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APPARATUS AND PROCESS FOR MANUFACTURING A MEDICAL DEVICE AT POINT OF CARE

Resumen de: AU2024231554A1

Aspects in accordance with the present invention pertain to an apparatus for manufacturing a medical device, said apparatus comprising at least two production modules, at least one integrating element, and at least one inspection gate, wherein the production module is configured to process the medical device, a medical device part, a medical device accessory, a medical device preform, or a raw material; the integrating element is configured to, between any two of the production modules, move the medical device, the medical device part, the medical device accessory, or the medical device preform; and the inspection gate is configured to, outside the production module, subject the medical device, the medical device part, the medical device accessory, or the medical device preform, to an inspection technique according to a predetermined inspection mode, the operations of said production modules, said integrating element, and said inspection gate, being administered by a controlling software, and said apparatus is constructed as a ready-to-transport compact unit.

A MICROFLUIDIC DEVICE AND A METHOD OF FORMING THEREOF

Resumen de: AU2024233284A1

A method of manufacturing a patient-specific microfluidic device and a patient-specific microfluidic device are provided. The method includes obtaining three-dimensional (3D) information associated with vascular geometry in a region of interest from one or more clinical images associated with a patient, and fabricating the patient-specific microfluidic device using said 3D information. The patient-specific microfluidic device includes a flow channel having a geometry that substantially corresponds to the vascular geometry in the region of interest.

NEW CUTOUT FOR ELASTIC ALIGNERS, METHOD OF MANUFACTURING SAME AND SYSTEM FOR ORTHODONTIC TREATMENT

Resumen de: EP4678137A1

This patent description outlines the comprehensive details of the improved elastic cutout in orthodontic aligners, comprising a polymeric material formed with multiple cavities configured to apply a load to at least one tooth to cause movement of said tooth. The integrated cutout for elastics is positioned on the aligner, wherein cutout for elastics is configured to retain an elastic band and wherein cutout for elastics is configured to be connected with the button arranged on the opposite aligner. The cutout for elastic is integrated into aligner and cutting of the cutout for elastic is performed on bubble-like element. This invention also provides a method for manufacturing of the cutout for elastics and the orthodontic treatment system which comprises the aligner with incorporated cutout for elastics, the opposite aligner on which a secure lock-up mechanism is fixed and elastic band which specifically is designed to create an elastic connection between the secure locking mechanism and the cutout for elastics.

DRY POWDER INHALER FOR PULMONARY OR NASAL DELIVERY

Resumen de: EP4679437A2

A dry powder inhaler (1) has a chamber (12) for housing a capsule and an inhalation channel (22), the chamber (12) is shaped in order to determine an agitated motion of the capsule in the chamber (12) during an inhalation of a user, the inhaler (1) comprises a capsule-piercing mechanism (30) arranged to pierce a capsule in the chamber (12) and a monitoring system (40) comprising an accelerometer (42) to measure mechanical oscillations determined at least by the agitated motion and by a flow of air through the chamber (12) and/or inhalation channel (22), the accelerometer (42) being arranged on a printed circuit board (48) arranged to transmit the mechanical oscillations from the inhaler body (10) to the accelerometer (42); a detection unit (44) arranged to detect an activation of the capsule-piercing mechanism (30); and an electronic processing unit (46) configured to receive signals from the detection unit (44) and from the accelerometer (42). Reception of a signal from the detection unit (44) triggers processing of signals from the accelerometer (42) by the electronic processing unit (46) in order to generate inhalation data. The monitoring system (40) is integrated in the inhaler body (10) or in a monitoring module (41) that is permanently or detachably attached to the inhaler body (10).

BIOMIMETIC SCAFFOLD FOR PERIPHERAL NERVE INJURIES

Resumen de: EP4678400A2

The disclosure relates to a nerve repair scaffold comprising: a sheath having a proximal end and a distal end, the sheath housing a plurality of microchannels traversing the sheath from the proximal end to the distal end, wherein the microchannels are configured to allow growth of nerve tissue; and a first overhang at the proximal end and a second overhang at the distal end.

