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93
resultados
Última actualización
08/06/2025 [07:15:00]
Resultados 75 a 93 de 93
Resumen de: CN119632986A
The invention provides medical application of sanguinarine in preparation of a salmonella flagellum inhibitor, and belongs to the technical field of biological medicine. According to the invention, the flagellum of salmonella is used as a potential target for researching and developing the anti-salmonella toxicity drug, and a natural product capable of inhibiting the flagellum of salmonella is screened through a salmonella sliding motion inhibition test and a real-time fluorescent quantitative PCR test; in combination with tests such as a minimum inhibitory concentration determination test, a growth curve, inhibition of salmonella from adhesion to Caco-2 cells and the like, it is verified that sanguinarine can effectively inhibit the salmonella flagellum-mediated swimming ability on the basis of not influencing normal growth of bacteria, so that the pathogenic potential of salmonella is remarkably reduced, the effect of bacteriostasis instead of sterilization is achieved, and the application prospect is broad. A new research thought and a candidate natural compound are provided for prevention and treatment of salmonella infection, and potential practical application value is achieved.
Resumen de: CN119633099A
The invention belongs to the technical field of bacterial infection and drug treatment, and discloses an ability of oridonin in combined synergism of anti-salmonella effect of polymyxin. The invention verifies that oridonin and polymyxin are combined to resist salmonella in a macrophage intracellular environment simulation culture medium that oridonin has a remarkable synergistic capability on the salmonella inhibition capability of polymyxin; a growth curve experiment and a combined sterilization curve experiment verify that oridonin enhances the salmonella infection resistance of polymyxin. A novel combined method and a research and development strategy are provided for clinically treating salmonella infection by polymyxin. Compared with a traditional action mechanism that antibiotics directly kill salmonella, oridonin inhibits salmonella infection by effectively enhancing the sterilization effect of polymyxin, bacterial infection can be effectively prevented and treated while the application concentration of polymyxin can be reduced, and salmonella is not prone to being induced to generate related drug resistance.
Resumen de: CN119639929A
The invention belongs to the field of biology, relates to a salmonella gene detection technology, and discloses a one-pot detection method combining LAMP (loop-mediated isothermal amplification) and CRISPR/BrCas12b mediated nucleic acid molecule detection. The method comprises the following steps: designing an LAMP primer, a small guide RNA (Ribonucleic Acid) and a transcription template overlapping PCR (Polymerase Chain Reaction) primer, performing loop-mediated isothermal amplification, constructing CRISPR/Cas shearing recognition (Cas-LAMP), constructing a single-tube one-pot reaction system of the CRISPR/Cas shearing recognition, detecting the specificity and sensitivity of Cas-LAMP amplification, and the like. In order to solve the technical problem that amplification and shearing recognition cannot be carried out synchronously, the invention provides a Cas-LAMP technology capable of linking two-step reaction of amplification and shearing recognition, and accurate, sensitive and rapid detection of nucleic acid molecules is realized in an in-vitro single reaction tube system. Compared with a traditional nucleic acid molecule detection method, the method has the following advantages that one-pot detection can be directly carried out without step-by-step operation, high sensitivity and strong specificity are achieved, and rapid field detection can be achieved. The method provides technical support for conventional nucleic acid detection, and has a wide field instant detecti
Resumen de: CN119633101A
本发明公开了SseB蛋白在制备交叉免疫同源或异源血清型肠炎沙门菌的疫苗中的应用。本发明使用动物实验评估其免疫保护力，结果发现肠炎沙门菌SseB蛋白具有良好的免疫反应性，可以显著减轻肠炎沙门菌同源或异源血清型野生菌株引起的临床症状。本发明涉及的具有交叉免疫保护作用的肠炎沙门菌SseB蛋白，具有作为研制肠炎沙门菌亚单位疫苗的潜力。
Resumen de: CN119632962A
The invention belongs to the technical field of biological medicine, and discloses application of isoliquiritigenin as a polymyxin synergist. Through combination of isoliquiritigenin and polymyxin, it is found that isoliquiritigenin and polymyxin have a good effect on in-vivo and in-vitro salmonella inhibition. The isoliquiritigenin is safe in component, can achieve a good synergistic effect with the polymyxin, can significantly reduce the dosage of the polymyxin, is not easy to induce the generation of bacterial drug resistance, and has the characteristics of low price and good curative effect.
Resumen de: CN119607001A
The invention discloses a composition for resisting necrotic enteritis and application thereof, and the composition is prepared from the following components in parts by mass: 5 parts of paeonol, 5 parts of farnesol and 1 part of soybean saponin. The composition can also be prepared into oral liquid, tablets, granules and powder by taking paeonol, farnesol and soyasaponin as effective components and adding auxiliary materials, and the use dosage is 100-1000mg/kg of body weight. Or the composition is directly added into the feed, and the addition amount is 0.1-1% of the total weight of the chicken feed. The composition formed by paeonol, farnesol and soyasaponin is used as a medicine or a feed additive, is high in safety and free of toxic and side effects, can effectively inhibit proliferation of chicken-derived pathogenic bacteria such as clostridium perfringens, salmonella and escherichia coli, effectively improves the antibody titer of a newcastle disease vaccine, and has a good application prospect. And the effects of reducing chicken production performance, increasing proinflammatory cytokines and damaging intestinal absorption and barrier functions caused by chicken coccidiosis and necrotizing enteritis can be relieved.
