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BODY ATTACHABLE UNIT FOR CONTINUOUS BLOOD GLUCOSE MEASUREMENT

Resumen de: EP4796031A2

The present invention relates to a body attachment unit for continuous blood glucose monitoring, in which a body attachment unit is manufactured so as to be assembled in an applicator, thereby minimizing additional work and allowing attachment of the body attachment unit to a body simply by operation of the applicator. In particular, a wireless communication chip is provided in the body attachment unit to enable communication with an external terminal, thereby enabling simple and convenient use without additional work of connecting a separate transmitter, and allowing easier maintenance. In addition, activation occurs by a user's operation after the body attachment unit is attached to the body, such that an activation start time can be adjusted to a time appropriate to the user's needs, and activation can occur in a stabilized state, and thereby allowing more accurate blood glucose monitoring.

SYSTEM AND METHOD OF ASSISTED DRIVING FOR DRIVERS WITH DIABETES UNDER CONTINUOUS BLOOD GLUCOSE MONITORING

Resumen de: GR1011264B

The present invention consists in an assisted driving system for drivers with diabetes, installable into vehicles that have a central brain (16), a steering system (EPS - Electric Power Steering) (10), a braking system (EHB - Electrohydraulic Brakes) (11) and a telematics unit (15). It consists of: a) a biometric identification unit (FacelD) (2), b) a camera for monitoring the physical state of the driver (Driver Monitoring System) (7), c) a Lidar sensor (9), d) a Radar sensor (9,17), e) a GPS receiver (14), f) a continuous glucose monitoring sensor (CGM sensor) (4), g) a high-performance microcontroller (3) and h) a CAN-bus interface adapter to connect the high-performance microcontroller to the central brain. By the implemented assisted driving method, the system, upon detecting that the glucose level falls below 80 mg/dL, takes control of the vehicle, steering it safely to a location where it can be immobilized safely.

MEDICATION DELIVERY SYSTEM

Resumen de: EP4797275A1

A medication delivery system, including a wearable device configured to automatically deliver medication based on food order information received from a user computing device. The medication is delivered via a pump, and the medication may be insulin. The food order information includes timing information and/or information about the food ordered necessary to change a medication delivery. A controller determines a medication adjustment based on an estimated physiological response to the food order information. A delivery pump automatically delivers the medication, e.g., an insulin bolus, prior to or in anticipation of food consumption.

COUPLING A CATHETER TO A LIQUID DRUG INFUSION PUMP

Resumen de: EP4796158A1

0001 L'invention concerne un ensemble (1) d'administration d'un médicament liquide, de préférence de l'insuline, comprenant une pompe (10) de perfusion comprenant un réservoir (11) pour stocker le médicament liquide, et un premier connecteur (13) comprenant un taraudage (14), en communication fluidique avec le réservoir (11), et un cathéter (20) comprenant un tuyau flexible (21) équipé d'un second connecteur (23) comprenant un filetage (24) complémentaire du taraudage (14) du premier connecteur (13) de manière à pouvoir coupler par vissage les premier et second connecteurs (13, 23), l'un à l'autre, et ainsi raccorder fluidiquement le cathéter (20) à la pompe (10). Le couplage par vissage des premier et second connecteurs (13, 23), l'un à l'autre, comprend un déplacement en rotation (R) relatif de l'un par rapport à l'autre, selon un angle de rotation compris entre 100° et 200°.

ANTI-IGF1R ANTIBODIES AND USES THEREOF

Resumen de: ZA202508070B

Provided are anti-IGF1R (insulin-like growth factor 1 receptor) antibodies, antigen-binding fragments, and the uses thereof.

