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Method for 3D printing of vascularized tissues and organs

Resumen de: AU2026226381A1

Abstract: The 3D printing method disclosed here for the production of vascularized tissues and organs requires a droplet printer to produce photorealistic high-resolution prints and a device for applying non-directional or directional electromagnetic waves. The process uses a new type of capillary ink that crosslinks or undergoes a layer-forming reaction only in the edge area of the ink drops. Unbound capillary ink components are removed. The resulting cavities form a capillary network with diameters of up to approx. 10 µm. Also disclosed is a novel printer table for supplying the printed tissue with medium during printing and a printer head supply unit for individually mixing the bio-inks from cell concentrate and various ink concentrates. concentrate and various ink concentrates. ep b s t r a c t : e p c o n c e n t r a t e a n d v a r i o u s i n k c o n c e n t r a t e s

DYNAMIC EQUIVALENT ON BOARD ESTIMATOR

Resumen de: US20260279537A1

Adaptive on board estimation of exogenous pharmacon responsive to transient (i.e., impermanent) physiological effects is provided. Dynamically estimating an equivalent amount of an exogenous pharmacon on board (XOB), such as insulin and/or carbohydrates, left in the subject, is based on predictions of glucose time-series data. These estimated values, such as insulin on board (IOB), are useful for diabetes management software, including decision support and/or artificial pancreas (AP) algorithms, for example.

IMPLANTABLE OBJECTS FABRICATED BY ADDITIVE MANUFACTURING AND METHODS OF FABRICATING THE SAME

Resumen de: US20260273626A1

An implantable object 1000′ and a method 100 of fabricating an implantable object is disclosed. The method 100 comprises melting a powder 210 comprising at least nickel and titanium with an energy source 220 and iteratively forming a plurality of stacked metallic layers 330 from the melted powder using an additive manufacturing technique. The implantable object is biased to expand from a first configuration 501 to a second configuration 502 when at or above a transformation temperature.

Noninvasive Determination of Resting State Diastole Hemodynamic Information

Resumen de: US20260279596A1

A diastole-based hemodynamic index, such as instantaneous wave-free ratio (IWFR), may be calculated noninvasively for a patient by receiving image data respective of an anatomical region of the patient, creating an electronic model of the anatomical region, creating one or more boundary conditions model value sets representative of flow conditions during diastole, calculating one or more pressure drops at a location in the anatomical region, and determining, based on the calculated pressure drop(s) and based on a reference pressure, a hemodynamic index value, such as IWFR, for the location.

SYSTEMS AND METHODS FOR ORTHOPEDIC IMPLANTS

Resumen de: US20260272660A1

A system and computer-implemented method for manufacturing an orthopedic implant involves segmenting features in an image of anatomy. Anatomic elements can be isolated. Spatial relationships between the isolated anatomic elements can be manipulated. Negative space between anatomic elements is mapped before and/or after manipulating the spatial relationships. At least a portion of the negative space can be filled with a virtual implant. The virtual implant can be used to design and manufacture a physical implant.

SYSTEMS AND METHODS FOR GENERATION OF HEALTH RECOMMENDATIONS

Resumen de: US20260279532A1

Disclosed are systems and methods that generate real-time health recommendations by computing higher-order derivatives, including jerk (third derivative), of physiological parameters and composite indices to detect early trend inflections that may indicate changes in health conditions. The systems may include a server with a health recommendation unit, databases, and data models that time-align heterogeneous inputs and optionally smooth signals prior to differentiation. Derivatives may be estimated from irregularly sampled clinical data. Events may be detected using magnitude thresholds, sign changes, and persistence windows, triggering intervention, confirmation, or monitoring-cadence recommendations. Examples include LDL cholesterol trajectories and allostatic load (AL) methods that select, normalize, and weight multi-system physiological parameters to determine an allostatic load index AL(t), followed by computation of one or more derivatives of AL(t) including at least a third derivative. Outputs may used to feed a closed-loop that adapts thresholds, weights, and goal difficulty to personalize future guidance. The approach enables earlier, explainable recommendations than absolute levels alone.

