Alerta

APPARATUS AND METHODS FOR USE WITH IMAGE-GUIDED SKELETAL PROCEDURES

Absstract of: US20260335013A1

0000 A tool (538) is advanced along an insertion path (542) into a skeletal portion within a body of a subject. 3D image data of the skeletal portion is acquired using a 3D imaging device. The tool is positioned at a location along the insertion path and a 2D x-ray of the at least a portion of the tool and the skeletal portion is acquired using a 2D x-ray imaging device. Using at least one computer processor (22), the single 2D x-ray is registered to the 3D image data. The computer processor reconstructs a 3D location of the tool with respect to the skeletal portion based on the at least a portion of the tool in the single 2D x-ray that is registered to the 3D image data, and generates an output, at least partially in response thereto. Other applications are also described.

CELL MACROENCAPSULATION DEVICES, METHOD OF FABRICATION AND USE THEREOF

Absstract of: US20260337551A1

It is provided a cell macroencapsulation device for implanting cells in a recipient comprising cells encapsulated in a porous membrane, wherein the porous membrane consists of a sugar network coated with a polymeric solution comprising porogen, which can be used as a graft to transplant islets while protecting the graft from the immune system as well as providing enhanced convection and diffusion to ensure long-term cell survival and physiological insulin delivery.

APPARATUS AND METHOD FOR SUBJECT MONITORING AND DIAGNOSING WITH NON-INVASIVE MEASURES

Absstract of: US20260334885A1

An apparatus and method for subject monitoring and diagnosing with non-invasive measures are disclosed. The apparatus includes a memory contains instructions configuring at least a processor to receive non-invasive measurement data associated with a subject, wherein the non-invasive measurement data comprises electrocardiogram (ECG) data received from an ECG machine and echocardiogram (echo) data received from an echocardiogram device, and extract at least an ECG feature of the ECG data and at least an echo feature of the echo data, generate a synthetic computed tomography (CT) image of the subject as a function of the fused non-invasive measurement datum, wherein the synthetic CT image is generated without using CT imaging data or magnetic resonance imaging (MRI) imaging data of the subject as an input, and transmit the synthetic CT image to a remote device.

SYSTEMS AND METHODS FOR IMPLEMENTING AN INDIVIDUALIZED DRUG DELIVERY PROFILE FOR A RECIPIENT OF A COCHLEAR IMPLANT SYSTEM

Absstract of: US20260341452A1

An exemplary system comprises a memory that stores instructions and a processor communicatively coupled to the memory and configured to execute the instructions to perform a process. The process may comprise generating, based on a recipient-specific anatomical structure of a cochlea of a recipient of a cochlear implant system and historical procedure data associated with one or more previously performed lead insertion procedures, an individualized drug delivery profile for the recipient; and controlling, in accordance with the individualized drug delivery profile for the recipient, a release of a drug from a stimulating portion of a stimulating lead within the recipient based on a command transmitted to a cochlear implant that includes the stimulating lead.

ROBOTIC ENCODING SYSTEM AND METHOD

Absstract of: US20260336889A1

0000 A lockable container encoding system and method is disclosed. The lockable container encoding system is for use in the manufacture of encodable lockable containers, wherein the encodable lockable container comprises an annular sidewall having a plurality of annular rings, the annular rings having an inner and outer surface, the inner surface featuring a plurality of selectable removable tabs for the encoding of lockable containers. The lockable container encoding system includes a tumbler for receiving unencoded encodable lockable containers, a receptor having a sidewall dimensioned and configured to hold a plurality of encodable lockable containers, a first articulating arm comprising a plurality of ring manipulators, a vision system in communication with the ring manipulators to monitor the physical position of the plurality of annular rings of the encodable lockable container, and a second articulating arm comprising a plunger having a shearing blade; wherein the shearing blade comprises guide rails couplable to the shearing blade, wherein the shearing blade removes a plurality of selected removable tabs from an unencoded lockable container to encode the container.

