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102
resultados
Última actualización
27/04/2026 [07:56:00]
Resultados 50 a 75 de 102
Resumen de: CN121540789A
The invention belongs to the technical field of biosensing analysis and food safety detection, and particularly relates to a CRISPR/Cas12a-based double-layer microfluidic electrochemical biosensor as well as a preparation method and application thereof. A single-walled carbon nanohorn-polypyrrole-gold nanoparticle compound modified electrode is constructed and integrated with an electrochemical detection system, then the electrochemical detection system and a micro-fluidic chip are integrated to obtain the double-layer micro-fluidic electrochemical biosensor, targeted detection of different pathogenic bacteria can be achieved by replacing crRNA, and the electrochemical biosensor has the advantages of high specificity, high sensitivity, high sensitivity and the like. Good universality and expansibility are realized; the biosensor can rapidly and sensitively detect staphylococcus aureus and salmonella in dairy products, the detection ranges are 1.06 * 10 < 1 >-1.06 * 10 < 7 > CFU/mL and 1.04 * 10 < 1 >-1.04 * 10 < 7 > CFU/mL respectively, the detection limits are as low as 3 CFU/mL, and the biosensor has good practicability.
Resumen de: CN121538126A
The invention discloses a Rongchang pig source ZH30 strain and application thereof, and belongs to the technical field of agricultural livestock feed additives. The ZH30 strain provided by the invention has bacteriostatic activity on a plurality of common pig pathogenic bacteria such as escherichia coli, staphylococcus aureus, salmonella typhimurium, salmonella pullorum and enterococcus faecalis, is wide in antibacterial spectrum, and is beneficial to reducing the load of pathogenic bacteria in intestinal tracts of pigs. Meanwhile, the ZH30 strain is sensitive to streptomycin, gentamicin and ampicillin, infectious microbe pollution can be conveniently controlled through a conventional antibiotic means in the fermentation and preparation production process, and meanwhile the drug resistance spreading risk is reduced. As a functional strain of a probiotic preparation for pigs, the ZH30 strain disclosed by the invention can improve the intestinal health of pigs and improve the mechanical barrier integrity of the intestinal tracts, has potential application values of reducing the diarrhea risk of piglets and improving the feed utilization rate and the production performance, and is of great significance to the development of animal husbandry and feed industry.
Resumen de: EP4650361A1
The present invention relates to an arginine fluorescent optical probe. Specifically, the present invention provides an arginine-sensitive polypeptide, wherein the arginine-sensitive polypeptide is a variant of an arginine binding protein, and formula (1) thereof has a sequence as shown in SEQ ID NO: 1 and has mutations at one, two, or three or more sites selected from the following. Compared with a probe formed by a wild arginine-sensitive polypeptide, the fluorescent probe of the present invention has greater dynamic changes in fluorescence and better specificity, and can be used for the high-throughput and quantitative detection of arginine inside and outside of cells.
