Resumen de: CN121550182A
本发明属于微生物技术领域,提供了一种包裹有金属‑多酚二次配位纳米涂层的微生物及其制备方法与应用。本发明通过聚乙烯吡咯烷酮、金属离子与多酚自组装形成金属‑多酚纳米颗粒,随后利用纳米颗粒与金属离子的二次配位作用在微生物表面快速沉积连续纳米涂层,所得涂层厚度约为100 nm。本发明的涂层构建方法适用于不同类型微生物,且涂层对微生物的正常生长无显著影响,具有良好的生物相容性。同时该纳米涂层能够选择性促进革兰氏阴性益生菌EcN的生物膜形成。在模拟肠道黏液体系中,该促进效果仍能保持。本发明可用于提高益生菌黏附及定植能力,并适用于益生菌制剂、微生态调控体系的构建。
Resumen de: US2025313845A1
The present disclosure provides compositions and methods for modifying a PCSK9 gene. In some aspects, the present disclosure provides a guide RNA, compositions thereof, and pharmaceutical compositions comprising a guide RNA or a composition as described herein. In some aspects, the present disclosure also provides uses and methods of using a guide RNA, a composition thereof, or a pharmaceutical composition as described herein, for inducing a double-strand break or a single-strand break in a PCSK9 gene, for reducing expression of a PCSK9 gene in a cell or subject, and for treating a patient having or at risk of having a PCSK9-related disease or condition.
Resumen de: GB2641968A
Nanoparticles suitable for delivery of a linear DNA molecule are provided. Nanoparticles suitable for delivery of mRNA or DNA are provided. Further provided are uses of the nanoparticles including the use of the nanoparticles for treating disease and the use of the nanoparticles in vaccines.
Resumen de: MX2025007688A
Compounds, compositions, uses, and methods for increasing cell viability of a dopaminergic neuron, or for preventing or treating dopaminergic neuronal death, are provided herein. In certain examples, methods for reducing symptoms and/or for preventing or treating Parkinson's disease in a subject in need thereof are provided which may include a step of treatment with a GDP-bound form of Rab1a (Rab1a<sup>GDP</sup>), one or more expressible nucleic acids encoding Rab1a<sup>GDP</sup>, or a combination thereof.
Nº publicación: CN121568684A 24/02/2026
Solicitante:
苏州艾博生物科技有限公司
Resumen de: WO2025026304A1
Provided are lyophilized formulations of lipid nanoparticles comprising a cationic lipid and a cryoprotectant combination, which contains sucrose and a non-polar amino acid.