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86
results.
Updated on
15/07/2026 [07:35:00]
Results 50 to 75 of 86
Absstract of: JP2025032179A
To provide a vaccine composition to induce immunity against a coronavirus in a subject.SOLUTION: A vaccine composition comprises a recombinant nucleic acid that encodes N-ETSD, a modified nucleocapsid protein that includes an endosomal targeting sequence, and/or that encodes S-Fusion, a modified spike protein that has improved surface expression. The vaccine may be formulated as a recombinant nucleic acid, recombinant yeast, and/or recombinant virus such as an adenovirus and can be administered via injection and/or mucosal delivery.SELECTED DRAWING: Figure 25
Absstract of: WO2026112937A1
Relate to an isolated vNAR single domain antibody that specifically binds to SARS-CoV-2 nucleocapsid protein, and a process for preparing the same.This isolated vNAR single domain antibody are also included.
Absstract of: US20260151415A1
0000 Compounds and pharmaceutical formulations including a compound and an oil, which may be formulated for intermediate- or long-acting intramuscular injection. Methods for treating respiratory syncytial virus (RSV), human immunodeficiency virus (HIV), coronavirus, SARS CoV-2, and other RNA virus infections in mammals.
Absstract of: US20260151414A1
0000 Embodiments of therapeutic protocols to treat Post-Acute Sequelae SARS-COV-2 infection (“PASC”), a.k.a. “long Covid,” are described. The PASC treatment protocols focus on a moderating a hyperimmune response; destroying and removing the SARS COV-2 spike protein from the gut and body, detoxifying the body and the brain; replenishing key nutrients; mitigating depression and anxiety; and a regimen of physical and mental exercises. A standard six-week protocol and a shorter, three-week protocol are disclosed for those with a milder form of PASC are disclosed.
Absstract of: WO2025022303A1
The present invention relates to monoclonal antibodies or antigen-binding portion thereof that have a potent neutralizing activity against Coronavirus, in particular against at least one virus selected from SARS-CoV-2, SARS-CoV-1 and variants thereof. The invention relates also to the use of such monoclonal antibodies or antigen-binding portion thereof in therapy, prophylaxis, and diagnosis of Coronavirus, in particular SARS-CoV-2 and/or SARS-CoV-1 dependent diseases.
Absstract of: EP4751733A2
The present invention relates to method of producing a lipidated protein, a pharmaceutical composition comprising the protein of any of SEQ ID NOs: 1, 2, and/or 3 and/or the lipidated form of a protein comprising the protein of SEQ ID NO: 7 (C-TAB.GS) and/or SEQ ID NO: 8 (C-TAB.G5.1), especially the protein of SEQ ID NO: 12 (Lip-C-TAB.G5.1), and/or a lipidated form of a protein comprising the protein of SEQ ID NO: 15 (Spike protein of SARS-CoV-2) and/or a lipidated form of a protein comprising the any of the proteins of SEQ ID NOs: 16-22 (hMPV F protein), and the pharmaceutical composition for use as a medicament, particularly a vaccine and/or for use in a method for eliciting an immune response in a human against Lyme disease, a disease caused by Clostridium difficile or hMPV and/or of SARS-CoV-2 (COVID-19).
Absstract of: EP4751641A2
Disclosed are methods and devices for analyzing non-volatile organics in exhaled breath and other aerosols using various diagnostic tools that enable rapid, low cost point of care assays for several diseases including respiratory tract diseases such as COVID-19. The disclosed methods and systems selectively capture non-volatile organics in exhaled breath and other aerosols in a packed bed column. The non-volatile organics are eluted and samples are analysis using diagnostic devices including MALDI-TOFMS. The disclosed systems and methods provide for a diagnostic test result in less than about 20 minutes and provides for autonomous operation with minimal human intervention.
Absstract of: KR20260080874A
본 발명은 코로나19에 따른 제주 입도수요 충격 데이터 보정 방안을 기반으로한 모델 학습을 위한 충격 데이터 보정 방안 연구 에 관한 것으로서 제주 관광 수요 예측 정확도를 높이고 외부 충격에 대한 대응 능력을 강화하는 데 기여한다. 또한 체계적 표준화가 미흡한 현 관광 산업의 데이터 분석 환경에 새로운 방법론을 제시함으로써, 데이터 기반의 과학적 분석과 의사 결정이 가능한 체계를 구축하는 데 기여할 것으로 기대된다.하도록 함으로써 기존의 제주도 관광 산업은 지역 GRDP의 21%를 차지하며 2023년 관광객 1,400만 명을 기록했다. 그러나 관광 수요예측은 계절, 경제, 사회적 요인의 영향 및 복잡한 비선형 관계를 가지고 있어 선형 중심의 전통적 통계모형으로는 외생 요인들의 영향을 효과적으로 반영하기 어렵다. 특히 코로나19와 같은 충격 데이터를 단순 제거하면 중요한 정보가 손실될 수 있다. 따라서 본 연구는 통계모형과 기계학습을 결합해 충격 데이터의 특성을 반영한 새로운 관광 수요 예측 방법을 제시한다. 문제점을 해소 하도록 한 것이다.즉 본 발명은, 기존 관광 산업의 수요예측은 기본적 통계모델(Arima)로만 진행됨 에 있어서 통계모형과 기계학습을 결합해 충격 데이터의 특성을 반영한 새로운 관광 수�
Absstract of: US12643063B1
0000 The present development is a nanofilter, i.e. a filter material that comprises inorganic nanowires impregnated into a non-woven polymer or cloth fabric material. The nanofilter comprises a fabric infiltrated with a nanowire powder slurry selected from anatase titania (TiO<2>), zinc oxide (ZnO), silica, tin oxide, alumina (Al<2>O<3>), or combinations thereof. Exemplary fabrics include a non-woven polymer and a cotton fabric cloth. The nanowire powder slurry effectively produces a coating on the fabric. Optionally, the nanowires may be functionalized using nanoparticles and/or disinfecting salt particles. The infiltrated nanowires form a porous network with sub-micron scale openings and provide filtration of any airborne particles, liquid droplets and viruses including COVID 19. The nanofilter may be used in a variety of applications, such as a nanofilter respirator as described herein.