一种马鹿角粉支架材料制备装置及其系统

Resumen de: CN121313949A

本发明涉及骨修复材料技术领域，具体涉及一种马鹿角粉支架材料制备装置及其系统，装置包括骨化程度预处理单元、粉碎单元、混合单元、打印单元和调控单元；骨化程度预处理单元包括传输台和控制器，传输台的传输部表面设有定位输送组件，传输台的支架部上设有检测组件和切割组件；制备系统包括：骨化程度预处理模块、气压粉碎模块、配比混合模块、3D打印模块和降解速率调控模块。本发明设计对原料马鹿角进行骨化程度分级预处理对骨松质区域进行精准识别与定向切割，剔除骨密质核心，解决因骨化程度个体差异导致的活性成分波动及孔隙结构不均一问题。

抗感染导管及制作方法

Resumen de: US2025128021A1

Systems and methods for altering the geometry of a fluid channel to prevent upstream mobility of bacteria, using angled obstacles on the interior of the channel that among other things creates vortices that restrict the mobility. An optimized geometry can be realized by an artificial intelligence algorithm or similar methods based on performance of various configurations of obstacle parameters.

复合生物墨水及其制备方法和基于复合生物墨水构建的骨类器官

Resumen de: CN121313943A

本发明涉及复合生物墨水及其制备方法和基于复合生物墨水构建的骨类器官。所述复合生物墨水为可用于挤出式3D生物打印的复合生物墨水，该复合生物墨水采用甲基丙烯酰化明胶（GelMA）为基质，引入具有M2极化能力的芦荟凝胶以及赋予材料结构稳定性的纳米黏土。本发明提供的复合生物墨水为一种具备内源性免疫调节功能与优异成骨性能的多功能复合生物墨水，其突破了传统依赖短效外源细胞因子的免疫调节方式，以实现对局部免疫微环境的精准调控，促进骨组织的功能性再生，具备更高的生物安全性与临床转化潜力。所述复合生物墨水采用3D挤出式打印成型方法，可以构建出一种具有免疫诱导、生物相容、力学强化与成骨促进等多重功能的复合支架。基于所述复合支架，可以进一步制备得到骨类器官。

用于脊柱畸形手术的4D打印仿生椎板

Resumen de: CN121313964A

本发明公开了用于脊柱畸形手术的4D打印仿生椎板，本发明涉及脊柱畸形手术技术领域，包括：由形状记忆材料制成的椎板主体，所述形状记忆材料为镍钛形状记忆合金。该用于脊柱畸形手术的4D打印仿生椎板，椎板主体通过采用镍钛形状记忆合金制成，其触发温度区间与人体体温高度匹配，手术中可将椎板预制成便于植入的“第一形状”，降低植入操作难度，缩短手术时间；植入体内后，椎板可响应人体温度、体液酸碱度及离子浓度等环境刺激，自动转变为与患者矫正后脊柱生理曲度完全贴合的“第二形状”，实现“植入后自主塑形”；这种形状自适应能力无需医生术中反复调整，避免了器械塑形对椎板力学性能的破坏。

用于设计对象的系统和方法

Resumen de: US2024342995A1

Systems and methods for designing additively manufactured objects are provided. In some embodiments, a method includes receiving a treatment plan for a patient's teeth, and determining a set of appliance parameters for a dental appliance configured to implement the treatment plan. The method can also include determining a set of manufacturing parameters for a fabrication system to be used to additively manufacture the dental appliance. The method can further include generating a 3D digital representation of an appliance geometry for the dental appliance. The appliance geometry can be configured to mitigate loss of fidelity at a target region of the dental appliance due to at least one manufacturing parameter of the fabrication system.

