ三个方向各由三个二重G型胞元组成；所述二重G型胞元包括互穿且重心重合的第一G型胞元和第二G型胞元，且所述第二G型胞元绕Z轴旋转180度后与所述第一G型胞元重合。本发明的微创人工骨支架的基础胞元具有更高生物相容性，更适用于成骨细胞的生长，还具有更高的比表面积增益，在力学层面增加了载荷接触点，进一步强化承载能力；此外，本发明通过互穿结构构成的二重G型胞还可调控力学性能来实现超弹性，而更好的弹性更适用于人体植入。
Absstract of: CN121154913A
本申请提供了一种医用植入体及其制备方法和人工膝关节。该医用植入体包括高分子多孔隙支架以及至少填充在所述高分子多孔隙支架孔隙内的水凝胶复合材料，所述高分子多孔隙支架的材料包括可降解高分子材料和分布于所述可降解高分子材料中的碳纳米管，所述水凝胶复合材料包括水凝胶材料基质以及分布于所述水凝胶材料基质中的种子细胞。本申请通过将可降解高分子材料和水凝胶材料进行结合，并在可降解高分子材料中引入碳纳米管，同时通过在水凝胶材料基质中设置种子细胞，进而提供了一种具有适宜的降解性能、良好的力学性能并可再生的植入支架材料。
Absstract of: CN121154341A
本发明涉及足部矫治技术领域，提供一种基于特异性建模的足踝力线异常疾病的矫治方法和系统，方法包括：采集不同人群的基础健康数据信息、静态足部数据信息以及动态足踝数据信息；将采集的所有数据信息进行多模态数据融合，形成多模态数据信息，识别多模态数据信息中对应多种不同足踝病症的特异性数据信息；基于特异性数据信息进行三维建模，构建出对应不同足踝病症的基础足辅具模型；选择适用于特定患者的基础足辅具模型，并基于基础足辅具模型构建出适合该特定患者的精准足辅具模型；3D打印精准足辅具模型，对特定患者进行足踝疾病矫治。本发明可以使得足辅具模型的制造更加精准高效，能够有效提高对患者足部疾病矫治的效果和效率。
Absstract of: CN121154933A
本发明属于生物医用材料技术领域，公开了牙槽骨修复的天然牙复合材料植骨支架、设计及制备方法。本发明通过收集口腔医疗中拔除的正畸牙、阻生牙、多生牙、松动牙等天然牙，通过技术处理获得原材料粉末；将生物活性玻璃粉末、碳基材料粉末和天然牙粉体球磨混合，得到混合粉末；以混合粉末为原料，通过计算机辅助设计和数字光处理工艺3D打印获得植骨支架；使用聚多巴胺‑碳基材料复合涂层修饰3D打印支架的表面，得到天然牙复合材料植骨支架。本发明所得天然牙复合材料植骨支架的具有良好的机械性能、可控降解性能和抗菌性能，且具有良好的生物相容性和成骨效能。
Absstract of: CN121159778A
本发明提供了3D打印超声体模水凝胶材料及其制备方法与应用，涉及医用材料领域。本发明的3D打印超声体模水凝胶材料包含水性聚氨酯丙烯酸酯乳液、光固化单体、无机盐、散射体、稳定剂、去离子水、光引发剂、光吸收剂；其中，所述光固化单体包含质量比为1:(0.3～0.7)的水性光固化单体和含磺酸基光固化单体。本发明提供的3D打印超声体模水凝胶材料，具有良好的力学性能和抗溶胀性能，具有与人体组织相似的声速、声衰减系数等声学特性，满足超声体模对超声特性的要求。
Absstract of: WO2024206597A1
An orthodontic appliance system for orthodontic treatment of teeth. The system includes a template with a cavity. An attachment is removably received in the receptacle and has a surface including a bonding surface. A method of manufacturing includes constructing a scaffold assembly including a base and placing a template in contact with the scaffold assembly. The method includes inserting the attachment into the receptacle. During separating, the attachment remains coupled to the template in the receptacle. A method of manufacturing includes providing a mold of the patient's teeth. The mold including at least one projection and a through-passage. The method includes placing a container of dental composite in fluid communication with the through-passage, placing a template over the at least one projection, injecting dental composite from the container through the through-passage and into the receptacle, and removing the template from the at least one projection with the filled receptacle.
