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磁驱动多模态电子导管及其制备方法

Absstract of: CN119837496A

本发明公开了一种磁驱动多模态电子导管及其制备方法。该磁驱动多模态电子导管包括：多通道铁磁导管、位于所述多通道铁磁导管一端的若干多参数微电极；所述多通道铁磁导管用于所述磁驱动多模态电子导管的磁驱动导航和导电，所述多参数微电极插入所述液态金属通道中，所述多参数微电极用于生化检测；所述多通道铁磁导管包括磁响应基体外鞘、空心通道和若干液态金属通道；所述空心通道和若干所述液态金属通道嵌入至所述磁响应基体外鞘中；所述磁响应基体外鞘的材料包括：由热塑性柔性聚合物和磁性颗粒按照预设比例得到的复合材料。本申请中有利于降低检测复杂度，提升检测准确度。本发明可广泛应用于生理参数检测技术领域内。

用于正畸器具的转移设备和相关的制造方法

Absstract of: US2024238069A1

A method of making a transfer apparatus includes providing a physical mockup having a shape that corresponds to a positive shape of a patient's dental arch and one or more carrier assemblies that each include a crane body releasably connected to an orthodontic appliance. A transfer apparatus may be formed over the physical mockup, with the transfer tray representing a negative replica of at least a portion of the mockup. The transfer apparatus may be used to seat the appliance on a patient's dental arch, after which point the appliance can be separated from the crane body and bonded to the associated tooth.

一种多尺度分级镁合金支架及其制备方法和应用

Absstract of: CN119838055A

本发明属于生物医用材料技术领域，公开了一种多尺度分级镁合金支架及其制备方法和应用。本发明以镁合金为基材，采用激光粉末床熔融技术，得到基体支架；将基体支架进行化学抛光，然后进行高温氧化处理，在表面形成氧化层，再进行水热反应，在表面形成水滑石层，得到多尺度分级镁合金支架。利用L‑PBF技术实现支架宏观结构的精准控制，通过结构设计实现支架介观孔隙的优化设计，支架表面的氧化层和水滑石层形成的微米级涂层可抑制快速降解，水滑石纳米片可提升表面粗糙度和亲水性，有利于成骨细胞的附着和分化。本发明支架的多尺度设计(宏观形状、介观孔隙、微观涂层、纳米表面)有效模仿了天然骨的层次结构，提升了支架的生物适应性。

一种3D打印多孔复合支架的制备方法及应用

Absstract of: CN119838059A

本发明属生物医用材料领域，具体公开了一种3D打印多孔复合支架的制备方法及应用。将I型胶原和丝素蛋白复合凝胶修饰在聚多巴胺涂层的3D打印三元素掺杂羟基磷灰石/聚己内酯(PCL)复合支架上，所述三元素掺杂羟基磷灰石使用化学沉淀法合成，晶格内掺杂有Mg2+、Sr2+和SeO32‑离子。本发明的提供的3D打印多孔复合支架有效地模拟天然骨软硬结合的结构与功能，有助于调控干细胞命运来改善骨再生进程，在消除肿瘤的同时修复骨缺损，可应用于骨缺损修复或骨肉瘤治疗。

一种咬合重建中后牙诊断饰面及其数字化制备方法

Absstract of: CN119837652A

本发明提供了一种咬合重建中后牙诊断饰面及其数字化制备方法，该方法包括：获取全牙列扫描数据；基于戴用��垫适应后的咬合高度，设计后牙蜡型，得到后牙咬合面数据OCCLU1；将后牙咬合面数据OCCLU1进行间断分割，间断删除部分后牙咬合数据，得到后牙咬合数据OCCLU2；分别基于全牙位蜡型模型和间断牙位蜡型模型进行3D打印；基于3D打印模型，制作成型阴模INDEX1及成型阴模INDEX2；利用成型阴模INDEX2对部分待修复后牙进行注射成型；利用成型阴模INDEX1对剩余待修复后牙进行注射成型。本方案实现了后牙诊断饰面的快速、高精度成型，且制作的诊断饰面具有良好的稳定性和耐用性。

