Alerta

一种用于缓释药物的4D打印胃滞留制剂及其制备方法与应用

Absstract of: CN121774869A

本发明属于生物医药与先进制造交叉技术领域，具体涉及一种用于药物缓释的4D打印胃滞留制剂。所述的4D打印胃滞留制剂由包含药物和形状记忆聚合物的复合材料经4D打印制成；所述形状记忆聚合物为聚乳酸（PLA）与聚乙烯醇（PVA）的共混物，且所述PLA与PVA的配比被配置为调控所述制剂在胃部环境中的药物释放行为与物理滞留性能；所述的胃滞留制剂设置有第一永久形状和第二临时形状，且第一永久形状可以通过第二临时形状在触发温度下触发得到，所述触发温度为35℃‑40℃。该装置可在人体胃部温度（37℃）和体液环境下被触发，发生从紧凑临时形状到扩张永久形状的转变，且能实现在胃内滞留8h，释药后能安全排出，实现长效胃内滞留和药物控制释放。

一种多生物结构特征的人工血管制造方法

Absstract of: CN121777421A

本发明涉及生物制造与组织工程领域，具体公开了一种多生物结构特征的人工血管制造方法，包括：构建人工血管的参数化模型，所述模型定义了血管的多层生物结构特征并明确其与打印路径的对应关系；基于模型生成控制跨尺度径向3D打印的G代码，通过同一回转轴接收装置及联动控制，在一次成形过程中实现宏观层状结构与微观纤维网络结构的一体化制造。其中，通过失稳态同轴挤出结合网格型紧密路径，精确成形具有波纹力学特性的内外弹性膜；通过螺旋型大导程路径堆积载有平滑肌细胞的毫米级纤维，构建具备收缩功能的中膜；通过网格型宏观近场直写静电纺丝构筑纳米级纤维网络，形成仿生外膜以促进细胞粘附。

用于通过熔融沉积成型3D打印颜色和结构梯度陶瓷的热端

Absstract of: WO2025060867A1

A hot end (16) for a fused deposition modeling (FDM) printer has two entrances for low-fluidity materials that may differ from each other by color and/or structure. Two separate channels (21a, 21b) of the hot end (16) lead from the entrances to a common end at a central tube (25). The two channels (21a,21b) are in the form of two special angle-skewed tubes that meet at their ends and that narrow gradually from the extruders (19') toward their ends. The central tube (25) extends from the ends of the channels (21a, 21b) to an nozzle (26). An SK type static mixer (24) is located in the central tube (25) and a heating unit (11) surrounds the hot end (16). A controller (15) operates the two extruders (19') that supply the low-fluidity materials to the two entrances of the hot end (16) in such a way as to produce ceramic (e.g., zirconia) objects that have 3D color and structural gradients.

正畸矫治牙套及其制作和设计方法

Absstract of: CN121774664A

本发明提供了一种正畸矫治牙套及其制作和设计方法，所述正畸矫治牙套包括牙套本体，所述牙套本体限定了牙齿矫治的目标位置，所述牙套本体中设置有容纳通道，所述容纳通道中设置有与其轮廓相适应的弯丝。所述正畸矫治牙套的制作方法包括：通过3D打印形成牙套初步形体，所述牙套初步形体限定一容纳槽；将与所述容纳槽的轮廓相适应的预制的弯丝放置于所述容纳槽内；在所述牙套初步形体基础上继续通过3D打印形成牙套本体，从而所述弯丝包埋于所述牙套本体中。

一种抗菌钛铜锌合金粉末及其制备方法、和抗菌钛铜锌合金的制备方法

Absstract of: CN121780933A

本发明涉及一种抗菌钛铜锌合金粉末及其制备方法、和抗菌钛铜锌合金的制备方法，属于生物医用金属材料技术领域。所述抗菌钛铜锌合金粉末按质量百分比计包含：Cu 3.0%~6.0%，Zn 0.5%~3.0%，余量为Ti和不可避免的杂质；且本申请采用选区激光熔化技术对抗菌钛铜锌合金粉末进行成型处理，得到抗菌钛铜锌合金，所得到的合金显微组织由α‑Ti相和弥散分布的Ti2Cu相构成，兼具优良力学性能与抗菌性能，抗拉强度890~1350 MPa，断后伸长率3.5%~17.5%，对金黄色葡萄球菌抗菌率达到93.6%。本发明适用于制造齿科种植体、义齿支架等修复体，在提升服役可靠性的同时有效防控术后感染。

