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90
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Última actualización
30/09/2025 [07:09:00]
Resultados 50 a 75 de 90
Resumen de: CN120361018A
The invention discloses a pharmaceutical composition or a vaccine for treating and/or inhibiting salmonella infection, and an application of a small molecule compound Epetrabole hydrochloride. The invention further discloses an application of the pharmaceutical composition or the vaccine and the small molecule compound Epetrabole hydrochloride for treating and/or inhibiting salmonella infection. The MIC value of the small molecule compound is 0.48 mu M, and compared with existing antibiotics for clinically treating salmonella enteritidis infection, the small molecule compound has relatively strong antibacterial activity when the small molecule compound is in a trace amount. An in-vitro killing bacteriostatic activity experiment result shows that the small molecule compound has a certain effect on reduction of the number of bacteria. The Salmonella enteritidis strain has obvious antibacterial activity on a J774A.1 cell model, and can inhibit the expression of a salmonella enteritidis virulence factor T3SS1 in a targeted manner. According to the present invention, the small molecule compound Epetrabole hydrochloride provides a certain inhibition effect on salmonella isolates from different sources, and has a wide application value;
Resumen de: WO2025152055A1
Provided is a method for testing the in-vitro bactericidal function of a typhoid vaccine immune serum, comprising: testing the in-vitro bactericidal function of a typhoid vaccine immune serum against Salmonella typhi bacteria by means of an opsonophagocytic killing assay, wherein when the phagocytic killing step of the opsonophagocytic killing assay is completed, the Salmonella typhi bacteria having undergone the phagocytic killing step are cultured at the pH of 7.5-9.5. The opsonophagocytic killing assay is applied to Gram-negative Salmonella Typhi bacteria for the first time, and the in-vitro bactericidal levels of typhoid vaccine immune serums are effectively and accurately evaluated.
Resumen de: CN120349878A
The poultry salmonella drug resistance detection equipment comprises a bottom plate, the upper end of the bottom plate is fixedly connected with a first vertical plate and a second vertical plate which are arranged left and right, the upper end of the bottom plate is provided with a positioning frame located between the first vertical plate and the second vertical plate, and the upper end of the positioning frame is provided with a storage mechanism; a discharging opening located in the inner side of the positioning frame is formed in the bottom plate in a penetrating mode, a bearing mechanism is arranged on the inner side of the discharging opening, a positioning ring located on the left side of the positioning frame is arranged at the upper end of the bottom plate, a guide rod is fixedly connected between the first vertical plate and the second vertical plate, and the guide rod is sleeved with a sliding sleeve in a sliding mode. According to the device, continuous operation of taking and moving the drug sensitive paper and pasting the drug sensitive paper into the culture dish can be completed, mechanical linkage is utilized, reliability is good, independent driving is not needed, cost is reduced, the situation that the drug sensitive paper is manually taken out of the containing plates in sequence and then taken for pasting operation is not needed, the experiment efficiency is improved, and meanwhile the pollution risk is reduced.
Resumen de: CN120349938A
The invention discloses a broad-spectrum antibacterial lactobacillus plantarum, and belongs to the technical field of microorganisms. The lactobacillus plantarum 9-6 is separated from animal feed, the preservation number is CGMCC (China General Microbiological Culture Collection Center) No.32568, the lactobacillus plantarum 9-6 and fermentation liquor thereof have an obvious inhibition effect on common vibrio parahaemolyticus, vibrio alginolyticus, vibrio harveyi and vibrio vulnificus, and the lactobacillus plantarum 9-6 and the fermentation liquor thereof have the advantages that the lactobacillus plantarum 9-6 and the fermentation liquor thereof have the obvious inhibition effect; and in addition, the antibacterial agent has a relatively good antibacterial effect on common staphylococcus aureus, escherichia coli, listeria monocytogenes, salmonella enterica and bacillus cereus. The lactobacillus plantarum 9-6 has probiotic safety, can grow under an initial pH condition of 4-10 and a high-salt environment, and plays a role in bacteriostasis under an acidic condition. The invention lays a foundation for developing a good antibacterial probiotic preparation and application of a fermentation culture thereof.