一种3D打印多孔复合支架的制备方法及应用

Absstract of: CN119838058A

本发明属生物医用材料领域，具体公开了一种3D打印多孔复合支架的制备方法及应用。将含生长因子的I型胶原和丝素蛋白复合凝胶修饰在聚多巴胺涂层的3D打印三元素掺杂羟基磷灰石/聚己内酯(PCL)复合支架上，所述三元素掺杂羟基磷灰石使用化学沉淀法合成，晶格内掺杂有Zn2+、Sr2+和SeO32‑离子。本发明的提供的3D打印多孔复合支架有效地模拟天然骨软硬结合的结构与功能，有助于调控干细胞命运来改善骨再生进程，在消除肿瘤的同时修复骨缺损，可应用于骨缺损修复或骨肉瘤治疗。

TRANSCATHETER DELIVERABLE PROSTHETIC HEART VALVES AND METHODS OF DELIVERY

Absstract of: AU2025202301A1

A prosthetic valve includes a frame and a flow control component. The frame has an aperture extending through the frame about a central axis. The flow control component is mounted within the aperture and is configured to permit blood flow in a first direction approximately parallel to the vertical axis from an inflow end to an outflow end of the flow control component and to block blood flow in a second direction, opposite the first direction. The frame has an expanded configuration with a first height along the central axis, a first lateral width along a lateral axis perpendicular to the central axis, and a first longitudinal length along a longitudinal axis perpendicular to the central axis and the lateral axis. The frame has a compressed configuration with a second height less than the first height and a second lateral width less than the first lateral width.

SYSTEMS AND METHODS FOR GENERATING PATIENT-SPECIFIC IMPLANTS FOR ANATOMICAL STRUCTURES OF PATIENTS

Absstract of: US2025120816A1

Embodiments for generating patient-specific implants for anatomical structures of patients are disclosed. One embodiment includes a method that includes receiving image data of an anatomical structure of a patient, where the image data indicates a fracture site associated with the anatomical structure; receiving manipulation data associated with manipulation of one or more parameters associated with the fracture site in a virtual reality environment; visualizing a three-dimensional (3D) model of the anatomical structure based on the image data, the one or more parameters, and the manipulation data, where the 3D model is visualized in a 3D space; generating a set of instructions for a printer based on the 3D model, and controlling the printer for generating a 3D printed model of the anatomical structure based on the set of instructions. The 3D printed model is configured to receive an implant, such that the implant is contoured to match the fracture site.

SPINAL INTERBODY FUSION DEVICE

Absstract of: US2025120822A1

A bellows shaped spinal implant, comprising an upper plate, a lower plate and a bellows shaped shell extending between and joining the upper and lower plates. The bellows shaped shell is formed of titanium or an alloy comprising titanium and includes a wall extending therearound that defines a hollow interior. The wall has a thickness in the range of 0.5 mm to 1.0 mm to provide for radiographic imaging through the wall. The wall is angled or curved inwardly or outwardly between the upper and lower plates to provide stiffness mimicking the stiffness properties of a similarly sized polyetheretherketone (PEEK) implant. The upper and lower plates each comprise porous contact regions including a three-dimensional gyroid lattice structure defined by a plurality of struts and pores in communication with the hollow interior. The outer surfaces of at least a portion of the struts may comprise a laser ablated textured surface.

System For Forming A Patient Specific Surgical Guide Mount

Absstract of: US2025120727A1

A system for making a resection of a bone having localized anatomical surface features prior to resection, comprising: a resection guide locator including a body, the body including opposing medial and lateral wings extending outwardly from the body, the body defining a recess being a socket defined by an annular wall, the annular wall including an upper wall, a lower wall, a resection guide having a body defining a resection slot, at least a portion of the resection guide body sized and configured to be received within the recess defined by the resection guide locator.

BIOINK FOR REPRODUCIBLE PRODUCTION OF 3D TUMOR TISSUE SCAFFOLDS

Absstract of: US2025122468A1

The present invention relies on the discovery that certain proteins are enriched in the tumor microenvironment of different types of tumors and subgroups of tumors but not in others and that such proteins can be used as components of bioinks. The bioinks can be used in production of reproducible tumor type-specific 3D scaffolds to provide tumor type-specific in vitro models for various cancer research applications.

Microscope Enabled 3D Bioprinting System

Absstract of: US2025123476A1

An apparatus controls a series of actuators mounted onto inverted microscope assemblies to add 3D bioprinting and pick and place capabilities on a microscopic scale. One or more syringes are also mounted to the apparatus and the plunger of each syringe is independently actuated to extrude or extract fluids from the optically aligned needle. A software package communicates with the microscope x, y stage as well as the on-board motor controller which actuates the syringes and needle to set the x, y, z position and syringe in real time.

