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SYSTEMS AND METHODS FOR REDUCING SENSOR VARIABILITY

Resumen de: US2025160703A1

A system for reducing sensor variability includes a sensor configured to generate real-time data relating to glucose sensitivity. The system causes performance of accessing the real-time data from the sensor relating to glucose sensitivity and inputting the real-time data into a machine learning model. The system also causes performance of estimating by the machine learning model an expected glucose sensitivity based on the real-time data and correcting the glucose sensitivity based on the expected glucose sensitivity.

SENSOR APPLICATOR ASSEMBLY FOR CONTINUOUS GLUCOSE MONITORING SYSTEM

Resumen de: US2025160748A1

The present invention relates to a sensor applicator assembly for a continuous glucose monitoring system and provides a sensor applicator assembly for a continuous glucose monitoring system, which is manufactured with a sensor module assembled inside an applicator, thereby minimizing additional work by a user for attaching the sensor module to the body and allowing the sensor module to be attached to the body simply by operating the applicator, and thus can be used more conveniently. A battery is built in the sensor module and a separate transmitter is connected to the sensor module so as to receive power supply from the sensor module and be continuously used semi-permanently, thereby making the assembly economical. The sensor module and the applicator are used as disposables, thereby allowing accurate and safe use and convenient maintenance.

SENSOR APPLICATOR ASSEMBLY FOR CONTINUOUS GLUCOSE MONITORING SYSTEM

Resumen de: US2025160749A1

The present invention relates to a sensor applicator assembly for a continuous glucose monitoring system and provides a sensor applicator assembly for a continuous glucose monitoring system, which is manufactured with a sensor module assembled inside an applicator, thereby minimizing additional work by a user for attaching the sensor module to the body and allowing the sensor module to be attached to the body simply by operating the applicator, and thus can be used more conveniently. A battery is built in the sensor module and a separate transmitter is connected to the sensor module so as to receive power supply from the sensor module and be continuously used semi-permanently, thereby making the assembly economical. The sensor module and the applicator are used as disposables, thereby allowing accurate and safe use and convenient maintenance.

Adaptable asymmetric medicament cost component in a control system for medicament delivery

Resumen de: AU2025203062A1

The exemplary embodiments provide medicament delivery devices that use cost functions in their control systems to determine medicament dosages. The cost function may have a medicament cost component and a performance cost component. The exemplary embodiments may use cost functions having medicament cost components that scale asymmetrically for different ranges of inputs (i.e., different candidate medicament dosages). The variance in scaling for different input ranges provides added flexibility to tailor the medicament cost component to the user and thus provide better management of medicament delivery to the user and better conformance to a performance target. The exemplary embodiments may use a cost function that has a medicament cost component (such as an insulin cost component) of zero for candidate dosages for a range of candidate dosages (e.g., below a reference dosage).

Treatment of ocular diseases with fully-human post-translationally modified anti-VEGF Fab

Resumen de: AU2025203154A1

Abstract: Compositions and methods are described for the delivery of a fully human post- translationally modified (HuPTM) monoclonal antibody ("mAb") or the antigen-binding fragment of a mAb against human vascular endothelial growth factor ("hVEGF") - such as, e.g., a fully human-glycosylated (HuGly) anti-hVEGF antigen-binding fragment - to the retina/vitreal humour in the eye(s) of human subjects diagnosed with ocular diseases caused by increased neovascularization, for example, neovascular age-related macular degeneration ("nAMD"), also known as "wet" age-related macular degeneration ("WAMD"), age-related macular degeneration ("AMD"), and diabetic retinopathy.