WEARABLE DEVICE FOR NON-INVASIVE MONITORING OF INTRACRANIAL PRESSURE THROUGH OPHTHALMIC BIOMARKERS

Absstract of: WO2026226212A1

A wearable device for non-invasive monitoring of intracranial pressure includes a wearable structure configured to be secured to a head of a user; an ultrasound transducer positioned to align with an eye of the user when worn; a motorized control mechanism that dynamically adjusts a position and angulation of the ultrasound transducer; a fluid management system that maintains an acoustic coupling between the ultrasound transducer and the eye of the user; an integrated air vent system to regulate pressure, prevent condensation, and maintain imaging quality within the wearable structure; and a processor coupled to the ultrasound transducer. The processor is to employ a reinforcement learning-based control system for optimizing transducer placement; acquire ultrasound images of an optic nerve sheath; analyze the ultrasound images to measure an optic nerve sheath diameter (ONSD); and determine a likelihood of elevated intracranial pressure based on the measured ONSD.

INTELLIGENT INFUSION BASED ON ANTICIPATING PROCEDURAL EVENTS

Absstract of: US20260334872A1

0000 An intelligent control device provides an option to select a medical procedure and receives a selection of the medical procedure. The intelligent control device also operates an infusion device to administer a medication at a first rate. Further, the intelligent control device identifies a set of events associated with the selected medical procedure, including a procedural event expected to cause a physiological change for which an administration of the medication is prescribed. Moreover, the intelligent control device determines that the procedural event is about to occur based on the infusion information, the physiological information, or the selected medical procedure. After determining that the procedural event is about to occur, and before the procedural event occurs, the intelligent control device prompts an operator to cause an adjustment of the infusion device to administer the medication at a second rate; or the intelligent control device causes the adjustment of the infusion device.

TECHNOLOGY FOR INEXPENSIVE AND QUANTIFIED ASSESSMENT OF INFANT SUCKLING BEHAVIOR

Absstract of: US20260334811A1

Provided herein is a method for evaluating infant suckling behavior, comprising: collecting suckling data from an infant using a vacuum measurement device, transmitting the collected suckling data to a processor, processing the collected suckling data by the processor using a pre-trained Machine Learning (ML) algorithm to identify one or more abnormalities in the infant's suckling behavior, wherein the ML algorithm has been trained on a set of training data comprising a plurality of dimensions associated with the training data, and wherein the identified one or more abnormalities are corresponding to one or more of the plurality of dimensions.

BIOMATERIAL-INK FOR 3D PRINTING

Absstract of: US20260335503A1

Three-dimensional (3D) bioprinting has tremendous potential to aid in the creation of engineered tissues and organs that are so desperately in need. In this disclosure, a new type of bio-ink for 3D bioprinting made of sheared slurries of biomaterial hydrogel, in particular alginate hydrogel having micro-capillary structure (Capgel), in particular Capgel having increased stackability and thus self-assembly capability through the formation of a polyelectrolyte complex “skin” on the outer surfaces of the Capgel block with poly-L-lysine (PLL) coating prior to printing needle extrusion is provided as injectable biomaterial tissue scaffolding system, so that such stackable structure as weave patterns and cylindrical structures can be successfully printed with the new Capgel bio-ink. Further, the micro-capillary structure inherent in the original Capgel blocks is retained in the printed bio-ink making up the larger 3D structures and allows for cell culture in it.

SYSTEM AND METHOD FOR ANALYTE MONITORING

Absstract of: AU2025257886A1

Apparatuses, systems, and methods for autonomously-initiated analyte measurements and/or calculation of analyte concentrations based on the analyte measurements. An apparatus (e.g., an analyte sensor or a sensing device of the analyte sensor) may be configured to take and sets of sensor measurements at a first frequency having a period equal to a threshold number of cycles of the clock. The stored sets of sensor measurements may include first sets of sensor measurements at the first frequency and second sets of sensor measurements at a second frequency, and the first frequency is greater than the second frequency. Another apparatus (e.g., a transceiver, display device, and/or data management system) may be configured to receive sets of sensor measurements conveyed by the analyte sensor, calculate time stamps for the sets of sensor measurements, and calculate analyte concentrations based on the sets of sensor measurements and the calculated time stamps.

