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352
results.
Updated on
15/04/2026 [07:54:00]
Results 200 to 225 of 352
Absstract of: US2022184276A1
The present disclosure is directed to a degradable 3D-printable scaffold for use in tissue engineering, which scaffold has a combined gradient and staggered structure. Further provided is a medical device for use in tissue engineering, comprising such a scaffold. The present disclosure also provides a method for preparing a scaffold by additive manufacturing, e.g. 3D-printing, a method for in vivo tissue engineering, use of the scaffold in an in vitro cell culture system, in an in vitro method for culturing of cells and/or in an in vitro method for regenerating tissue. Also provided is a scaffold and a medical device for use in a method for in vivo tissue engineering. Further disclosed is a novel degradable copolymer of ε-caprolactone and p-dioxanone, which can be printed without degradation and which is particularly suitable for use as scaffold material in the scaffold and method according to the present disclosure.
Absstract of: EP1000000A1
The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.
Absstract of: EP4715752A2
Disclosed is a computer-implemented method of generating a dental model based on an objective function output, comprising creating an objective function comprising at least one quality estimation function which trains at least one machine learning method that generates quality estimation output, and an objective function output is the output of the objective function providing a model as an input data to the objective function and generating model-related objective function output; and modifying the model based on the model-related objective function output to transform the model to a generated model, wherein the generated model is the dental model.
Absstract of: EP4714352A2
0001 A system that executes a process for mapping cardiac fibrillation and optimizing ablation treatments. The process, in some embodiments, includes: positioning a two dimensional electrode array to several locations in a patient's heart and at each location, obtaining a conduction velocity and a cycle length measurement from at least two local signals in response to electrical activity in the cardiac tissue. In some embodiments, a regional wavelength is calculated by multiplying the local conduction velocity with the local minimum cycle length. The system can then create a wavelength distribution map that identifies the location of the drivers in the heart. In certain embodiments, the system uses variability of conduction velocity and cycle length in an area to determine the driver type. In some embodiments, the system calculates average distance of drivers to non-conductive tissue boundaries. The system then selects ablation placements that maximize treatment efficacy while minimizing tissue damage.
Absstract of: GB2644212A
A method of manufacturing a dental implant device 200 comprising affixing a first 210 and second 220 implant member using laser welding, joining or soldering such that there’s no gap. The first implant member is at least partially formed of a ceramic material and the second implant member is at least partially formed of a metal. The implant member comprises melting at least part of the material of the first and second implant member at the same time using a two-wavelength laser. Wherein the first wavelength is selected to be adsorbed by the first material and the second wavelength is selected to be adsorbed by the second implant. An associated dental implant is also provided. Additional methods are also provided which may comprise the use of infra or near infra red lasers, depositing metal on the implant members, positioning biocompatible soldering material in the vicinity of the first and second implant member and forming, using a 3d printer, the first and second implant member using a first and second powder material respectively.
Absstract of: GB2700860A
A bioprinting apparatus 100 for 3D printing a model comprises a printing nozzle 115 for dispensing a magnetic or magnetisable bioink for forming the model; a bath 130 containing a model-supporting fluid; a mechanism 110 for moving the nozzle relative to the bath; and at least one magnet 140/145, i.e. a single magnet, a magnet array, magnetisable material or an electromagnet, at or adjacent to the bath 130 suitable for providing a magnetic field 10 in the bath of sufficient strength to influence bioink in the bath and hold bioink in the bath, for example in a stationary manner, until crosslinking occurs. The magnet element may be a magnet array arranged as a Halbach array. Preferably, the magnetic field may hold the bioink at a desired height at which embedded printing is to take place and a controller is operable to control the magnet to move to a different height corresponding to a different layer. The printed material may contain cells, such as eukaryotic cells, and the fluid may contain nutriments for the cells. Printing error correction is described also. Figure 1
Absstract of: EP1000000A1
The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.
Absstract of: AU2024276549A1
Methods of manufacturing a porous device for diffusing a fragrance using additive manufacturing including iteratively spreading a loose powder and selecting at least one process parameter to create a porosity within the porous device adapted to carry the fragrance from a fragrance reservoir to an exterior surface of the porous device. An additively manufactured device for diffusing a fragrance includes a diffuser having a plurality of pores defining a porosity of the diffuser, the porosity defining at least one of a rate of absorption, an amount of storage, and a rate of diffusion of the fragrance. A method of using a porous device includes filling the plurality of pores with fragrance and diffusing the fragrance from an exterior surface.