PROTECTION DEVICE FOR FRONT END OF INSULIN PEN NEEDLE

Resumen de: WO2025102531A1

A protection device for the front end of an insulin pen needle, comprising: a housing (1); a needle hub (2), which is fixed in the housing (1), the needle hub (2) being provided with an injection needle extending out of the head end of the housing (1); a sliding fastener (3), which is sleeved on the needle hub (2) and is in sliding fit with the needle hub (2), the outer surface of the sliding fastener (3) being provided with a snap-fit portion (31); and a needle tip protective sleeve (4), which is slidably provided in the housing (1), an elastic piece (41) being provided on single side of the inner wall of the needle tip protective sleeve (4), and a spring (5) is clamped between the needle tip protective sleeve (4) and the needle hub (2). When the insulin pen needle is in an injection state, the needle tip protective sleeve (4) presses the spring (5) to retract into the housing (1), such that the needle tip protective sleeve (4) is sleeved on the sliding fastener (3), and in the case that the elastic piece (41) slides to the position of the snap-fit portion (31), the elastic piece (41) hooks the snap-fit portion (31), so as to expose the needle tip of the injection needle (21). When the insulin pen needle is in a retraction state, the needle tip protective sleeve (4) extends out of the housing (1) under the elastic force of the spring (5) and drives the sliding fastener (3) to withdraw from the needle hub (2); the sliding fastener (3) is offset with the needle hub (2) under t

INSULIN PEN NEEDLE FRONT-END PROTECTION APPARATUS

Resumen de: WO2025102533A1

An insulin pen needle front-end protection apparatus, comprising a housing (1), the housing(1) being provided with a first through hole (11) in a head end; a needle base (2) fixedly connected to a tail end of the housing (1), the needle base (2) being provided with a protruding portion (21) extending towards the head end of the housing (1), and an injection needle (22) extending out of the first through hole (11) being arranged on the protruding portion (21); a sliding buckle (3) sleeved on the protruding portion (21), a constriction structure being arranged at a tail end of the sliding buckle (3), and a head end of the sliding buckle (3) being provided with a second through hole (31); and a needle tip protection sleeve (4) at least partially arranged in the housing (1), a spring (5) being clamped between a tail end of the needle tip protection sleeve (4) and the needle base (2), a head end of the needle tip protection sleeve (4) extending out of the first through hole (11) and being provided with a third through hole (41), and at least two clamping buckles (42) being arranged on an inner wall of the needle tip protection sleeve (4).

INSULIN PEN NEEDLE REAR END PROTECTION DEVICE

Resumen de: WO2025102532A1

Provided is an insulin pen needle rear end protection device, which comprises: a housing (1), wherein the tail end of the housing (1) is arranged to be connected with an insulin injection pen; a needle holder (2) fixed in the housing (1), wherein an injection needle extending to the tail end of the housing (1) is arranged on the needle holder (2), a guide groove (22) is formed in the side wall of the needle holder (2), and a protruding block (23) is further arranged on the inner surface of the side wall of the needle holder (2); and a rear needle protective sleeve (3) arranged in the needle holder (2) in a penetrating manner, wherein a spring (4) is clamped between the rear needle protective sleeve (3) and the needle holder (2), and a positioning column (31) and an elastic clamping jaw (32) are arranged on the outer surface of the rear needle protective sleeve (3). When the insulin pen needle is connected to the injection pen, the rear needle protective sleeve (3) is compressed into the needle holder (2), the positioning column (31) moves in the guide groove (22) to a first position, and the elastic clamping jaw (32) is located on the side of the protruding block (23) away from the tail end of the needle holder (2); when the insulin pen needle is separated from the injection pen, the positioning column (31) moves to a second position along the guide groove (22) under the acting force of the spring (4), such that the rear needle protective sleeve (3) pops up, and the elastic c

MICROFLUIDIC PATCH-PUMP FOR DELIVERY OF LIQUID DRUGS

Resumen de: WO2025106990A1

Integrated patch-pump devices to deliver drugs, e.g., macromolecular drugs that are difficult to deliver through an oral pathway and/or that require transdermal delivery. Embodiments are slim, powerless, painless, and relatively inexpensive. The microfluidic pump is used to drive the fluid flow powered by pressurized air or the user's pulse, and the microneedle array is used to inject the fluid through the skin painlessly. The flow rate generally positively correlates with the actuation pressure. For devices with wider flow channels, the flow rate generally negatively correlates with the actuation frequency, whereas the flow rate increases and then decreases with increasing actuation frequency for devices with narrower flow channels. This property of these devices is beneficial in insulin delivery because the demand for insulin is generally reduced in vigorous exercise (with elevated heart rate/ actuation frequency) and is increased in hypertension patients (with elevated blood/actuation pressure).