Novel animal-source-component-free tumor cell amplification culture medium and process

Resumen de: CN122628993A

The invention relates to the field of tumor cell amplification and metabolism regulation, and discloses a novel animal-source-component-free tumor cell amplification culture medium and process, which comprises the following steps: inoculating tumor cells by adopting an animal-source-component-free culture medium, monitoring the concentration of residual glucose in an exponential growth phase, and when the concentration of the glucose is reduced to a trigger threshold interval, starting the operation of the culture medium; stopping supplying the basic solution, injecting a sugar-free metabolism reversal pulse solution containing sodium pyruvate and N-acetylcysteine into the culture system for one time, maintaining an intervention state, driving lactic dehydrogenase to generate reverse catalysis by utilizing a concentration gradient formed by exogenous pyruvic acid, inducing tumor cells to take in and assimilate lactic acid, and culturing the tumor cells. According to the method, a metabolic flow endogenous closed-loop regulation mechanism is established, acid metabolic waste self assimilation is achieved through lactic acid endogenous removal, autocrine microenvironment damage caused by physical dilution is avoided, and it is ensured that the genetic characteristics of a cell line are stable.

Super-hydrophobic microneedle patch integrating minimally invasive blood sampling and SERS blood detection functions as well as preparation method and application of super-hydrophobic microneedle patch

Resumen de: CN122624062A

The invention discloses a super-hydrophobic microneedle patch integrating minimally invasive blood sampling and SERS (Surface Enhanced Raman Scattering) blood detection functions as well as a preparation method and application of the super-hydrophobic microneedle patch, and belongs to the technical field of clinical laboratory medicine and biosensing. A microneedle sampling layer containing arrayed conical protrusions is prepared through mold casting-vacuum forming, the microneedle sampling layer is sequentially modified with a polydopamine coating, a silver nanoparticle array layer and a hydrophobic protection layer, and the super-hydrophobic microneedle patch integrating sampling, enhancement and detection is constructed. The super-hydrophobic micro-needle patch can realize minimally invasive painless blood sampling, substances such as hemoglobin and glucose in blood can be detected at high sensitivity based on the surface enhanced Raman spectrum effect, and the detection time is 1t; the method is high in biological interference resistance, does not need large equipment, can be directly deployed in a street blood donation scene, remarkably improves the blood donation screening efficiency and safety, and can solve the problems that an existing blood donation screening technology depends on large equipment and is high in sampling invasiveness and low in detection efficiency.

Metabolism regulation culture medium and method for inhibiting haploid embryonic stem cell doubling by applying metabolism regulation culture medium

Resumen de: CN122628980A

The invention relates to a metabolism regulation culture medium and a method for inhibiting haploid embryonic stem cell duplication by applying the metabolism regulation culture medium, the metabolism regulation culture medium comprises a basic culture medium and metabolism regulation functional components, and the metabolism regulation functional components comprise mitoxantrone mesylate, Enricasan, fructose diphosphate Forsfuctose, 2-DeoxyD-glucose, UK5099 and VLX600. The invention further discloses a preparation method of the metabolism regulation culture medium for inhibiting the haploid embryonic stem cell duplication by applying the metabolism regulation culture medium for inhibiting the haploid embryonic stem cell duplication by applying the metabolism regulation culture medium for inhibiting the haploid embryonic stem cell duplication by applying the metabolism regulation culture medium for inhibiting the haploid embryonic stem cell duplication. A novel culture system of mouse haploid embryonic stem cells is established, and the system verifies the haploidy maintenance effect, the cell pluripotency, the differentiation capacity and the genome stability of the system. According to the method, the haploidy maintaining capability of the haploid embryonic stem cells can be remarkably improved, the culture cost is reduced, and a simple, convenient and economical culture strategy is provided for popularization and application of the haploid embryonic stem cells.

Culture medium for hippophae rhamnoides pollen in-vitro germination as well as preparation method and application of culture medium

Resumen de: CN122628969A

The invention relates to the technical field of plant tissue culture, in particular to a culture medium for in-vitro germination of hippophae rhamnoides pollen as well as a preparation method and application of the culture medium. Each 100 mL of the culture medium comprises 0.5 to 1 g of agar, 15 to 25 g of cane sugar, 0.0001 to 0.1 g of boric acid and 0.0003 to 0.001 g of calcium chloride. By adding the agar, the cane sugar, the boric acid and the calcium chloride, the germination of sea buckthorn pollen and the elongation of pollen tubes are promoted.

