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141
resultados
Última actualización
23/08/2025 [06:58:00]
Resumen de: EP4603003A2
Continuous Glucose Monitoring (CGM) devices provide glucose concentration measurements in the subcutaneous tissue with limited accuracy and precision. Therefore, CGM readings cannot be incorporated in a straightforward manner in outcome metrics of clinical trials e.g. aimed to assess new glycaemic-regulation therapies. To define those outcome metrics, frequent Blood Glucose (BG) reference measurements are still needed, with consequent relevant difficulties in outpatient settings. Here we propose a "retrofitting" algorithm that produces a quasi continuous time BG profile by simultaneously exploiting the high accuracy of available BG references (possibly very sparsely collected) and the high temporal resolution of CGM data (usually noisy and affected by significant bias). The inputs of the algorithm are: a CGM time series; some reference BG measurements; a model of blood to interstitial glucose kinetics; and a model of the deterioration in time of sensor accuracy, together with (if available) a priori information (e.g. probabilistic distribution) on the parameters of the model. The algorithm first checks for the presence of possible artifacts or outliers on both CGM datastream and BG references, and then rescales the CGM time series by exploiting a retrospective calibration approach based on a regularized deconvolution method subject to the constraint of returning a profile laying within the confidence interval of the reference BG measurements. As output, the retrofitting algor
Resumen de: EP4604136A1
A method performed by an electronic apparatus is disclosed. The method comprises receiving information about a user's glucose concentration from an analyte monitoring device attached to the user's body, receiving an alert condition set by a follower of the user at the follower's device, determining whether the alert condition is satisfied based on the information about the user's glucose concentration, and controlling the follower's device to output an alert when the alert condition is satisfied.
Resumen de: GB2638147A
A system 100 comprises a number of devices 102 in communication with one another. The devices 102 are associated with a user 104 and may comprise a smartphone 102A, wearable devices such as a headset 102B or heart rate monitor 102C, and other local devices 102D,102E such as smart speakers including a microphone, cameras, motion sensors or other devices used for monitoring the area around the user 104. The wearable devices may comprise sensors for monitoring physiological parameters or an IMU for monitoring position or movement of the user 104. One or more of the devices 102 can be configured to detect a critical event. A critical event is an event considered to be dangerous or causes the user to require assistance such as cardiac events, a drop in blood sugar level, or a fall. If a critical event occurs, one or more of the devices 102 can raise an alarm or contact assistance. Before such takes place, the system confirms that a prospective critical event is an actual critical event by obtaining additional data from another device 102 in the system. This can help to avoid false alarms or other calls for assistance being raised unnecessarily.
Resumen de: WO2024077402A1
The present disclosure provides a matrix microneedle patch made of a hyaluronic acid (HA) polymeric backbone functionalized with dopamine (DA) and 4-amino-3-fluorophenylboronic acid (AFBA, pKa ~7.5) that quickly and spontaneously crosslinks upon mixing of the polymer solutions by auto-oxidation of catechol groups and reversible interactions between AFBA and catechol functional groups in the absence of any chemical crosslinking agent. The DA and AFBA content were selected for conjugation into the backbone of the HA polymer for the desired hormone delivery profile. The patch provides high drug loading capacity for long-term drug delivery application. The crosslinking mechanism for microneedle fabrication is biocompatible and beneficial for sustaining hormone drug stability and bioactivity as it does not require harsh crosslinking conditions. Facile pH adjustment of the matrix hydrogel can be easily casted into a microneedle patch without multistep processes that conventional patch polymerization requires. The present matrix microneedle patch demonstrates sufficient skin penetration, rapid swelling in interstitial media, high drug loading capacity and effective hypo/hyperglycemia prevention by the automated hypo/hyperglycemia-triggered delivery of hormones through the skin.
Resumen de: LU600247B1
The invention belongs to the technical field of pressure monitoring, in particular to a blockage detection device for a diabetic insulin injection pump, which comprises a gun shell, wherein an injection refill is arranged in the barrel of the gun shell, a refill piston is arranged in the injection refill, an injection pipeline is arranged at one end of the injection refill near the muzzle of the gun shell, the injection pipeline extends out of the gun shell; one side of the refill piston near the injection pipeline is provided with a membrane pressure sensor, a driving mechanism for driving the refill piston to move is arranged inside the gun body of the gun shell; a handle of the gun shell is provided with a manual switch assembly, a controller, a blood sugar monitoring module and an alarm prompt system.
Resumen de: US2025259720A1
This disclosure relates to a method, a mobile device, and a computer program, for managing medical data such as, e.g., glucose concentrations, by an electronic disease management system. In the method a change of the local time between generation of a first set of medical data and a second set of medical data is detected.
