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95
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Updated on
05/07/2025 [07:45:00]
Absstract of: CN120249162A
本发明提供一种减毒鼠伤寒沙门氏菌及其应用，所提供的减毒鼠伤寒沙门氏菌，是通过敲除relA基因、manA基因和sifA基因制备的。本发明所提提供的三基因沙门氏菌减毒株，通过口服免疫将抗原呈递给宿主细胞，从而诱导机体产生免疫应答。沙门氏菌作为活载体的作用机理为携带细菌抗原通过肠道上皮后，通过肠道粘膜将其转运至免疫细胞，触发了宿主的免疫应答。本发明构建的减毒株经安全性检测发现，该减毒株安全性高，可作为载体，运载其他致病抗原或药物到达作用部位，进而起到载体作用。
Absstract of: WO2025143588A1
The present invention relates to a spheroplast protein y (Spy)-exogenous protein-secreting Salmonella strain, which possesses a Spy protein-coding gene and has the rpoE gene deleted. The recombinant Salmonella strain according to the present invention, while exhibiting attenuated virulence due to the Spy protein, can maintain structural stability when fused with exogenous proteins such as pathogenic viruses, therapeutic proteins, or antigenic epitopes, through the structure and chaperone functions of the Spy protein. Therefore, the present invention can serve as a live attenuated vaccine. Furthermore, the present invention can be used as a protein delivery vehicle, a drug delivery vehicle, and in antigen-antibody reaction-based techniques for applications in other areas of biotechnology.
Absstract of: CN120230694A
本发明提供一种同时缺失invF基因、spaL基因、sipC基因、prgH基因中的两种或两种以上的多基因缺失的鼠伤寒沙门菌。本发明还公开了上述多基因缺失的鼠伤寒沙门菌的构建方法，及其在制备鼠伤寒沙门菌减毒活疫苗中的应用。本发明提供的四基因同时缺失的鼠伤寒沙门菌缺失株较野生型鼠伤寒沙门菌的毒力显著下降，在宿主体内的定殖时间显著缩短，接种后小鼠无不良反应，对强毒力鼠伤寒沙门菌提供良好的保护作用，可有效清除强毒力菌株的感染；应用于鼠伤寒沙门菌减毒活疫苗具有良好的免疫原性，可对小鼠提供坚实的免疫保护效果，具有广泛的应用前景。
Absstract of: CN120209102A
本发明涉及一种赖氨酸光学探针及其制备方法和应用。一方面，本发明涉及一种光学探针，包含赖氨酸敏感多肽或其功能变体和光学活性多肽或其功能变体，其中光学活性多肽或其功能变体位于赖氨酸敏感多肽或其功能变体的序列内。本发明也涉及上述探针的制备方法及其在检测赖氨酸中的应用。
Absstract of: US2025206809A1
The invention provides anti-ETEC adhesin protein antibodies and methods of using the same.
Absstract of: US2025207141A1
Methods for making synthetic gene clusters are described.
Absstract of: WO2025134131A1
PROCESS FOR PREPARATION OF NATURAL AND ORGANIC POTASSIUM SORBATE The present invention relates to the process for production of natural and organic potassium sorbate. The natural and organic potassium sorbate is produced through microbial fermentation of natural carbohydrate source obtained from organic raw material tuber crop cassava followed by downstream processing steps of filtration, carbon treatment, evaporation, centrifugation and spin flash drying. The fermentation was carried out utilizing the Lactobacillus delbrueckii NCIM 2365, Bacillus coagulans MTCC 3543 and Lactobacillus acidophilus NCIM 5705, which were modified by the way of strain improvement through media optimization, filtration, carbon treatment, evaporation and centrifugation, the pellet material received was further dried in spin flash dryer resulting in finished product in powder form as potassium sorbate with sorbic acid (70-72%), other organic acids (10%),bioavailable potash (12%) and moisture (<5%). The natural and organic potassium sorbate powder produced has antimicrobial activity and addition of 0.1 to 0.5 % of the said natural preservative in food preparation of different food products like cheese and paneer, pickles, meat products, beverages like wines, canned food items, storage food items and bakery preparations enhances the shelf life of the product. It kills variety of food pathogens viz. Listeria sp., Salmonella sp., and Shigella sp in breads, paneer and pickles and on crops as foliar an
Absstract of: US2025205325A1
The present invention relates to proteins and nucleic acids derived from Klebsiella pneumoniae as well as therapeutic and diagnostic uses of the proteins and nucleic acids.
