Absstract of: CN120000611A
The invention discloses a microalgae exosome nano-particle for targeting liver cancer tissue and a preparation method thereof, and belongs to the technical field of biomedical materials, the method comprises the following steps: (1) preparing a microalgae cell exosome by combining an ultracentrifugation method, an ultrafiltration method and a size exclusion method, microalgae cells being chlorella cells or synechocystis cells, and the particle size of the microalgae cell exosome being 30-150nm; and (2) loading an immune checkpoint inhibitor into the microalgae cell exosome by an electroporation method to obtain a drug-loaded microalgae exosome, and carrying out membrane fusion on a liver tumor cell membrane and the drug-loaded microalgae exosome to prepare the microalgae exosome nanoparticles targeting the liver cancer tissue. The prepared microalgae exosome nanoparticles have the advantages of good liver cancer tissue targeting property, good biological safety and exact and accurate drug curative effect, and have wide application prospects in tumor treatment.
Absstract of: CN222877925U
The utility model discloses a floating algae culture device, which belongs to the technical field of microalgae biology and comprises a floating component floating on a water body, a microalgae fixing part used for fixing microalgae is arranged in the floating component, a feed port is arranged on one side of the floating component and connected with a feed pump through a feed pipe, and a discharge port is arranged on the other side of the floating component and connected with the feed pump through a discharge pipe. The discharging port is connected with a discharging pipe, and a transparent protective film is arranged above the floating assembly. The floating assembly is placed in a water body, microalgae are attached to the microalgae fixing piece before production, then the feeding pump is started, waste water rich in nitrogen and phosphorus enters the floating assembly sequentially through the feeding pump, the feeding pipe and the feeding port, and the waste water is discharged back to the water body again through the discharging port and the discharging pipe after passing through the microalgae fixing piece attached with the microalgae. Nitrogen and phosphorus in the wastewater are absorbed by the microalgae, so that the production requirements of the microalgae can be met, and the wastewater can be treated; the device has the advantages that the occupied area is not wasted, the equipment investment is reduced and the like.
Absstract of: CN120000623A
The invention discloses a multifunctional microneedle patch as well as a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations. The multifunctional microneedle patch comprises a substrate layer and a microneedle array, the microneedle array is arranged on the substrate layer, the microneedle array is loaded with microalgae exosomes and copper sulfide nanoparticles, the hydrogel material is used for encapsulating the microalgae exosomes and the copper sulfide nanoparticles to prepare the microneedle patch, and the microneedle patch has the advantages that the microneedle patch is used for preparing the microneedle patch; the microalgae exosome has a treatment effect of repairing radiation injury, the copper sulfide nanoparticles have a photoresponsive anti-infection effect, and the microneedle structure has the advantages of minimally invasive, painless and slow release of drugs, so that local surface and deep tissues maintain ideal drug concentration in a certain period of time. The multifunctional microneedle patch disclosed by the invention has good biocompatibility, is simple and feasible in preparation process, is easy to store and use, and has a wide application prospect in the field of radioactive injury.
Absstract of: CN120004656A
The invention relates to the technical field of microbial fertilizers, in particular to a microalgae biological fertilizer and a preparation method and application thereof, and the method comprises the following steps: step 1, algae liquid inoculation, step 2, graded propagation cultivation, step 3, algae cell screening, step 4, compounding and mixing, and step 5, finished product preparation. According to the invention, the microalgae such as the terriella variabilis, the small monofidus algae and the chlorella pyrenoidosa are adopted and combined with the microalgae biological fertilizer prepared by the preparation method disclosed by the invention, so that the competition of the microalgae for nutrients can be reduced, meanwhile, the nutrients can be better produced, and the growth of crops is facilitated.