Resumen de: US2025259727A1
Disclosed is a meal detection and meal size estimation machine learning technology. In some embodiments, the techniques entail applying to a trained multioutput neural network model a set of input features, the set of input features representing glucoregulatory management data, insulin on board, and time of day, the trained multioutput neural network model representing multiple fully connected layers and an output layer formed from first and second branches, the first branch providing a meal detection output and the second branch providing a carbohydrate estimation output; receiving from the meal detection output a meal detection indication; and receiving from the carbohydrate estimation output a meal size estimation.
Resumen de: US2025255561A1
A method performed by an electronic apparatus is disclosed. The method comprises receiving information about a user's glucose concentration from an analyte monitoring device attached to the user's body, receiving an alert condition set by a follower of the user at the follower's device, determining whether the alert condition is satisfied based on the information about the user's glucose concentration, and controlling the follower's device to output an alert when the alert condition is satisfied.
Resumen de: US2025256027A1
The embodiments described herein may relate to methods and systems for adjusting insulin delivery. Some methods and systems may be configured to adjust insulin delivery to personalize automated insulin delivery for a person with diabetes. Such personalization may include receiving and/or determining one or more user specific dosage parameters.
Resumen de: AU2024219128A1
Disclosed herein are intravascular artificial pancreas devices and methods for their manufacture.
Resumen de: EP4599866A2
An infusion pump system is disclosed for dispensing liquid medication, such as insulin. The infusion pump system includes a first reservoir for storing liquid medication, a first fluid driver for exerting pressure on the first reservoir, a second reservoir for storing liquid medication, and a second fluid driver for exerting pressure on the second reservoir. One or more valves are used to permit flow of liquid medication from the first reservoir to the second reservoir, and to permit flow of liquid medication from the second reservoir to an infusion site. Each of the valves is selectively opened or closed to fill the second reservoir with liquid medication from the first reservoir and to dispense liquid medication from the second reservoir to the infusion site. A controller and one or more sensors are used to monitor and control the system.
Resumen de: EP4601218A2
A system is provided for monitoring analyte in a host, including a continuous analyte sensor that produces a data stream indicative of a host's analyte concentration and a device that receives and records data from the data stream from the continuous analyte sensor. In one embodiment, the device includes a single point analyte monitor, from which it obtains an analyte value, and is configured to display only single point analyte measurement values, and not any analyte measurement values associated with data received from the continuous analyte sensor. Instead, data received from the continuous analyte sensor is used to provide alarms to the user when the analyte concentration and/or the rate of change of analyte concentration, as measured by the continuous analyte sensor, is above or below a predetermined range. Data received from the continuous analyte sensor may also be used to prompt the diabetic or caregiver to take certain actions, such as to perform another single point blood glucose measurement. In another embodiment, the device provides for toggling between two modes, with one mode that allows for display of glucose concentration values associated with the continuous glucose sensor and a second mode that prevents the display of glucose concentration values associated with the continuous glucose sensor.
Resumen de: EP4599864A2
Infusion systems, infusion devices, and related operating methods are provided. An exemplary method of operating an infusion device (100, 500) to deliver fluid to a body of a user involves obtaining measurement values for a physiological condition influenced by the fluid, autonomously operating the infusion device to deliver the fluid based at least in part on the measurement values, and detecting a nonactionable condition based on the measurement values. In response to detecting the nonactionable condition, delivery of the fluid is limited while maintaining autonomous operation of the infusion device. In one exemplary embodiment, the nonactionable condition is a rescue condition indicative of the user having consumed fast-acting carbohydrates, and thus insulin delivery may be automatically limited in response to detecting the rescue carbohydrate consumption.
Resumen de: EP4601278A2
Method, device and system for providing consistent and reliable glucose response information to physiological changes and/or activities is provided to improve glycemic control and health management.
Resumen de: WO2024077303A2
Glucose systems that include a minimally invasive scalp-worn device that includes first and second sensors. The systems are adapted to determine one or more glucose states based on sensed EEG signals using the scalp-worn device.
Resumen de: US12383675B1
In an aspect, the present disclosure provides a method comprising: (a) positioning an insulin delivery device on a body of a subject via a single puncture site in said body of said subject; (b) using said insulin delivery device to deliver an insulin or insulin analog formulation to said subject via said single puncture site; and (c) using a sensor of said insulin delivery device to measure a glucose concentration in said body of said subject via said single puncture site, wherein (b) and (c) are performed at substantially the same time for a time period of at least 1 hour subsequent to said positioning in (a), while maintaining a sensitivity of said sensor of at least 50% of an initial sensitivity of said sensor.
