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Methods of treatment of infections using bacteria

Resumen de: AU2026203814A1

The present disclosure relates generally to compositions, dosage forms, and methods for preventing and treating infections. The compositions include intact and substantially non- viable Gram-negative bacterial cells which have been treated to reduce lipopolysaccharide (LPS)-associated endotoxin activity, which surprisingly have increased activity to trigger immune cell production of cytokines. ay a y

METHODS AND SYSTEMS FOR THE RAPID DETECTION OF LISTERIA USING INFECTIOUS AGENTS

Resumen de: MX2026005882A

Disclosed herein are methods and systems for rapid detection of microorganisms such as Listeria spp. in a sample. A genetically modified bacteriophage is also disclosed which comprises an indicator gene in the late gene region. The specificity of the bacteriophage, such as Listeria-specific bacteriophage, allows detection of a specific microorganism, such as Listeria spp. and an indicator signal may be amplified to optimize assay sensitivity.

Bacillus mucilaginosus for inhibiting systemic infection type, pneumonia type and nerve type salmonella pullorum and application of bacillus mucilaginosus

Resumen de: CN122104492A

The invention discloses bacillus mucilaginosus for inhibiting systemic infectious, pneumonia and nerve type salmonella pullorum and application of the bacillus mucilaginosus. The bacillus mucilaginosus for inhibiting systemic infectious, pneumonia and nerve type salmonella pullorum is named as Anti-S. gallinarum, and is preserved in the China Center for Type Culture Collection (CCTCC), and the preservation number is CCTCC NO: M20251300.

Lactobacillus salivarius with anti-salmonella and anti-inflammatory repair functions and application of lactobacillus salivarius

Resumen de: CN122104522A

The invention discloses lactobacillus salivarius ZY-01 with salmonella resistance and anti-inflammatory repair functions, the strain is preserved in the China General Microbiological Culture Collection Center on March 9, 2026, and the preservation number is CGMCC (China General Microbiological Culture Collection Center) No.37873. The strain can inhibit salmonella, escherichia coli and staphylococcus aureus, can reduce expression of proinflammatory factors such as IL-6, IFN-gamma and TNF-alpha by inhibiting a JAK-STAT signal channel, can promote expression of an IL-10 anti-inflammatory factor and mucous membrane repair factors such as EGF, EGFR and TGF-beta1, and can achieve intestinal tract anti-inflammation and mucous membrane repair. The lactobacillus salivarius ZY-01 and the bacterial liquid, the bacterial powder and the fermentation product thereof can be used as core raw materials of animal feed additives, microecologics and veterinary drugs, are used for preventing and controlling salmonella infection in animal breeding and improving animal intestinal health, and have wide application prospects.

Function and application of lactic acid bacteria Ligilbacillus salvarius SunLab-GHL02

Resumen de: CN122104496A

The invention belongs to the technical field of microorganisms, and particularly relates to lactic acid bacteria and application thereof. The bacterial strain is Ligilbacillus salvarius SunLab-GHL02 (for short, L. salvarius GHL02), is separated from lungs of high-production-performance Aitujiaci broiler chickens, is preserved in the China Center for Type Culture Collection (CCTCC), and has the preservation number of CCTCC NO: M 20251726. The invention further discloses a method for preparing the high-production-performance Aitujiaci broiler chicken with the high-production-performance Aitujiaci broiler chicken with the high-production-performance Aitujiaci broiler chicken with the high-production-performance Aitujiaci broiler chicken. Through morphology, physiology and biochemistry, 16S rRNA and whole genome identification, the classification status and functional characteristics of the gene are determined. The strain has good acid resistance, cholate resistance and acid production capacity, and can remarkably inhibit pathogenic bacteria such as escherichia coli, pathogenic escherichia coli, salmonella, staphylococcus aureus and pseudomonas aeruginosa. Animal experiments show that fowl growth performance and feed conversion rate can be improved, anti-stress capability can be enhanced and health can be promoted by atomizing the strain. The strain and the application thereof can be widely applied to development of feed additives, probiotic preparations and animal health-care pr