BLOOD SUGAR LEVEL MEASURING DEVICE

Resumen de: WO2025104963A1

This blood sugar level measuring device comprises: a light output unit that includes a green light source that outputs incident light; a light detection unit that detects transmitted light that has passed through a living body; and a computation unit that calculates the blood sugar level of the living body. In the spectrum of the incident light, the center wavelength is located at 430-580 nm, the intensity at 600-615 nm is at least 0.01% of the intensity at the center wavelength, and the intensity at 480-515 nm is at least 1% of the intensity at the center wavelength. The light detection unit includes a first light detector having a first detection wavelength range of 460-535 nm and a second light detector having a second detection wavelength range of at least 580 nm. The computation unit calculates the blood sugar level of the living body on the basis of the intensity of the transmitted light detected by the first light detector and the intensity of the transmitted light detected by the second light detector.

NON-INVASIVE BLOOD GLUCOSE MEASUREMENT SYSTEM

Resumen de: WO2025102900A1

A non-invasive blood glucose measurement system (100), comprising an optical transceiver assembly (110); a filtering unit (120), electrically connected to the optical transceiver assembly (110); and a micro-processing unit (130), electrically connected to the filtering unit (120). The optical transceiver assembly (110) comprises: at least two light sources (111), a first detector (112) and at least two second detectors (113), the at least two light sources (111) being used for emitting laser detection signals, and the first detector (112) and the at least two second detectors (113) being used for detecting returned laser signals. The at least two light sources (111) are provided around the first detector (112); the at least two second detectors (113) are provided around the light source (111); and a light detection surface of the first detector (112), light detection surfaces of the at least two second detectors (113), and light emergent surfaces of the at least two light sources (111) face the same direction. Data analysis and processing of short-path optical signals and long-path optical signals can obtain an optical concentration difference between a dark portion and a light portion of skin, thereby reducing the influences caused by melanin and skin, and improving the accuracy in non-invasive blood glucose measurement.

SYSTEMS AND METHODS FOR REDUCING SENSOR VARIABILITY

Resumen de: EP4555928A1

A system for reducing sensor variability includes a sensor configured to generate real-time data relating to glucose sensitivity. The system causes performance of accessing the real-time data from the sensor relating to glucose sensitivity and inputting the real-time data into a machine learning model. The system also causes performance of estimating by the machine learning model an expected glucose sensitivity based on the real-time data and correcting the glucose sensitivity based on the expected glucose sensitivity.

DETERMINATION OF CARBOHYDRATE-TO-INSULIN RATIOS

Resumen de: EP4557303A1

Disclosed herein are techniques related to determining medical parameters. In some embodiments, the techniques involve: obtaining a metric of insulin dosage for a patient; and determining at least one carbohydrate-to-insulin ratio for the patient based at least in part on a model and using the obtained metric of insulin dosage for the patient, wherein parameters of the model were determined based on data associated with a population of patients.

INTEGRATION OF IN VIVO PREDICTIVE MODEL OUTPUT FEATURES FOR CGM ALGORITHM PERFORMANCE IMPROVEMENT

Resumen de: EP4555927A1

Techniques disclosed herein relate to glucose level measurement and/or management. In some embodiments, the techniques involve obtaining in vivo characteristics of a glucose sensor predicted using fabrication process measurement data associated with the glucose sensor, the in vivo characteristics including an in vivo sensitivity, an in vivo intercept, or a combination thereof; receiving sensor measurement data measured by the glucose sensor, the sensor measurement data including sensor current (Isig), counter voltage (Vcntr), electrochemical impedance spectroscopy (EIS) data, an age of the glucose sensor, or a combination thereof; and estimating a sensor glucose (SG) value using an SG model, wherein input parameters of the SG model include the in vivo characteristics of the glucose sensor and the sensor measurement data, and the SG value is an output of the SG model.