Absstract of: CN120005729A
The invention relates to the technical field of plant preservation, and discloses a method for preserving microalgae plants. The invention aims to improve the existing microalgae plant preservation method, especially the preservation method for bait microalgae, so as to solve the problems that the existing microalgae preservation time is short, nutritional ingredients are lost after preservation, the activity is reduced and the like. According to the microalgae preservation method, choline chloride is added to maintain the balance of a carbon source and a nitrogen source in a culture medium, nickel salt is added to promote the activity of algae photosynthetic pigments in a stable period, and the purpose of prolonging the preservation time and activity of algae is achieved. The microalgae preserved by the method disclosed by the invention can be preserved for a longer time on the premise of the same activity, and has higher activity on the premise of the same preservation time, and the activity of the microalgae preserved by the method is several times of that of microalgae preserved by a conventional method. The microalgae plant preservation method does not use toxic and expensive reagents, is environment-friendly, and can greatly promote the popularization and application of the microalgae industry.
Absstract of: CN222877916U
The utility model discloses a microalgae culture device for strong light, which belongs to the technical field of microalgae biology and comprises a light source system and a microalgae culture system, the light source system comprises a high-power LED lamp, a condenser, a light guide optical fiber and a light guide plate, and the high-power LED lamp converges light through the condenser and transmits the light to the light guide plate through the light guide optical fiber; and the light guide plate is arranged in the microalgae culture system. Microalgae liquid is placed in the cultivation device, the light source system provides strong light for the cultivation device, the high-power LED lamp gathers light through the condenser and transmits the light to the light guide plate through the light guide optical fiber, the light guide plate evenly disperses the light, light and heat are separated, only light is guided into the cultivation system, and the trouble of too high temperature is avoided. The device disclosed by the utility model can meet the production and application requirements of strong-light microalgae.
Absstract of: CN222877929U
The utility model relates to the technical field of marine microalgae culture, and discloses a marine microalgae culture device which comprises an S-shaped culture tube, the S-shaped culture tube is arranged in an S shape, and the two ends of the S-shaped culture tube are open. By arranging the S-shaped culture tube, the S-shaped culture tube can be used for culturing marine microalgae, meanwhile, the S-shaped culture tube is of an S-shaped design, openings in the two ends of the S-shaped culture tube can be used for adding sterilized seawater, releasing algae species, inflating oxygen and the like, cultured bait can be discharged through the arrangement of the discharge port, and algae which sink to the bottom and die can be cleaned in time; the cover body can seal the discharge port, cultured baits or algae which are cleaned to be dead at the bottom can directly fall into the material bearing box at the bottom after being discharged from the discharge port, after the materials are collected by the material bearing box, the buckle is pushed open by a hand, the clamping state of the buckle and the material bearing box is relieved, and therefore the material bearing box can be pulled out from the bottom of the S-shaped culture tube, and the culture tube can be conveniently and rapidly taken out from the bottom of the S-shaped culture tube. And the device is convenient to clean.
Absstract of: WO2025100941A1
The present invention provides Dunaliella salina microalgae having the ability to produce beta-carotene at a NaCl concentration of 0.1M or less. In addition, the present invention provides a method for producing beta-carotene, comprising a step of culturing the Dunaliella salina microalgae.
Absstract of: WO2025101437A1
In an aspect, the disclosure provides methods for making LC-PUFA and VLCFAs in a host organism. The LC-PUFA and VLCFAs can be new chemical entities, well-known LC-PUFA, and derivatives of LC-PUFA as well as VLCFAs. The host cells can be microalgae, fungi or other host cells. In a related aspect, the disclosure provides host cells engineered to have biochemical pathways for making LC-PUFA and VLCFAs.
Absstract of: WO2024008896A1
The present invention relates to an engineered unicellular Stramenopile microalga comprising a loss of function of the homologous Seipin gene, an in vitro method of producing triacylglycerols (TAG), and uses thereof.
Absstract of: EP4553150A1
The present invention relates to a cell culture composition containing an extract from microalgae of the Thraustochytrid family. It has been found that when muscle cells are cultured in a medium containing an extract derived from the biomass of microalgae belonging to the Thraustochytrid family according to the present disclosure, the proliferative capacity of muscle cells is enhanced. Therefore, the cell culture composition including the microalgae extract can be used as a substitute for fetal bovine serum among the components of cell culture media.