Resumen de: CN121517526A
本发明属于生物技术领域，涉及一种沙门菌靶向抗菌肽Yisi‑1及其应用。所述靶向抗菌肽Yisi‑1的氨基酸序列为丙氨酸‑异亮氨酸‑赖氨酸‑甘氨酸‑缬氨酸‑赖氨酸‑丙氨酸‑甘氨酸‑异亮氨酸‑精氨酸‑亮氨酸‑甘氨酸‑赖氨酸‑赖氨酸‑甘氨酸‑亮氨酸‑精氨酸‑丙氨酸，该靶向抗菌肽Yisi‑1的分子量为1836.3Da，等电点为12.1，带6个正电荷，两亲性高，对金黄色葡萄球菌、大肠杆菌、奇异变形杆菌、绿脓杆菌、白色念珠菌等均没有抑菌活性，仅对沙门菌具有抑菌活性，对鸡红细胞具有较低的溶血性。本发明的靶向抗菌肽Yisi‑1有望成为一种新的抗生素替代物，将在预防、诊断、治疗和鉴定沙门菌及其感染中具有良好的应用前景。
Resumen de: CN121522155A
本发明公开了一种巴氏杀菌乳中沙门氏菌的检测方法，涉及食品检测技术领域，本发明通过构建铂基聚合物纳米酶复合探针，结合免疫磁珠分离与信号放大策略，提出了一种适用于巴氏杀菌乳中沙门氏菌的一步法快速高灵敏检测方法。本发明基于铂基聚合物纳米酶优异的类过氧化物酶活性，该复合探针可在低浓度目标菌存在下催化显色底物产生强信号放大效应，实现在巴氏杀菌乳基质中对沙门氏菌的低至10CFU/mL的检测限，较传统培养法及部分现有免疫学方法灵敏度提升一至两个数量级，显著增强了低污染水平沙门氏菌的检出能力。
Resumen de: CN121522153A
本发明公开了肠道菌群代谢物水杨酸作为大肠杆菌性犊牛腹泻预测标志物的应用。通过非靶向代谢组学技术从腹泻犊牛粪便中筛选出显著上调的代谢物水杨酸，并在一组新的独立样本中，通过ELISA试验验证了腹泻组犊牛粪便水杨酸浓度显著高于健康组。ROC曲线分析表明，SA预测大肠杆菌性犊牛腹泻的曲线下面积（AUC）为0.8148，具有良好的预测能力。本发明提供了一种非侵入性、廉价、快速且特异性强的预测方法，可用于大肠杆菌性犊牛腹泻的早期预警和辅助诊断，对指导临床精准用药、降低犊牛死亡率具有重要意义。
Resumen de: CN121518528A
The invention discloses recombinant lactobacillus casei for expressing sialyltransferase ST6GALNAC1, and belongs to the technical field of genetic engineering and microorganisms. The recombinant bacterium is obtained by cloning an ST6GALNAC1 gene to a pPG612 vector and electrically transforming the ST6GALNAC1 gene into lactobacillus casei ATCC393. Experiments show that the engineering bacterium can significantly enhance glycosylation modification of intestinal mucoprotein MUC2, improve expression of tight junction proteins (ZO-1, Occludin and Claudin-1), inhibit activation of a p38/MAPK inflammation pathway and regulate an intestinal flora structure, so that intestinal injury and systemic inflammatory response caused by salmonella are effectively relieved. The invention provides a strain basis and technical support for developing a novel oral microecological preparation.
Resumen de: CN121517555A
本发明公开了一种结合K88ac的特异性纳米抗体、制备方法及其应用，属于生物工程技术领域。所述纳米抗体命名为NBK88，其氨基酸序列如SEQ ID NO:2所示。同时公开了其编码基因、重组表达载体、宿主细胞及制备方法与应用。本发明公开的纳米抗体NBK88对K88ac抗原具有纳摩尔级的高亲和力（KD=1.733×10‑7 M），使其在识别过程中兼具高灵敏度与高特异性；基于该抗体构建的检测方法能够有效捕获样本中微量K88ac蛋白，即使在低菌量或复杂样本中也可实现早期准确检测，显著降低检测限；同时，其与K88ac的结合高度特异，在K88阳性与阴性菌株间呈现统计学显著差异，可有效避免与其他ETEC血清型或肠道菌群的交叉反应，杜绝假阳性，确保检测结果精准可靠。
Resumen de: CN121517554A
本发明公开了鼠疫抗体Fm25及其应用，所述鼠疫抗体Fm25是一种靶向鼠疫菌F1蛋白的抗体，其重链可变区中的HCDR1‑3分别如SEQ ID NO:1‑3所示，轻链可变区中的LCDR1‑3分别如SEQ ID NO:5‑7所示，其对F1蛋白具有较高的结合活性和较好的结合特异性，能够用于鼠疫菌感染的检测和治疗中，对防控鼠疫具有重要意义。
Resumen de: WO2025003117A1
The present invention relates to a gelled reaction medium for detecting, identifying, and/or isolating at least one Shiga toxin-producing strain of E. coli, the reaction medium comprising: - at least one toxin inducer, - at least one agglutinating conjugate comprising at least one specific binding partner of STX1 and/or at least one specific binding partner of STX2, coupled to a nanoparticle; - a concentration gradient of a compound for inhibiting non-target bacteria. The present invention also relates to the associated method for detecting and/or isolating Shiga toxin-producing E. coli which is likely to be present in a sample comprising enterobacteria.