Cell surface glycopeptide identification method and half-life period determination method

Resumen de: CN122631793A

The invention discloses a cell surface glycopeptide identification method and a half-life period determination method. Wherein the cell surface glycopeptide at least comprises sialylated glycopeptide, and the half-life period determination comprises the following steps: S1, sequentially carrying out glycometabolism labeling and biotin labeling on a cell surface sugar chain on a living cell to obtain a sugar chain labeled cell; s2, carrying out label-free culture medium culture on the labeled cells, and collecting to-be-detected cells at different time points; s3, sequentially performing protein extraction treatment, enzymolysis treatment and enrichment treatment on the to-be-detected cells to obtain a product containing the to-be-detected glycopeptide, then performing qualitative and quantitative analysis on the to-be-detected glycopeptide, and calculating the half-life period of the to-be-detected glycopeptide according to a quantitative analysis result. According to the glycopeptide identification method and the half-life period determination method, high-specificity enrichment and dynamic quantitative analysis of the sialylated complete glycopeptide on the surface of the living cell can be realized, and the glycopeptide identification method and the half-life period determination method have the advantages of high compatibility, high labeling efficiency, low labeling background and the like.

Double-closed-loop insulin delivery system, application thereof and medical product

Resumen de: CN122641490A

The invention belongs to the technical field of medical instruments, and particularly relates to a double-closed-loop insulin delivery system, application thereof and a medical product. The invention discloses a double-closed-loop insulin delivery system. The double-closed-loop insulin delivery system specifically comprises a dynamic blood glucose monitoring system, a double-closed-loop control algorithm, an insulin pump and a specific sugar response insulin analogue. The blood glucose is controlled in a double-closed-loop mode, the high time proportion of the blood glucose in the target range can be achieved, more stable, safer, simpler and more convenient blood glucose control is achieved, human intervention is not needed in the system using process, and a more intelligent and humanized treatment scheme is provided for diabetics.

First-aid monitoring system and method integrating vital sign monitoring and automatic defibrillation

Resumen de: CN122624827A

The invention discloses a first-aid monitoring system and method integrating vital sign monitoring and automatic defibrillation, which are applied to the field of medical instruments, for the first time, three vital sign data of heart rate, blood pressure and blood sugar are fused with AED heart rhythm analysis data, the misjudgment rate of single data is reduced through an AI algorithm, high-risk accurate pre-judgment of sudden cardiac arrest is realized, and the accuracy of cardiac arrest is improved. Full-process automation of monitoring, pre-judgment, defibrillation and help calling is achieved, the rescue time of golden 4 minutes is shortened to 1-2 minutes, and the survival rate of cardiac arrest patients is greatly increased; by means of voice guidance and one-key SOS operation, non-professionals can quickly complete first aid, and the risk of misoperation is avoided; a multi-sign fusion algorithm is combined with an AI technology, so that the misjudgment rate of single data is reduced, and high-risk pre-judgment of sudden cardiac arrest is realized; data is synchronized to a 120 dispatching center in a full-link mode, information and positions of patients are obtained in advance, and the response time of first-aid personnel is shortened; automatic self-checking and dual-power-supply modes ensure all-weather availability of equipment, and the problems of equipment faults, missing and the like are avoided.

Nymphaea tetragona extract-containing anti-saccharification compound for improving face skin staying up late

Resumen de: CN122624346A

The invention belongs to the technical field of skin care and saccharification resistance, and discloses a water lily extract-containing compound for improving the saccharification resistance of face skin staying up late, which is called'staying up late Shu 'for short. The core active components comprise a water lily embryo extracting solution, a compound fermentation filtrate of cordyceps militaris bacteria and ganoderma lucidum bacteria, a water lily leaf cell culture solution, nicotinamide, carnosine and ergothioneine, the active components are compounded according to a preset proportion, and the anti-saccharification effect can be achieved through a multi-channel synergistic effect; the plant mucopolysaccharide in the fermentation filtrate can construct a three-dimensional moisturizing network on the skin surface layer, a continuous hydration microenvironment is formed, the saccharification reaction rate is indirectly delayed, and the anti-sugar skin care requirements of the damaged muscle staying up late are met. The anti-saccharification efficiency of the compound is remarkably superior to that of a conventional single-channel anti-saccharification formula and a common plant crude extract formula, the problems of dark yellow skin color, cutis laxa and abnormal grease secretion caused by staying up late can be synchronously solved, and the compound is mild, free of sensitization, suitable for people with different skin types and capable of being widely applied to various