Long-tail bacteriophage and application thereof

Resumen de: CN122104609A

The invention discloses a long-tailed bacteriophage and application thereof. The preservation name of the bacteriophage is WHSATYSB-2501, the preservation number of the bacteriophage is CCTCC No: M 2026038, and the bacteriophage is preserved in the China Center for Type Culture Collection on January 8, 2026. The bacteriophage can be used for preparing a bactericide or a disinfectant, and can also be used for inhibiting or cracking salmonella typhimurium. The long-tailed bacteriophage WHSATYSB-2501 obtained through separation can efficiently kill salmonella typhimurium in sewage, the titer can reach 6.8 * 10 < 11 > PFU/mL when the optimal infection complex number is 0.01, and the splitting and inhibiting effects on salmonella typhimurium are remarkably higher than those of existing bacteriophages. The application scene and the application range of the bacteriophage in salmonella prevention and control are remarkably widened, and an efficient and stable novel technical means is provided for biological prevention and control of salmonella.

Application of phellinus igniarius in preparation of product for relieving salmonella-induced intestinal injury of chicks

Resumen de: CN122097342A

The invention discloses application of phellinus igniarius in preparation of a product for relieving salmonella-induced intestinal injury of chicks, and belongs to the technical field of veterinary drugs. In a salmonella enteritidis infected chick model, 20 mg/kg BW of phellinus igniarius is drenched to chicks. Experimental results show that the phellinus igniarius can significantly relieve the growth performance of chicks, improve the diarrhea condition and the fecal state of the chicks, and improve the intestinal structure and permeability through ileum M cells to relieve chick intestinal injuries caused by salmonella enteritidis. The method for resisting the enteritis type salmonella by the chicks, provided by the invention, is beneficial to replacing a traditional antibiotic treatment method and assists the development of poultry breeding.

SYSTEM AND METHOD FOR DETECTING, ENUMERATING, OR EXTRACTING MICROORGANISMS IN A SAMPLE

Resumen de: US20260146994A1

A system and method for detecting, enumerating, or extracting microorganisms in a sample is disclosed. Target microorganisms, such as Salmonella bacteria, may be of interest. Magnetic beads may be bound to the target microorganisms. After which, the bead-bound cells may be isolated. For example, a magnetic field may be applied in order to separate the target cells (with the magnetic beads attached thereto) and move then to a predetermined section of the well. Agar, or other immobilizing agent, may be added to the wells in order to immobilize the target cells. After which, the target cells are incubated and periodically analyzed to determine whether the target cells are growing, thereby indicating that the microorganisms are contained within the well.

NANOBODY FOR DETECTING ESCHERICHIA COLI O157:H7 AND PREPARATION METHOD THEREFOR

Resumen de: WO2026108702A1

Disclosed in the present invention are a nanobody for detecting Escherichia coli O157:H7 and a preparation method therefor. The present invention aims to provide a nanobody for detecting Escherichia coli O157:H7 with high detection accuracy and a simple acquisition method. The amino acid sequence of the nanobody is set forth in SEQ ID NOs. 1-3. The present invention belongs to the technical field of biopharmaceuticals.

SHIGELLA MULTIPLE ANTIGEN PRESENTING IMMUNOGENIC COMPOSITION AND FUSION PROTEINS THEREOF

Resumen de: US20260144857A1

Technologies for the prevention and/or treatment of Shigella infections.

IMMUNOGENIC COMPOSITION

Resumen de: MX2026000807A

The present invention relates to immunogenic compositions comprising antigens from Salmonella enterica serovar Typhimurium (S. Typhimurium), Salmonella enterica serovar Enteritidis (S. Enteritidis), and Salmonella enterica serovar Typhi (S. Typhi). The present invention further relates to methods and uses of compositions comprising GMMA for boosting an immune response to an S. Typhi antigen, vaccines comprising the immunogenic compositions and methods and uses of the immunogenic compositions.