Resumen de: US2025248667A1
An artificially intelligent, voice-based method for prescribing, managing and administering at least one medication for management of type 2 diabetes to a patient. Aspects of the present disclosure provide for a system and method for configuring one or more clinical algorithms according to one or more clinical protocols to configure a conversational AI model. The conversational AI model is configured to drive a conversational AI agent configured to facilitate a plurality of multi-turn conversational interactions between a patient user and the conversational agent to enable automated initiation and titration of one or more diabetes medications for the patient.
Resumen de: US2025248654A1
Embodiments of the invention provide skin adhesive patches designed to ease a diabetic patient's maneuverability and alignment of a glucose sensing device as the patient adheres the device to their skin. Embodiments of the invention can be adapted for use with a wide variety of medical components that are coupled to the skin of patients, including insulin infusion sets, patch pumps, and all-in-one patch sets.
Resumen de: US2025248627A1
Provided is an implant apparatus for a continuous glucose monitor. The implant apparatus includes a housing assembly and a driving assembly disposed in the housing assembly. The housing assembly includes an outer housing. The outer housing has an opening at an end of the outer housing. The driving assembly has a locked state in which the driving assembly is fixed relative to the outer housing and a triggered state in which the driving assembly is movable towards the opening. The implant apparatus further includes a trigger. The outer housing includes a guiding channel located at a side wall of the outer housing and extending towards the opening. The trigger is movable along the guiding channel towards the opening and has a first position and a second position relative to the outer housing, to enable the driving assembly to switch from the locked state to the triggered state.
Resumen de: US2025248633A1
Devices are provided for measurement of an analyte concentration, e.g., glucose in a host. The device can include a sensor configured to generate a signal associated with a concentration of an analyte; and a sensing membrane located over the sensor. The sensing membrane comprises a diffusion resistance domain configured to control a flux of the analyte therethrough. The diffusion resistance domain comprises one or more zwitterionic compounds and a base polymer comprising both hydrophilic and hydrophobic regions.
Resumen de: US2025248666A1
An artificially intelligent, voice-based method for prescribing, managing and administering at least one medication for management of type 2 diabetes to a patient. Aspects of the present disclosure provide for a system and method for configuring one or more clinical algorithms according to one or more clinical protocols to configure a conversational AI model. The conversational AI model is configured to drive a conversational AI agent configured to facilitate a plurality of multi-turn conversational interactions between a patient user and the conversational agent to enable automated initiation and titration of one or more diabetes medications for the patient.
Resumen de: US2025249170A1
A variety of location-based and/or proximity-based features related to diabetes management systems can be used to improve maintenance compliance and/or to provide important information to PWD designated assistance entities (e.g., family, friends, givers, HCPs, emergency medicine providers) under certain conditions. In some cases, a user's location can be tracked or determined to trigger and/or time alerts about upcoming maintenance tasks in a way that will increase the likelihood that the PWD will immediately perform the designated maintenance task. In some cases, methods, devices, and systems provided herein can use proximity to non-paired mobile computing devices to deliver data to PWD designated assistance entities.
Resumen de: WO2025161630A1
A Raman spectroscopy-based non-invasive glucose meter, comprising a light source module (110), a dichroic mirror (130), a lens module (150), an optical filter (191), and a photoelectric spectral measurement module (170). The light source module (110), the photoelectric spectral measurement module (170), and the lens module (150) are all arranged to correspond to the dichroic mirror (130). The optical filter (191) is disposed on a light-incident side of the photoelectric spectral measurement module (170) to filter out short-wavelength excitation light, and the photoelectric spectral measurement module (170) obtains spectral information by changing the refractive index in its own material.
Resumen de: WO2025166261A1
A computer implemented method for controlling insulin dosing for a subject includes saving field collected glucose and insulin data for the subject. The method implements a virtual personal model, or digital twin, of the subject by using the field collected data to save electronic field collected traces of blood glucose levels and electronic field collected traces of insulin levels for the subject. A replay phase of the virtual personal model emulates test insulin therapies to generate virtual insulin doses that correspond to the field collected data. The method converges to a result by comparing field collected glucose traces and regenerated glucose traces. This method recommends a basal rate profile for the subject using saved replay data by calculating inversions of the virtual personal model by deconvolution.
Nº publicación: WO2025164955A1 07/08/2025
Solicitante:
BENCH SOFT CO LTD [KR]
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Resumen de: WO2025164955A1
Provided is a system for managing blood glucose, the system comprising: a bio-apparatus for measuring biosignals including blood glucose; and a drug injection device for injecting drug for controlling blood glucose in the body, wherein the bio-apparatus and drug injection device are each provided with at least one electrode for connecting to the human body, and transmit and receive electrical signals between each other with the human body as the medium, and the bio-apparatus is provided with a power reception circuit for receiving operational power from the drug injection device.
BOPI
Sede Electrónica