Resumen de: CN120350143A
The invention discloses a method for rapidly detecting salmonella pullorum by fluorescent quantitative PCR (polymerase chain reaction) and used primers, and the method for rapidly detecting salmonella pullorum by fluorescent quantitative PCR specifically comprises the following steps: (1) collecting a sample; (2) nucleic acid extraction; (3) preparing a reaction system; (4) running a sample detection program; and (5) detecting a test result and judging. According to the rapid detection method disclosed by the invention, an ultra-short-range PCR program is designed as follows: pre-denaturation is performed at 95 DEG C for 2 minutes; according to the present invention, with the program setting, the salmonella pullorum detection time is shortened by about 60% compared with the salmonella pullorum detection time of the commercially available kit and the commercial standard program, and the detection efficiency is substantially improved; the cost of a single detection reagent is reduced by 40% compared with that of an imported kit, and the economic cost is reduced; compared with a traditional culture method, the method has the advantages that the time is 3-5 days earlier, the detection result is reliable, the repeatability is good, and the method can be used for clinical diagnosis and monitoring of SP.
Resumen de: CN120330263A
The invention belongs to the technical field of biology, and particularly relates to a construction method of a TXNIP gene overexpressed macrophage cell strain and application of the TXNIP gene overexpressed macrophage cell strain in salmonella typhimurium infection.The TXNIP gene overexpressed RAW264.7 macrophage cell strain (oeTXNIP-RAW264.7) is successfully constructed by utilizing CAGG-TXNIP recombinant plasmids and combining with a lentivirus expression system, and the TXNIP gene overexpressed RAW264.7 macrophage cell strain (oeTXNIP-RAW264.7) can be used for treating salmonella typhimurium infection. The gene overexpression effect is verified through an RT-qPCR (Reverse Transcription-Quantitative Polymerase Chain Reaction) method and a Western blot method. A design test proves that after the over-expression TXNIP vector is constructed and transferred into RAW264.7, compared with a control group (a CAGG empty vector is transferred into RAW264.7), infection of salmonella can be remarkably resisted. The invention has the characteristics of strong innovation, good safety and the like, provides a reliable technical platform for antibacterial target screening and innovative drug research, and has important application value in the field of biomedicine.
Resumen de: CN120330357A
The invention provides a primer probe combination, a kit and a method for detecting salmonella pullorum, and belongs to the technical field of rapid detection of pathogenic microorganisms. A series of primer probes are designed aiming at the ipaJ gene of the salmonella pullorum strain, a primer probe combination with the best amplification effect is screened from the primer probes, and the salmonella pullorum is detected by utilizing the primer probe combination and adopting a fluorescent RAA method. The detection efficiency, sensitivity (the lowest detection limit is 1.5 * 10 <-1 > pg/mu L) and accuracy of the detection method are higher than those of common PCR, and rapid specific detection of salmonella pullorum can be achieved.
Resumen de: CN120324365A
The invention belongs to the field of biotechnology and medical preparations, and provides a yeast microcapsule delivery BBR/EGCG probiotic preparation and application thereof. The probiotic Nissle1917 and the anti-inflammatory and anti-oxidation natural products BBR and EGCG are packaged by adopting the yeast membrane, so that the probiotic Nissle1917 has good tolerance and cell targeting property, is easy to colonize in intestinal tracts and exert anti-inflammatory and mucous membrane repairing functions, particularly has a better treatment effect on enteritis caused by salmonella typhimurium, and has a wide application prospect. The problem that an existing probiotic agent is poor in bacterial enteritis treatment effect is solved.
Resumen de: CN120324371A
The invention relates to a radioiodine-labeled drug-loaded bacterial outer membrane vesicle as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The preparation method comprises the following steps: expressing casein-rich attenuated salmonella typhimurium VNP20009 to secrete bacterial outer membrane vesicles, loading an anti-tumor drug by using an ultrasonic method, and combining with an oxidant-mediated radioiodine labeling technology to construct radioiodine-labeled drug-loaded bacterial outer membrane vesicles with tumor targeting property, so as to prepare the drug-loaded bacterial outer membrane vesicles. The performance is optimized through polyethylene glycol modification, the drug loading mass ratio is controllable, the radiolabeling rate is high, the in-vitro stability is good, and the in-vivo safety is good. The drug-loaded bacterial outer membrane vesicle can simultaneously realize SPECT/PET imaging and targeted therapy, is suitable for solid tumors such as brain glioma, colon cancer and the like, has the functions of drug delivery, immune activation and radiodiagnosis, has a good application prospect, and provides a new tool for diagnosis and treatment of tumors.
