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3D bioprinting

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LastUpdate Updated on 31/08/2024 [08:10:00]
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一种颅颌面手术用导板

Publication No.:  CN221617156U 30/08/2024
Applicant: 
上海交通大学医学院附属第九人民医院
CN_221617156_U

Absstract of: CN221617156U

本实用新型公开了一种颅颌面手术用导板,属于颅颌面手术技术领域,其中包括导板本体,所述导板本体表面开设有两个通孔,两个所述通孔对称设置在导板本体表面,两个所述通孔表面均固定连接有多个连接环,两个所述通孔表面均插接有插管,两个所述插管表面均设置有卡接组件,所述卡接组件包括多个腔体、多个定位槽、多个伸缩杆、多个弹簧、多个连接板和多个卡块,多个所述插管内壁均设置有夹持组件,通过设置通孔,从而便于使插管插接在导板本体表面,通过设置夹持组件,从而使螺纹柱带动夹持块穿过通孔,使夹持块搭接在颌骨表面,从而将导板本体夹持固定在颌骨表面,从而避免在手术过程中导板本体发生偏移。

打印设备和包括自动位置校准的增材制造方法

Publication No.:  CN118574720A 30/08/2024
Applicant: 
迪赫西斯数字健康系统有限公司
CN_118574720_A

Absstract of: AU2022395642A1

The present invention relates to a printing apparatus for additive manufacturing methods, comprising: one or more print heads (1, 2), which each comprise a printing nozzle, the print head or print heads being optionally vertically movable; and a print bed which has a print table that is movable in a horizontal direction and optionally in a vertical direction and comprises a printing surface (3), the print table having an optical device (4) which is designed to capture an optical reproduction of the printing nozzle or printing nozzles at least from below. The invention also relates to a method comprising automatic position calibration of the printing nozzle(s) for the additive manufacturing of objects, preferably pharmaceutical administration forms, using the apparatus according to the invention.

栅格填充类牙模打孔方法、装置、电子设备及存储介质

Publication No.:  CN118557317A 30/08/2024
Applicant: 
深圳市创必得科技有限公司
CN_118557317_A

Absstract of: CN118557317A

本发明属于3D打印技术领域,提供一种栅格填充类牙模打孔方法、装置、电子设备及存储介质;方法为:遍历牙齿模型及栅格填充结构的全部三角网格;确定打孔基准面;获取基准面与全部三角网格的截取路径生成多个线段闭合环;由多个线段闭合环中选取最大线段闭合环;确定最大线段闭合环为外环并确定其余线段闭合环为内环;依次确定内环线段端点与外环线段距离以筛选出小于预设距离的内环线段并确定为待选线段;确定待选线段特征点作为孔洞中心点;根据孔洞中心点坐标和向量以及孔洞参数生成孔洞模型并与全部三角网格作布尔运算生成孔洞及整体三角网格空间模型;存储数据。本方法可在打孔时避开牙齿模型栅格填充结构的骨架位置,和提升打印稳定性。

一种负载rh BMP-2的3D打印骨缺损修复支架及其制备方法

Publication No.:  CN118557786A 30/08/2024
Applicant: 
湖北双星药业股份有限公司
CN_118557786_A

Absstract of: CN118557786A

本发明公开了一种负载rh BMP‑2的3D打印骨缺损修复支架及其制备方法。该制备方法包括以下步骤:将所选定的光敏树脂、光引发剂、分散剂混合均匀,再按不同固含量配比将一定量的β‑磷酸三钙纳米粉体加入预混匀的树脂体系中,配好氧化锆球,在球磨机中以300 rad/min的速度球磨6h,球磨后筛出球磨珠,避光脱泡处理后使用SLA 3D打印机打印多孔β‑磷酸三钙支架,使用清洗剂清洗干净,干燥后在一定温度制度下脱脂烧结后将多孔β‑磷酸三钙支架浸泡含有rh BMP‑2醋酸溶液中。置于真空玻璃干燥器中,用真空泵抽真空并保持30 min,吸去表面溶液后取出得多孔β‑磷酸三钙支架。本发明通过rhBMP‑2的加入,在一定程度上,提高了β‑磷酸三钙骨缺损修复支架的成骨活性和骨诱导性能。