SYSTEMS AND METHODS FOR PRINTING THREE-DIMENSIONAL OBJECTS

Absstract of: US20260091555A1

Dental restoration technologies include dental prosthesis components such as implants, abutments, crowns, and the like that are mapped to a patient's mouth prior to and during installation. Fabricating at least a portion of one or more components of the dental prosthesis using a fully calibrated and characterized fabricator can reduce sources of error that affect the success of fabrication and installation processes. The components of the dental prosthesis are represented by library files that are tailored to reflect particular characteristics of the components of the prosthesis to be fabricated, the fabricator, the material used during fabrication, and/or the environment surrounding the fabricator. The library files may be determined based on an acquired scan of the patient and/or based on inputs received from a user during the design process. The library files may be generated using virtual modeling techniques, and/or based on a component design that falls within pre-determined parameters.

PROCESS FOR PREPARATION METHACRYLATED DECM

Absstract of: AU2024328750A1

Process for methacrylation of dECM comprising placing a carbonate buffer with a concentration of 1M in the reaction vessel and heating to a temperature of 50 °C, adding dECM to the carbonate buffer to obtain a dECM solution with a concentration of 4% (w/v), sterilizing this solution by irradiation with radiation UV for 15 minutes, adding methacrylic anhydride in an amount of 0.5 mL/1g dECM and reacting at 50 °C for 1 h, then adding a phosphate-buffered saline solution to obtain a 5-fold dilution of the mixture, placing the obtained solution in dialysis tube, and then placing the dialysis tube in deionized water, this stage is carried out at a temperature of 40 °C for no longer than 4 days, after completing this stage, the solution contained in the dialysis tubes is transferred to aluminum trays and then placed at a temperature -80 °C for at least 3 hours, then the frozen solution is freeze-dried under the following conditions: shelf temperature 10 °C, pressure 0.1 mba, freeze-drying time 48 hours. The invention also relates to methacrylated dECM obtained by the above method and to the use of methacrylated dECM obtained by the above method in the bioprinting process.

SYSTEMS AND METHODS FOR MAGNETIC JOINTS

Absstract of: US20260090892A1

An orthopedic knee prosthesis includes a femoral component, a tibial bearing, a tibial component, a first magnetic portion associated with the femoral component and including a first pole having a first pole polarity the first magnetic portion not physically interrupting any articulating portion of the curved medial condyle surface or curved lateral condyle surface, and a second magnetic portion associated with one or both of the tibial bearing and/or the tibial component and including a second pole having a second pole polarity, the second pole polarity the same as the first pole polarity, the second magnetic portion not physically interrupting any articulating portion of the concave medial bearing surface or concave lateral bearing surface, wherein the first pole and the second pole are in sufficient proximity to each other such that a magnetic repulsive force is present therebetween.

GASTRORETENTIVE DOSAGE FORM FOR PROLONGED DRUG DELIVERY

Absstract of: AU2024327475A1

In this specification, a new design and formulation of an expandable, gastroretentive dosage form is presented where the post-expansion mechanical properties and the drug release rate can be independently controlled. The dosage form generally comprises a drug-laden formulation attached to an expandable, gastroretentive solid.

FLUID-ABSORPTIVE GASTRORETENTIVE DOSAGE FORM FOR PROLONGED DRUG DELIVERY

Absstract of: AU2024327179A1

In this specification, a new design and formulation of an expandable dosage form is presented where the post-expansion mechanical properties and the drug release rate by the dosage form can be independently controlled. The dosage form generally comprises a fluid-absorptive, expandable solid core, a mechanically strengthening semi-permeable layer substantially encapsulating said fluid-absorptive core, and a drug-containing solid applied outside said encapsulated core.

THIOL-ENE HYDROGELS

Absstract of: US20260091161A1

There is provided a hydrogel string for encapsulating a biological material. The hydrogel string has a thiol-ene crosslinked polymer with a first side-chain functionalized backbone polymer functionalized with an activated alkene crosslinked with a free or protected thiol-containing group present on a second side-chain functionalized backbone polymer. The biological material is encapsulated within the thiol-ene crosslinked polymer.

SYNTHETIC HEMOCOMPATIBLE VASCULAR GRAFTS MANUFACTURED FROM POLYVINYL ALCOHOL-BASED BIOMATERIALS

Absstract of: US20260091160A1

Synthetic hemocompatible vascular grafts manufactured from polyvinyl alcohol-based biomaterials containing crystalline segments of polyvinyl alcohol, which are long-term fully functioning vascular grafts that provide no activity towards immune systems in recognizing surfaces as foreign bodies that would normally lead to fibrosis, platelet activation and subsequent thrombi formation, and thus occlusion of the grafts.