Absstract of: US2025025552A1
The present invention provides methods and compositions for specific activation of inflammatory responses in dendritic cells (DCs). 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine (PAPC) and its oxidized variant (oxPAPC) were identified to promote DC-mediated immunity, and are provided as adjuvants in immunostimulatory compositions, including vaccines.
Absstract of: CN120192426A
本发明涉及一种预防沙门氏菌感染的融合蛋白、免疫原性组合物、重组疫苗以及分子架构设计和应用等。本发明选取能够在真核细胞中顺利表达的PstS‑LpfB、PstS‑YidR、LpfB‑SinH三种融合蛋白设计进行动物免疫实验，验证保护效果。本发明发现PstS‑LpfB等融合蛋白分子可减弱沙门氏菌感染引起的组织病变，具有良好的免疫原性，起到有效预防和免疫保护作用，高效预防沙门氏菌感染，具有广泛的应用前景。
Absstract of: AU2023382983A1
The present invention relates to a DNA construct including: a gene encoding a flagellin protein; and a gene encoding an immunoenhancer (adjuvant) protein. For effective cancer therapy by selectively killing only cancer cells, an attenuated Salmonella strain according to the present disclosure is designed to produce immunogenic substances in cancer tissue to induce a strong anti-cancer immune response, whereby tumor sizes in metastatic cancers as well as primary cancers can be significantly inhibited. Thus, the strain can be advantageously used in a prophylactic or therapeutic composition for improving survival rates.
Absstract of: US2025195631A1
To make an immunotherapy that is effective for a larger group of cancer patients, Salmonella have been genetically engineered to deliver proteins from prior vaccines into the cytoplasm of tumor cells.
Absstract of: US2025195635A1
A method of generating a Salmonella free egg is disclosed. The method includes administering a vaccination to a poultry animal that is less than one year old. The method further includes boosting the vaccination of the poultry animal when the poultry animal is between about 50 weeks old and about 60 weeks old, the boosting comprising administering killed virus if the poultry animal molted subsequent to the vaccination, and the boosting comprising administering live virus if the poultry animal did not molt subsequent to the vaccination at the time of boosting.
Absstract of: US2025197951A1
This disclosure relates to methods of isolating rare or non-dominant serotypes of Salmonella species from a sample. The disclosure further relates to the isolation of non-dominant serotypes of Salmonella in a sample related to one or more products for human or animal consumption.
Absstract of: AU2023323947A1
The invention is directed to immunogenic compositions and method of treatment comprising a peptide or nucleic acid that encodes the peptide that induces an immune response in a mammal that is protective against infection by one or more pathogens. The peptide sequence contains multiple epitopes, wherein at least one epitope is a composite epitope which is a combination of two or more conserved epitopes of the pathogen wherein the amino acid sequence of the composite is not an amino acid sequence of the pathogen. In addition, the invention is directed to vaccines comprising the peptide or nucleic acid that encodes the peptide for treating and preventing an infection in mammals such as animals and humans.
Absstract of: US2025025552A1
The present invention provides methods and compositions for specific activation of inflammatory responses in dendritic cells (DCs). 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine (PAPC) and its oxidized variant (oxPAPC) were identified to promote DC-mediated immunity, and are provided as adjuvants in immunostimulatory compositions, including vaccines.
Absstract of: WO2025122955A1
Provided herein are methods and compositions for treating cancer. One composition includes an engineered bacterial cell comprising: a) a lysis gene or lysis cassette operably linked to an intracellularly induced Salmonella promoter; b) one or more of the bacterial cell genes selected from the group consisting of recA, recB, recF, sbcB, sbcCD, red, sseJ or any combination thereof are knocked out; and c) a nucleic acid sequence coding for an oncolytic virus genome.