剪切力场驱动的仿骨三维有序结构体及其制备方法

Publication No.:  CN118557796A 30/08/2024
Applicant: 
天津大学
CN_118557796_A

Absstract of: CN118557796A

本发明提供了一种剪切力场驱动的仿骨三维有序结构体及其制备方法,属于假体材料、外科用品材料或化学方法技术领域。剪切力场驱动的仿骨三维有序结构体的制备方法包括:利用3D打印机打印出牺牲模板,牺牲模板具有与天然骨组织的微观结构相互补的三维连通孔结构;提供包括羧基化纤维素纳米晶须、可固化凝胶材料和引发剂的生物墨水;向牺牲模板内灌注生物墨水,生物墨水在牺牲模板内流动,剪切力场驱动羧基化纤维素纳米晶须取向,在三维连通孔结构内有序排列;施加温度场或光照使可固化凝胶材料固化以固定羧基化纤维素纳米晶须的三维有序排列,形成仿骨三维有序结构体‑牺牲模板复合体;去除牺牲模板,得到仿骨三维有序结构体。

一种自适应固定护具生成方法及系统

Publication No.:  CN118557349A 30/08/2024
Applicant: 
嘉兴博集医疗科技有限公司
CN_118557349_A

Absstract of: CN118557349A

本申请涉及固定护具技术领域,提供一种自适应固定护具生成方法及系统。所述方法包括:获取目标视频,基于预定拍摄方案记录目标用户的目标部位的视频信息;分析视频得到多张部位图像,构建目标三维模型;根据预定特征指标设定自适应方案;以自适应方案为约束仿真生成固定护具结构;获取目标用户的舒适性需求,分析护具材料数据库获得目标护具材料;结合护具结构和护具材料,生成目标用户的自适应固定护具。本申请解决了传统固定护具无法适应不同用户的个性化需求和生理特征,导致护具固定效果不佳、穿戴不舒适的技术问题,实现了根据目标用户的部位特征和舒适性需求,得到护具结构和护具材料,提高护具的适配性和舒适度的效果。

一种门型钉及其高效生产设备

Publication No.:  CN118557240A 30/08/2024
Applicant: 
苏州市康力骨科器械有限公司
CN_118557240_A

Absstract of: CN118557240A

本发明公开了一种门型钉及其高效生产设备,所述门型钉包括门型钉本体,所述门型钉本体包括强度组件和防护组件;所述强度组件包括压接臂和固定臂,所述固定臂一体成型于压接臂的左右两侧壁上;所述防护组件包括陶瓷防护层和生物防护层。本发明通过对患者骨折部位进行建模,依据患者具体骨折的程度,建模获得门型钉模型,并通过仿真测试系统对门型钉模型进行仿真测试,确保植入后的门型钉与患者高度匹配,不会对患者的骨头等造成影响;基于经过仿真测试得到的门型钉模型制备得到的门型钉,在满足强度的同时可以与患者更好的结合,极大的提升了患者的体验,避免出现不适的情况,减轻了患者的心理和身体负担,有利于患者康复,具有很好的推广价值。

Verfahren zum Herstellen eines optischen Elements mittels Bearbeitens eines optisch reaktiven Materials und optisches Element

Publication No.:  DE102023104907A1 29/08/2024
Applicant: 
XOLO GMBH [DE]
Xolo GmbH