METHODS OF ASSESSMENT OF PRE-CLINICAL ALZHEIMER'S DISEASE

Absstract of: AU2025258407A1

Described herein are methods of assessing the risk of dementia in a subject using an odor-based test, or "smell test". These methods can be self-administered by the subject under the instruction of a computing device via a user interface. Methods of administering a smell test as described herein can optionally be combined with measuring and quantifying the level of at least one biomarker for dementia (e.g., CXCL10, CCL2, IL-6) in a biological sample collected from the subject. Also provided are methods to treat dementia (e.g., dementia associated with Alzheimer's disease, dementia associated with a subset of Alzheimer's disease patients with TDP-43 pathology).

METHODS OF TREATING TRAUMATIC ENCYPHALOPATHY SYNDROME

Absstract of: US20260335333A1

0000 Disclosed is a method of treating traumatic encephalopathy syndrome (TES) in a patient in need thereof by administering a therapeutically effective amount of a rho-kinase inhibitor. In one embodiment, the rho-kinase inhibitor is fasudil.

ACCESSORY DOCK FOR WIRELESS MEDICAL ACCESSORIES

Absstract of: US20260335663A1

0000 An accessory dock is described, the accessory dock for docking wireless accessories that are configured to be used with a medical device. The accessory dock has at least one docking receptacle configured to receive a wireless accessory. In some examples, the wireless accessory receives power from the medical device upon being positioned within a threshold distance of the medical device to charge a battery of the wireless accessory. In some examples, the wireless accessory pairs with the medical device upon being positioned within a threshold distance of the medical device. In some examples, a processor of the medical device causes performance of an accessory health check upon the wireless accessory being docked in the docking receptacle, the accessory health check for determining a readiness of the wireless accessory.

TECHNIQUES FOR BIOFEEDBACK USING HEART RATE DATA

Absstract of: US20260341516A1

Methods, systems, and devices for biofeedback are described. A user device may acquire physiological data associated with a user from a wearable device. The user device may select a feedback response that may include one or more of audio, haptic, or visible light feedback. The user device may determine parameters for the feedback response. The parameters may include one or more of a magnitude, a duration, or a frequency, associated with one or more of the audio, haptic, or visible light feedback. The user device or the wearable device may output the feedback response indicative for regulating the physiological data associated with the user.

MOTORIZED STRUT WIRELESS COMMUNICATION

Absstract of: US20260334977A1

A spatial frame apparatus for positioning on a patient to treat an injury. The apparatus includes a frame having one or more motor modules including one or more motorized struts. One or more motorized struts include one or more motors configured to cause movement of one or more motorized struts in one or more directions in accordance with one or more treatment plans. At least one motor module is wirelessly coupled to at least another motor module. The motor modules include one or more processing components communicatively coupled to one or more motorized struts and/or one or more motors. The processing components execute at least one adjustment of one or more motorized struts based on the treatment plans and in accordance with one or more wireless signals received from one or more motor modules and/or one or more external devices communicatively coupled to one or more motor modules.

DYNAMIC ALLOCATION FOR MULTI-PUMP BOLUS VOLUMES

Absstract of: US20260335546A1

Certain aspects of the disclosure provide infusion systems and methods for generating an infusion plan for a set of infusion devices. For example, the method may include receiving an infusion order for a patient, determining the infusion order exceeds a bolus threshold, and identifying a set of infusion devices associated with the patient. The method may further include generating an infusion plan for the set of infusion devices based on the infusion order and adjusting one or more operational parameters of the set of infusion devices according to the infusion plan.