Resumen de: EP4692335A1
An aim of the present disclosure is: (i) to provide a novel bacteriophage having bacteriolytic activity against bacteria of the genus Salmonella, such as S. Enteritidis, or a bacteriolytic agent consisting of the same; (ii) to provide a bacteriophage having a wide host range for bacteria of the genus Salmonella, or a bacteriolytic agent consisting of the same; (iii) to provide a host-specific bacteriophage or an effective Salmonella bacteriolytic agent consisting of the same; or (iv) provide a bacteriophage capable of effectively controlling S. Typhimurium, and in particular, multidrug-resistant S. Typhimurium, or a bacteriolytic agent consisting of the same. The present disclosure provides: a bacteriophage having a specific genomic DNA sequence; a Salmonella bacteriolytic agent consisting of the bacteriophage; and a composition comprising the same.
Resumen de: EP4692334A1
An aim of the present invention is to provide a bacteriophage having a wide host range for bacteria of the genus Salmonella. The present invention is a bacteriophage with bacteriolytic activity against bacteria of the genus Salmonella, in which the bacteriophage has a genomic DNA sequence comprising a gene encoding a tail tip protein consisting of a specific amino acid sequence.
Resumen de: CN121495875A
The invention discloses an enterococcus faecalis bacteriophage vBEfaPFA1, a bacteriophage composition and application of the enterococcus faecalis bacteriophage vBEfaPFA1, the enterococcus faecalis bacteriophage vBEfaPFA1 has a specific lysis effect on enterococcus faecalis and also has a cross-species lysis effect on salmonella, the acid-base adaptability of the bacteriophage is high, and the enterococcus faecalis bacteriophage vBEfaPFA1 can be used as an active component to be prepared into the bacteriophage composition or a bacteriophage pharmaceutical preparation. The enterococcus faecalis bacteriophage and the bacteriophage composition are applied to preparation of drugs or bacteriostatic agents for preventing and treating enterococcus faecalis and salmonella infection, are safe to use, have no side effects, are easy to industrially produce, and are wide in lysis spectrum and wide in application range based on the cross-species lysis performance of the enterococcus faecalis bacteriophage and the bacteriophage composition.
Resumen de: CN121495796A
The invention relates to lactobacillus casei LC189 capable of inhibiting intestinal pathogenic bacteria and application of the lactobacillus casei LC189 capable of inhibiting the intestinal pathogenic bacteria, the lactobacillus casei capable of inhibiting the intestinal pathogenic bacteria is named as a lactobacillus casei LC189 strain, the preservation number is GDMCC No: 63092, and the preservation date is December 26, 2022. A novel lactobacillus casei strain with the effect of inhibiting enteropathogenic bacteria is separated from intestinal mucosa of a healthy sow and is preserved, the strain can inhibit the enteropathogenic bacteria such as escherichia coli, salmonella and staphylococcus aureus, and also can maintain the intestinal health of animals, and the specific expression is as follows: the diarrhea rate of piglets is reduced; the content of ammonia gas and methyl mercaptan in the excrement is reduced, and the pH value of the excrement returns to normal from a weak acid environment; beneficial bacteria are promoted to colonize in intestinal tracts, and the number of the beneficial bacteria is increased; the content of calprotectin in excrement is reduced, the inflammation level in the intestinal tract is reduced, and the intestinal tract health is promoted.
Resumen de: CN121495779A
The invention relates to the technical field of microbiology and molecular biology, in particular to sheep-derived bacillus velezensis AKH-1 and application thereof, the AKH-1 strain is preserved in China Center for Type Culture Collection on October 9, 2025, and the preservation number is CCTCC NO: M20252187. Experiments show that the strain has good gastrointestinal fluid and cholate tolerance, self-aggregation and hydrophobicity, can produce cellulase, amylase and protease, and has a remarkable inhibition effect on various pathogenic bacteria such as escherichia coli, salmonella and the like. Animal tests prove that the strain is safe and non-toxic, and can significantly promote the weight gain of mice and reduce the level of serum inflammatory factors. The AKH-1 strain disclosed by the invention has a wide application prospect in the aspect of preparing feed additives for inhibiting pathogenic bacteria, producing enzymes and promoting the growth of ruminants.
Resumen de: CN121494931A
The invention belongs to the technical field of biology, and discloses an antibacterial peptide for regulating and controlling micro-ecology as well as a preparation method and application of the antibacterial peptide. The antibacterial peptide or the salt thereof is disclosed for the first time, and the antibacterial peptide has a good antibacterial effect on common oral pathogenic bacteria (such as fusobacterium nucleatum and streptococcus gordoni), genital tract pathogenic bacteria (such as staphylococcus aureus, gardnebacterium and enterococcus faecalis) and other pathogenic bacteria (such as escherichia coli, salmonella enteritidis and streptococcus suis); and the compound shows slight cytotoxicity to mammalian cells only at a high concentration.