IMMUNOGENIC COMPOSITION

Resumen de: WO2025021695A1

The present invention relates to immunogenic compositions comprising outer membrane vesicles (OMVs) adsorbed to an aluminium hydroxide adjuvant, whereby the aluminium hydroxide adjuvant is quenched. The present invention also relates to the use of the immunogenic compositions for providing protection against diseases caused by Gram-negative bacteria. The present invention also relates to a method for reducing particle aggregation and/or average particle diameter in compositions comprising OMVs and an aluminium hydroxide adjuvant.

Chicken salmonella intestinal lesion spectral characteristic pattern recognition method and system

Resumen de: CN122087393A

The embodiment of the invention provides a chicken salmonella intestinal lesion spectral characteristic pattern recognition method and system, and relates to the technical field of chicken salmonella intestinal lesion spectral characteristic pattern recognition, and the method comprises the steps: obtaining a chicken intestinal tissue original spectrum; determining a distortion mode of the surface of the spectral probe; correcting the original spectrum according to the distortion mode to obtain a corrected spectrum; matching the corrected spectrum with a standard lesion spectrum, and calculating a matching degree between the corrected spectrum and the standard lesion spectrum to obtain a spectrum matching degree; and according to the spectrum matching degree, judging whether chicken intestinal tissues have chicken salmonella lesion or not. According to the invention, the detection accuracy and reliability of the spectrum identification system in a complex environment of a large-scale chicken farm can be improved.

Salmonella choleraesuis phage SCP512 and application thereof

Resumen de: CN122081243A

The invention discloses an enterosalmonella choleraesuis phage SCP512 and application thereof, and belongs to the technical field of microorganisms. The Salmonella choleraesuis phage SCP512 is preserved in the China General Microbiological Culture Collection Center (CGMCC), the preservation number is CGMCC No.47021, and the preservation date is February 4, 2026, and the Salmonella choleraesuis phage SCP512 is preserved in the China General Microbiological Culture Collection Center (CGMCC). The invention belongs to muscular tail bacteriophage family in tail bacteriophage. The bacteriophage SCP512 has multivalent splitting decomposition characteristic, excellent biological characteristic and environmental adaptability, can destroy the formation of a pathogenic bacteria biological membrane, and can solve the technical problems of limited splitting decomposition spectrum range, insufficient coverage on common food-borne pathogenic bacteria, weak biological membrane removal capability and weak application potential in an actual food matrix of the bacteriophage in the prior art.

Primer and probe combination for detecting avian salmonella based on RAA-LFD method and application of primer and probe combination

Resumen de: CN122081526A

The invention belongs to the technical field of molecular biological detection, and particularly relates to a primer and probe combination for detecting avian salmonella based on an RAA-LFD method and application of the primer and probe combination. The invention particularly relates to a primer and probe combination for detecting three avian serotype salmonella such as salmonella pullorum, salmonella enteritidis and salmonella typhimurium based on an RAA-LFD method and application of the primer and probe combination. Different types of probes and primers are respectively designed aiming at genes of serotype salmonella SP, SE and STM, rapid, sensitive and specific detection of salmonella and three serotype avian salmonella such as SP, SE and STM can be realized by adopting the primer and probe combination, the detection period of avian salmonellosis is greatly shortened, the detection time is shortened, and the detection efficiency is improved. The detection efficiency and accuracy of the avian salmonellosis are improved.

油脂饲料添加剂中沙门氏菌的快速筛查定量检测方法

Resumen de: CN122084896A

本发明公开了油脂饲料添加剂中沙门氏菌的快速筛查定量检测方法，涉及饲料添加剂检测技术领域，所述检测方法包括以下步骤：基质兼容化预处理；选择性亲和富集：快速筛查通道以及定量通道；内参与矩阵响应校准。本发明通过可逆性脂质屏蔽的基质兼容化预处理，降低油脂对捕获层与检测反应的界面干扰，克服高油脂基质中游离油脂导致的抗体配体位点遮蔽、试剂吸附以及核酸酶反应抑制等问题，避免单纯强烈化学去脂带来的目标标志破坏或检测失效，在不损伤目标识别位点的前提下显著改善下游捕获与检测灵敏度，提高样品兼容性并缩短现场前处理的复杂度，利于快速质检流程落地。