RESOURCE ACCOUNTABILITY MANAGEMENT

Resumen de: WO2026193372A1

Techniques are disclosed for resource accountability management. An apparatus includes at least one processing device configured to determine, for a workflow comprising tasks associated with locations, assignment of resources to the tasks and hierarchical associations between different ones of the resources. The at least one processing device is also configured to monitor, at a given location associated with a given task, presence of respective ones of the resources utilizing sensor devices associated with the resources, and to generate, based at least in part on the monitored presence of respective ones of the resources, one or more accountability management visualizations for the given task.

ALZHEIMER'S DETECTION AND PATIENT PROTECTION

Resumen de: WO2026190546A1

A method, comprising: receiving user data from a device; creating a user profile based on the user data; training an artificial intelligence (AI) model using the user profile and historical user profiles; determining a long term cognitive state score (CSS) and a real-time CSS using the trained AI model; determining that an Alzheimer's risk score is below a predetermined Alzheimer's threshold based on the long term CSS and the real-time CSS; and providing a notification in response to the Alzheimer's risk score being below the predetermined Alzheimer's threshold.

SYSTEM, METHOD, AND COMPUTER PROGRAM PRODUCT FOR PROVIDING ACCESS TO FLUID INJECTION SYSTEMS

Resumen de: EP4807758A2

A system for securely accessing a fluid injection system is disclosed. The system includes at least one processor programmed or configured to authenticate a user for access to an fluid injection system, provide data identifying one or more features of a software application for accessing the fluid injection system, receive data identifying a selected feature of the software application for accessing the fluid injection system, and provide access to the selected feature of the software application for accessing the fluid injection system.

RADIATION-CURING COMPOSITION FOR PRODUCING DENTAL COMPONENTS IN A 3D PRINTING PROCESS

Resumen de: WO2025099123A1

The invention relates to a radiation-curing composition for producing dental components in a 3D printing process, comprising, based on the total mass of the radiation-curing composition: i) one or more radically polymerisable monomers in a combined mass fraction of 30% or more; ii) one or more first fillers in a combined mass fraction of 5% or more, wherein the first filler or fillers has or have an average particle diameter D50 of 150 nm or less; iii) one or more second fillers, different from the first filler, in a combined mass fraction of 5% or more, wherein the second filler or fillers is or are selected from the group consisting of feldspars; and iv) one or more photoinitiators having a combined mass fraction in the range of 0.001 to 10%, wherein the combined mass fraction of fillers is 30% or more.

CRYOPRESERVATION OF BIOPRINTED TISSUE FIBERS

Resumen de: WO2025099488A1

Aspects of the disclosure include cryopreserved tissue fibers and multilayer structures comprising said fibers, wherein the fibers encapsulate dissociated cells, and where the fibers and/or structured are cryopreserved prior to aggregation of the encapsulated cell population. Methods of making and using such fibers and structures are also provided.

SYSTEM, DEVICE, AND METHOD FOR SAFEGUARDING WELLBEING OF PATIENTS FOR FLUID INJECTION

Resumen de: EP4806337A2

A system and method for promoting and safeguarding the wellbeing of patients in relation to a fluid injection may obtain patient data; determine, based on the patient data, an initial risk prediction for a patient for a fluid injection to be administered to the patient, the initial risk prediction including a probability that the patient experiences at least one adverse event in response to the fluid injection; provide, to a user device, before the fluid injection is administered to the patient, the initial risk prediction; determine, after the fluid injection is started, sensor data associated with the patient; determine, based on the sensor data determined after the fluid injection is started, a current risk prediction including a probability that the patient experiences the at least one adverse event in response to the fluid injection; and provide, to the user device, the current risk prediction.

STEREOLITHOGRAPHIC RESIN COMPOSITION

Resumen de: EP4806415A1

The present invention provides a stereolithographic resin composition that possesses excellent shape accuracy and exhibits superior strength, toughness, and water resistance in the shaped article while reducing leachables from the shaped article. The present invention relates to a stereolithographic resin composition comprising a polyfunctional (meth)acrylic polymerizable compound (A), and a photopolymerization initiator containing four or more heteroatoms within a single molecule (B). Preferably, the stereolithographic resin composition further comprises a monofunctional (meth)acrylic polymerizable compound (C). Preferably, the polyfunctional (meth)acrylic polymerizable compound (A) comprises a polyfunctional (meth)acrylic polymerizable compound (A)-I having a molecular weight of less than 500.