Absstract of: WO2024155027A1
The present invention relates to an attenuated Salmonella gallinarum expressing FliC or FliC-hiL2 and use thereof. The Salmonella strain according to the present invention has excellent immune activity and exhibits excellent anti-cancer efficacy, and thus can be used as a therapeutic agent for cancer together with or independently of existing anti-cancer drugs.
Absstract of: CN120118166A
本发明通过筛选、实验验证获得一段能够代表沙门氏菌作为抗原的特异性蛋白片段，以这一段特异性蛋白片段作为抗原免疫小鼠，利用细胞融合技术得到可以稳定分泌单克隆抗体的杂交瘤细胞，最终制备了效价高、特异性好的抗沙门氏菌单克隆抗体。同样以该特异性蛋白片段免疫兔子，获得了抗沙门氏菌多克隆抗体。基于鼠单克隆抗体和兔多克隆抗体，建立沙门氏菌胶体金免疫层析检测方法，该检测方法特异性良好，为食品中沙门氏菌的检测提供了快速、简便的检测手段。
Absstract of: US2025177534A1
This invention describes method for inactivation of microorganisms in thermostable dry formulations at ambient temperatures (AT) using UV light irradiation. According to this method microorganisms are inactivated at ambient temperatures (AT) in dry formulations where the amount of free radicals formed is relatively small and damage of nucleic acids is the main cause for the microorganism's death. The method will allow production of thermostable inactivated vaccines from wild type and live attenuated microorganisms, thermostable inactivated microbiome products, and thermostable sterilized none-live blood components, therapeutic proteins, antibodies and other fragile biopharmaceuticals.
Absstract of: US2025177508A1
Described is a method for the generation of a live vaccine containing stable bacteria carrying at least three attenuating mutations and a vaccine containing bacteria obtained by said method.
Absstract of: AU2023312737A1
Provided herein are vaccine composition comprising a
Absstract of: CN120081916A
本发明公开了一种鼠伤寒沙门菌特异性抗原片段及其在检测鼠伤寒沙门菌抗体中的应用。所述鼠伤寒沙门菌特异性抗原片段的氨基酸序列如SEQ ID NO.1所示。本发明首次公开了以鼠伤寒沙门菌特异性抗原片段作为间接ELISA的包被抗原，建立了鼠伤寒沙门菌间接ELISA抗体检测方法，鼠伤寒沙门菌特异性抗原片段含有鼠伤寒沙门菌FliC蛋白的优势B细胞表位，能够特异性识别诱导产生的鼠伤寒沙门菌FliC蛋白抗体，在提高抗原抗体特异性结合方面有显著性的增效作用。本发明能够用于鼠伤寒沙门菌抗体的检测，为鼠伤寒沙门菌的流行病学调查以及沙门菌的防控提供了有力的技术支持。
Absstract of: NZ752690A
An extract of an herbal composition comprising at least two different dried plants useful as antimicrobial and/or antibiofilm agent in the treatment or prevention of microbial infections caused by bacteria, such as for example Escherichia, Klebsiella, Listeria, Pseudomonas, Salmonella, Streptococcus or Staphylococcus, or by fungi, such as for example is herein described. It has been found that in such extract, the active ingredients exert their biological effects in a synergistic manner. The extract may constitute the active ingredient of a food supplement, a nutraceutical, pharmaceutical or cosmetic composition or a functional food or a food additive. A process for preparing said extract is also described here.
Nº publicación: US2025170230A1 29/05/2025
Applicant:
JANSSEN PHARMACEUTICALS INC [US]
Janssen Pharmaceuticals, Inc
Absstract of: US2025170230A1
The subject relates to an isolated antibody that specifically binds to O25b antigen of multi drug resistant (MDR) E. coli strains, its medical and diagnostic use, method of producing the antibody, including an isolated nucleotide sequence, plasmids and host cells as used in the production of the antibody; and further an isolated epitope recognized the specific antibody.
BOPI
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