Resumen de: WO2024152149A1
The uses of a composition containing N-arachidonoyl ethanolamine anandamide or a derivative thereof for in preparation ofpreparing nutritional supplements and health-care products, foods and beverages used for regulating the intestinal flora. The composition can remarkably improve the level of a first intestinal microflora microbiota in a subjects and also reduce the level of a second intestinal microflora in the subjects, thereby improving the intestinal health. The first intestinal microflora microbiota is selected from one or more of the following groups: Roseburias, Bacteroides and Prevotellas, and the second intestinal microflora is Salmonella or Escherichia coli.
Resumen de: WO2024155027A1
The present invention relates to an attenuated Salmonella gallinarum expressing FliC or FliC-hiL2 and use thereof. The Salmonella strain according to the present invention has excellent immune activity and exhibits excellent anti-cancer efficacy, and thus can be used as a therapeutic agent for cancer together with or independently of existing anti-cancer drugs.
Resumen de: KR20240114328A
본 발명은 플라젤린 단백질을 방출하여 면역활성이 증가되고 운동능력의 상실로 인하여 약독화가 강화된 변이 살모넬라 균주 및 이를 포함하는 항암 조성물에 관한 것으로, 보다 상세하게는 fliD 유전자가 불활성되어, 플라젤린 단백질의 분비가 증가된 변이 살모넬라 균주 및 이를 포함하는 항암 조성물에 관한 것이다.
Resumen de: CN118373883A
The invention relates to the technical field of biology, in particular to a CATH-2 derived peptide and application thereof. The invention aims to design and prepare an antibacterial peptide which is good in effect of resisting drug-resistant pathogenic bacteria, high in safety and strong in stability, takes antibacterial activity, hemolytic activity, cytotoxicity and stability as indexes, and utilizes a NovoPro tool to synthesize the antibacterial peptide. The amino acid sequences of the chicken-derived antibacterial peptide CATH-2 with high toxicity and low antibacterial activity and the amino acid sequences of the truncated peptide CATH-2 (1-15) with low antibacterial activity are replaced and modified, and five CATH-2 derived peptides with good expected effects are redesigned and prepared. In-vivo and in-vitro tests prove that the compound has very strong antibacterial activity on pathogenic bacteria such as drug-resistant escherichia coli, salmonella and haemophilus paragallinarum, is low in hemolysis rate, small in cytotoxicity and high in safety, has relatively strong stability on heat, acid, alkali and salt ions, and can be used as a novel antibacterial veterinary drug or a novel antibiotic-replacing feed additive.
Resumen de: CN118373886A
The invention provides an antibacterial lipopeptide CFH resistant to protease hydrolysis and a preparation method and application thereof, and belongs to the field of bioengineering, and the amino acid sequence of the antibacterial lipopeptide CFH is C14-(FHHFHHH) 3-(Dab) 6; myristic acid provides self-assembly driving force for the antibacterial lipopeptide, template polypeptide provides hydrophobic force for killing pathogens for the antibacterial lipopeptide, Dab provides positive charges for adsorbing a pathogen film for the antibacterial lipopeptide and prevents the positive charges from being recognized by trypsin, and the high-stability antibacterial lipopeptide CFH is prepared. The antibacterial lipopeptide CFH has efficient bactericidal activity on salmonella paratyphi in the presence of trypsin, chymotrypsin, artificial gastric juice and artificial intestinal juice, and has no toxicity to human red blood cells, so that the antibacterial lipopeptide CFH has the potential of becoming a feed antibiotic substitute.
Resumen de: CN118374459A
The invention discloses a broad-spectrum salmonella bacteriophage YZ26 and application thereof, the bacteriophage is separated from pig manure of a Yangzhou slaughter house, and the bacteriophage can be used for cracking various serotype salmonella such as salmonella typhimurium, salmonella enteritidis, salmonella pullorum, salmonella Indiana, salmonella salmonella and the like, and non-salmonella such as shigella, escherichia coli and the like. The bacteriophage can effectively inhibit proliferation of salmonella typhimurium. Meanwhile, the bacteriophage can keep relatively good stability under the conditions that the pH is 2-13 and the temperature is 30-70 DEG C. The whole genome sequence analysis of the bacteriophage shows that the whole genome length of the bacteriophage YZ26 is 47548bp, and the bacteriophage YZ26 does not carry any virulence or antibiotic resistance gene and can be safely applied to prevention and control of salmonella in food.
Resumen de: CN118379075A
The invention relates to the technical field of data processing, in particular to a food full-cycle traceability method based on food safety, which comprises the following steps: obtaining traceability numerical data and timestamps of each batch of food, including multiple dimension data; and calculating the intake and the vulnerability coefficient of salmonella eaten by the consumer. And analyzing the traceability data of the batch to be analyzed, and determining a target batch. And evaluating the traceability data correlation among different batches, and determining an associated traceability link according to the traceability data correlation. And comprehensively referring to the batch number, updating the abnormal score and the time interval, and evaluating the reliability of each batch of food. And evaluating the food safety in combination with the food quantity, the safety risk coefficient and the consumer data. According to the invention, a more accurate food risk assessment result is provided.