Resumen de: CN121494939A
The invention belongs to the technical field of biology, and discloses an antibacterial peptide with activity of inhibiting human pathogenic bacteria as well as a preparation method and application of the antibacterial peptide. The antibacterial peptide or the salt thereof is disclosed for the first time, and the antibacterial peptide has a good antibacterial effect on common genital tract bacteria (such as staphylococcus aureus, gardnerella and candida albicans), oral pathogenic bacteria (such as fusobacterium nucleatum and streptococcus gordoni) and other pathogenic bacteria (such as escherichia coli, salmonella enteritidis and streptococcus suis); and the compound shows slight cytotoxicity to mammalian cells only at a high concentration.
Resumen de: CN121496077A
The invention discloses a method for detecting salmonella typhimurium based on strand displacement reaction and CRISPR/Cas12a in combination with a colorimetric sensor and a dairy product detection method, and belongs to the technical field of food safety rapid detection. The invention provides a method for detecting salmonella typhimurium based on strand displacement reaction and CRISPR (clustered regularly interspaced short palindromic repeats)/Cas12a combined with a colorimetric sensor in order to solve the problems of low sensitivity and inaccurate result of detection of salmonella typhimurium in dairy products by a traditional method in the prior art. According to the method, DNA-Ag/Pt NCs is used as a signal molecule to construct the aptamer colorimetric sensor for detecting salmonella typhimurium; the colorimetric sensor has relatively high sensitivity and specificity, and can quickly and conveniently realize on-site detection of salmonella typhimurium.
Resumen de: CN121471323A
The invention provides a nano antibacterial peptide based on a leucine zipper and a preparation method and application thereof, and belongs to the technical field of biology, and the amino acid sequence of the nano antibacterial peptide is as shown in SEQ ID No.1. The antibacterial peptide disclosed by the invention has self-assembly capability, can be assembled to form a compact nanofiber net, has an antibacterial effect on gram-negative bacteria including escherichia coli, pseudomonas aeruginosa and salmonella typhimurium and gram-positive bacteria including staphylococcus aureus, staphylococcus epidermidis and enterococcus faecalis, and meanwhile, has relatively high biocompatibility, so that the antibacterial peptide can be used for preparing the antibacterial peptide. Moreover, the antibacterial peptide disclosed by the invention can stably exert an antibacterial effect under the conditions of serum, acid and alkali. In conclusion, the antibacterial peptide disclosed by the invention is an antibacterial peptide with relatively good antibacterial activity and biocompatibility.
Resumen de: CN121472283A
The invention discloses bacillus subtilis for recombinant expression of a hermetia illucens HIAMP0438 gene and a construction method of the bacillus subtilis, and belongs to the technical field of gene engineering. The hermetia illucens recombinant protein used in the invention is obtained by expression of bacillus subtilis WB800N transferred into a pHT43-HIAMP0438 high-efficiency expression vector, and the pHT43-HIAMP0438 high-efficiency expression vector is obtained by a homologous recombination technology, so that high-level expression of the HIAMP0438 gene is realized, the HIAMP0438 gene can be efficiently secreted out of cells, the preparation process of the recombinant protein is greatly simplified, and the production cost is reduced. According to the present invention, the recombinant protein can significantly inhibit the growth of Escherichia coli, Salmonella and Listeria monocytogenes, and the recombinant protein can be used as the animal health product, and can be used for preventing and treating pig and chicken intestinal diarrhea caused by Escherichia coli and Salmonella and food-borne digestive tract diseases caused by Listeria monocytogenes.