Absstract of: CN222861292U
The utility model relates to the technical field of sewage treatment, in particular to a multi-stage ecological pig raising wastewater treatment system, which comprises an anaerobic baffled reactor, an anaerobic baffled reactor, an anaerobic baffled reactor and an anaerobic baffled reactor, a plurality of partition walls are arranged in the anaerobic baffled reaction tank and are divided into a plurality of independent anaerobic baffled reaction chambers, water passing pipes are arranged at the upper parts of the partition walls, and sewage sequentially flows among the anaerobic baffled reaction chambers through the water passing pipes; mud guide inclined walls are arranged on two sides of the bottom of the anaerobic baffling reaction tank; a settling mud inclined wall is arranged below the water outlet of the anaerobic baffling reaction tank; the multi-stage reverse-flow anaerobic biological filtration unit is communicated with the anaerobic baffling reaction tank; comprising a plurality of filter chambers filled with filler, and the filter chambers are sequentially communicated through water passing holes which are formed in a high-low staggered manner; the aerobic ecological purification system comprises a middle water tank, and part of effluent of the middle water tank flows back to the anaerobic baffled reactor and the microalgae purification tank. The device is friendly to ecological environment, low in energy consumption, small in dosage, low in operation cost and simp
Absstract of: CN119979332A
The invention belongs to the technical field of microalgae culture, and particularly provides a haematococcus pluvialis culture medium and a preparation method thereof.The haematococcus pluvialis culture medium is prepared from 1-3 mg/L of sodium acetate, 0.01-1 mg/L of cobalt nitrate hexahydrate, 0.01-1.6 mg/L of copper sulfate, 0.1-1.2 mg/L of zinc sulfate heptahydrate, 1-3 mg/L of manganese chloride tetrahydrate, 1-10 mg/L of boric acid, 1-30 mg/L of sodium carbonate, 1100-1500 mg/L of sodium nitrate, 0.01-6 mg/L of EDTA, 20-50 mg/L of calcium chloride, 70-100 mg/L of magnesium sulfate heptahydrate, 40-100 mg/L of monopotassium phosphate trihydrate and 0.02 g of inorganic phosphorus; the method comprises the following specific steps: S1, culturing haematococcus pluvialis to a stable phase by a conventional method, inoculating haematococcus pluvialis species into a haematococcus pluvialis culture medium, and culturing; s2, shaking table; s3, culturing for 45 hours; s4, inoculating the seed solution into a haematococcus pluvialis culture medium, and continuously culturing in the shaking table for 6-15 days; the culture medium disclosed by the invention has a good promotion effect on the growth of haematococcus pluvialis and the accumulation of astaxanthin.
Absstract of: CN119979414A
The invention relates to application of boron nitride in microalgae culture and a method for culturing microalgae, which comprises the step of adding boron nitride into a culture system. By constructing a hexagonal boron nitride-cyanobacteria co-culture system and combining the carbon dioxide adsorption performance of a nano material and the biological directional synthesis capability of cyanobacteria, more efficient carbon dioxide capture and conversion are realized, and meanwhile, the growth speed and biomass of cyanobacteria and the yield of a target product are also improved. The innovative strategy not only can enhance the photosynthetic carbon sequestration efficiency of cyanobacteria, but also provides a new technical route for promoting green and low-carbon development, and gives consideration to both high economic benefit and low-carbon environmental protection.
Absstract of: CN119977172A
The invention relates to application of synechocystis in removal of cadmium ions and a method for reducing cadmium ions in an environment, and the method comprises a step of culturing synechocystis in the environment. By means of the method, the concentration of free-state cadmium ions in the environment can be reduced to about 10 micrograms/L, and cadmium in the environment is greatly reduced after cadmium particles outside microalgae and cells are removed. Although the concentration of cadmium ions which can be treated by the method provided by the invention is relatively low and is 1mg/L or below, the concentration of the cadmium ions in the supernatant can be finally reduced to a very low value, so that the method can be used for further cadmium removal after primary cadmium removal of a water sample, and extremely low cadmium emission is realized.