Resumen de: CN119614404A
The invention discloses saccharomyces cerevisiae FOSU-QQT as well as a screening method and application thereof, and belongs to the field of microbe application. The saccharomyces cerevisiae FOSU-QQT screened and cultured by the invention does not have hemolytic activity, is gamma hemolysis and has inhibition effects on escherichia coli, salmonella, listeria monocytogenes and staphylococcus aureus, and a strain is prepared into direct vat set freeze-dried powder, so that industrial production is facilitated; saccharomyces cerevisiae FOSU-QQT with strong aroma production is added to brewing of the pineapple peel pomace fruit wine, the aroma production flavor can be obviously improved, the pineapple peel pomace fruit wine has the properties of acid resistance, SO2 resistance, ethanol resistance and the like, and the effect of improving the aroma of the composite fruit wine is facilitated; meanwhile, the saccharomyces cerevisiae FOSU-QQT can also be used for extracting a large amount of nutrient substances in the pineapple peel pomace by a compound fermentation technology with other strains, so that the quality of the fruit wine is improved.
Resumen de: CN119613568A
The invention discloses a chicken infectious anemia virus subunit vaccine, and belongs to the technical field of animal disease vaccines. The invention provides a chicken infectious anemia virus subunit vaccine. Active ingredients of the chicken infectious anemia virus subunit vaccine are recombinant fusion protein of chicken infectious anemia virus VP1 protein B cell epitope and salmonella typhimurium flagellin. The B cell epitope of the chicken infectious anemia virus VP1 protein is obtained by connecting B cell antigen epitopes contained in the chicken infectious anemia virus VP1 protein through a connecting peptide. The salmonella typhimurium flagellin is obtained by deleting a hypervariable region of the salmonella typhimurium flagellin FliC. The fusion expression protein provided by the invention can induce generation of a specific IgG antibody after one-day-old SPF chicken, and after immunization for 28 days, immunized chicken flocks can resist challenge of chicken infectious anemia virus virulent strains, and 70% of challenge chicken flocks are protected without disease attack. The invention has great potential for clinical prevention and control of chicken infectious anemia virus infection.
Resumen de: CN119614725A
The invention discloses a qualitative detection method and a quantitative detection method of salmonella based on RPA-CRISPR/Cas12a (recombinase polymerase amplification-CRISPR/CRISPR/Cas12a). The qualitative detection method comprises the following steps: reacting a mixed system at least comprising an RPA reagent, a salmonella upstream primer, a salmonella downstream primer, a CRISPR/Cas12a system and a to-be-detected sample to obtain a reaction product of the to-be-detected sample; and detecting the reaction product of the to-be-detected sample by adopting a fluorescence detection method or an electrochemical test paper detection method, and qualitatively detecting the salmonella in the to-be-detected sample according to an absorption peak at 500-520nm of a fluorescence spectrum or a T line and a current value of electrochemical test paper. According to the salmonella detection method provided by the invention, potential pollution risks in a traditional step-by-step reaction process are avoided, and meanwhile, the detection method shows high stability, relatively high specificity, excellent sensitivity and excellent field detection capability.
Resumen de: CN119607119A
The invention discloses a pharmaceutical composition, the pharmaceutical composition comprises a traditional Chinese medicine extract and citric acid, the traditional Chinese medicine extract is prepared from the following raw materials in parts by weight: 5-20 parts of fig, 1-30 parts of achyranthes aspera, 1-30 parts of honeysuckle, 1-30 parts of moutan bark, 1-20 parts of blackberry lily, 1-20 parts of radix ophiopogonis, 1-20 parts of adenophora tetraphylla and 1-20 parts of liquorice. The traditional Chinese medicine extract and the citric acid are combined for use, the inhibition effect on escherichia coli, staphylococcus aureus and salmonella is remarkably improved, and acute pharyngitis and chronic pharyngitis can be treated.
Resumen de: WO2025054360A1
The disclosure provides for a vaccine depot formulation that comprises a biodegradable thermosensitive hydrogel that has been loaded or embedded with nanoparticles that comprise an antigen and adjuvant, and uses thereof for protecting a subject from an infection or disease.
Resumen de: US2025082751A1
The presently-disclosed subject matter relates to antibodies, compositions, and methods for inhibiting and treating virus infection in the respiratory tract and virus transmission through the respiratory tract. In particular, the presently-disclosed subject matter relates to inhibiting and treating virus infection in a subject using compositions and antibodies that trap viruses in mucus of the respiratory tract, thereby inhibiting transport of virus across or through mucus secretions.