Absstract of: DE102023104907A1

Die Offenbarung betrifft ein Verfahren zum Herstellen eines optischen Elements mittels Bearbeitens eines optisch reaktiven Materials, aufweisend: Bereitstellen eines Ausgangsmaterial (3), welches optisch reaktiv ist und ein Arbeitsvolumen (2) ausfüllt; optisches Bearbeiten des Ausgangsmaterials (3) in dem Arbeitsvolumen (2) mittels Einstrahlen von Licht einer ersten Wellenlänge und Licht einer zweiten Wellenlänge, die von der ersten Wellenlänge verschieden ist, wobei das Licht erster Wellenlänge und das Licht zweiter Wellenlänge von einer Beleuchtungseinrichtung bereitgestellt werden, wobei mittels des optischen Bearbeitens wenigstens eine Materialeigenschaft des Ausgangsmaterials verändert wird und wobei das optische Bearbeiten Folgendes umfasst: Bestrahlen eines ersten Schichtteilvolumens des mit dem Ausgangsmaterial (3) ausgefüllten Arbeitsvolumens (2) mit dem Licht erster Wellenlänge; Bestrahlen des ersten Schichtteilvolumens des Arbeitsvolumens (2) mit dem Licht zweiter Wellenlänge, wobei das Licht zweiter Wellenlänge hierbei mittels einer Projektionseinrichtung (7) nur das erste Schichtteilvolumen ganz oder teilweise erfassend in das Arbeitsvolumen (2) projiziert wird; Bestrahlen eines zweiten Schichtteilvolumens des mit dem Ausgangsmaterial (3) ausgefüllten Arbeitsvolumens (2), welches von dem ersten Schichtteilvolumen verschieden ist, mit dem Licht erster Wellenlänge; Bestrahlen des zweiten Schichtteilvolumens des Arbeitsvolumens (2) mit dem Licht zweiter

POLYMERIZABLE POLYURETHANES AND COMPOSITIONS CONTAINING THE SAME FOR USE IN 3D PRINTABLE DENTAL MATERIALS

Publication No.:  WO2024178244A1 29/08/2024
Applicant: 
ALIGN TECH INC [US]
ALIGN TECHNOLOGY, INC
WO_2024178244_A1

Absstract of: WO2024178244A1

The present disclosure provides curable compositions comprising one or more of photo-polymerizable urethane prepolymers having alternating hard and soft blocks, as well as polymeric materials formed from the curable compositions. Further provided herein are methods of producing the compositions and using the same for the fabrication of medical devices, such as orthodontic appliances.

PERSONALIZED SUPPORT DEVICE FOR MECHANICALLY AFFECTING A PULSATING ORGAN'S DYNAMIC BEHAVIOR

Publication No.:  WO2024176233A1 29/08/2024
Applicant: 
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIV OF JERUSALEM LTD [IL]
HADASIT MEDICAL RES SERVICES AND DEVELOPMENT LTD [IL]
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD,
HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD
WO_2024176233_A1

Absstract of: WO2024176233A1

A support device for a pulsating organ is comprised of a structure formed at least partially of one or more polymers. The structure is configured to transition, in response to a stimulus, between a placement shape, in which the support device is dimensioned larger than the dimensions of the organ, and a treatment shape, in which the support device provides therapeutic support to the organ; wherein the treatment shape is smaller than the placement shape. Preferably, the polymers are shape memory polymers. The support device may be manufactured in an initial shape in which the one or more shape memory polymers are in their permanent shapes, and the placement shape is larger than or equivalent to the initial shape. Optionally, the stimulus is application of an aqueous medium. Embodiments of support devices may be used for treatment of heart failure with reduced ejection fraction and with preserved ejection fraction.