Absstract of: CN119998442A
The present invention relates to a cell culture composition comprising an extract of thraustochytriaceae microalgae. It has been found that the proliferative capacity of muscle cells is enhanced when the muscle cells are cultured in a culture medium according to the present disclosure comprising an extract derived from a microalgae biomass belonging to the Thraustochytridae family. Thus, the cell culture composition comprising the microalgae extract can be used as a substitute for fetal calf serum in the cell culture medium component.
Absstract of: CN119970620A
The invention provides RU.521-EVs anti-radiation nanogel as well as a preparation method and application of the RU.521-EVs anti-radiation nanogel. The RU.521-EVs anti-radiation nanogel is a nanogel obtained by loading microalgae-derived extracellular vesicles and a small molecule compound RU.521 on chitosan nanoparticles formed by cross-linking chitosan, and the extracellular vesicles and the small molecule compound RU.521 are derived from microalgae. The RU.521-EVs anti-radiation nanogel has higher adhesion and permeability in the lung and effectively releases RU.521 and EVs, the RU.521 and EVs can synergistically play anti-inflammatory and anti-oxidation roles, local anti-oxidation and anti-inflammatory defense reactions of the lung are effectively started, the excellent anti-radiation effect is shown, and the RU.521-EVs anti-radiation nanogel can be used for preventing and treating radiation-induced lung injury.
Absstract of: KR20250066401A
본 발명은 0.1M 이하의 NaCl 농도에서 베타카로틴 생산 능력을 갖는, 두날리엘라 살리나(Dunaliella salina) 미세조류를 제공한다. 또한 본 발명은 상기 두날리엘라 살리나 미세조류를 배양하는 단계를 포함하는, 베타카로틴 생산방법을 제공한다.
Absstract of: CN119979626A
The invention discloses a method for assisting microalgae oil production by nitrogen-fixing bacteria and treating fermentation waste gas at the same time. The method comprises two stages of microalgae breeding and co-culture oil production. In the breeding stage, the microalgae take CO2 in fermentation waste gas which is not pretreated as a carbon source, and high-density culture is realized in a nitrogen-containing culture medium. When the nitrogen source in the culture medium is consumed, inoculating multifunctional nitrogen-fixing bacteria into a culture system and co-culturing with the microalgae. Nitrogen in the fermentation waste gas is converted into a nitrogen source of the microalgae under the action of nitrogen-fixing bacteria, so that the concentration of the low nitrogen source is maintained to promote the microalgae to produce oil, and secretions mainly comprising extracellular polymeric substances and volatile organic compounds derived from the fermentation waste gas, which are generated by microalgae culture, are decomposed. Effective treatment of fermentation waste gas and high-density culture of microalgae are achieved, the oil content of the microalgae is increased, culture water can be repeatedly used by reducing the content of residual organic matter and total nitrogen, the problem that the amount of microalgae culture wastewater is large is solved, and good environmental benefits and application prospects are achieved.
Absstract of: CN119949439A
The invention discloses a feed for improving the quality of semen of an old boar and an application of the feed. The feed disclosed by the invention is prepared from the following components in parts by weight: 8 to 10 parts of corn, 18 to 23 parts of red sorghum, 37 to 43 parts of hulled barley, 12 to 17 parts of bran, 0.5 to 1.5 parts of functional fiber, 7 to 9 parts of soybean meal, 1.5 to 2.5 parts of fish oil or microalgae powder, 1.3 to 1.4 parts of mountain flour, 1 to 1.2 parts of monocalcium phosphate, 0.4 to 0.5 part of sodium chloride, 0.2 to 0.3 part of lysine, 0.1 to 0.15 part of L-threonine, 0.1 to 0.15 part of choline chloride, 1 to 1.5 parts of betaine and 0.5 to 1 part of a premix for boars. After the feed is applied, the total effective sperm number of the aged boars is remarkably increased, the sperm motility and form are improved, the breeding age limit is prolonged, the production value is increased, and the biological safety risk caused by the high renewal rate is reduced.
