Alerta

Method for Automatic Creation of 3D Models for Dental and Orthodontic Use

Absstract of: US20260087741A1

A system and method that is a web based application for creating and managing 3D models used in orthodontic laboratory prescriptions within a dental clinic or lab. The method includes automatically detecting and removing any appliances contained within the 3D image file. After the appliances have been removed, the system then automatically infers new image data that is calculated to approximate the surface of the tooth disposed beneath the deleted appliance in order to create a clean, second 3D image. The method may further automatically refine the second 3D image of the patient's teeth or delete any artifacts which remain after creation of the second 3D image. The second 3D image may then be used as the basis on which to change the patient's orthodontic or dental prescription.

SYSTEMS, ARTICLES, AND METHODS RELATED TO HYDROGELS

Absstract of: WO2026064563A1

Systems, articles, and methods related to the fabrication microgels with non-spherical shapes and anisotropy are described herein. In one aspect, a technique to fabricate microgels is generally described. In some embodiments, by tuning the aspect ratio of the microgels, it is possible to incorporate anisotropic behavior within the microgels. Such anisotropic behavior can be used in certain embodiments to control and/or influence cellular arrangement in three dimensional space, and can be utilized for biomedical applications ranging from their application as injectable materials to mimicking and/or resembling biological tissues.

BIOPRINTING LIPID-LADEN TISSUE

Absstract of: WO2026064565A1

Methods for additive manufacturing, biological structures, cultivated meats, and additive manufacturing systems are provided. The method comprises dispensing an ink composition from a nozzle of an additive manufacturing system. The ink composition comprise adipocytes and a hydrogel. The deposition occurs at a suitable shear stress such that the ink composition can flow through the needle and an integrity of the adipocytes is substantially maintained. The method comprises repeating, as necessary, repositioning of the nozzle and dispensing ink composition from the first nozzle, thereby forming the structure.

CARDIAC PROCEDURES USING CONDUCTION SYSTEM DATA

Absstract of: WO2026062543A1

A method of machine-assisted setting up of a procedure for conduction system pacing in a patient with a heart, comprising: (a) identifying a conduction system location on an image data set of said heart, said image acquired using data collection from outside the heart; and (b) providing machine-assisted guidance of a pacemaker electrode placement to a target location associated with a portion of said conduction system in said heart, said target location suitable for capture of said conduction system by pacing with a pacing pulse from said lead.

METHOD FOR DEPLOYMENT OF MEDICAL KITS IN TRAUMA SCENARIOS

Absstract of: WO2026064030A1

The present invention is a system and method for providing real-time guidance to untrained individuals in emergency medical situations using pre-positioned medical kits. The system leverages artificial intelligence (AI) and color-coded, icon-labeled packaging to enable users to quickly identify and properly use the appropriate medical items in a given emergency.

SYSTEM AND METHOD FOR MONITORING AND ENGAGING PATIENTS TO FACILITATE MEDICATION ADHERENCE

Absstract of: WO2026063922A1

A system and method are provided for improving medication adherence of a patient, comprising: determining whether a time window for a medication intake event for a patient has occurred; determining a status of the patient by activating a sensor to generate echo signals reflected from objects in a designated space including the patient and a medication location containing a prescribed medication; determining whether the patient's behavior indicates that the patient is available to complete the event; sending to a patient device a first notification instructing the patient to complete the event by taking the prescribed medication; determining whether the patient has interacted with the medication location; sending to the patient device a confirmation request asking the patient to indicate whether the event is completed; and responding to the confirmation reply by storing the completed event and sending a notification to a physician device indicating completion of the event.

RADIOMICS BASED METHOD FOR PREDICTING THE ONSET OF HUMAN DISEASES USING NEURAL NETWORKS AND COLOR SPACE ANALYSIS

Absstract of: US20260088170A1

0000 The present invention provides a radiomics-based method and system for predicting the onset of human diseases using medical imaging and advanced machine learning techniques. This non-invasive approach combines Convolutional Neural Networks (CNNs) with pseudo-color transformation in the CIELAB color space to enhance early disease detection. The method begins by acquiring grayscale medical images from diagnostic techniques such as CT, MRI, or X-ray, followed by CNN-based feature extraction to identify clinically relevant regions of interest. These regions are then converted into pseudo-color representations using the CIELAB color space, improving tissue contrast and visualization of subtle abnormalities. A machine learning classifier is applied to the pseudo-colored images to predict the likelihood of disease onset, generating an output report that includes a heatmap, probability score, and diagnostic recommendations. The invention offers a fully automated process that facilitates early detection, improved visualization, and personalized diagnostics, providing a versatile solution for various medical conditions.

