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Resultados 129 resultados
LastUpdate Última actualización 17/01/2026 [07:49:00]
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Solicitudes publicadas en los últimos 60 días / Last 60 days publications
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PARKINSON'S DISEASE THERAPY BY DEVELOPING A TREG-MEDIATED RESPONSE SPECIFIC TO ALPHA-SYNUCLEIN AND DIAGNOSIS METHODS

NºPublicación:  WO2025239904A1 20/11/2025
Solicitante: 
FUND CIENCIA PARA LA VIDA [CL]
MASS CLIFFORD J [US]
FUNDACI\u00D3N CIENCIA PARA LA VIDA,
MASS, Clifford J
WO_2025239904_PA

Resumen de: WO2025239904A1

The application relates to monoclonal antibody clone 1A11, which is highly specific for a C-terminal sequence of human alpha-synuclein (hαSyn) containing three nitrated tyrosines (3NYαSyn) and does not bind to the corresponding unmodified sequence. A CAR specific for 3NYαSyn has been produced, comprising the antigen-recognizing site of the mAb 1A11 fused to an intracellular region containing the signaling motifs of CD3zeta and CD28. Tregs expressing said anti-3NYαSyn CAR have been shown to attenuate neurodegeneration and neuroinflammation in a mouse model for Parkinson's disease. The T reg-response specific for 3YNαSyn exerts a therapeutic effect attenuating the loss of dopaminergic neurons in a preclinical model and represents a promising therapeutic strategy to treat Parkinson's disease patients..

HETEROCYCLIC COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE

NºPublicación:  US2025353841A1 20/11/2025
Solicitante: 
HUFF SARAH ELIZABETH [US]
MUSTAFA DARSHEED NASSER [US]
TOSZEWSKI ADAM [US]
MONDAL DIBYENDU [US]
BIOGEN MA INC [US]
HUFF Sarah Elizabeth,
MUSTAFA Darsheed Nasser,
TOSZEWSKI Adam,
MONDAL Dibyendu,
BIOGEN MA INC
JP_2025525683_PA

Resumen de: US2025353841A1

The present disclosure provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof and its use in, e.g. treating a condition, disease, or disorder in which lowering mutant huntingtin protein (“mHTT”) in a subject is of therapeutic benefit, specifically in treating Huntington disease (“HD”). This disclosure also features a composition containing the same as well as methods of using and making the same.

PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING BRAIN DISEASES, COMPRISING MODIFIED MITOCHONDRIA

NºPublicación:  WO2025239588A1 20/11/2025
Solicitante: 
PAEAN BIOTECHNOLOGY INC [KR]
UNIV INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIV [KR]
\uC8FC\uC2DD\uD68C\uC0AC \uD30C\uC774\uC548\uBC14\uC774\uC624\uD14C\uD06C\uB180\uB85C\uC9C0,
\uACBD\uD76C\uB300\uD559\uAD50 \uC0B0\uD559\uD611\uB825\uB2E8
WO_2025239588_PA

Resumen de: WO2025239588A1

The present invention relates to: a fusion protein comprising a mitochondrial outer membrane anchoring peptide and a cerebrovascular endothelial cell surface protein binding site; modified mitochondria to which the fusion protein is bound; and a pharmaceutical composition comprising the modified mitochondria as an active ingredient. The modified mitochondria comprising the cerebrovascular endothelial cell surface protein binding site according to the present invention can pass through the blood-brain barrier at the cellular and animal level. In addition, administering the modified mitochondria to a Parkinson's disease mouse model can alleviate movement disorders. Therefore, the modified mitochondria according to the present invention can be used as a therapeutic agent for brain diseases caused by mitochondrial dysfunction.

METHODS AND COMPOSITIONS FOR SCREENING AND TREATING ALZHEIMER'S DISEASE

Nº publicación: EP4649317A2 19/11/2025

Solicitante:

POPULATION BIO INC [US]
Population Bio, Inc

US_2024310389_PA

Resumen de: US2024310389A1

This document provides methods and materials related to screening for and treating Alzheimer's disease (AD), including late-onset Alzheimer's disease (LOAD).

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