Absstract of: CN121240894A
The present disclosure relates to a hydrogel ink comprising a lipid particle, a polynucleotide supported within the lipid particle, and a bio-ink. In one embodiment, the lipid particles comprise extracellular vesicles. The disclosure also relates to hydrogels thereof and their use in treating neurological diseases or conditions or regenerating soft tissue.
Absstract of: CN121127203A
A computer-implemented method for predicting tooth positions, comprising: a) defining a plurality of tooth positions corresponding to a plurality of teeth in a dental arch; b) defining a plurality of appliance positions of the orthodontic appliance; c) determining one or more tooth position differences for each tooth; d) determining one or more appliance position differences for each tooth; e) determining one or more appliance-tooth relative differences for each tooth; f) modifying each tooth position of the plurality of tooth positions based on the corresponding one or more appliance-tooth relative differences; g) iteratively repeating steps c) to f) until a maximum change in each of the plurality of tooth positions is less than a convergence threshold; and h) defining the plurality of tooth positions obtained in the final iteration of step g) as a plurality of predicted tooth positions.
Absstract of: CN121398761A
Fixation devices for implants and related methods are generally described. The fixation device may be wrapped around the implant prior to delivery to reduce the risk of implant migration after implantation. The device may have porosity to induce tissue ingrowth around the implant and improve surgical outcome. The device can be used for rapidly preparing implants and can adapt to implants of various sizes. In some embodiments, the device may include a central portion for covering an anterior surface of a breast implant and a peripheral portion for covering a posterior surface of the implant. The peripheral portion, which may include a continuous rim or a plurality of legs, may include a tab that secures the fixation device to an implantation site. In some embodiments, a tether may be coupled to a distal end portion of the peripheral portion, thereby serving as a pull cord that quickly wraps the device around the implant.
Absstract of: WO2024182473A1
Systems, methods, and computer program products are provided for automated diagnostic imaging procedures. An example system includes at least one processor configured to: communicate, with a fluid injection system including a fluid injector, an imaging system including an imager, a sensor system including at least one sensor, and a user device, procedure data associated with a patient and a patient procedure associated with the patient; determine, based on the procedure data, whether a threshold for performing a next portion of the patient procedure is satisfied; and enable, based on a determination that the threshold for performing the next portion of the patient procedure is satisfied, at least one of the fluid injection system including the fluid injector, the imaging system including the imager, the sensor system including the at least one sensor, and the user device, to perform the next portion of the patient procedure.
Absstract of: EP1000000A1
The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.
Absstract of: EP1000000A1
The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.
Absstract of: US20260013994A1
Implantable devices for spinal cord and peripheral nerve injury are described. The implants include a three-dimensional printed structure having stem cells disposed therein. Also disclosed are methods of treating neuronal injuries with the disclosed implants.
Absstract of: US2025367422A1
A microneedle array is provided for administrating a drug or other substance into a biological tissue. The array includes a base substrate; a primary funnel portion extending from one side of the base substrate; and two or more solid microneedles extending from the primary funnel portion, wherein the two or more microneedles comprise the substance of interest. Methods for making an array of microneedles are also provided. The method may include providing a non-porous and gas-permeable mold having a two or more cavities each of which defines a microneedle; filling the cavities with a fluid material which includes a substance of interest and a liquid vehicle; drying the fluid material to remove at least a portion of the liquid vehicle and form a plurality of microneedles that include the substance of interest, wherein the filling is conducted with a pressure differential applied between opposed surfaces of the mold.