一种半互穿聚合物网络及其制备方法和应用

Resumen de: CN121313915A

本发明涉及血管闭合装置技术领域，具体是一种半互穿聚合物网络及其制备方法和应用。所述半互穿聚合物网络由功能化的聚醚和聚酯共混后，通过光交联制备得到；且具粘附功能基团以及光交联功能基团。本发明将形状记忆分子开关与粘附功能基团通过互穿网络结构设计集成到一种材料中，利用光交联实现材料3D打印和原位交联的协同，提升打印装置的结构稳定性和形状记忆性能，实现了血管闭合装置的智能自部署和稳定粘附封堵。

牙颌模型

Resumen de: CN223787727U

本实用新型公开一种牙颌模型，用作热压膜成型制作壳状牙齿矫治器的模具，包括牙颌模型本体，牙颌模型本体的两侧后牙区分别设有向对颌方向延伸的重定位颌元件；重定位颌元件包括分体设置的由第一材料制作的固定部和由第二材料制作的主体部，主体部与固定部以可拆卸方式连接；固定部与牙颌模型本体的一侧表面固定连接，固定部朝向主体部的一侧设置有第一连接部；主体部设置有与第一连接部匹配且沿颊舌向可拆卸安装的第二连接部。

一种股骨颈骨折治疗定位板、制备设备及制备方法

Resumen de: CN121313292A

本发明公开了一种股骨颈骨折治疗定位板、制备设备及制备方法，所述定位板包括主体板和可调式导向模块，所述主体板其形状与股骨近端外侧骨面解剖形态相匹配，并设有至少一个骨钉孔。本发明通过引入与患者解剖形态精准匹配的个体化主体板，并结合多种创新设计的可调式导向模块，有效解决了传统定位板通用性差的问题，能够完美适应不同患者的解剖差异与手术需求；其导向模块所采用的球铰链、偏置滑块‑弧形导轨、弹性变形环及模块化导套等结构，在确保空间角度无级调节功能的同时，显著简化了机械结构，消除了冗余部件，从而实现了高刚性、无间隙锁定，彻底避免了术中微动与移位，极大提升了置钉的精准度和可靠性。

一种3D打印件微孔表面制造工艺及3D打印件

Resumen de: CN121295114A

本发明提出一种3D打印件微孔表面制造工艺及3D打印件，涉及表面处理领域；工艺包括：将3D打印件置于源极靶材制成的外罩内部构成空心阴极后整体置于直流脉冲等离子真空炉内，真空炉顶部设置有电源正极，外罩作为活性屏；在直流脉冲电源作用下放电启辉，并在活性屏和空心阴极效应增强下将源极靶材通过等离子形式轰击至高温的3D打印件表面，以便通过吸附和互扩散方式在3D打印件表面形成均匀分布的微孔结构和表面合金层。方案利用活性屏耦合空心阴极技术获得高密度、活性的等离子与高温的3D打印件表面碰撞实现离子的互扩散合金化，不仅将表面未充分熔合的粉末颗粒再次熔合，解决致敏问题，且在打印件表面获得微孔结构。

一种颌骨囊肿的根管冲洗治疗系统及制备方法

Resumen de: CN121287334A

本发明公开了一种颌骨囊肿的根管冲洗治疗系统及制备方法，颌骨囊肿的根管冲洗治疗系统包括冲洗治疗器，根管冲洗治疗系统包括用于嵌设在病牙内部的嵌设体，嵌设体包括固定部和与固定部连接的导向部；牙髓腔与根管通道连通。固定部用于嵌设在病牙的牙根部开设的根管通道上，固定部内形成有第一腔体，导向部内形成有第二腔体，第一腔体和第二腔体连通；导向部上开设有导向通孔，导向通孔与第二腔体连通，固定部与颌骨囊肿接触，以使冲洗治疗器穿过导向通孔、第二腔体和第一腔体与颌骨囊肿接触。本发明的有益效果是：冲洗治疗器穿过导向通孔可以直接作用于颌骨囊肿腔，避免在颌骨的其他位置开辟新的冲洗通路而造成损伤，冲洗治疗器穿过导向通孔，冲洗和给药目标明确，效率极高。

包含可生物降解聚合物的植入物、其制造方法及其组合物

Resumen de: TW202506210A

Provided is an implant, which comprises a first biodegradable polymer and a second biodegradable polymer, wherein the first biodegradable polymer comprises a copolymeric polyhydroxyalkanoate (PHA), and the copolymeric polyhydroxyalkanoate (PHA) comprises a repeat unit derived from 4-hydroxybutyrate (4-HB) in an amount of 0.1% by weight to 50% by weight based on the total weight of the copolymeric polyhydroxyalkanoate (PHA).