Resumen de: AU2023312737A1
Provided herein are vaccine composition comprising a
Resumen de: US2025084490A1
The invention refers to a method for simultaneous detection and quantification of Listeria monocytogenes, Salmonella spp. and Shiga toxin-producing Escherichia coli (STEC), from any kind of sample related to food production, including complex food matrices such as fish, meat, or fruit; or simple matrices such as water, or food contact surfaces. The method of invention allows specific quantification of the above-mentioned pathogens simultaneously thanks to specificity of designed primers for the qPCR reaction. It is also highly reliable because the method includes a system to adequately control the quantification of pathogens within the matrix. This system comprises the inoculation of samples with a known concentration of a transformed microorganism (host) carrying a chimeric sequence, acting as an internal control host for the whole process.
Resumen de: CN119592717A
The invention relates to the technical field of infectious disease pathogen detection, and discloses a reagent method for ultra-fast detection of digestive tract infectious disease pathogens, which comprises the following steps: S1, the core of a TaqMan probe method is that a complete probe with free probe molecules cannot detect a fluorescence signal; fluorescence emitted by the luminous group can be absorbed and quenched by the quenching group, the probe is hydrolyzed, and a fluorescence signal can be detected when the luminous group is far away from the quenching group. According to the reagent method for ultrafast detection of the pathogens of the infectious diseases of the digestive tract, a PCR method is combined with a fluorescent probe detection technology, highly conserved sequences of salmonella, vibrio parahaemolyticus and campylobacter jejuni are taken as target regions respectively, specific primers and fluorescent probes are designed, and the three bacteria are detected; the whole process of sampling of a sample to be detected, PCR reaction amplification efficiency and the like is monitored, and then three pathogens and one internal reference are detected at the same time through one reaction hole.
Resumen de: CN119591671A
The invention belongs to the technical field of biochemistry, and particularly relates to a derived peptide based on frog-derived antibacterial peptide CPF-C1 as well as a preparation method and application of the derived peptide. The general formula of the derivative peptide is as follows: Trp1-Phe2-X3-X4-Leu5-Leu6-X7-X8-Ala9-Leu10-Arg11-Leu12-Trp13-X14-X15-Val16-Leu17-CONH2, X represents lysine, the lysine at the third site, the lysine at the fourth site, the lysine at the seventh site, the lysine at the eighth site, the lysine at the fourteenth site and the lysine at the fifteenth site can be independently selected from alpha-lysine or epsilon-lysine, and the amino acid at the sixth site to the amino acid at the eleventh site can be independently selected from L-type amino acid or D-type amino acid. The derived peptide obtained by the invention has broad-spectrum antibacterial activity, the antibacterial activity on gram-negative bacteria, especially klebsiella pneumoniae, salmonella typhimurium and pseudomonas aeruginosa is obviously higher than that of a parent peptide CPF-C1, and the derived peptide shows relatively low hemolytic activity and relatively good stability; the compound shows a wide application prospect in preparation of clinical antibacterial drugs.
Resumen de: CN119591558A
The invention relates to the field of medicinal chemistry, and particularly discloses an emodin Mannich base as well as a preparation method and application thereof. The emodin Mannich base has a structure as shown in a formula I. The emodin Mannich base is simple in structure and has relatively strong in-vitro antimicrobial activity; the compound has very high inhibitory activity on bacteria such as staphylococcus aureus, bacillus subtilis, micrococcus luteus, escherichia coli, proteusbacillus vulgaris, pseudomonas aeruginosa, shigella dysenteriae and salmonella typhimurium, and fungi such as candida utilis, candida albicans, saccharomyces cerevisiae and monascus purpureus. The compound can be used for preparing antibacterial and/or antifungal drugs. # imgabs0 #
Nº publicación: CN119591700A 11/03/2025
Solicitante:
UNIV SHANXI AGRICULTURAL
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Resumen de: CN119591700A
The invention discloses a nano antibody for resisting salmonella enteritidis, a kit and application of the nano antibody, and belongs to the technical field of genetic engineering. The nano-antibody comprises at least one of the following: A1) a nano-antibody containing amino acid sequences of a complementary determining region CDR1 as shown in SEQ ID NO: 1, a complementary determining region CDR2 as shown in SEQ ID NO: 2 and a complementary determining region CDR3 as shown in SEQ ID NO: 3; a2) a nano-antibody containing a complementary determining region CDR1 shown as SEQ ID NO.6, a complementary determining region CDR2 shown as SEQ ID NO.7 and a complementary determining region CDR3 shown as SEQ ID NO.8. The nano-antibody for resisting salmonella enteritidis provided by the invention is strong in affinity and good in specificity, so that the nano-antibody has a relatively good application prospect in detection of salmonella enteritidis.
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