Immune cell chemically limited culture medium and immune cell culture method

Resumen de: CN122628988A

The invention relates to the technical field of cell culture, in particular to an immune cell chemically limited culture medium and an immune cell culture method.The culture medium comprises a basic culture medium, Mito-TEMPO, 2-deoxy-D-glucose, sodium butyrate, interleukin-2, sodium selenite, alanine-glutamine, insulin and transferrin. The culture medium does not contain an anti-CD3 antibody, an anti-CD28 antibody or an anti-CD3/CD28 coupling carrier used as a cell activator in the immune cell culture and amplification process, can be used for in-vitro culture and amplification of T cells or NK cells, and is beneficial to reduction of dependence on strong activation antibodies and high-concentration cell factors.

Storage method and storage system for NT cells

Resumen de: CN122629142A

Provided are a storage method and a storage system for cells prepared using somatic cell nuclear transfer (NT) technology, the cells having homozygous genotypes of genes of human leukocyte antigen (HLA)-A, HLA-B, HLA-DR, etc. The storage of NT cell-derived stem cells may be suitable for autologous or allogeneic patients and may provide transplantable cells and tissue materials for the treatment of various diseases, such as diabetes, osteoarthritis, Parkinson's disease, and the like.

Smart watch noninvasive blood glucose health monitoring method based on multi-mode perception

Resumen de: CN122624057A

The invention relates to the technical field of intelligent wearing physiological monitoring, in particular to an intelligent watch noninvasive blood glucose health monitoring method based on multi-modal perception, which comprises the following steps: acquiring skin optical and electrical characteristics and body surface vibration data by using an intelligent watch multi-modal sensor to form a multi-modal physiological perception signal; corresponding features are obtained through spectral feature purification, impedance feature analysis and pulse wave form analysis, and a fusion physiological feature spectrum is generated through heterogeneous feature coupling. Inputting the atlas into a blood glucose correlation depth assessment model to complete nonlinear mapping, outputting a blood glucose estimation sequence with a timestamp, obtaining a blood glucose change trend and an abnormal fluctuation mark through time sequence mode mining, and completing comprehensive risk assessment in combination with individual physiological baseline characteristics of a user. According to the mode, multi-modal physiological feature representation can be refined, physiological signal correlation information is integrated, complex correlation of physiology and blood glucose is adapted, and the pertinence and dynamic judgment fitting degree of blood glucose monitoring are improved.

Poria cocos-derived extracellular vesicle and application of high-abundance miRNA of poria cocos-derived extracellular vesicle in relieving obesity

Resumen de: CN122624545A

The invention relates to the technical field of biological medicines, and discloses application of poria cocos-derived extracellular vesicles and abundance miRNAs thereof in relieving obesity, cell experiments and animal experiments find that the poria cocos-derived extracellular vesicles and the abundance miRNAs thereof can up-regulate the expression quantity of white fat browning key genes in 3T3-L1 fat cells and mouse bodies; the glucose tolerance and insulin resistance of obese mice are obviously improved, and the fatty degeneration and lipid accumulation of livers are obviously relieved; the polypeptide not only improves obesity from phenotypes, but also can regulate lipid metabolism, and has a value of being applied to preparation of drugs for preventing or relieving obesity and related metabolic complications thereof.