Resumen de: CN121472086A
The invention provides a strain of high-temperature-resistant and inflammation-relieving Witzia ciliaris and an application thereof, the high-temperature-resistant and inflammation-relieving Witzia ciliaris is Witzia ciliaris CN985 and is preserved in the China Center for Type Culture Collection (CCTCC), the preservation date is April 7, 2024, and the preservation number is CCTCC NO: M 2024641. The invention further provides a preparation method of the high-temperature-resistant and inflammation-relieving Witzia ciliaris strain for preventing and treating inflammation of the high-temperature-resistant and inflammation-relieving Witzia ciliaris strain for preventing and treating inflammation of the high-temperature-resistant and inflammation-relieving Witzia ciliaris strain. The invention provides a brand new strain of Witzia ciliaris CN985, which is resistant to high temperature, has better acid resistance and bile resistance, and has no hemolysis risk when being applied to a human body. The Witzia coagulans CN985 has excellent antibacterial performance, and especially can significantly inhibit streptococcus pyogenes, salmonella enteritidis and/or group B streptococcus; besides, experimental results show that the Witzia ciliaris CN985 can relieve enteritis, improve the immunity of the organism and relieve pharyngitis, and especially when the Witzia ciliaris CN985 and the phytobacterium plantarum CE18 are combined for use, the Witzia ciliaris CN985 and the phytobacterium plant
Resumen de: CN121471322A
The invention provides an antibacterial peptide ATMP23 mutant with improved antibacterial activity and application of the antibacterial peptide ATMP23 mutant in preparation of an antibacterial agent. The amino acid sequence of the antibacterial peptide ATMP23 provided by the invention is shown as SEQ ID NO: 1, amino acid mutation and screening are carried out on the basis of the amino acid sequence, and antibacterial peptide mutants A23-M4, A23-M5 and A23-M6 with significantly improved antibacterial activity are obtained. The antibacterial peptide ATMP23 mutant provided by the invention is small in molecular weight, convenient to artificially synthesize and low in cost, and has a good bactericidal effect on clostridium welchii, staphylococcus aureus, streptococcus, vibrio parahaemolyticus, vibrio alginolyticus, vibrio splendidus, salmonella, escherichia coli and the like; when being applied to livestock and aquatic feed, the feed conversion ratio of livestock and aquatic products can be remarkably reduced, the growth performance and immune function indexes of bred animals can be improved, and the feed additive can be widely applied to the industries of feed, food, medicine and the like.
Resumen de: CN121471909A
本发明属于食品安全检测技术领域，具体涉及一种叶酸‑邻苯二胺共掺杂碳量子点、大肠埃希氏菌O157:H7检测探针、检测试剂及应用。叶酸‑邻苯二胺共掺杂碳量子点由叶酸和邻苯二胺加热反应制得。基于本发明的叶酸‑邻苯二胺共掺杂碳量子点的检测探针或检测试剂对大肠埃希氏菌O157:H7进行检测，检测限低、特异性优异，实用性强。
Resumen de: CN121472232A
本发明涉及生物技术领域，具体公开了一种阪崎克罗诺杆菌核酸适配体及其在制备生物传感器中的应用。本发明针对阪崎克罗诺杆菌MipA蛋白设计了DNA序列如SEQ ID No:1所示的核酸适配体，5’端氨基修饰。该适配体可用于构建荧光淬灭型生物传感器，包括荧光探针（枸橼酸二铵、硫脲、正硅酸甲酯及二氧化铈合成荧光纳米粒子，第一适配体羧基修饰）和淬灭探针（柠檬酸还原金纳米粒子，第二适配体巯基修饰，SEQ ID No:2）。与传统方法相比，筛选效率显著提升，检测时间<1h，抗干扰强，亲和常数13.28nM，适用于婴幼儿食品快速监测，经济成本降低至少40%。
Nº publicación: CN121476591A 06/02/2026
Solicitante:
合肥工业大学
Resumen de: CN121476591A
本发明具体涉及一种用于检测大肠杆菌的双模态生物传感器检测试剂盒及制备方法，属于食品安全检测技术领域。双模态生物传感器检测试剂盒由网状靶向磁珠和生物传感器检测试剂组成；生物传感器检测试剂为适配体修饰的铜金属掺杂碳点溶液，适配体为氨基化适配体。本发明的双模态传感器提供的双信号可以互相校准，避免单信号输出的偶然性误差，还可根据不同的场景选择优势检测模态；以网状PGA结构为中间体包覆四氧化三铁磁珠，高负载的网状结构为识别元件提供更多结合位点进一步增强了磁分离技术的捕获效率；增强磁分离技术驱动的双金属靶向改性碳点在检测大肠杆菌O157:H7时具有良好的检测性能，在食品基质中捕获低浓度目标菌的效率可达90%以上。
BOPI
Sede Electrónica