INSTRUMENT FOR OPHTHALMIC SURGERY

Publication No.:  WO2024175367A1 29/08/2024
Applicant: 
MORIA SA [FR]
MORIA SA
WO_2024175367_A1

Absstract of: WO2024175367A1

Instrument comprising: a. forceps (1) with an active end (1d) and a sleeve (2) receiving the forceps (1) with sliding, b. a central body (3) with a first, proximal end (3p) integral with a handle (4) and a second, distal end (3d) to which is fixed a first end (1p) of the forceps, opposite the active end (1d) of said forceps (1), c. an actuator (5) formed by a set of levers (6) extending around the central body (3) and having first ends (6p) connected to the central body (3) and second ends (6d) joined by a socket (7) to which the sleeve (2) is fixed, the levers (6) being elastically deformable between a first, deactivated position of the forceps (1), in which position the active end (1d) of the forceps (1) is open and projects from the sleeve (2), and a second, activated position, in which the sleeve (2) exerts a force on the active end (1d) of the forceps (1), forcing the closure of the active end (1d) of the forceps (1), wherein the central body (3), the actuator (5) and the socket (7) are a one-piece component.

PRINTED COMPOSITION FOR BIOMEDICAL USES

Publication No.:  US2024285535A1 29/08/2024
Applicant: 
PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US]
President and Fellows of Harvard College
WO_2022241205_PA

Absstract of: US2024285535A1

A printed composition for biomedical uses comprises a liquid droplet prior to crosslinking and a gelled particle after crosslinking, where the liquid droplet comprises a formulation including a hydrogel precursor and abiologic, and the gelled particle comprises a cross-linked hydrogel matrix with the biologic dispersed therein. The formulation has a viscosity in a range from about 100 mPa-s to about 500,000 mPa-s.

METHODS AND APPARATUSES FOR ATTACHING DENTAL ATTACHMENTS

Publication No.:  US2024285376A1 29/08/2024
Applicant: 
ALIGN TECH INC [US]
Align Technology, Inc
US_2021386524_A1

Absstract of: US2024285376A1

Methods and apparatuses for attaching one or more dental attachments to a dentition. Methods may include placing an attachment placement apparatus on the dentition such that contoured surfaces of the attachment placement apparatus are aligned with correspondingly shaped tooth surfaces of the dentition. A body of the attachment placement apparatus may position the dental attachment(s) against specified location(s) on one or more teeth of the dentition. The dental attachment(s) may be coupled to supports that extend from the body. The supports may include breakable regions configured to be broken to facilitate removal of a corresponding dental attachment from the body. The supports may position the dental attachment(s) within corresponding aperture(s) of the attachment placement apparatus. The dental attachment(s) may be secured at the specified location(s) on the teeth.

TRIAL IMPLANT

Publication No.:  US2024285417A1 29/08/2024
Applicant: 
KUMOVIS GMBH [DE]
KUMOVIS GMBH
JP_2024522866_PA

Absstract of: US2024285417A1

The present invention relates to a trial implant, in particular for spinal surgery, a total knee or hip endoprosthesis or a shoulder prosthesis, with at least one head, with at least one reinforcing core and with at least one stem, wherein the head is produced by means of 3D printing, and wherein the head and the stem are made of plastic.

CROSSLINKED BIORESORBABLE POLYESTER NETWORKS

Publication No.:  US2024287242A1 29/08/2024
Applicant: 
UNIV GENT [BE]
UNIVERSITEIT GENT
WO_2022243567_A1

Absstract of: US2024287242A1

The present invention relates to the field of bioresorbable crosslinked materials. More specifically, the present invention pertains to a combination comprising a polyester having a crystalline backbone and at least one end-capping group attached to a first crosslinkable group and a compound comprising a second crosslinkable group, a crosslinked polyester wherein said combination forms a crosslinked network, a process of manufacturing thereof and the use of said crosslinked polyester.

DESIGN METHOD OF AN INTRAORAL DEVICE

Publication No.:  US2024285426A1 29/08/2024
Applicant: 
BIOTECHNOLOGY INST I MAS D S L [ES]
BIOTECHNOLOGY INSTITUTE, I MAS D, S.L
MX_2023013258_A

Absstract of: US2024285426A1

Design method of an intraoral splint-type device (1) to treat bruxism and/or sleep apnoea among others, using CAD/CAM software technology, where the method of the invention starts with an intraoral scan and is subsequently characterized by converting the arch (2, 3) defined as a one-piece mesh, into as many pieces as dental pieces (4) needed to be discerned, by means of thermal simulation. This segmentation makes it possible to isolate the geometry of each dental piece (4) in order to design the intraoral device (1) around each dental piece (4). In other words, it allows for the modification of the thickness (6c), height, etc. in a non-uniform way for each dental piece (4) according to the needs of the patient. This method allows the user very precise manipulation of the intraoral device (1) that is created, satisfying the mechanical and dental needs of each dental piece (4), and providing greater comfort to the patient.