Absstract of: US2025380975A1
A screw element for use in spinal, orthopaedic, or trauma surgery, has a screw axis, a screw thread, and a drive portion including a wall that defines an axially extending recess for engaging a tool. The recess has a cross-sectional profile that extends from a first end to a second end in a direction of the screw axis. The cross-sectional profile has a first portion positioned closest radially to the screw axis and a plurality of drive grooves that extend radially away from the first portion and that are spaced apart from each other in a circumferential direction around the screw axis. A portion of the wall includes a protrusion that protrudes laterally away from the wall into the recess. The protrusion is spaced apart axially from the first and second ends of the recess.
Absstract of: WO2025259676A1
This document provides bioprinting systems and methods of generating one or more hollow channels in a soft matrix. This document also provides methods of generating one or more hollow channels in the soft matrix that can comprise translating the nozzle of the bioprinting device within the soft matrix. This document also provides methods for generating one or more branched channels within the soft matrix.
Absstract of: WO2025257796A1
A system and a method are disclosed for generating a first three-dimensional (3D) representation of oral care data, which is fabricated as a physical object using a 3D printer and designed to apply forces to a second 3D representation of oral care data. The method includes receiving 3D representations of a patient's dentition and providing them to a generative machine learning module configured to produce 3D representations of oral care appliances. The system generates one or more first 3D representations and computes estimated forces and moments exerted by these representations on the patient's dentition. These force and moment estimates, along with the dentition data, are provided to finite element analysis (FEA) modules to generate FEA maps. The FEA maps are then encoded into latent representations, which are output for further use in appliance design or simulation.
Absstract of: US2025381711A1
A method is for manufacturing a shell. The method includes forming the shell over a mold. The mold includes a first portion and a second portion. One or more weakened regions of the mold are associated with the first portion and the second portion. The method further includes causing the first portion of the mold to separate from the second portion of the mold via the one or more weakened regions. The method further includes removing the first portion of the mold from the shell. The method further includes removing the second portion of the mold from the shell. The shell is configured to be worn in a mouth of a patient.
Absstract of: US2025381065A1
A moisture chamber adapted for use with eyeglasses. The moisture chamber is a single-use, disposable, component that is temporarily adhered to the inside of a the lens of a pair of glasses. The moisture chamber may be used on one or both of the lenses and works by creating a moist environment for the eye to help alleviate dry eyes. The moisture chamber may be made of silicon and may be 3-D printed.
Absstract of: WO2025259944A1
The invention relates, in part, to methods of 3D topological nanofabrication within hydrogel scaffolds. The method including contacting a hydrogel comprising one of more photosensitizers and catalysts with light to pattern the hydrogel.
Absstract of: WO2025255682A1
This disclosure relates to the field of extracellular matrix-based hydrogels, and in particular, to hydrogel formulations comprising a decellularized extracellular matrix (dECM) and surface-modified cellulose nanofibers (CNFs) for precise tissue modeling and methods of making and uses thereof.
Absstract of: DE102024116966A1
Die Erfindung betrifft die Herstellung einer individuell angepassten intelligenten Dentalvorrichtung (600). Bei der Herstellung kann ein Schürzenabschnitt-Digitaldatensatz verwendet werden. Der Schürzenabschnitt (200) passt eng an die faziale, linguale und/oder okklusale Zahnflächentopologie einer Person. Der Schürzenabschnitt-Digitaldatensatz definiert eine Innenflächenkontur. Der Schürzenabschnitt-Digitaldatensatz definiert außerdem eine Außenflächenkontur des Schürzenabschnitts, die einen oder mehrere Anbringungsflächenabschnitte (216) zur Anbringung elektronischer Komponenten (630-1; 630-2; 630-3) aufweist. Die Außenflächenkontur des Schürzenabschnitts (400) definiert eine schürzenseitige Abdichtungsstruktur (218), die so ausgebildet ist, dass sie abdichtend mit einer formseitigen Abdichtungsstruktur eines Formabschnitts (400) zusammengreift. Die schürzenseitige Abdichtungsstruktur definiert eine Grenzlinie eines gebildeten Formhohlraums.