Absstract of: CN121714758A
本发明公开了一种时空响应性多功能3D打印骨修复支架及其制备方法和应用。将PDGF‑BB负载于快释载体，MgP负载于慢释载体，通过3D打印制备出内层负载MgP、外层负载PDGF‑BB的多功能3D打印骨修复支架。其中PDGF‑BB作为免疫调节剂，MgP作为再生诱导剂，将其植入体内后可根据载体降解速率的不同，时空响应性先降解释放PDGF‑BB实现早期免疫调节和内皮细胞募集，后降解释放镁离子和磷酸根离子与PDGF‑BB协同促进中后期血管化和成骨。经体外体内实验证实，本发明提供的3D打印骨修复支架兼具免疫调节、促进血管生成和成骨性能，能够用于炎症性骨损伤修复，尤其是适用于糖尿病引起的炎症性骨损伤修复。
Absstract of: CN121718752A
本发明公开了一种用于骨植入的Ti‑Zr‑Nb中熵合金多孔构件及制备和应用。该多孔构件的各元素的原子百分比为：Ti 52‑57 at.%，Zr 27‑32 at.%，Nb 12‑16 at.%，以不可避免的杂质元素；且多孔构件的结构由相互连通的大孔和小孔构成，孔隙率为 35%‑45%。屈服强度为 127‑216 MPa，弹性模量为 5.0‑8.5 GPa，且所述大孔孔径为 550‑700μm；所述小孔孔径为 200‑400μm，且大孔与小孔的连通率≥90%。该多孔构件在模拟体液中表现出优异的耐腐蚀性（自腐蚀电流密度 0.22×10⁻6 A/cm2），且能支持骨髓间充质干细胞的黏附、增殖与成骨分化，生物相容性良好。本发明为高性能、个性化骨植入物的制备提供了新的材料体系和成形工艺，具有重要的临床应用价值。
Absstract of: CN121714763A
本发明涉及一种生物墨水、4D生物活性支架及其制备方法与应用，属于生物技术领域。本发明提供的生物墨水包括重组贻贝粘蛋白、表皮生长因子（EGF）、甲基丙烯酸酐化明胶、透明质酸、聚多巴胺、N‑异丙基丙烯酰胺、海藻糖、四丁基溴化铵、LAP和18‑冠醚‑6。本发明的生物墨水用于制备4D生物活性支架，得到的支架具有良好的细胞粘附作用，能按需释放活性因子，同时具有温度响应性，能在37℃体温触发变形，实现对组织的快速修复，且安全性良好，可应用于组织再生与医疗美容修复。
Absstract of: KR102943316B1
본 발명은 프로세서에 의해 수행되는 치아 삭제 가이드 제작 방법에 있어서, (a) 구강 스캐너를 기초로 환자의 삭제 전 치아의 3차원 스캔 데이터를 획득하는 단계; (b) 상기 치아에 부착될 미리 결정된 라미네이트 보철물의 도면 데이터를 획득하는 단계; (c) 상기 3차원 스캔 데이터와 상기 도면 데이터를 정합하는 단계; (d) 상기 정합된 데이터를 기반으로 상기 3차원 스캔 데이터와 상기 도면 데이터 간의 표면 거리 차이를 계산하여 삭제가 필요한 영역 및 삭제량을 연산하는 단계; (e) 상기 분석된 삭제 영역 및 삭제량을 기반으로 치아 삭제 가이드 템플릿을 설계하는 단계; 및 (f) 상기 설계된 치아 삭제 가이드 템플릿을 3D 프린터를 사용하여 출력하는 단계를 포함할 수 있다.
Absstract of: US12583170B1
A method includes: receiving first and second digital models associated with a dental arch of a patient corresponding to first and second stages of orthodontic treatment; printing a first mold of a first dental arch based on the first digital model and a second mold of a second dental arch based on the second digital model; securing the first and second molds to a plate; heating a sheet of plastic to generate a heated sheet, and surrounding the sheet of plastic with a mask during the heating of the sheet of plastic to minimize heat transfer to other sheets of plastic; and simultaneously thermoforming the heated sheet over the first and second molds to form a first aligner shaped to fit the first dental arch and a second aligner shaped to fit the second dental arch.
Absstract of: EP4306235A2
Methods and systems are provided for using optical interferometry in the context of material modification processes such as surgical laser or welding applications. An imaging optical source that produces imaging light. A feedback controller controls at least one processing parameter of the material modification process based on an interferometry output generated using the imaging light. A method of processing interferograms is provided based on homodyne filtering. A method of generating a record of a material modification process using an interferometry output is provided.
Absstract of: CN121175081A
A method of modifying a surface of a three-dimensional (3D) article includes immersing at least a portion of the 3D article in a buffer solution of a functionalized peptide such that the functionalized peptide reacts with a reactive group on the surface of the 3D article; and washing at least a portion of the 3D article to remove unreacted functionalized peptides. The surface-modified 3D article comprises a plurality of peptides covalently bonded to a surface of the 3D article by cysteine bridging. The surface-modified 3D articles can be used as scaffolds for constructing biological tissues or implants.
Absstract of: EP1000000A1
The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.
Nº publicación: KR20260040104A 23/03/2026
Applicant:
보스톤싸이엔티픽싸이메드인코포레이티드
Absstract of: EP1000000A1
The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.
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