DEVICES, SYSTEMS AND METHODS FOR BLOOD GLUCOSE MONITORING

Resumen de: WO2024012479A1

Devices, systems and methods for blood glucose monitoring. The device includes a light emitter, configured to emit light signals; a light receiver, configured to receive the reflected light signal; a controller, configured to operatively connect with the light emitter and the light receiver; and an enclosure. The light signal comprises a first light signal having a first wavelength of about 940nm, a second light signal having a second wavelength of about 1350nm, and/or a third light signal having a third wavelength of about 1500nm, wherein the controller comprises an operating module, and further comprises or operatively connects with a data processing system comprising a machine learning module that analyzes the data signal to generate an output data. The devices, systems and methods are non-invasive and monitor blood glucose levels in real time with high accuracy.

USE OF NON-INVASIVE GLUCOSE SENSORS AND GLUCOSE RATE OF CHANGE DATA IN AN INSULIN DELIVERY SYSTEM

Resumen de: AU2023373672A1

Invasive glucose sensors and noninvasive glucose sensors may be used in conjunction to improve glucose management for a user. The rate of change (ROC) of glucose levels from a noninvasive glucose sensor may be used rather than or in conjunction with a glucose level of the user from a CGM. A basal insulin delivery rate to the user may be adjusted responsive to the ROC glucose level data from the noninvasive sensor. The glucose level ROC from a noninvasive glucose sensor may be used to predict future glucose level ROCs of the user between operational cycles of an insulin delivery device and/or to identify possible hypoglycemic or hyperglycemic events. These predicted future glucose level ROCs may be used in a cost function of the control system of the insulin delivery device to select basal insulin delivery doses. Glucose level readings may be used to calibrate a noninvasive glucose level sensor.

SYSTEM AND METHOD FOR INSULIN PUMP MEDICAL DEVICE INCLUDING A SLIDER ASSEMBLY WHEREIN IMAGES ON DISPLAY ALLOW FOR HIGHLIGHTING AND MAGNIFYING IMAGES

Resumen de: US2025152809A1

A medical system includes an input assembly for receiving one or more user inputs. The input assembly includes at least one slider assembly for providing an input signal. Processing logic receives the input signal from the input assembly and provides a first output signal and a second output signal. A display assembly is configured to receive, at least in part, the first output signal from the processing logic and render information viewable by the user. The second output signal is provided to one or more medical system components. The information rendered on the display assembly may be manipulatable by the user and at least a portion of the information rendered may be magnified.

BLOOD GLUCOSE ASSESSMENT METHOD, ELECTRONIC DEVICE, AND COMPUTER-READABLE STORAGE MEDIUM

Resumen de: US2025152051A1

This application provides a blood glucose assessment method, an electronic device, and a computer-readable storage medium. The method is applied to a wearable device, and includes: collecting vital sign data of a user in a first cycle of blood glucose assessment; performing blood glucose assessment on the user based on valid vital sign data in the vital sign data, to obtain a blood glucose assessment result corresponding to the first cycle; displaying the blood glucose assessment result corresponding to the first cycle; and automatically starting a next cycle of the blood glucose assessment. According to the technical solutions of this application, blood glucose assessment can be periodically and automatically performed, helping reduce operation complexity for the user.

METHOD FOR DETERMINING A SUBSTANCE CONCENTRATION AND DETECTOR DEVICE

Resumen de: WO2025099149A1

The invention concerns a method for determining a substance concentration in a sample comprising liquid containing particles, in particular glucose in blood, wherein a refractive index of the liquid is dependent on a concentration of the substance dissolved therein and a density of particles in the liquid is substantially constant. The method comprises obtaining a PPG first signal during a first time period and estimating a set of complex coefficients from the first obtained signal. The phase difference is determined from those coefficient or a subset thereof and subsequently used to derive the substance concentration or a change in the substance concentration.