三级淋巴结构生物模型的构建方法

Resumen de: CN122081186A

本发明公开了一种三级淋巴结构生物模型的构建方法，可以快速高效诱导原位TLS的产生，不依赖于特定的组织器官，不需要细胞编辑、转基因小鼠等复杂昂贵的制备流程，在2～3周内产生稳定、成熟、存续时间长的TLS结构，具有周期短、成本低、操作简单、可重复、安全有效的特点。

一种表达微管抑制蛋白的肿瘤靶向工程菌及其应用

Resumen de: CN122081185A

本发明属于生物医药技术领域，公开了一种用于肿瘤原位表达微管抑制蛋白的工程化细菌及其应用。通过将微管抑制蛋白基因构建至表达载体，最终转入细菌，形成工程菌。该工程菌能靶向定植于肿瘤微环境，表达微管抑制蛋白，有效抑制肿瘤细胞，显著抑制实体瘤生长，且安全性优良。

基于3D打印的便携按压式磁弹微生物传感器、制备方法及检测方法

Resumen de: CN122084894A

本发明公开了基于3D打印的便携按压式磁弹微生物传感器、制备方法及检测方法，属于生物传感器技术领域；传感器包括壳体、传感芯片、检测线圈、信号采集模块；壳体内设置有气泵腔体、微通道、反应腔；传感芯片内嵌于反应腔，检测线圈环绕于反应腔外侧并与信号采集模块电连接；微通道一端与气泵腔体连通，另一端与反应腔连通；微通道设置有外部取样接口；壳体采用3D打印技术制备，通过按压气泵腔体产生的压力驱动样本沿微通道进入反应腔，进而对污水样本进行检测；本发明解决了集成化与便携性问题，适配现场即时检测；全流程封闭化操作无需样本转移，检测数据可靠性有效提升。

Lactobacillus plantarum strain LT303 and application thereof

Resumen de: CN122081173A

The invention relates to the technical field of microorganisms, in particular to a lactobacillus plantarum strain LT303 and application thereof.The lactobacillus plantarum strain LT303 is separated from an acid material, and a fermentation product obtained after fermentation of the strain and leaf mustard has the antibacterial effect on salmonella enteritidis, staphylococcus aureus and/or listeria monocytogenes; the content of sweet amino acids, namely threonine, alanine, serine, glycine and proline, of the pickled Chinese cabbages prepared by fermentation of the strain LT303 is remarkably high, and the fermented pickled Chinese cabbages are the most sweet and fresh in taste and the most abundant in sweet amino acid content; besides, the texture of the pickled Chinese cabbages prepared by adding the mango juice, the pitaya juice and the siraitia grosvenorii juice is enhanced, and the content of sweet amino acids is more remarkably increased, so that the LT303 strain can be used for preparing the pickled Chinese cabbages which are more sweet in taste and more unique in flavor, fermentation liquor has the value of researching and developing antibacterial peptides, and new raw materials and thoughts are provided for increasing the additional value of products in the later period.

MULTIPLE DETECTION COMBINATION FOR DETECTING VIRAL,

Resumen de: CN122095108A

Described herein are compositions, methods, and kits for detecting diarrhea-causing pathogens from a patient, food, or environmental sample. One embodiment described herein is a primer pair and probe for a multiplex polymerase chain reaction (PCR)-based assay for the detection of gastrointestinal pathogens, these gastrointestinal pathogens such as adenovirus, astrovirus, rotavirus, Norovirus, fiveleaf virus, Campylobacter strain, Clostridium difficile, Enteroaggregating Escherichia coli (EAEC), Enteropathogenic Escherichia coli (EPEC), Enterotoxigenic Escherichia coli (ETEC), Shiga-like toxin producing Escherichia coli (STEC), Shigella/Enteroinvasive Escherichia coli (EIEC), Escherichia coli O157, Escherichia coli O157, Escherichia coli O157, Escherichia coli O157, Escherichia coli O157, Escherichia coli O157, Escherichia The composition is prepared from the following raw materials: bacillus subtilis, bacillus subtilis, bacillus subtilis, bacillus subtilis, listeria monocytogenes, plesiomonas shigelloides, salmonella strains, yersinia enterocolitica, vibrio strains, cryptosporidium strains, banquette sporidium, entamoeba histolytica, giardia intestinal or giardia blue. Other embodiments include methods and kits for detecting gastrointestinal pathogens.