Comfortable large-plane insulin pen needle

Resumen de: CN224671898U

The utility model belongs to the field of insulin pen needles, and particularly relates to a comfortable large-plane insulin pen needle which comprises an outer needle cap, an inner cavity of the outer needle cap is fixedly connected with a pen needle body, and an expansion mechanism is arranged at the top of the outer needle cap. Through rotation of the rotating ring block, the rotating ring block can smoothly pull the expansion block through the rotating plate and the rotating rod, and the expansion block can smoothly rotate to one side far away from the circle center of the fixed ring block by taking the circle center of the mounting rod as the center, so that the expansion block can rotate to one side far away from the circle center of the fixed ring block after rotating to a certain distance. By means of contact between the pen needle body and the skin of people, the stability of the pen needle body during use is improved, the pen needle body is not prone to greatly shaking or shaking when insulin is injected after the pen needle body is inserted into the body of people, and therefore the situation that the pen needle body is not stable enough during use, and the insulin injection difficulty is lowered is reduced. The pain of people is improved, and the comfort of the pen needle body during use is improved.

Dismounting device for insulin needle

Resumen de: CN224671896U

The utility model discloses an insulin needle dismounting device, and relates to the technical field of medical treatment. The upper end of the barrel is provided with a first barrel sliding hole and a second barrel sliding hole, and the lower end of the barrel is of an opening structure; the clamping assembly is arranged in the cylinder body and used for clamping a needle base of an insulin needle; and the driving assembly is arranged in the cylinder body, is connected with the clamping assembly and is used for driving the clamping assembly to move by changing the height between the handle and the cylinder body, so that a needle head base of the insulin needle head is clamped and loosened.

Insulin pen

Resumen de: CN122624779A

The invention provides an insulin pen. The insulin pen comprises a pen body barrel, a dosage rotating barrel, a transmission barrel, a medicine feeding mechanism and a driving mechanism. The dosage rotating barrel is rotationally arranged in the pen body barrel and is in spiral transmission connection with the pen body barrel. The transmission cylinder is coaxially arranged in the dosage rotating cylinder, is in limiting fit with the dosage rotating cylinder in the axial direction and can be driven by the dosage rotating cylinder to move in the first direction; the medicine feeding mechanism is rotationally arranged in the pen body barrel, is in threaded connection with the pen body barrel and is in limiting fit with the transmission barrel in the circumferential direction; the driving mechanism is in circumferential limiting connection with the dosage rotating cylinder, can move in the second direction in the axial direction so as to enable the transmission cylinder and the dosage rotating cylinder to be in circumferential limiting connection, and drives the dosage rotating cylinder, the transmission cylinder and the dosing mechanism to rotate synchronously so as to achieve dosing of the dosing mechanism in the second direction. In the application, the driving mechanism can realize the power coupling of the dosage rotary drum and the dosing mechanism in the circumferential direction only along the second direction, the transmission path is short, the structure is simple, and

Automatic peritoneal dialysis method based on blood glucose dynamic monitoring

Nº publicación: CN122624770A 25/08/2026

Solicitante:

FUZHOU DONGZE MEDICAL DEVICE CO LTD
\u798F\u5DDE\u4E1C\u6CFD\u533B\u7597\u5668\u68B0\u6709\u9650\u516C\u53F8

Resumen de: CN122624770A

The invention discloses an automatic peritoneal dialysis method based on blood glucose dynamic monitoring, which comprises the following steps: acquiring blood glucose monitoring data of a user, diet time of the user, carbohydrate intake, insulin use record, dialysate concentration of previous peritoneal dialysis treatment and proportion of the dialysate, and extracting a blood glucose key change point according to the data; obtaining a blood sugar key structure sequence; constructing a blood glucose prediction model through the time sequence model, and inputting the blood glucose key structure sequence into a pre-trained blood glucose prediction model to obtain a first blood glucose prediction sequence; on the basis of the first blood glucose prediction sequence, by taking blood glucose stabilization as a first-layer optimization target, calculating to obtain an optimal dialysate concentration and a proportion thereof, updating a blood glucose key structure sequence according to the optimal dialysate concentration and the proportion thereof, and inputting the blood glucose key structure sequence into a blood glucose prediction model to obtain a second blood glucose prediction sequence; calculating a blood glucose fluctuation risk index based on the second blood glucose prediction sequence, constructing a second-layer stage control target according to the blood glucose fluctuation risk index of each peritoneal dialysis stage, and generating peritoneal dialysis control paramet