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CATIONIC POLY(OXAZOLINE) LIPID CONJUGATES AND LIPID NANOPARTICLES AND POLYPLEXES INCLUDING SAME

Nº publicación: WO2026206901A1 01/10/2026

Solicitante:

SERINA THERAPEUTICS AL INC [US]
SERINA THERAPEUTICS (AL), INC.

WO_2026206901_A1

Resumen de: WO2026206901A1

Poly(oxazoline)-lipid conjugates with pendant cationic groups (cationic POZ-lipid) and lipid nanoparticles (LNPs) including cationic POZ-lipids used to facilitate delivery of an encapsulated payload. LNPs and polyplexes including cationic POZ-lipid and a nucleic acid payload such as, but not limited to, mRNA or modified mRNA are disclosed. Such LNPs have no immunogenicity or reduced immunogenicity as compared to a corresponding LNP containing an ionizable lipid.

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