SYSTEMS AND METHODS FOR PRINTING HIGH-DENSITY TISSUE FIBERS

Resumen de: WO2025099487A1

Aspects of the disclosure include microfluidic print heads for bioprinting core/shell fibers having consistent diameters and shell thicknesses, and methods of making high-density tissue fibers comprising cell populations of therapeutic interest for implantation, as well as the high-density tissue fibers produced thereby.

METHOD AND SYSTEM FOR REAL-TIME EMOTIONAL STATE SHIFT DETECTION AND ADAPTIVE RESPONSE GENERATION

Resumen de: EP4807757A1

Current emotional detection technologies often struggle to consistently identify emotional state shifts in real-time, particularly in noisy environments where signals fluctuate due to minor external changes, and also fail to provide a robust mechanism that can account for and filter out these transient signals. Method and system disclosed herein perform real-time emotional state shift detection of a user and adaptive response generation. The system captures and processes a multi-modal input data in real time, during which weight of each multi-modal input data is determined based on a sensitivity factor that is determined by performing dynamic sensitivity adjustment for each multi-modal input data. An adaptive question is generated for the facilitator and the response is collected. The user is made to play a generative game until the user is identified to be in a pre-defined state. Further, a customized interview structure is generated for the user.

非心臓医療処置中のデカップリングを予測するための方法および装置

Resumen de: WO2025043061A2

Methods and apparatus for predicting decoupling during a non-cardiac medical procedure are provided. The method includes receiving one or more patient characteristics associated with a patient scheduled for a non-cardiac medical procedure, providing the one or more patient characteristics as input to a machine learning model trained to output a decoupling prediction, processing, using at least one computer processor, the one or more patient characteristics using the machine learning model to output a decoupling prediction for the patient, wherein the decoupling prediction is associated with the non-cardiac medical procedure, and displaying, on a user interface, an indication of the decoupling prediction for the patient output from the machine learning model.

SYSTEM FOR PREVENTION, MODERATION, AND/OR TREATMENT OF COGNITIVE INJURY

Resumen de: EP4806501A2

0001 This disclosure describes methods and systems for preventing, moderating, and/or treating brain injury. The systems herein may include a processor configured to induce a stimulator to stimulate a nerve. The processor is configured to receive a test result and determine a stimulation parameter based on the test result, wherein the test result reflects a condition of a brain in the subject or a vagus nerve activity. The processor is configured to induce the stimulator to stimulate the nerve with a stimulation signal characterized by the stimulation parameter, to: (i) generate negative pressure in a thoracic cavity of a subject; (ii) reduce brain cell damage; or (iii) inhibit transmission of an aberrant signal by the nerve.

MULTIPLE MODALITY BODY COMPOSITION ANALYSIS

Resumen de: EP4806359A2

Systems and methods for determining body composition by combining dual-energy x-ray (DXA) technology with three-dimensional (3D) optical technology and/or bioimpedance technology are disclosed. A multi-modality scanning system may include a dual-energy x-ray source and an x-ray detector mounted to opposing sides a c-arm and configured to scan a patient on a optically translucent table. A bioimpedance machine may also be included in the multi-modality scanning system. Data based on the dual-energy x-rays may be combined with the data from the 3D optical images and/or the bioimpedance data to generate values of at least three compartments selected from: bone, fat tissue, lean tissue, dehydrated lean tissue, and water. The system may also include one or more 3D optical imaging devices to capture 3D optical images of the patient substantially concurrently with the emission of the dual energy x-rays.

METHOD AND SYSTEM FOR DETERMINING A RISK OF HEMODYNAMIC COMPROMISE AFTER CARDIAC INTERVENTION

Resumen de: EP4806394A2

A method and system for predicting a measure of hemodynamic compromise as a result of transcatheter cardiac treatment. The method includes providing a patient-specific anatomical model representing cardiac region and an implant model representing a three-dimensional representation of a cardiac implant. The method includes virtually deploying said implant model into said patient-specific anatomical model. A deformation of the patient-specific anatomical model is calculated as a result of implant model deployment A measure of hemodynamic compromise is determined from the virtually deployed implant model and the deformed patient-specific anatomical model.

DEVICE FOR GUIDED BONE REGENERATION AND PRODUCTION METHOD

Resumen de: UA131203C2

The present invention relates to a device for guided bone regeneration, intended for the reconstruction of a buccal bone defect, composed of zirconium dioxide and having a shape which covers said buccal bone defect. The present invention also relates to a method for producing a device of the invention, comprising a step of constructing the device of the invention according to a three-dimensional representation obtained by means of a technique of maxillo-dental imaging of the bone defect.