Implant and method for covering large-scale bone defects for thorax

Absstract of: AU2026202035A1

Abstract The invention provides an implant for covering a thorax bone defect, comprising: 5 at least one lattice structure of individual lattice cells, each lattice cell comprising one or more ring elements, each ring element comprising a through-hole configured for receiving a fixation device, at least some of the ring elements of each lattice structure 10 being connected via non-linear bridge elements to one another, wherein the implant is made at least predominantly from a plastic material. ar b s t r a c t a r h e i n v e n t i o n p r o v i d e s a n i m p l a n t f o r c o v e r i n g a t h o r a x b o n e d e f e c t , c o m p r i s i n g : a t l e a s t o n e l a t t i c e s t r u c t u r e o f i n d i v i d u a l l a t t i c e c e l l s , e a c h l a t t i c e c e l l c o m p r i s i n g o n e o r m o r e r i n g e l e m e n t s , e a c h r i n g e l e m e n t c o m p r i s i n g a t h r o u g h - h o l e c o n f i g u r e d f o r r e c e i v i n g a f i x a t i o n d e v i c e , a t l e a s t s o m e o f t h e r i n g e l e m e n t s o f e a c h l a t t i c e s t r u c t u r e b e i n g c o n n e c t e d v i a n o n - l i n e a r b r i d g e e l e m e n t s t o o n e a n o t h e r , w h e r e i n t h e i m p l a n t i s m a d e a t l e a s t p r e d o m i n a n t l y f r o m a p l a s t i c m a t e r i a l

NOVEL 3D PRINTING CONCEPT FOR PHARMACEUTICAL DOSAGE FORMS VIA SELECTIVE LASER SINTERING

Absstract of: WO2024240762A1

The present invention relates to a process for producing a Pharmaceutical dosage form by powder bed fusion selective laser 3-dimensional printing, in particular selective laser sintering 3-dimensional printing (SLS), and a pharmaceutical dosage form manufactured by that process.

基于生物力学的正畸矫治器设计方法、系统及正畸矫治器

Absstract of: CN121754330A

本发明公开了一种基于生物力学的正畸矫治器设计方法、系统及正畸矫治器，涉及牙齿矫正技术领域，所述方法包括：获取目标对象的口腔信息，并根据所述口腔信息构建初始牙颌数字模型；根据所述初始牙颌数字模型确定优化咬合关系的目标牙颌数字模型，并根据所述目标牙颌数字模型生成正畸矫治器模型；根据所述初始牙颌数字模型及目标牙颌数字模型分别计算各牙齿的移动轨迹；根据所述移动轨迹修正所述正畸矫治器模型，以在所述正畸矫治器模型的齿槽中形成交替排布的挤压部和避让部。采用本发明，能够使得牙齿自然排齐，同时降低牙根吸收或牙槽骨损伤的风险，保证对牙齿的矫治效果。

一种多材料3D打印仿生梯度软-硬一体化水凝胶及其制备方法和应用

Absstract of: CN121754723A

本发明涉及生物医用材料技术领域，具体涉及一种多材料3D打印仿生梯度软‑硬一体化水凝胶及其制备方法和应用。本发明基于高强度超分子N‑丙烯酰甘氨酰胺与乙烯基磷酸的共聚体系，采用DLP多材料打印技术将NAGA水溶液和NAGA‑VPA水溶液打印成梯度结构的水凝胶，然后依次浸泡于钙磷混合水溶液（Ca/P=1.67）、氨水、氯化钙水溶液和去离子水中，以实现羟基磷灰石（HAP）的原位梯度沉积及熟化。本发明制备的多材料3D打印仿生梯度软‑硬一体化水凝胶具备连续生化‑力学梯度，其中，表层低模量区匹配软骨性能，深层高矿化区整合骨组织，过渡区HAP结晶度呈空间依赖性分布，适用于骨软骨缺损修复及仿生关节假体的制造。