基于多重涂覆和UV固化工艺的组织黏附型软骨化双层人工耳廓材料及其制备方法

Resumen de: CN121288005A

本发明公开了一种基于多重涂覆与UV固化工艺的组织黏附型软骨化双层人工耳廓材料及其制备方法。方法包括：1）采用微流控‑浸渍技术制备负载Kartogenin的甲基丙烯酸化透明质酸（HAMA）微球；2）通过甲基丙烯酰化及羧酰亚胺偶合反应，合成兼具多巴胺功能与光交联能力的双改性HAMA‑DA；3）基于LiDAR与三维重建技术，通过光固化3D打印制备高保真人工耳廓模具；4）配制复合间充质干细胞与载药HAMA微球的甲基丙烯酸化明胶（GelMA）复合浆料；5）在模具表面依次多重涂覆丙三醇层、HAMA‑DA溶液层、GelMA复合浆料层和HAMA‑DA溶液层，过程中配合UV预固化和二次UV固化，制得具备湿态组织黏附性与软骨诱导潜能的双层耳廓结构。该体系为人工耳廓构建提供了先进的材料平台与工艺路径。

一种淀粉-壳聚糖复合凝胶材料及其制备方法和应用

Resumen de: CN121287922A

本发明属于功能性凝胶材料技术领域，公开了一种淀粉‑壳聚糖复合凝胶材料及其制备方法和应用。方法一：将氧化淀粉和矿物质离子溶液混合均匀，进行糊化处理，制得凝胶化浆料，所述凝胶化浆料中还含有壳聚糖；将所述凝胶化浆料进行热挤压3D打印，制得具有三维结构的淀粉‑壳聚糖复合凝胶材料；方法二：将氧化淀粉和矿物质离子溶液混合，进行糊化处理，制得凝胶化浆料；并配制壳聚糖浆料；将两种浆料通过双喷头交替进行热挤压3D打印，制得具有多层交替结构的淀粉‑壳聚糖复合凝胶材料。本发明工艺简单可控，制得的复合凝胶具有优异的胃部稳定性和肠道靶向性，能同步激活小肠细胞旁途径和结肠跨细胞途径双重吸收机制，显著提高镁的生物利用度。

一种增材制造的生物型胫骨托假体及其制作方法

Resumen de: CN121287371A

本发明一种增材制造的生物型胫骨托假体及其制作方法，涉及一种人工膝关节假体技术领域。生物型胫骨托假体包括四种类型：生物型对称胫骨托、生物型对称无柄胫骨托、生物型解剖型胫骨托和生物型解剖型无柄胫骨托。假体主要由托体、多孔结构和堵销等组件构成，通过增材制造技术一体成型，确保精度和强度。多孔结构设计为非规则空间立体网格状，厚度为0.6‑1.6mm，用于促进骨小梁长入，实现生物固定。定位钉采用子弹头形设计，配有排气槽和缺口，简化安装并增强稳定性。制作方法包括设计建模、应力优化、增材制造及后处理步骤，假体采用钛合金材料，满足相关国际标准。本发明具有安装简易、固定可靠、骨长入效果好等优点。