Preparation method of sheep-strengthening powder

Resumen de: CN122074590A

The invention belongs to the technical field of feed additives, and particularly relates to a preparation method of sheep Zhuang powder, which comprises the following specific steps: preparing an astragalus extract, preparing berberine hydrochloride, and mixing for preparation. In the preparation process of the sheep strengthening powder, the feed additive is added, the feed additive effectively replaces the previous aureomycin, the antibacterial effect (MIC) of the feed additive on escherichia coli AZ1, escherichia coli 8-1 and salmonella sk77 is obviously better than that of the aureomycin, the dosage every time is smaller, animals are healthier, both pathogenic bacteria are killed, the immunity is improved, and the sheep strengthening powder is suitable for being used for preparing sheep strengthening powder. The feed is safe and compliant, has no residue and no withdrawal period, and has the effects of fattening and weight gaining and fierce eating and fierce growth.

医薬組成物及びその製造方法と使用

Resumen de: CN118846069A

The invention relates to the field of medicine, in particular to a pharmaceutical composition and a preparation method and application thereof.The pharmaceutical composition comprises a first effective component, a second effective component and a pharmaceutically acceptable carrier or auxiliary material, the microbial agent comprises any one or more of staphylococcus aureus, bordetella pertussis, diphtheria toxoid, tetanus toxoid, typhoid bacillus or paratyphoid bacillus, and the second effective component comprises polyinosinic acid, polycytidylic acid and vitamin. The pharmaceutical composition belongs to artificial active immunotherapy aiming at tumors, can'stimulate 'the whole immune system, enables the therapy of activating the human immune system by bacteria to kill cancer cells to be quite stable and reliable, can remarkably save and prolong the life of cancer patients, has extremely high safety and extremely small toxic and side effects, and is suitable for clinical application. And the preparation cost is low.

Salmonella choleraesuis phage SCP531 and application thereof

Resumen de: CN122081242A

The invention discloses an enterosalmonella choleraesuis phage SCP531 and application thereof, and belongs to the technical field of microorganisms. The Salmonella choleraesuis phage SCP531 is preserved in the China General Microbiological Culture Collection Center (CGMCC), the preservation number is CGMCC No.47020, and the preservation date is February 4, 2026, and the Salmonella choleraesuis phage SCP531 is preserved in the China General Microbiological Culture Collection Center (CGMCC). The invention belongs to muscular tail bacteriophage family in tail bacteriophage. The bacteriophage SCP531 has broad-spectrum and high-efficiency lysis activity and excellent biological characteristics and stability, can destroy the formation of a biological membrane of pathogenic bacteria, and can solve the technical problems that in the prior art, the bacteriophage is narrow in lysis spectrum, insufficient in biological membrane removal capacity and limited in application potential in a food matrix.

一种沙门菌H：i抗原表位特异性单克隆抗体及其应用

Nº publicación: CN122081240A 26/05/2026

Solicitante:

扬州大学

Resumen de: CN122081240A

0001 本发明公开了一种沙门菌H:i抗原表位特异性单克隆抗体及其应用，其由保藏编号为CCTCC NO:C202645的杂交瘤细胞分泌得到，该抗体具有效价高、特异性强的优势。本发明以此抗体构建的阻断ELISA检测试剂盒及其检测方法可特异性检测感染动物血清中含H：i抗原表位沙门菌的抗体，且与不含H:i抗原表位沙门菌及非沙门菌的抗体均不反应，敏感性、特异性和稳定性良好，为鼠伤寒和肯塔基等含H:i抗原表位沙门菌感染的直接血清学检测提供了新方法。