Resumen de: CN120330356A
The invention provides a primer probe combination, a kit and a method for detecting salmonella enteritidis, and belongs to the technical field of rapid detection of pathogenic microorganisms. A series of primer probes are designed aiming at the Prot6e gene of the salmonella enteritidis, a primer probe combination with the best amplification effect is screened from the primer probes, and the salmonella enteritidis is detected by utilizing the primer probe combination and adopting a fluorescent RAA method. The detection efficiency, sensitivity (the lowest detection limit is 1.5 * 10 <-1 > pg/mu L) and accuracy of the detection method are all higher than those of common PCR, and rapid specific detection of salmonella enteritidis can be achieved.
Resumen de: CN120330108A
The invention relates to the technical field of microorganisms, in particular to bacillus altitudinis MLF-1 and a complex microbial inoculant and application thereof.The bacillus altitudinis strain MLF-1 is obtained by being separated from healthy cattle rectum contents by a research group, and it is detected that the strain has the good beta-1, 4-glucanase producing capacity, and the beta-1, 4-glucanase producing capacity is high; the antibacterial effect is achieved on enterobacter aerogenes, staphylococcus aureus, salmonella typhimurium and escherichia coli; the bacillus altitudinis MLF-1 has good fermentation capacity on the siraitia grosvenorii residues, after the bacillus altitudinis MLF-1 is mixed with the bacillus licheniformis strain JSF-9 and the bacillus safensis strain MLL-5 to prepare the complex microbial inoculant, the nutritional value and the disease resistance of the siraitia grosvenorii residues fermented by the complex microbial inoculant are remarkably improved, 10%-15% of the complex microbial inoculant is added into a basic ration, and the content of the complex microbial inoculant in the siraitia grosvenorii residues fermented by the complex microbial inoculant is reduced. The Jersey cattle feed has the effects of reducing cost and improving efficiency for feeding Jersey cattle.
Resumen de: WO2025151522A2
A broadly protective Shigella-ETEC vaccine includes components to cover multiple Shigella species and serotypes as well as multiple different colonization factors of ETEC. ETEC colonization factors CS2 and CS3 are among the most prevalent CFs found on ETEC isolates associated with diarrhea. These two factors are important components of a vaccine that can confer broad protection against ETEC. High level expression of these heterologous antigens in Shigella live vectors results in stronger immune responses. This specification describes the genetic engineering of DNA sequences encoding upstream sequences, including promoter and ribosome binding sites, that results in increased expression of CS2 and CS3 in Shigella live vectors and that leads to stronger immune responses when used as a vaccine in animal models.
Resumen de: AU2023338191A1
The present invention provides compositions and methods for inducing an immune response in a subject in need thereof, comprising administering to the subject an immunologically-effective amount of a live
Resumen de: WO2024050627A1
Purified antigens are usually weakly immunogenic and require the addition of immunostimulatory agents and/or delivery systems to generate robust antigen-specific responses. The present application relates to self-assembling polypeptides that may be conjugated to immunogens and have the ability to self-assemble into immunogen-displaying nanofilaments that activate the humoral and cellular immune responses. The self-assembling polypeptide comprises an amino acid sequence having at least 60% identity with the sequence of the R4 and R5 domains from a Curli-specific gene A (CsgA) protein. The present application also relates to nucleic acids encoding the self-assembling polypeptide/immunogen conjugates, to compositions and vaccines comprising the self-assembling polypeptide/immunogen conjugates or nucleic acids, as well as to methods for inducing an immune response against an immunogen and/or for preventing and/or treating a microbial infection, cancer or any pathological conditions in which vaccination may be useful such as autoimmune diseases and allergies, in a subject.
Resumen de: CN120309697A
The invention discloses a polypeptide drug for resisting gram-negative bacteria and application, and belongs to the technical field of biological medicine. The MIC of the antibacterial peptide obtained through screening on escherichia coli, salmonella typhimurium, pseudomonas aeruginosa, klebsiella pneumoniae, shigella sonnei and stenotrophomonas maltophilia is 16 mu g/mL, 2 mu g/mL, 16 mu g/mL, 4 mu g/mL, 2 mu g/mL and 4 mu g/mL respectively, and the antibacterial peptide has broad-spectrum antibacterial performance. The hemolytic activity and toxicity of the compound are lower than therapeutic concentration threshold values, and the compound can be used for preparing drugs or medical products for treating multi-drug-resistant bacterium infection.