INFORMATION PROCESSING DEVICE, MONITORING DEVICE, AND NON-TRANSITORY COMPUTER-READABLE MEDIUM

Absstract of: US20260083336A1

An interface receives a signal corresponding to a waveform of physiological information involving cyclic changes from a sensor attached to a subject. A processor causes, in response to the signal, an output device to output information corresponding to an estimated value of a respiration rate of the subject. The processor extracts multiple feature quantities corresponding to respiration of the subject from the signal. The processor applies frequency analysis processing with respect to each of the feature quantities to acquire multiple preliminary estimation values of the respiration rate. The processor excludes one of the preliminary estimation values in response to state information corresponding to a state of the subject. The processor determines the estimated value based on at least one of the preliminary estimation values as remained.

Therapeutische Vorrichtung

Absstract of: DE102025002943A1

Als Hauptanspruch für die therapeutische Vorrichtung dient eine Einrichtung zur Erkennung, Auswertung und der dauerhaften Beseitigung körperlicher Fehlhaltungen im orthopädischen Sinn und betrifft hauptsächlich die Sitzhaltung, ist aber auch geeignet für andere alltägliche Situationen und gilt in selbem Maße auch für langanhaltende stehende Tätigkeiten- Die dafür eingesetzte therapeutische Einrichtung besteht im Sinne der Erfindung unter anderem aus im Alltag gebräuchlichen, handelsüblichen Oberbekleidungsstücken in alltäglicher Ausführung und Form, sowie für jedes Geschlecht und jedes Alter, die nachfolgend als Haltevorrichtung bezeichnet werden- Die Haltevorrichtungen 10 oder 11 werden für den täglichen Gebrauch vom(von der) Anwender(in) derart vorbereitet, in dem die kompakten Funktionseinheiten 41a bis 41d auf verschiedene Art und Weise in die Haltevorrichtung 10 oder 11 eingesetzt werden. Grundsätzlich wird dies rückennah im Winkel von 90° symmetrisch zur Senkrechten (Wirbelsäule) vorgenommen- Das geschieht zum einen dadurch, dass in die Haltevorrichtung 10 oder 11 jeweils eine maßgenau passende Tasche positionsgerecht befestigt wird, in die dann die Teilfunktionseinheiten 20a bis 21b lose eingesteckt werden. Tasche bedeutet in diesem Kontext, dass auf die Unterlage 30 eine Stoffabdeckung dergestalt aufgenäht wird, dass eine Tasche entsteht, die entweder nach oben oder seitlich offen ist. Außerdem bleibt ringsum ein schmaler Rand stehen, damit di

NERVE CONDUIT FROM DECELLULARIZED PLANT THAT CAN BE USED WITH OR WITHOUT ANY DRUG RELEASE POTENTIAL

Absstract of: WO2026063889A1

The present invention relates to a nerve conduit obtained by plant decellularization, which does not require 3D printing, is multi-channel, low-cost and capable of drug release. This nerve conduit is functionalized with GelMA and has properties that promote nerve healing.

LIMITING AND SETTING THE MAXIMUM SPEED OF BATTERY-POWERED SURGICAL INSTRUMENTS

Absstract of: US20260083443A1

0000 A cordless surgical instrument that is configured to let users set and limit a maximum speed for safer and more precise operation. The tool features a handpiece, a battery, and a control mechanism, along with a special mode that allows the user to program the maximum speed. The instrument includes a processor and a non-transitory memory storing program instructions executable to record a maximum speed set by the user and to limit the speed of the surgical accessory to the recorded maximum during subsequent operation, regardless of the extent of actuation of the control mechanism. Once set, the tool will not exceed the maximum speed. The system uses built-in electronics to record and enforce the maximum speed maximum.

TURF TOE REHABILITATION DEVICE AND METHOD OF USING A TURF TOE REHABILITATION DEVICE

Absstract of: US20260083613A1

Turf Toe is an injury that affects the mobility of an individual's big toe, most commonly affecting the metatarsophalangeal joint (MPJ). An assistive rehabilitation device facilitates several phases of rehabilitation treatment for the injury, namely an active phase and passive phase. These exercises are needed for the patient after a few weeks of recovery. The device provides the assistive as well as resistive forces needed for the process of rehabilitation helping the patient to recover faster and carry out exercises in a structured and right way.

CONCURRENT OPTIMIZATION OF PARTICLE EMITTER SYSTEM FOR MULTI-PHASED TREATMENT

Absstract of: US20260083983A1

0000 Aspects of this technical solution can determine a first dose of radiation concurrently with a second dose of radiation, the first dose associated with a first phase of operation of a particle emitter device, and the second dose associated with a second phase of operation of a particle emitter device, generate a first phase metric concurrently with a second phase metric, the first phase metric for a first objective on the first dose during the first phase, and the second phase metric for a second objective on the second dose during the second phase, determine, based on the first dose and the second dose, a combined dose over the first phase and the second phase, modify, at least one of the first dose or the second dose to reduce the combined metric, and cause the particle emitter device to emit the first dose and the second dose.