Absstract of: MX2026005520A
Disclosed are monoclonal antibodies, antigen binding fragments, and multi-specific antibodies that specifically bind a coronavirus spike protein, such as SARS-CoV-2. Also disclosed is the use of these antibodies and multi-specific antibodies for inhibiting a coronavirus infection, such as a SARS-CoV-2 infection. In addition, disclosed are methods for detecting a coronavirus, such as SARS-CoV-2, in a biological sample, using the disclosed antibodies and multi-specific antibodies.
Absstract of: WO2025090605A1
The present disclosure provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
Absstract of: MX2026005926A
This disclosure relates to the field of RNA to prevent or treat coronavirus infection. In particular, the present disclosure relates to methods and agents for vaccination against coronavirus infection and inducing effective coronavirus antigen-specific immune responses such as antibody and/or T cell responses. Specifically, in one embodiment, the present disclosure relates to methods comprising administering to a subject RNA encoding a peptide or protein comprising an epitope of SARS-CoV-2 spike protein (S protein) for inducing an immune response against coronavirus S protein, in particular S protein of SARS-CoV-2, in the subject, i.e., vaccine RNA encoding vaccine antigen.
Absstract of: CA3126560A1
A method of treating or preventing a Coronaviridae infection in a subject comprising administrating a therapeutically effective amount of a compound of Formula I or a stereoisomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, and the Coronaviridae comprises at least one selected from 2019-nCov virus, HCov 229E virus, SARS virus, MERS virus,
Absstract of: KR20260078113A
본 발명은 오시머티닙(osimertinib)을 유효성분으로 포함하는 SARS-CoV-2 바이러스 또는 SARS-CoV-2 변이체 바이러스에 대한 항바이러스용 조성물에 관한 것으로서, 세포 생존율 감소와 무관하게 hACE2를 발현하는 세포 및 3D 스페로이드에 처리 시 야생형뿐만 아니라 변이체 바이러스의 감염이 감소되는 효과를 가지므로, ARS-CoV 바이러스 또는 SARS-CoV-2 변이체 바이러스의 감염 예방, 개선 및 치료에 사용할 수 있을 것으로 기대된다.
Absstract of: US20260144861A1
0000 This disclosure relates to the field of RNA to prevent or treat multiple infectious agents. In particular, the present disclosure relates to methods and agents for vaccination against coronavirus infection, influenza infection, and/or RSV infection and inducing effective coronavirus, influenza virus, and/or RSV antigen-specific immune responses such as antibody and/or T cell responses. Specifically, in one embodiment, the present disclosure relates to methods comprising administering to a subject (i) a bivalent RNA vaccine encoding peptides or proteins comprising epitopes of SARS-CoV-2 spike proteins (S proteins) and (ii) a tetravalent RNA vaccine encoding peptides or proteins comprising epitopes of hemagglutinin (HA), for inducing an immune response against coronavirus S proteins, in particular S proteins of SARS-CoV-2, and influenza proteins, in particular HA proteins of type A and type B influenza viruses, in the subject.
Absstract of: US20260146077A1
0000 Disclosed are monoclonal antibodies, antigen binding fragments, and bi-specific antibodies that specifically bind SARS-CoV-2. Also disclosed is the use of these antibodies for inhibiting a coronavirus infection, such as a SARS-CoV-2 infection. In addition, disclosed are methods for detecting a coronavirus, such as SARS-CoV-2, in a biological sample, using the disclosed antibodies. In some embodiments, the SARS-CoV-2 is the BA.4 or BA.5 variant.
Absstract of: US20260146062A1
0000 Compositions and methods are provided for inhibiting the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Absstract of: AU2024395949A1
The present disclosure relates to methods of diseases and/or conditions associated with Covid-19 infection, including long COVID, comprising administration of a COX-2 inhibitor, an antiviral compound, and one or more additional active ingredients, such as a combination of nirmatrelvir and ritonavir, molnupiravir, BCG vaccine, or ivermectin.