Absstract of: KR20250064315A
실내 공기질 개선을 위한 미세조류 배양 및 수확장치에 관한 것으로서, 보다 구체적으로, 상기 미세조류 배양 및 수확장치는 각각 별도로 설치된 미세조류 배양기, 배수부 및 건조부를 포함함으로써 보다 간편하게 미세조류를 배양하고 이를 수확하는 것에 특징이 있다.
Absstract of: CN119954907A
The invention relates to the technical field of biology, in particular to a marine microalgae-derived antibacterial oligopeptide and application thereof. The antibacterial oligopeptide is Qz5707, Qz16317, Qz1933 or Qz13244 which is derived from marine microalgae, and the antibacterial oligopeptide is prepared from the marine microalgae; and modifying any one or more amino acids in the oligopeptide to obtain a sequence. The antibacterial oligopeptide disclosed by the invention has relatively strong antibacterial activity and wide antibacterial spectrum, can be applied to aquatic feed additives and food preservatives, and can also be developed into antibacterial agents, antibacterial drugs and the like, so that the antibacterial oligopeptide has a wide application prospect.
Absstract of: CN119954315A
The invention relates to the technical field of biological sewage treatment, in particular to a water treatment optimization method and system based on microalgae growth prediction. Acquiring a real-time water quality pollution parameter set and real-time water environment data of the target water treatment area, constructing a real-time water environment simulation field by using the real-time water environment data, simulating and generating a microalgae future growth model through the real-time water environment simulation field, and performing spatial hash coding analysis and optimization treatment on the polluted water quality of the real-time water quality pollution parameter set; and combining the real-time water quality pollution parameter set and the real-time water environment data to construct a real-time water quality pollution scale thermal model of the target water treatment area, and querying and judging whether the water quality pollution scale of the local water treatment area is abnormal or not through the real-time water quality pollution scale thermal model to execute sewage treatment of microalgae growth regulation. According to the invention, corresponding water treatment operation can be carried out by analyzing the sewage purification performance of microalgae growth, so that water treatment rationalization is ensured, and the water quality is effectively improved.
Absstract of: CN119955871A
The invention belongs to the technical field of microalgae oil biosynthesis, and discloses a method for improving microalgae oil accumulation through mannose induction. The invention relates to application of mannose in culturing microalgae to improve oil accumulation of the microalgae. The concentration of the mannose in a culture medium is not lower than 0.5 g/L. Specifically, the method comprises the following steps: inoculating a microalgae seed solution into a culture medium containing mannose for inducing grease accumulation culture; or firstly inoculating the microalgae seed solution into the culture medium for culture, and then adding mannose into the culture medium for continuous culture in the culture process, so that the accumulation of the microalgae grease is improved by utilizing the mannose. The invention reveals that the grease accumulation of the microalgae can be improved when the mannose is applied to microalgae culture for the first time, and the grease content of the microalgae under different environmental conditions and growth states can be simply, flexibly and quickly induced and improved by using the concentration of the mannose which is not lower than 0.5 g/L.
Nº publicación: CN119968116A 09/05/2025
Applicant:
KAI MING SOIL CO LTD
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Absstract of: CN119968116A
Systems and methods for growing microalgae, preferably Chlorella genus (Chlorella sp.), capable of metabolism of mixed nutrition. Microalgae grown in a system using the method can survive and grow in dark refrigeration, which enables the algae to be stored and transported for application as live cultures. Furthermore, the microalgae can grow in sufficient amounts for commercial sales for application as a biostimulant to crops.