ADDITIVELY-MANUFACTURED COMPOSITE ROD FOR SPINAL INSTRUMENTATION

Absstract of: US2025121117A1

A composite rod for spinal instrumentation may include a metal rod forming an inner core; and a composite polymer derived from a hybrid of PEEK and negatively (−) charged zeolite molecules forming an outer coating around at least a top portion of the inner core. The inner core and the outer coating each have a variable thickness, thereby forming a composite rod having a uniform overall thickness. The composite rod may be 3D-printed and may optimize fusion via rod stiffness and osteoconductive matrix spanning the levels fused, while maximizing pre-operative customization and surgeon intra-operative flexibility.

ADJUSTABLE SECUREMENT DEVICE FOR ENDOTRACHEAL TUBE

Absstract of: US2025121147A1

The present disclosure generally relates to devices, and related methods of treatment using the same, for securing an endotracheal tube (commonly abbreviated as “ETT”) or other medical line to a patient, and more particularly to infants, babies in a neonatal unit, small children, etc.). The disclosure also relates to techniques and devices to remove the presence of unplanned extubations. In an exemplary embodiment, as taught in the present disclosure, a device may be used to secure an endotracheal tube to a small child or newborn infant such that the device may be configured to adjust the grip of the endotracheal tube to achieve optimal securement and stabilization of the endotracheal tube.

SYSTEMS, METHODS, AND DEVICES FOR MICROSTRUCTURE CHARACTERIZATION

Absstract of: US2025125018A1

Systems, methods, and devices disclosed herein include three-dimensional bioprinting technologies which produce cell scaffolds with a high degree of complexity and precision. A bioprinting ink mixture can be formed with coated gold nanoparticles in an alginate-gelatin solution. Upon bioprinting a 3D scaffold microstructure from the bioink mixture, an imaging procedure is performed on the 3D scaffold microstructure using the coated gold nanoparticles as a contrasting agent. A microstructure characterization is determined from the imaging procedure, and a virtual 3D reconstruction of the microstructure characterization can be generated for presentation on a graphical user interface (GUI) of a computing device. These techniques can be used to determine whether the resultant internal core of the microstructure properly mimics the architecture of the native tissue extracellular matrix (ECM) present in-vivo by determining the degree of pore interconnectivity which can improve cell distribution, attachment, and growth in the 3D scaffold microstructure.

A METHOD AND A COMPUTER PROGRAM FOR PERFORMING SCAFFOLD DESIGN OPTIMIZATION TOWARDS ENHANCED BONE HEALING, AND A METHOD TO MANUFACTURE A SCAFFOLD

Absstract of: US2025124195A1

The invention concerns a method, in particular a computer-implemented method, for performing scaffold design optimization (h) towards enhanced bone healing, the method comprising the steps of a) Inputting a set of parameters comprising information about a geometry and a material of a scaffold (3) to a computational model, the computational model comprising a finite element model and a mechano-biological computational model, wherein the finite element model determines and provides a set of mechanical information data for the set of parameters to the mechano-biological computational model, wherein the mechano-biological computational model determines from the set of mechanical information data a regenerated bone volume; b) Determining a plurality of regenerated bone volumes for a plurality of sets of parameters according to step a), such as to generate a scaffold bone data associating the regenerated bone volume with the corresponding set of parameters; c) Determining a computational surrogate model consisting of an analytical expression configured to associate the regenerated bone volumes with the sets of parameters from the scaffold bone data; and d) Determining from the computational surrogate model an optimum set of parameters for which the computational surrogate model puts out a maximum regenerated bone volume. The invention also concerns a computer program and a method to manufacture a scaffold (3).

SYSTEM AND METHODS FOR MANUFACTURING IN VITRO HIGH PERFORMANCE WOOD

Absstract of: US2025122469A1

An exemplary embodiment of the present disclosure provides a method for generating in vitro wood. The method can comprise culturing a plurality of wood forming plant cells; encapsulating the plurality of wood forming plant cells in one or more hydrogels; developing one or more bioinks; and generating structures comprising the one or more bioinks. The one or more bioinks can comprise one or more plant cell culture medium components. In an exemplary embodiment, the plurality of wood forming plant cells are cambial meristematic cells, and can include genetically modified plant cells. The one or more bioinks can be configured to be loaded into a bioprinting system, which can generate the structures via an extrusion based method. The generated structures can be incubated to induce wood formation, monitored, and tested for superior material properties.