一种用于慢性创面修复的复合型水凝胶敷料及其制备方法和应用

Absstract of: CN121754718A

本发明属于组织工程与创面修复领域，涉及一种用于慢性创面修复的复合型水凝胶敷料及其制备方法和应用，该制备方法包括：S1、将肉桂醛分散在明胶水溶液中，反应充分后透析至溶液澄清；冷冻干燥后得到肉桂醛接枝的改性明胶；S2、将祛褥生肌粉、S1得到的肉桂醛接枝的改性明胶、甲基丙烯化明胶、光引发剂在PBS溶液中混合，得到混合溶液；S3、向S2得到的混合溶液中加入Ga(NO3)3·6H2O溶液，得到水凝胶前驱体溶液；S4、使用S3得到的水凝胶前驱体溶液进行3D打印，光固化，得到复合型水凝胶敷料。本发明中，通过GelMA、CA‑Gel与镓离子形成的三维网络对药粉进行包埋与缓释，实现对慢性创面的高效抗菌、促愈和结构支撑，提升治疗效果与使用安全性。

APARATUS AND METHOD FOR COHERENT IMAGING AND FEEDBACK CONTROL FOR MODIFICATION OF MATERIALS

Absstract of: EP4306235A2

Methods and systems are provided for using optical interferometry in the context of material modification processes such as surgical laser or welding applications. An imaging optical source that produces imaging light. A feedback controller controls at least one processing parameter of the material modification process based on an interferometry output generated using the imaging light. A method of processing interferograms is provided based on homodyne filtering. A method of generating a record of a material modification process using an interferometry output is provided.

3D resin composition for patient-specific 3D printing denture

Absstract of: KR20260042809A

본 발명은 환자 맞춤형 3D프린팅 덴쳐용 레진 조성물에 관한 것으로서, 더욱 상세하게는 광중합방식의 3D프린팅을 이용하여 덴쳐용 의치상을 환자 맞춤형으로 제작할 수 있으면서 생체적합성, 안전성, 물리적 특성이 우수한 레진 조성물에 관한 것이다. 본 발명의 환자 맞춤형 3D프린팅 덴쳐용 레진 조성물은 비스페놀 A 글리세롤레이트 디메타크릴레이트(bisphenol A glycerolate dimethacrylate) 10 내지 20중량%, 비스페놀 A 에톡실레이트 디메타크릴레이트(bisphenol A ethoxylate dimethacrylate) 10 내지 20중량%, 트리에틸렌글리콜 디메타크릴레이트(triethylene glycol dimethacrylate) 5 내지 15중량%, 2-하이드록시에틸메타크릴레이트(2-hydroxyethyl methacrylate)　 5 내지 15중량%, 디우레탄 디메타크릴레이트(diurethane dimethacrylate) 20 내지 40중량%, 광중합개시제 0.1 내지 5중량%, 안료 0.1 내지 5중량%가 혼합되어 조성된다.

3D GUIDE OF REDUCTION FOR CLAVICLE AND BONY TUNNEL AND MANUFACTURING METHOD THEREOF USING 3D PRINTER

Absstract of: WO2024237771A1

The present invention relates to a bone reduction and bone tunnel guide using a 3D printer, and a manufacturing method therefor. The clavicle reduction and bone tunnel guide according to the present invention comprises: a guide body which is located below an acromion and is in close contact with the upper surface of a clavicle to be seated thereon; one or more screw fastening holes which are provided in the guide body, and into which screws for reduction, for fixing the guide body to the clavicle, are fastened; and one or more guide tubes which are provided in the guide body and through which a surgical tool or a suture for reducing the clavicle can enter or exit from the clavicle and a coracoid process or in which a bone tunnel for maintaining the reduced clavicle is formed.

Bioactive implant and method of its production

Absstract of: PL452934A1

Przedmiotem zgłoszenia jest bioaktywny implant zawierający rusztowanie złożone z warstw polimerowych i kompozytowych o budowie włóknistej, które pokryte jest warstwą hydroksyapatytu i wzbogacone w nośnik z substancją biologicznie aktywną, charakteryzujący się tym, że rusztowanie ma strukturę warstwową, na którą składają się warstwy materiału głównego i warstwy materiału elastycznego i w którym to rusztowaniu warstwy materiału głównego stanowią od 50% do 99% ilości wszystkich warstw, tak, że pozostałą ilość warstw stanowią warstwy materiału elastycznego, przy czym materiał główny stanowi kompozyt o osnowie poli (ϵ—kaprolaktonu), o stopniu dyspersyjności w zakresie od 1,7 do 4,3 i maximum piku rozkładu masy cząsteczkowej w zakresie od 40 do 100 kDa, z dodatkiem od 40% wag. do 60% wag. dwufazowej ceramiki fosforanowo—wapniowej, o stosunku masowym hydroksyapatytu i ortofosforanu (V) wapnia 50:50, a materiał elastyczny bazuje na poli(ϵ—kaprolaktonie), o stopniu dyspersyjności w zakresie od 1,7 do 4,3 i maximum piku rozkładu masy cząsteczkowej w zakresie od 40 do 100 kDa, przy czym każda warstwa materiału głównego i materiału elastycznego ma grubość od 0,8% do 0,95% średnicy włókien, z których jest wytworzona, a rusztowanie ma strukturę porowatą, o otwartych porach między włóknami, tworzących trójwymiarową sieć połączonych kanałów, stanowiących od 40% do 80% objętości całkowitej rusztowania oraz zaw