Absstract of: US2025381413A1
An implantable medical device can include a housing including electronic devices within the housing, a header attached to the housing and including one or more bores, and a plurality of connectors extending from the housing to the header and coupled to a plurality of electrical contacts within the one or more bores, wherein at least one of the plurality of connectors includes a first end coupled to a feedthrough pin on the housing and second end coupled to one of the plurality of electrical contacts, wherein the first end includes a contoured shape configured to provide a feedthrough connection section having a non-uniform cross-section.
Absstract of: US2025381729A1
The invention provides a method for producing a 3D item (1) by means of fused deposition modelling, the method comprising: a 3D printing stage comprising layer-wise depositing 3D printable material (201), to provide the 3D item (1) comprising 3D printed material (202), wherein the 3D item comprises layers (322) of 3D printed material, wherein the 3D printable material comprises a thermoplastic material (401) and a photocatalytic material (409) wherein during at least part of the 3D printing stage the method comprises producing pores (423) in the 3D printable material.
Absstract of: WO2025258739A1
Titanium-based metal implants have brought about revolutionary changes in dental and orthopedic treatments, leading to advances in therapeutic technologies. However, metal-based implants still face unresolved challenges, such as difficulties or delays in osseointegration and inflammation caused by immune responses. To address these challenges, technologies such as plasma treatment of the surface of a metal-based implant or inclusion of bioactive components in implant materials are being researched, but there are problems with fracture and separation from metal implant materials. The present invention relates to a technology for providing osseointegration implant powder for use in a selective laser melting (SLM)-type metal 3D printer. The present invention provides a technology that enables printing by sintering and pulverizing horse bone and mixing the resulting horse bone with a metal powder implant material. Through the above-described configuration, the present invention has addressed the problem in which it was not possible to normally print a 3D implant structure since osseointegration components were burned off during a 3D printing process in an SLM-type metal 3D printer, and enables the printing of 3D structures including osseointegration components in an SLM-type metal 3D printer.
Absstract of: WO2025259403A1
A moisture chamber adapted for use with eyeglasses. The moisture chamber is a single-use, disposable, component that is temporarily adhered to the inside of a the lens of a pair of glasses. The moisture chamber may be used on one or both of the lenses and works by creating a moist environment for the eye to help alleviate dry eyes. The moisture chamber may be made of silicon and may be 3-D printed.
Absstract of: WO2024127250A1
The invention is in the field of additive manufacturing. There is provided a positive model of one or more teeth and/or gum, suitable for producing a dental aligner, the model comprising a polyhydroxyalkanoate (PHA). There is also provided such a model, comprising sintering or fusing a powder comprising a polyhydroxyalkanoate (PHA).
Absstract of: US2025382483A1
Modeling material formulations usable in additive manufacturing of a denture structure, and additive manufacturing methods employing same are provided. Kits comprising the modeling material formulation, optionally in combination with a support material formulation, are also provided.
Absstract of: US2025361480A1
A method for generating reinforced engineered cellularized construct, which utilizes a biocompatible small-molecule reinforcing agent that do not affect the viability of the cells, a reinforced engineered cellularized construct obtained thereby and used the engineered cellularized construct are provided.
Nº publicación: EP4663388A1 17/12/2025
Applicant:
TOKUYAMA DENTAL CORP [JP]
Tokuyama Dental Corporation
Absstract of: EP4663388A1
The present invention provides a curable composition for three-dimensional photofabrication, the curable composition being used in a vat photopolymerization method and containing 100 parts by mass of a polymerizable monomer component (A), 40 parts by mass to 400 parts by mass of an inorganic filler (B) that is composed of a single kind or plural kinds of inorganic particulate matter, and 0.01 part by mass to 5 parts by mass of a photopolymerization initiator (C), wherein: 80% or more of all primary particles that constitute the inorganic filler (B) have a particle diameter of 0.05 µm to 5.0 um; and a sample, which is formed of this curable composition for three-dimensional photofabrication and has a thickness of 0.5 mm, has a transmittance of 1.00% to 50.00% with respect to activation light. The present invention also provides a method for producing this curable composition for three-dimensional photofabrication. The present invention also provides a method for producing a three-dimensional photofabricated product and a method for producing a dental restoration, each using this curable composition for three-dimensional photofabrication.
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