METHOD AND APPARATUS TO FACILITATE OPTIMIZING A RADIATION TREATMENT PLAN

Absstract of: US20260083984A1

A control circuit (which may comprise a graphics processing unit) accesses a plurality of radiation treatment planning objectives for a particular patient. The control circuit then optimizes a first candidate radiation treatment plan for the particular patient as a function of those objectives. The control circuit can then detect modification of at least one of those objectives to provide a corresponding one or more modified radiation treatment planning objective. The control circuit can then optimize a second candidate radiation treatment plan as a function of the at least one modified objective. The control circuit can then present, via a shared user display, at least a first dose volume histogram that corresponds to the first treatment plan and at least a second dose volume histogram that corresponds to the second treatment plan. The first and second dose volume histograms can be visually distinguished from one another by other than color.

GRAPHICAL USER INTERFACE FOR DISPLAY OF FLOW RATE EXTRACTED FROM ANGIOGRAPHIC INFORMATION

Absstract of: WO2026064596A1

A computer-implemented method and system for assessing vascular disease is disclosed. The disclosure provides receiving angiography image data, including a plurality of image frames captured over a sampling time-period for a subject; identifying a representative image frame from the plurality of image frames; segmenting the plurality of image frames to isolate a vessel region; inferring a plurality of centerline node points associated with a centerline of the vessel; tracking movement of the plurality of centerline node points between successive centerline node points of the plurality of angiogram image frames; registering each segmented frame of the plurality of image frames to the representative image frame; and determining a flow rate of the vessel based in part on a change in length of the vessel represented in successive registered image frames. In embodiments, resultant measurements and results may be displayed upon one or more user interfaces.

MEDICAL VIRTUAL ASSISTANT

Absstract of: US20260088146A1

A method includes receiving, by a user device, a prompt associated with treatment of a patient. The method includes determining a treatment context for the treatment of the patient based on access to a back-end treatment context support system. The method includes processing the prompt in view of the treatment context using one or more trained machine learning models to generate one or more actionable recommendations. The method includes outputting the one or more actionable recommendations via at least one of the user device or an additional device associated with the user device.

METHOD FOR GUIDING A USER THROUGH SELF-APPLICATION OF A MEDICAL DEVICE VIA AN ELECTRONIC DEVICE APPLICATION

Absstract of: WO2026064351A1

It is disclosed a method for guiding a user through self-application of a medical device via an electronic device application, the electronic device application being at least partially executed by an electronic device comprising a camera. The method comprises the steps of: collecting data about the user's posture; detecting at least a medical device parameter; guiding the user in positioning the medical device onto the user's body; detecting the position of the medical device onto the user's body and verify if this position is within a range of a predetermined position defined as the correct position; collecting data of the medical device for verifying the activation of the medical device.

Diagnoseverfahrens-Software

Absstract of: DE102024127337A1

Die Erfindung betrifft eine Diagnoseverfahrens-Software zur Bereitstellung von Daten zur Herstellung einer Kiefer-Gebiss-Schiene für eine Person, wobei ein Ist-Zahnraum-Zustand und/oder Zahnstellung (1) und eine Ist-Kieferfunktion (2) erfasst werden, wobei- eine Ist-Körperhaltung (3) erfasst wird, und- ein Ist-Fußflächendruck (4) erfasst wird, und- der Ist-Zahnraum-Zustand und/oder Zahnstellung (1) mit einem Soll-Zahnraum-Zustand und/oder Zahnstellung (11) abgeglichen wird, um eine erste Abweichung (a) zwischen dem Ist-Zahnraum-Zustand (1) und dem Soll-Zahnraum-Zustand (11) zu ermitteln,- die Ist-Kieferfunktion (2) mit einer Soll- Kieferfunktion (12) abgeglichen wird, um eine zweite Abweichung (b) zwischen der Ist-Kieferfunktion (2) und der Soll-Kieferfunktion (12) zu ermitteln,- die Ist-Körperhaltung (3) mit einer Soll-Körperhaltung (13) abgeglichen wird, um eine dritte Abweichung (c) zwischen der Ist-Körperhaltung (3) und der Soll-Körperhaltung (13) zu ermitteln,- der Ist-Fußflächendruck (4) mit einem Soll-Fußflächendruck (14) abgeglichen wird, um eine vierte Abweichung (d) zwischen dem Ist-Fußflächendruck (4) und dem Soll-Fußflächendruck (14) zu ermitteln, wobei- die erfassten Daten zur Herstellung der Kiefer-Gebiss-Schiene genutzt werden, geeignet um die Abweichungen (a, b, c, d) zu verringern.