Absstract of: WO2026112441A1
The present disclosure relates to compositions and methods, including prodrugs of (S)-3-(3-(((3,4- dimethoxybicyclo4.2.0octa-1,3,5-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H- benzodazepin-2-one that find use in the treatment of diseases and disorders, such as therapies for cardiovascular disease, including cardiac arrhythmias, including, without limitations, sinus tach (e.g. inappropriate sinus tachycardia (IST)), postural orthostatic tachycardia syndrome (POTS), coronavirus (COVID-19) (e.g. long COVID) and COVID-associated cardiovascular abnormalities, supraventricular tachycardia (SVT), tachycardia (e.g. rapid heart rate, atrial tachycardia), heart failure (e.g. congestive heart failure (CHF), systolic heart failure, pediatric heart failure, chronic heart failure), myocardial ischaemia, angina (e.g. angina pectoris), myocardial infarct, rhythm disturbances (e.g. supraventricular rhythm disturbances), chest pain, cardiomyopathy, coronary artery disease, and left ventricular dysfunction (LVD).
Absstract of: WO2026108766A1
Provided herein are live attenuated viruses for protection against respiratory syncytial virus (RSV) and/or coronavirus Sars-CoV-2. The live attenuated chimeric virus strains utilize a master backbone based on a live attenuated influenza virus (LAIV), which includes a deletion of the viral virulence element, the NS1 (non-structural protein 1) (DeLNS1). These chimeric strains are engineered to express one or more antigens of RSV alone or in combination with Sars-CoV-2. The chimeric virus strain can protect a subject in need thereof against a challenge from any of RSV, Sars-CoV-2, influenza, or a combination thereof. This viral vector system offers an important strategy for developing highly attenuated and immunogenic live attenuated vaccines with the capacity to induce protective immunity against the three respiratory infections.
Absstract of: WO2026110758A1
Problem To provide a VHH which specifically binds to receptor binding domains of spike proteins of various types of variants of SARS-CoV2. Solution A VHH having any one or more of the characteristic properties mentioned below can recognize various types of variants of SARS-CoV2. (a) The VHH binds to Wuhan-Hu-1, delta variant, or micron variant of SARS-CoV2. (b) CDR1, CDR2, and CDR3 include the amino acid sequences represented by SEQ ID NOs: 1, 2, and 3, respectively; and/or (c) the VHH recognizes the amino acid sequence represented by SEQ ID NO: 4 and/or the amino acid sequence represented by SEQ ID NO: 5. This fusion protein which is obtained by fusing the VHH with ACE2 or an Fc form thereof enhances the SARS-CoV2 neutralizing capability and can be used in a pharmaceutical composition for treating or preventing COVID-19.
Absstract of: ZA202301746B
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the etiological agent for coronavirus disease 2019 (COVID-19), has emerged as an ongoing global pandemic. Presently, there are no clinically approved vaccines nor drugs for COVID-19. Hence, there is an urgent need to accelerate the development of effective antivirals. One or more members of the 8-Hydroxyquinoline and Benzylamine structural classes inhibited SARS-CoV-2 infection induced cytopathic effect in vitro, inhibited the exopeptidase activity of angiotensin converting enzyme 2 (ACE2), and disrupted the binding between ACE2 and the Spike protein of SARS-CoV-2. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Absstract of: MA70469B1
La présente invention concerne des anticorps et des fragments de liaison à l'antigène de ceux-ci qui se lient spécifiquement à la protéine de spicule du SARS-CoV-2 et des procédés de fabrication et d'utilisation de ceux-ci. Les anticorps peuvent être utilisés, par exemple, dans la prophylaxie, la prophylaxie post-exposition, ou le traitement d'une infection par le SARS-CoV-2. Les anticorps peuvent également être utilisés pour détecter le SARS-CoV-2, notamment une infection chez un sujet.
Absstract of: US12636282B1
Coronavirus disease of 2019 (COVID-19) is an acute viral infection that can trigger complicated immune system responses depending on the host. This disclosure discloses immunotherapy methods combining immunomodulators and antivirals to prevent and to reduce the severity of a COVID-19 infection. Successful treatment of COVID-19 requires prevention, early recognition and detection, the ruling out of co-infections, serial laboratory monitoring, and clinical monitoring for worsening and timely treatments during the acute phase and post-viral syndrome. Using this disclosure as preventive, management and therapeutic options for COVID-19, infected patients can be more resilient to viral challenges, recovering faster with less organ damages and adverse residual effects.
Nº publicación: WO2026106262A1 21/05/2026
Applicant:
KOREA RESEARCH INST OF CHEMICAL TECHNOLOGY [KR]
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Absstract of: WO2026106262A1
The present invention relates to a biomarker composition for diagnosing asthma caused by SARS-CoV-2 infection, and uses thereof. Through a change in the expression of CDHR3, SCGB3A2, PLAU, or NPY, which are biomarkers according to an embodiment of the present invention, it was confirmed that patients infected with SARS-CoV-2 have a higher incidence of asthma compared with healthy individuals, and thus the biomarker can be widely applied in the fields of diagnosis of SARS-CoV-2-induced asthma and drug screening.
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