GENERATION OF MAXILLOFACIAL IMAGING VOLUME WITH MOTION

Resumen de: EP4806361A1

0001 Various aspects of systems, methods, and related aspects to generate a maxillofacial imaging volume with motion, from a three-dimensional (3D) extra-oral x-ray system, are described. One example technique includes: obtaining imaging data of a patient, captured during movement of an upper jaw and the lower jaw of the patient; establishing a motion model that defines an expected movement of the upper jaw relative to the lower jaw; segmenting the imaging data into at least an upper jaw segment corresponding to the upper jaw and a lower jaw segment corresponding to the lower jaw, based on the expected movement defined by the motion model; performing motion artifact correction separately on the upper jaw segment and the lower jaw segment; and outputting an imaging volume that includes an artifact-corrected representation of the upper jaw segment and an artifact-corrected representation of the lower jaw segment.

ALLOPLASTIC AURICLE PROSTHESIS AND METHOD FOR MANUFACTURING THE SAME

Resumen de: WO2025099555A1

The invention relates to an alloplastic prosthesis (20) for the complete or partial reconstruction of the outer ear (22) of a patient (24). The alloplastic prosthesis comprises a plurality of shaped layers (26) stacked and joined to each other, wherein some layers are made of thermoplastic polyurethane (TPU) and other layers are made of polycaprolactone (PCL); at least the outer surface of the alloplastic prosthesis comprises a plurality of pores (28) having a predefined structure and surface comprised between 0.1 mm2 and 0.2 mm2. The invention further relates to a method (100) for manufacturing the alloplastic prosthesis.

经由充电基座对剂量检测模块的软件更新

Resumen de: WO2025178838A1

Disclosed embodiments relate to dose detection modules that are removably attachable to an actuator of a medication delivery device. A dose detection module may include a housing which couples to the actuator, and an electronics assembly disposed at least partially within the housing. The electronics assembly may include a processor and an actuation sensor configured to detect actuation of the actuator. The electronics assembly also includes a rechargeable energy storage element configured to deliver power to the processor and the actuation sensor, and an energy transfer element configured to deliver power to the energy storage element from an external energy source. The electronics assembly also includes a communication module configured to communicate with a base communications module of the charging base to, when the dose detection module is coupled to the charging base, receive data from the base communications module, and transmit data to the base communications module.

喉部生理信号传感器、连续监测系统及生理状态评估方法

Resumen de: CN122744722A

0001 本发明公开了一种喉部生理信号传感器、连续监测系统及生理状态评估方法，涉及生理信号监测评估技术领域；喉部生理信号传感器通过弹性摩擦层与皮肤之间接触状态、有效接触面积及分离距离的变化产生电荷转移信号；连续监测系统中的各电路模块构建了一体化读出链路，可高效地采集并输出多通道的喉部生理数字信号；本发明还提供了一种喉部生理状态评估方法，对喉部生理数字信号进行规整处理、有效动作提取和二维时空特征信号展开，进而采用卷积‑时序混合神经网络构建智能识别模型，实现喉部生理状态的自动识别与评估；本发明的技术方案可服务于声带麻痹、声带结节、喉炎、吞咽障碍等场景下的辅助筛查、康复训练反馈和长期随访。

処置および手術情報警告システム

Nº publicación: JP2026146209A 15/09/2026

Solicitante:

アルコンインコーポレイティド

Resumen de: CN116057921A

A procedure and procedure information alert system (10) is a procedure management system for capturing, storing, processing, tracking, and sharing patient and procedure identification data, including implant data, during medical/surgical procedures performed at a plurality of medical office (20) and/or surgical center (30) locations. A procedure and surgical information alert system (10) allows accurate verification of a predetermined procedure for verification between a physician and a patient during a scheduling process of a medical office (20), which is confirmed at the time by a signature of the patient. On the day of the surgical procedure, the patient re-verifies the patient information at the surgical center. Prior to the surgical procedure, a preoperative pause alert (240) is generated to freeze use of the system until the physician confirms verification of the patient information. An implant inventory alert alert is provided to an authorized surgical center worker based on the predicted implant inventory demand (192).