SYSTEMS AND METHODS FOR DETECTING CONDUCTION ABNORMALITIES

Absstract of: WO2026226845A1

In some embodiments, a method for detecting an abnormality in a conduction system of a patient includes receiving one or more cardiac activity signals associated with a heart of the patient, analyzing the one or more cardiac activity signals with a machine learning model to predict presence of a conduction system abnormality in the patient, and generating instructions to display an indication of the presence of the conduction system abnormality. For example, rather than a full 12-lead ECG set, one or two ECG leads and/or one or two EGM sensing vectors can be used, in combination with a machine learning algorithm, to classify the ECG signals indicative of a conduction system abnormality or not. Such diagnostic functionality can, for example, be advantageous in determining whether the patient needs a device upgrade or therapy adjustment.

METHODS AND SYSTEMS FOR PREDICTING RISK OF VERTEBRAE FRACTURE

Absstract of: WO2026226625A1

Provided herein is a computer-implemented method for predicting risks of vertebrae fracture in a patient. A computer-implemented method may include obtaining image data of a patient. A computer-implemented method may include identifying one or more vertebrae of the image data. A computer-implemented method may include analyzing, by a machine learning model, the one or more vertebrae to predict a future risk of vertebrae fracture of the one or more vertebrae for the patient, wherein the machine learning model is trained on a cohort of a population comprising at least one radiation naïve patient and wherein the analysis comprises processing features of the one or more images, the features comprising radiomic features, wherein the radiomic features correlate to a structural integrity of one or more segments of the one or more vertebrae.

MACHINE LEARNING SYSTEMS FOR IDENTIFYING BIOMARKERS IN TARGET CELLS AND METHODS OF TREATING A CANCER BY ADMINISTERING GILTERITINIB, ABEMACICLIB, CRIZOTINIB, BRIGATINIB, DASATINIB, OR DERIVATIVES THEREOF

Absstract of: WO2026226504A1

Described herein are methods of administering small molecules to reduce the proliferation or expansion of cancer educated or tumor educated immune cells. The small molecules may be administered alone or in combination and include, but are not limited to, gilteritinib, abemaciclib, crizotinib, brigatinib, dasatinib, SGI-7079, LDN193189, X-376, bortezomib, fedratinib, sorafenib, bosutinib, enasidenib, entrectinib, dubermatinib, vorinostat, STAT3-IN-7, and STAT3-IN-12.

AUTOMATED ROUTING OF CYTOLOGICAL SMEARS FOR SELECTIVE HUMAN REVIEW BASED ON AUTOMATIC CELL CLASSIFICATION

Absstract of: WO2026224675A1

Clinical laboratories face a growing mismatch between rising cytological smear volumes and limited specialist capacity. Methods and systems are disclosed for managing the human review workload associated with cytological smear analysis. An automatic cell classifier determines, from images of cytological smears obtained from multiple patients, hematological cell or cell type quantification metrics (HCQMs) for multiple abnormal cell types. The metrics are compared against respective predetermined thresholds, and samples are selectively presented or not presented as part of a default human review workflow based on the resulting pattern of threshold crossings, so that samples sharing the same count of crossings can be routed differently according to which abnormal cell types are involved. Performance of the automatic cell classifier may be monitored over time by comparison with human review results, and one or more thresholds are increased when performance improves beyond a predetermined level, reducing review volume while maintaining analysis quality.

METHOD AND APPARATUS FOR SIMULATING RIB CONTOUR AND PREDICTING RIB ORTHOPEDIC SURGERY RESULT

Absstract of: WO2026222918A1

The present invention relates to the field of surgical plan effect prediction, and in particular, to a method and apparatus for simulating a rib contour and predicting a rib orthopedic surgery result. A method for predicting a thoracic surgery result is characterized by comprising the following steps: constructing or simulating a rib contour to obtain a first contour line; on the basis of a segmentation point on the first contour line, segmenting the first contour line into a first line segment and a second line segment; the first line segment and the second line segment respectively rotating around ends thereof away from the segmentation point, the first line segment and the second line segment intersecting to form an intersection point, and the end of the first line segment away from the segmentation point to the intersection point, and the intersection point to the end of the second line segment away from the segmentation point, collectively forming a second contour line; and on the basis of the second contour line as a postoperative rib contour, determining a postoperative effect prediction result, wherein the positions of the intersection point on the first line segment and the second line segment are used as two cutting points for rib cutting in the thoracic surgery, and the rotation angles of the first line segment and the second line segment are used as the angles at which two segments of ribs need to be rotated in the thoracic surgery. The present invention further c