Resumen de: CN120305383A
The invention belongs to the technical field of medicines, and particularly relates to application of 10-undecylenic acid and polymyxin in preparation of an antibacterial drug, and the antibacterial drug aims at one or more of escherichia coli, salmonella and klebsiella pneumoniae. The antibacterial agent aims at bacteria which are resistant to polymyxin. The bacteria directed by the antibacterial agent are multi-drug-resistant gram-negative bacteria. Through a chessboard method minimum inhibitory concentration test, an in-vitro bacterial growth curve proves that 10-undecylenic acid synergistically enhances the antibacterial activity of polymyxin, and meanwhile, a mouse drug-resistant bacterial infection model test proves that 10-undecylenic acid can effectively enhance the in-vivo effectiveness of polymyxin at the animal level. The invention provides a new application of 10-undecylenic acid in enhancing the antibacterial activity of polymyxin antibiotics, and can solve the technical problems of low clinical drug resistance and therapeutic index of polymyxin and the like.
Resumen de: CN120314573A
The invention provides a polysaccharide antigen derived from salmonella pullorum and marked by fluorescent molecules as well as a preparation method and application of the polysaccharide antigen. The invention provides a simple, convenient and rapid extraction method of the salmonella pullorum polysaccharide antigen, and the polysaccharide antigen for bacterial serological detection is prepared by combining fluorescence labeling on the basis of the experimental principle of fluorescence polarization. The polysaccharide antigen prepared according to the method provided by the invention can be used for serological detection of salmonella pullorum and has good sensitivity, and a new method is provided for detection of salmonella pullorum infection.
Resumen de: CN120290759A
The invention discloses a method and a kit for rapidly detecting campylobacter jejuni based on a specific molecular target glnp. The sequence of the molecular target is as shown in SEQ ID NO. 1. The PCR/qPCR detection kit for detecting campylobacter jejuni is established based on the target glnp, has extremely high specificity, only has a specific amplification signal for nucleic acid of campylobacter jejuni, and does not have any cross reaction for other common food-borne pathogenic bacteria such as escherichia coli, salmonella and staphylococcus aureus. Meanwhile, the sensitivity is high, and the nucleic acid detection target can detect the campylobacter jejuni genome DNA as low as 132fg/mu L. The method has the advantages of short detection time, high specificity, high detection sensitivity, simplicity in operation and the like.
Resumen de: CN120285163A
The invention relates to the technical field of gene engineering, in particular to application of an RNF213 carboxyl terminal E3 structural domain or a coding gene thereof or a biological material containing the coding gene thereof in product preparation. The application of the RNF213 E3 structural domain in regulating the innate immune pathway is disclosed for the first time, and a powerful scientific basis and a tool are provided for prevention, control and treatment of bacteria such as salmonella and the like. The constructed vector containing the RNF213 E3 structural domain can significantly improve the expression level of immune factors, promote the activity of an NF-kappa B pathway and reduce the cell bacterium loading amount, provides a thought for scientific research and industrial application related to prevention and control of gram-negative bacteria such as salmonella, and lays a scientific foundation.
Resumen de: CN120285052A
The invention discloses an application of herba schizonepetae essential oil in preparation of a salmonella pigeonae resisting medicine. The herba schizonepetae essential oil is extracted by adopting a steam distillation method. The herba schizonepetae essential oil provided by the invention shows an obvious inhibition effect on salmonella pigeons. The herba schizonepetae essential oil is natural in source and simple in preparation method, and has important application value in the aspect of preparing anti-salmonella pigeon.
Resumen de: CN120288855A
The invention discloses a preparation method of nano ozone water and application of the nano ozone water in killing food-borne pathogenic bacteria, and belongs to the technical field of bactericides. The nano ozone water is prepared by utilizing the ultra-fine bubble generator and the ozone generator, and the prepared nano ozone water is high in stability, not easy to decompose and high in practicability. The nano ozone water can achieve an effective killing effect on escherichia coli, salmonella, enterococcus, campylobacter and clinical multi-drug-resistant bacteria thereof, and a new resource is provided for preparing a safe and reliable antibacterial product.