METHOD FOR DETERMINING A SUBSTANCE CONCENTRATION AND DETECTOR DEVICE

Resumen de: WO2025099153A1

The invention concerns a method for determining a substance concentration in a sample comprising liquid containing particles, in particular glucose in blood, wherein a refractive index of the liquid is dependent on a concentration of the substance dissolved therein and a density of particles in the liquid is substantially constant. The method comprises obtaining a PPG first signal during a first time period and estimating at last a portion of a noise spectrum from the first obtained signal in particular the frequency domain. At least a portion of the noise spectrum is used to derive the substance concentration or a change in the substance concentration.

AUGMENTED AND VIRTUAL REALITY EYEWEAR, SYSTEMS, AND METHODS FOR DELIVERING POLARIZED LIGHT AND DETERMINING GLUCOSE LEVELS

Resumen de: US2025152054A1

Various embodiments of a user-wearable device can comprise a frame configured to mount on a user. The device can include a display attached to the frame and configured to direct virtual images to an eye of the user. The device can also include a light source configured to provide polarized light to the eye of the user and that the polarized light is configured to reflect from the eye of the user. The device can further include a light analyzer configured to determine a polarization angle rotation of the reflected light from the eye of the user such that a glucose level of the user can be determined based at least in part on the polarization angle rotation of the reflected light.

PCLED LIGHT SOURCE AND SWIR SPECTROMETER FOR NONINVASIVE TISSUE GLUCOSE SELF-MONITORING

Resumen de: US2025152053A1

A glucose measurement device comprising a light emitting device comprising an SWIR phosphor having emission wavelengths in the range of 1600-2200 nm, the SWIR phosphor comprising a structurally disordered garnet material, a sensitizer ion, and at least one rare earth emitter ion, and a infrared light detector arranged to detect the intensity of short wavelength infrared light emitted by the light emitting device and reflected by a sample. The emission spectra provided by the light emitting device having a high temperature stability at infrared absorption minima and maxima wavelengths of glucose in tissue.

IMMUNOSUPPRESSANT RELEASING COATINGS

Resumen de: US2025152058A1

Embodiments of the invention provide compositions useful in implantable devices such as analyte sensors as well as methods for making and using such compositions and devices. In typical embodiments of the invention, the device is a glucose sensor comprising a polymeric composition disposed on a flexible assembly within the sensor that includes amounts of one or more immunosuppressant agents designed to provide such sensors with improved material properties such as enhanced biocompatibility.

OPTIMIZING ANALYTE SENSOR CALIBRATION

Resumen de: US2025152060A1

Method and apparatus for optimizing analyte sensor calibration including receiving a current blood glucose measurement, retrieving a time information for an upcoming scheduled calibration event for calibrating an analyte sensor, determining temporal proximity between the current blood glucose measurement and the retrieved time information for the upcoming calibration event, initiating a calibration routine to calibrate the analyte sensor when the determined temporal proximity is within a predetermined time period, and overriding the upcoming scheduled calibration event using the current blood glucose measurement are provided.

DIABETES RISK DETECTION METHOD, ELECTRONIC DEVICE, AND SYSTEM

Nº publicación: US2025152107A1 15/05/2025

Solicitante:

HUAWEI TECH CO LTD [CN]
PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCIENCES [CN]
HUAWEI TECHNOLOGIES CO., LTD,
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences

Resumen de: US2025152107A1

A diabetes risk detection method, an electronic device, and a system are disclosed and are applied to the field of terminal technologies, to resolve a problem in the conventional technology that an obtained diabetes risk detection result is inaccurate when time for collecting a photoplethysmography signal is short. The method includes: obtaining first data and second data, where the first data includes a photoplethysmography (PPG) signal obtained via a PPG sensor, and the second data includes one or more of the following: diet data, exercise data, physical symptom data, drug use data, sleep data, or emotion data; determining a diabetes risk detection result based on the first data and the second data; and outputting the diabetes risk detection result to prompt a user with a health status.