PRODUCTION METHOD FOR PERSONAL CARE PRODUCT

Publication No.:  US2024286340A1 29/08/2024
Applicant: 
KAO CORP [JP]
Kao Corporation
CN_117881379_PA

Absstract of: US2024286340A1

A production method for a personal care product applicable to a human body can include a forming step in which a nozzle is moved relative to an object while a composition having fluidity is supplied from the nozzle to the object to form a deposit derived from the composition on the object. A nozzle with a nozzle diameter of 0.01 mm or more and 2 mm or less may be used as the nozzle. In the forming step, the composition can be supplied such that a ratio of a distance between a tip of the nozzle and the object to the nozzle diameter (distance/nozzle diameter) is set to 0.35 or more and less than 3.

CENTRALIZED MANAGEMENT AND DECENTRALIZED FABRICATION OF CUSTOM MEDICAL DEVICES

Publication No.:  EP4419331A1 28/08/2024
Applicant: 
SAPIYEN LLC DBA PROTOSTHETICS [US]
Sapiyen LLC (DBA Protosthetics)
CA_3235527_PA

Absstract of: CA3235527A1

Methods for fabricating a custom medical device for an end-user are disclosed. Generally, the present disclosure relates to custom medical devices, and more particularly to three-dimensional modeling of custom medical devices and three-dimensional printing using these three-dimensional models.

一种基于微凝胶的生物打印基质

Publication No.:  CN118542980A 27/08/2024
Applicant: 
中国科学院动物研究所北京干细胞与再生医学研究院
CN_118542980_A

Absstract of: CN118542980A

本发明涉及组织工程和生物制造技术领域,具体涉及一种基于微凝胶的生物打印基质、其制备方法和应用。本发明的生物打印基质包含微凝胶、一种或多种光交联分子以及一种或多种生物活性物质。本发明的生物打印基质可以结合嵌入式打印或生物挤出打印策略,调控2D/3D内HUVEC的血管生成和血管发生行为,实现可直接血管吻合的多尺度血管组织的体内移植。

一种基于3D打印的甲状腺癌术后冰敷贴装置

Publication No.:  CN118542769A 27/08/2024
Applicant: 
中国人民解放军总医院第一医学中心
CN_118542769_A

Absstract of: CN118542769A

本发明涉及医疗器械技术领域,公开了一种基于3D打印的甲状腺癌术后冰敷贴装置,包括装置主体、固定带一、固定带二、固定机构、亲肤层、保护层、腔室一、腔室二、半导体制冷片、导冷片、散热片、通道、风扇和控制处理器。本发明通过半导体制冷片对装置以及冰敷处进行长期稳定的制冷,无需工作人员频繁更换,使用方便;装置主体采用石墨烯填充热塑性聚氨酯复合材料,可根据不同患者颈部情况进行个性化3D打印,可以更好的贴合患者颈部,且该复合材料在舒适性佳的同时具有很好的导热性能。

一种打印水凝胶支架的方法

Publication No.:  CN118555998A 27/08/2024
Applicant: 
朗格生物技术公共公益股份有限公司
CN_118555998_A

Absstract of: AU2022379458A1

A method of printing a hydrogel scaffold is provided which includes providing a container containing an ink and a liquid that is immiscible with the ink; applying light from a light source to the ink to form a portion of the hydrogel scaffold, and applying light from a light source one or more additional times to produce one or more additional portions of the hydrogel scaffold.