SYSTEMS AND METHOD FOR ADDITIVE MANUFACTURING OF DENTAL DEVICES USING PHOTOPOLYMER RESINS

Absstract of: EP4537787A2

Strategies that reduce shrinkage and ultimately warping of parts that are directly fabricated from photopolymer resins. This increases the accuracy of directly fabricated parts, which is essential for patient specific applications. Implementing these strategies can reduce the need for directly fabricated parts to have supporting structures, which can reduce pre-processing and post-processing steps and facilitate an easier route for production level scale of additive manufacturing.

MEDICAL DEVICE BASED ON BIOCERAMICS, ITS USE AS A SYNTHETIC BONE GRAFT AND PROCESS FOR THE PREPARATION THEREOF

Absstract of: AU2023282947A1

The present invention relates to a medical device manufactured using the additive manufacturing process (3D printing). It is a medical device used preferably as a bone graft composed of a porous structure based on bioceramics based on β-tricalcium phosphate (β-TCP) or hydroxyapatite, which may or not contain nanostructures in its composition, for example: carbon nanostructures (graphene, graphene oxide, reduced graphene oxide, carbon nanotubes, etc.) and, in preferred embodiments, stem cells and polymeric membrane. Also, the present invention relates to the use of this device as a bone graft and the process of preparing this device.

DEVICES AND METHODS OF MAKING AND USE THEREOF

Absstract of: WO2023244797A1

Disclosed herein are devices and methods of making and use thereof.

DEVICES AND METHODS OF MAKING AND USE THEREOF

Absstract of: WO2023244821A1

Disclosed herein are devices and methods of making and use thereof.

一种口腔正畸改良式3D打印横腭杆

Absstract of: CN222752154U

本实用新型公开了一种口腔正畸改良式3D打印横腭杆，涉及口腔正畸器械技术领域。包括横腭杆主体，横腭杆主体的中部开设有安装孔，安装孔中活动安装有种植钉，横腭杆主体的左右两端中部设置有凸块，凸块的上下两端安装有活动块，活动块的中部贯穿有固定栓，活动块的圆周表面安装有固定块，固定块远离活动块的一端安装有固定板，固定板远离固定块的一侧中部安装有连接块，连接块远离固定板的一端安装有固定半环，固定半环的上下两端中部安装有连接环，连接环的圆周表面安装有固定弓丝，凸块的外侧中部安装有固定柱，固定弓丝远离连接环的一端安装在固定柱的圆周表面上，固定板靠近凸块的一侧中部开设有固定孔，固定柱活动安装在固定孔中。

一种激光粉末床熔化制备可降解镁合金血管支架的方法

Absstract of: CN119819946A

本发明适用于增材制造技术领域，提供了一种激光粉末床熔化制备可降解镁合金血管支架的方法，包括以下步骤：按照以下质量百分比称取原料：Sr 1‑3%，Zr 0.5‑1.5%，Bi 0.2‑1%，Si 0.5‑2%，Ti 0.1‑0.5%，余量为Mg，熔炼形成均匀的液态合金，再使用高压氩气喷射液态合金，使其冷却形成粉末颗粒，筛选得到镁合金粉末；根据血管的尺寸和血流特性，设计支架的壁厚和孔隙结构；将镁合金粉末铺设在基板上，根据支架的结构设计激光扫描路径，采用层间扫描，制备镁合金支架；对镁合金支架进行抛光处理，清洗后烘干，再将支架进行氟化处理，再清洗吹干。本发明不影响镁合金材料的生物相容性和力学强度的前提下，成功制备出具有良好生物降解特性的血管支架。

一种钛基植入体表面双重药物释放系统及其制备方法与应用

Absstract of: CN119818720A

本发明属于医用材料技术领域，涉及一种钛基植入体表面双重药物释放系统及其制备方法与应用。包括钛基植入体和贴合在其表面的水凝胶层，钛基植入体表面为纳米管阵列结构，钛基植入体与水凝胶层之间设有氧化锌纳米颗粒和上转换发光材料颗粒，水凝胶层内装载MgO2纳米颗粒；其中，所述上转换发光材料颗粒的材质为NaYF4:Yb3+,Er3+，水凝胶层由明胶‑海藻酸钠水凝胶构成。本发明提供的钛基植入体表面双重药物释放系统不仅能够实现不同药物的装载，可以用于治疗多种疾病，而且具有较好的时序控制效果，作用时间长，成本低，具有广阔的应用前景。

一种改善明胶基水凝胶室温易凝固特性的方法

Nº publicación: CN119823581A 15/04/2025

Applicant:

中山大学·深圳