金属玻璃仿生人工骨植入体激光粉末床熔融增材制造方法

Absstract of: CN121732829A

本发明公开了金属玻璃仿生人工骨植入体激光粉末床熔融增材制造方法，属于增材制造技术与生物医用材料技术领域，采用激光粉末床熔融技术，通过三维模型设计、调控激光工艺参数，在不同位置成形具有不同孔隙率的显微组织，从而实现具有梯度孔隙结构的人工骨植入体一体化成形；本发明从三维建模和工艺参数两个角度出发，可在宏观、介观、微观三个层级实现对零件内部孔隙结构的控制，显著提升金属玻璃植入体的能量吸收能力及细胞组织渗透能力，并能有效降低金属玻璃植入体的弹性模量，实现对植入体性能的综合调控，有效缓解应力屏蔽效应，增强金属玻璃植入体整体的稳定性，有助于金属玻璃仿生人工骨植入体在人体骨缺损修复临床治疗中的应用。

用于3D打印用墨水的多肽

Absstract of: WO2025031978A1

The invention relates to a polypeptide that is excellently suited for use in an ink for 3D printing. Furthermore, the present invention also relates to a polynucleotide that encodes the polypeptide according to the invention, and to a host cell that expresses the polypeptide according to the invention. Another embodiment is a method for producing an ink for 3D printing, wherein the ink contains a polypeptide. Additional embodiments relate to methods for producing a 3D scaffold and to the 3D scaffold that can be obtained by said methods, including for use in medicine.

Diagnoseverfahrens-Software

Absstract of: DE102024127337A1

Die Erfindung betrifft eine Diagnoseverfahrens-Software zur Bereitstellung von Daten zur Herstellung einer Kiefer-Gebiss-Schiene für eine Person, wobei ein Ist-Zahnraum-Zustand und/oder Zahnstellung (1) und eine Ist-Kieferfunktion (2) erfasst werden, wobei- eine Ist-Körperhaltung (3) erfasst wird, und- ein Ist-Fußflächendruck (4) erfasst wird, und- der Ist-Zahnraum-Zustand und/oder Zahnstellung (1) mit einem Soll-Zahnraum-Zustand und/oder Zahnstellung (11) abgeglichen wird, um eine erste Abweichung (a) zwischen dem Ist-Zahnraum-Zustand (1) und dem Soll-Zahnraum-Zustand (11) zu ermitteln,- die Ist-Kieferfunktion (2) mit einer Soll- Kieferfunktion (12) abgeglichen wird, um eine zweite Abweichung (b) zwischen der Ist-Kieferfunktion (2) und der Soll-Kieferfunktion (12) zu ermitteln,- die Ist-Körperhaltung (3) mit einer Soll-Körperhaltung (13) abgeglichen wird, um eine dritte Abweichung (c) zwischen der Ist-Körperhaltung (3) und der Soll-Körperhaltung (13) zu ermitteln,- der Ist-Fußflächendruck (4) mit einem Soll-Fußflächendruck (14) abgeglichen wird, um eine vierte Abweichung (d) zwischen dem Ist-Fußflächendruck (4) und dem Soll-Fußflächendruck (14) zu ermitteln, wobei- die erfassten Daten zur Herstellung der Kiefer-Gebiss-Schiene genutzt werden, geeignet um die Abweichungen (a, b, c, d) zu verringern.

FORMULATIONS AND DESIGNS FOR DEGRADABLE SOFT TISSUE IMPLANTS

Nº publicación: WO2026062643A1 26/03/2026

Applicant:

COLLPLANT LTD [IL]
COLLPLANT LTD

Absstract of: WO2026062643A1

A photocurable formulation usable in additive manufacturing a three-dimensional object is disclosed. The formulation features, in at least a portion thereof, a biological or a biocompatible material, the photocurable formulation comprising a photoinitiator, a photocurable biological or biocompatible material, and a carrier, the formulation further comprising at least two photocurable polymeric materials. Implants comprising same are also disclosed.