目標データ生成方法、情報処理装置、プログラム及び頭蓋形状矯正ヘルメットの製造方法

Absstract of: JP2026173765A

0001 【課題】効率的に目標データを生成できる目標データ生成方法、情報処理装置、プログラム及び頭蓋形状矯正ヘルメットの製造方法を提供すること。 【解決手段】目標データ生成方法は、対象者４の頭蓋形状を矯正するための治療目標となる頭部の３次元形状を示す目標データを生成する目標データ生成方法であって、対象者４の頭部４１の３次元形状を示す形状データを取得する形状データ取得工程と、取得した形状データとその形状データを左右反転させた反転形状データとを重ね合わせた合成データを生成する合成データ生成工程と、合成データに基づいて、目標データを生成する生成工程と、を含む。 【選択図】図１０

運動耐容能予測方法、運動耐容能予測装置及びプログラム

Absstract of: JP2026173631A

0001 【課題】各種の生体情報が計測できないために未知である将来の時点での運動耐容能基礎数値を予測する運動耐容能予測方法、運動耐容能予測装置及びプログラムを提供する。 【解決手段】運動耐容能予測方法は、対象者に関する対象者情報を取得し、対象者について予測する将来の運動耐容能の予測条件を取得し、対象者以外の対象者情報、および、対象者以外の運動耐容能の時系列情報に基づいて生成される予測モデルを蓄積し、取得した対象者に関する対象者情報と、取得した予測条件と、蓄積された予測モデルとに基づいて、対象者の将来の運動耐容能を予測し、予測した将来の運動耐容能を出力する。 【選択図】図２

Snap-Off Hammertoe Device

Absstract of: US20260335096A1

A snap-off hammertoe device is disclosed, comprising a body component engaged with a shaft extension. The body component comprises a first end which engages the shaft extension and a second end with a penetrating tip. The shaft extension is a snap-off barrel component which is used to insert the hammertoe device and is broken off by means of torsion or bending torque after the body component is inserted. The snap-off barrel component or shaft extension and the body are both cannulated, such that a guidewire can be inserted. Further, the snap-off barrel component or shaft extension and the body are additively manufactured and grown as a single part.

MICROMECHANICAL RESONATORS

Nº publicación: WO2026224669A1 29/10/2026

Applicant:

NORTHERN DIGITAL INC [CA]
VOGTMEIER GEREON [NL]
GLEICH BERNHARD [DE]
MAZURKEWITZ PETER CAESAR [DE]
SCHILLING CHRISTIAN JOERG [CH]
NORTHERN DIGITAL INC.
VOGTMEIER, Gereon
GLEICH, Bernhard
MAZURKEWITZ, Peter C\u00E4sar
SCHILLING, Christian J\u00F6rg

Absstract of: WO2026224669A1

A device (e.g., a micromechanical resonator) can include an elongated housing having a first end, a second end, and a sidewall extending from the first end to the second end. A longitudinal opening can extend through the sidewall and extend from an axial center at the first end to the second end. The device can include a filament with a first end of the filament attached to the first end at the axial center. The device can include a first magnetic object with a second end of the filament attached to the first magnetic object. The device can include a second magnetic object and being spaced apart from the first magnet. The filament is configured to allow the first magnetic object to oscillate about a longitudinal axis of the elongated housing relative to the second magnetic object in response to a magnetic or electromagnetic field.