具有多个曲率的弹性密封形成结构

Resumen de: EP4674457A2

The present invention relates to a patient interface for sealed delivery of a flow of air at a continuously positive pressure with respect to ambient air pressure to an entrance to a patient's airways including at least an entrance of a patient's nares. The patient interface is configured to maintain a therapy pressure in a range of about 4 cmH2O to about 30 cmH2O above ambient air pressure in use, throughout a patient's respiratory cycle, while the patient is sleeping, to ameliorate sleep disordered breathing. The patient interface comprises a plenum chamber at least partially forming a cavity pressurisable to a therapeutic pressure of at least 6 cmH2O above ambient air pressure. The plenum chamber includes a plenum chamber inlet port sized and structured to receive the flow of air at the therapeutic pressure for breathing by a patient. The patient interface further comprises a seal-forming structure having a textile membrane constructed and arranged to form a seal with a region of the patient's face surrounding the entrance to the patient's airways inferior to a nasal bridge region of the patient's face. Said textile membrane has at least one hole such that the flow of air at said therapeutic pressure is delivered to at least the entrance to the patient's nares. The seal-forming structure is constructed and arranged to maintain said therapeutic pressure in the cavity throughout the patient's respiratory cycle in use. The textile membrane comprises a first layer constructed

一种基于金纳米夹层的表面合金微孔化方法及医用植入件

Resumen de: CN121295105A

本发明属于表面处理技术领域，公开了一种基于金纳米夹层的表面合金微孔化方法及医用植入件。所述方法包括：获取原工件；于所述原工件表面沉积一金薄膜以形成一中间工件；将所述中间工件置于等离子真空炉内；其中，加热台、活性屏与顶盖合围形成一空心阴极；所述活性屏及所述顶盖的材质均为靶材，中间工件则置于所述空心阴极内；对等离子真空炉依次抽真空、通入惰性气体后，打开直流脉冲电源进行等离子辉光放电，进而使来自靶材的等离子体对金薄膜进行轰击，并于中间工件表面形成第一合金簇及第二合金簇，第一合金簇与第二合金簇继续互相扩散以于原工件表面形成一具有微孔结构的表面合金层。本发明满足了医用植入件对表面合金化处理的应用需求。

一种用于屈光不正医学研究的小鼠头架构建方法及小鼠头架结构及其安装使用方法

Resumen de: CN121287355A

本发明涉及一种用于屈光不正医学研究的小鼠头架构建方法及小鼠头架结构及其安装使用方法，首先获取小鼠头颈部三维解剖学数据；基于该数据设计头部安装架和眼部实验架的三维模型，并采用增材制造工艺成型。小鼠头架包括头部安装架和眼部实验架，头部安装架设有头部夹孔和颈部套口；眼部实验架设有镜片支架，并连接头部安装架。将头部安装架套接于小鼠头颈部并用绳索固定；将屈光实验镜压入镜片支架中；可在维持头架固定的状态下，拆卸实验镜并通过实验通孔对眼部用药。本发明旨在克服目前的屈光不正实验研究中动物模型造模装置固定方式存在的创伤性大、操作复杂、稳定性差且难以配合眼部用药的技术难题。

CURABLE FORMULATIONS USABLE IN FORMING TRANSPARENT MATERIALS OR OBJECTS FEATURING HIGH MECHANICAL STRENGTH

Resumen de: WO2026009143A1

Curable formulations that provide, when hardened, transparent materials, and uses thereof, are provided. The curable formulations include two or more urethane (meth)acrylate materials which differ from one another at least by the number average molecular weight lower than 2000 grams/mol and/or the Tg, and optionally by the number of blocks and/or the NCO/OH ratio in the urethane (meth)acrylate material, and optionally a material or substance that is capable of interfering with the formation of micron-sized clusters in a hardened material formed of the formulations.

Implantable objects fabricated by additive manufacturing and methods of fabricating the same

Resumen de: AU2025275151A1

An implantable object 1000’ and a method 100 of fabricating an implantable object is disclosed. The method 100 comprises melting a powder 210 comprising at least nickel and titanium with an energy source 220 and iteratively forming a plurality of stacked metallic layers 330 from the melted powder using an additive manufacturing technique. The implantable object is biased to expand from a first configuration 501 to a second configuration 502 when at or above a transformation temperature. ec e c

3D PRINTED CITRATE-BASED SCAFFOLDS USING ADDITIVE TO IMPROVE PRINTABILITY

Nº publicación: WO2026011060A1 08/01/2026

Solicitante:

ACUITIVE TECH INC [US]
ACUITIVE TECHNOLOGIES, INC