Resumen de: CN120290433A
本发明公开了一种基于鞭毛蛋白和LPS减毒的鼠伤寒沙门氏菌EN‑VNP菌株及其制备方法和应用，具体涉及生物技术领域。该菌株是通过在沙门氏菌VNP 20009菌株基础上，依次敲除或沉默鞭毛蛋白基因fliC、fljB、磷酸乙醇胺转移酶基因eptA、4‑氨基‑4‑脱氧‑L‑阿拉伯糖转移酶基因arnT、磷酸转移酶yeiU，并敲入或过表达磷酸转移酶基因lpxE形成的。本发明的鼠伤寒沙门氏菌EN‑VNP菌株具有较高的安全性，减毒后的菌株不含有鞭毛蛋白且LPS的脂质A分子仅保留一个磷酸基团，提高了菌株的安全性，使其更适合作为疫苗和药物递送载体。
Resumen de: CN120290423A
The invention relates to the technical field of microorganisms, in particular to bacillus licheniformis JSF-9 and a complex microbial inoculant and application thereof.The strain JSF-9 is obtained by being separated from healthy cattle rectum contents by a research group, and it is detected that the strain has the good beta-1, 4-glucanase producing capacity, and the beta-1, 4-glucanase producing capacity is high. The antibacterial effect on staphylococcus aureus, salmonella typhimurium and shigella flexneri is achieved; the strain has a good bagasse fermentation capability, for example, after the strain, bacillus altitudinis MLF-1 and bacillus safensis MLL-5 are prepared into a mixed microbial inoculum, the bagasse fermentation capability is better, and verification shows that the complex microbial inoculum can effectively inhibit the reproduction of harmful bacteria, so that the preservation period of fermented feed is prolonged, and the yield of the fermented feed is improved. Animal feeding experiments find that the nutritional value and the disease resistance of the complex microbial inoculant fermented bagasse are remarkably improved, 10-15% of the complex microbial inoculant fermented bagasse is added into basic ration, and the cost-reducing and effect-increasing effects are achieved for feeding Jersey cattle.
Resumen de: CN120284881A
The invention discloses preparation and application of micromolecular coated oncolytic bacteria, and relates to the field of nano-drugs. According to the coated bacteria, the surface of attenuated salmonella VNP20009 is coated with a nano-coating formed by coordination of micantrone and calcium ions, a bacterial antigen signal is shielded, so that the peripheral clearance rate and toxicity risk of the attenuated salmonella VNP20009 in blood circulation are reduced, and the coated bacteria have good biocompatibility and can maintain natural physiological characteristics and biodegradability of the bacteria. In order to solve the problems of lack of effective molecular targets and high immunosuppression of triple negative breast cancer (TNBC), the coated oncolytic bacteria utilize the natural tropism of VNP20009 on TNBC and the physiological targeting motion characteristic to directionally deliver miltroquinone and calcium ions, and cooperate with the oncolytic bacteria to kill tumor cells; bacterial surface antigen signals are shielded, so that tumor accumulation is increased, peripheral toxicity is avoided, and a breakthrough is provided for overcoming long-term failure of oncolytic bacteria clinical tests.
Nº publicación: CN120285059A 11/07/2025
Solicitante:
INST OF ANIMAL SCIENCE AND VETERINARY HUBEI ACADEMY OF AGRICULTURAL SCIENCES
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Resumen de: CN120285059A
The invention belongs to the technical field of veterinary drugs, and discloses a Chinese pulsatilla root alcohol extract and gentamicin composition and application thereof in inhibition of drug-resistant salmonella typhimurium. The pulsatilla alcohol extract composition provided by the invention comprises pulsatilla alcohol extract and gentamicin, and for salmonella typhimurium, the optimal ratio concentration of the pulsatilla alcohol extract to the gentamicin is 31.25 mg/mL: 2 mu g/ml; the Chinese pulsatilla root alcohol extract and the gentamicin have the synergistic bacteriostatic effect on salmonella typhimurium, the composition reduces the concentration of single bacteriostasis of the Chinese pulsatilla root alcohol extract and the gentamicin, the cost is saved, and the composition has wide application prospects and development value in the fields of food processing, medicine and breeding industry.
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