METHOD OF ESTABLISHING MODEL AND METHOD FOR DETECTING ATRIAL FIBRILLATION AND SLEEP APNEA

Absstract of: US20260088174A1

A method of establishing a model for detecting atrial fibrillation (AF) and sleep apnea (SA) is implemented by a computer system that stores training electrocardiograms, and includes steps of: dividing the training electrocardiograms into training segments, each of which contains a common length of time of recorded electrical activity of a heart; for each of the training segments, labeling the training segment with a symptom indicator that indicates whether the training segment is related to AF and whether the training segment is related to SA; for each of the training segments, performing feature extraction on the training segment to obtain an entry of feature data; and establishing the model by using a machine learning algorithm based on the entries of feature data and the symptom indicators.

コンピュータ支援診断システム

Absstract of: EP1000000A1

The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.

Control of heating and cooling in 3D bioprinting

Absstract of: GB2700936A

A controller (300, figure 4) for a 3D bioprinter 10, the controller being operable to control the functioning of the 3D bioprinter housed within an internal area of an enclosure 100, to produce a 3D printed construct in accordance with a 3D printing file, said controller being further operable to control the temperature of at least two temperature regulating devices 112, 242, by means of control inputs from plural temperature sensors TP1,TP2,TP3, at least one sensor sensing the temperature of the print bed 240, of a print material store 210, and/or at least one temperature sensor of the bioprinter head 220, and wherein said temperature regulation includes causing: heating of one or more of said at least two devices, cooling of one or more of said devices, or heating of one of the devices at the same time as cooling of another of the devices. The temperature control may be a proportional-integral-derivative (PID) routine or circuit. A 3D printing assembly is also provided, suitable for bioprinting, including an enclosure defining an internal area 101 and one or more bioink material vial(s) 212 selectively fluidically interconnectable to the print head. Figure 2

MEASUREMENT OF READINESS FOR DAILY ACTIVITIES USING WEARABLE DATA AND SUBJECTIVE INPUT

Absstract of: EP4714345A1

A method of dynamically determining a readiness score of a user using a wearable device. The method includes detecting, by the wearable device when worn by the user, one or more sensor or physiological signals associated with the user, and determining, by a processor, an estimation of two or more readiness components based on the one or more sensor or physiological signals. The two or more readiness components include a physical energy of the user associated with physical energy consumption of the user, physical energy recovery of the user, or both. The two or more readiness components also include a mental energy of the user associated with mental energy consumption of the user, mental energy recovery of the user, or both. The method further includes determining the readiness score based on the estimation of each of the two or more readiness components.

錠剤印刷装置及び錠剤印刷方法

Absstract of: JP2023050476A

To execute efficient tablet printing.SOLUTION: A tablet printing device 1 includes: a conveyance part 21 for conveying tablets T by a conveyance belt 21a; a detection part 22 for detecting the conveyed tablets T; an inkjet head 24 for discharging ink to the tablets T detected by the detection part 22; a moving mechanism 26 for moving the conveyance belt 21a or the inkjet head 24 so as to change an interval between a surface on a conveyance belt 21a side of the inkjet head 24 and a surface on an inkjet head 24 side of the conveyance belt 21a; and a control part (e.g., a control device 40) for controlling the conveyance part 21 and the moving mechanism 26. The detection part 22 detects height information on the tablets T on the conveyance belt 21a. The control part controls the conveyance part 21 so as to decrease a conveyance speed of the conveyance belt 21a when the height of the tablets T exceeds a predetermined threshold on the basis of the height information, and controls the moving mechanism 26 so as to widen the interval.SELECTED DRAWING: Figure 1

SURGICAL INSTRUMENT COMPRISING A FLEX CIRCUIT INCLUDING A SENSOR SYSTEM

Absstract of: EP4714369A2

A surgical instrument including a flex circuit comprising a sensor system.

재조합 단백질, 재조합 DNA 서열, 벡터, 진핵생물 및 원핵생물 발현 시스템 및 그 용도

Nº publicación: KR20260040625A 25/03/2026

Applicant:

폴바이오니카스폴카즈오그라니초나오드포비에지알노시치아훈다치야바단이로즈보유나우키

Absstract of: AU2024288436A1

The invention relates to recombinant RE15mR and EJ17zipR hybrid proteins with the structure specified in the description, recombinant DNA sequences encoding recombinant hybrid proteins, vectors containing recombinant DNA sequences, as well as eukaryotic or prokaryotic expression systems transformed with recombinant DNA sequences. The invention also concerns the use of recombinant hybrid proteins as components of bioink intended for bioprinting, and also as components of biomaterials. Furthermore, the invention relates to the use of recombinant DNA sequences, vectors and eukaryotic or prokaryotic expression systems for the production of recombinant hybrid proteins.