一种脑机接口可降解支架的制备方法及其支架

Publication No.:  CN118544581A 27/08/2024
Applicant: 
上海交通大学医学院附属瑞金医院
CN_118544581_A

Absstract of: CN118544581A

本申请公开了一种脑机接口可降解支架的制备方法及其支架,将设计好的三维模型导入切片软件,分解为薄片用于逐层打印;清洗金属料筒和喷头,干燥后装入聚己内酯颗粒,加热至完全熔化;选择熔融沉积模式,设置喷头压力和扫描速度;校准打印平台和高温注射装置,上传路径程序并开始打印;打印结束,取下支架,泡入磷酸缓冲盐溶液,进行紫外灭菌;将PCL支架浸泡在酒精溶液中,去除表面杂质后用双蒸水冲洗并干燥,将干燥后的支架浸入含有1,6‑己二胺/异丙醇的溶液中,使支架表面引入氨基基团,进行清洗并干燥操作,获得氨基化的PCL支架;进行循环组装步骤;能够提高颅内参数监测的稳定性,促进骨愈合,具有良好的生物相容性。

一种提高生物活性及体外矿化能力的3D打印支架及其制备方法和应用

Publication No.:  CN118526636A 23/08/2024
Applicant: 
中国科学院福建物质结构研究所
CN_118526636_A

Absstract of: CN118526636A

本发明公开一种提高生物活性及体外矿化能力的3D打印支架及其制备方法和应用,本发明的支架由包括双相磷酸钙(所述双相磷酸钙由磷酸八钙(OCP)和无定形磷酸钙(ACP)组成)、海藻酸钠和分散剂的墨水经挤出式3D打印方法层层打印制备得到。本发明通过将OCP和ACP混合为双相磷酸钙(BCP)作为3D复合支架的无机相成分,并采用海藻酸钠(SA)作为有机相成分进行复合,同时有机物质海藻酸钠(SA)可模拟血凝块作为临时基质,还为从邻近组织迁移的细胞提供机械稳定性和牵引力,并在细胞逐渐降解支架过程中,为新骨替代支架提供一个稳定环境,对后续支架地进一步植入、吸引细胞迁入以及矿化诱导也具有巨大优势。

一种楔形角矫形鞋垫制作方法

Publication No.:  CN118526339A 23/08/2024
Applicant: 
吉林大学
CN_118526339_A

Absstract of: CN118526339A

本发明属于足部医疗辅具技术领域,提供了一种楔形角矫形鞋垫制作方法,包括以下步骤:采用逆向工程计算机辅助,使用3D扫描技术对患者膝关节以下部位进行3D建模,以FDM‑熔融沉积成型技术打印出产品;使用FSR阵列式柔性薄膜压力传感器嵌入矫正鞋垫中;传感器收集数据后,由单片机stm32通过espwifi模块与手机app链接进行数据的互相传输;本发明通过3D扫描技术对患者膝关节以下部位进行3D建模,可以精确地制作出符合患者脚型的矫正辅助鞋垫;并且通过在矫正鞋垫中嵌入FSR阵列式柔性薄膜压力传感器,可以实时监测足底压力数据,并通过手机APP进行分析,有助于医生了解患者的步态和运动情况,为制定更有效的治疗计划提供依据。

一种用于骨组织工程的复合支架及其制备方法

Nº publicación: CN118526634A 23/08/2024

Applicant:

北京印刷学院

CN_118526634_A

Absstract of: CN118526634A

本发明涉及生物材料及3D打印技术,特别是涉及一种用于骨组织工程的复合支架及其制备方法。其主要由聚乳酸、锶离子掺杂的矿化胶原按以下重量份比制成:8~12∶85~95。矿化胶原是矿物与胶原分子受控组装成周期排列结构。本发明由于通过矿化胶原和锶离子掺杂的矿化胶原制成,其具有理想的力学性能,而且还应提供良好的成骨活性来调节细胞反应和促进骨组织修复。

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