Resumen de: CN118362722A
本申请公开了一种沙门菌筛选方法及其应用,涉及沙门菌分离领域,其包括以下步骤:将活化磁珠与抗体共培养得到偶联磁珠,将偶联磁珠与样品混匀孵育后分离出结合有沙门菌的偶联磁珠,使用抗体标记去除试剂与结合有沙门菌的偶联磁珠混合孵育,分离出磁珠得到筛选出的沙门菌悬浮液;所述抗体包括PagN单克隆抗体、PagC单克隆抗体、FimA单克隆抗体和FimH单克隆抗体中的至少两种。本申请能提高沙门菌筛选的特异性和效率。
Resumen de: CN118360421A
The invention discloses a primer and a method for detecting and typing a salmonella Indiana CbtA/CbeA toxin-antitoxin system. The invention establishes a method capable of rapidly detecting and typing by analyzing different genotype sequences of the salmonella Indiana CbtA/CbeA toxin-antitoxin system, the method has the advantages of rapidness, simplicity, strong specificity and high sensitivity, the salmonella Indiana CbtA/CbeA toxin-antitoxin system can be rapidly detected and typed through one-step reaction, and the method has the advantages of high specificity and high sensitivity and can be used for rapidly detecting and typing the salmonella Indiana CbtA/CbeA toxin-antitoxin system. Compared with a whole genome sequencing analysis method, the Salmonella Indiana CbtA/CbeA toxin-antitoxin detection method has great advantages in the aspects of detection time and detection cost, is suitable for batch detection, and is expected to have a wide application prospect in the research field of a Salmonella Indiana CbtA/CbeA toxin-antitoxin system.
Resumen de: CN118360256A
The invention discloses a salmonella bacteriophage SP14 and application thereof, and relates to the technical field of biology. The salmonella bacteriophage SP14 is preserved in the China Center for Type Culture Collection on January 29, 2024, the preservation address is Wuhan University, Wuhan, China, and the preservation number is CCTCC NO: M 2024255. According to the invention, salmonella typhimurium ATCC14028 is taken as a host bacterium, a strong lytic bacteriophage SP14 is separated from pig farm sewage, and the basic biological characteristics and bactericidal effect of the strong lytic bacteriophage SP14 are analyzed. The salmonella bacteriophage SP14 provided by the invention has a relatively good killing effect on host bacteria salmonella typhimurium ATCC14028, has the advantages of high stability, good safety and easiness in preparation, has a very good treatment effect on animals infected with salmonella, and has a very good killing effect on environments polluted by salmonella.
Resumen de: CN118355914A
The purine compound disclosed by the invention is used for agricultural fungi such as rhizoctonia solani, botrytis cinerea, magnaporthe oryzae and the like; the pesticide composition can be applied to agricultural bacteria such as Xanthomonas oryzae pv. Oryzae ACCC 11602, Xanthomonas citri pv. Citri, Xanthomonas campestris and the like; the method comprises the following steps: detecting food-borne bacteria such as escherichia coli O157: H7ATCC 35150, salmonella enteritidis ATCC 14028 and the like; the method comprises the following steps: killing food-borne fungi such as aspergillus flavus ACCC 32601, monilinia coerulea ACCC 36263 and the like; the compound shows certain antibacterial activity on dairy cow mastitis pathogenic bacteria such as streptococcus agalactiae ATCC 27956, Escherichia coli ATCC 25922 and staphylococcus aureus, particularly has an obvious and broad-spectrum inhibition effect on 2-fluoroadenine and 2-fluoroadenosine, and has the value of being further researched and developed into an antibacterial agent.
Resumen de: US2024240140A1
Disclosed are attenuated Salmonella gallinarum expressing FliC (flagellin) or FliC-hIL2 (human IL2 fused to FliC) and use thereof, wherein the Salmonella strain exhibits excellent immune activation ability and anticancer efficacy and thus can be used as a cancer therapeutic agent, together with or independently from existing anticancer agents.
Resumen de: AU2022343176A1
Provided herein is the ability for intravenous delivery of bacteria without the septic side-effects and for delivery of immune modulating proteins that are systemically toxic to be delivered directly to the tumor micro-environment without any systemic toxicity.
Resumen de: WO2023047129A1
The invention relates to fusion polypeptides, and to immunogenic polypeptides and their use as vaccines for treating, preventing or ameliorating a wide range of infectious diseases, for example caused by a virus, bacterium or fungus, or cancer. The fusion polypeptide comprises: a first amino acid sequence comprising a non-toxic B subunit of an AB5 Toxin, or a fragment or variant thereof; a second amino acid sequence comprising an immunoglobulin Fc region (Ig-Fc), or a fragment or variant thereof; and a third amino acid sequence comprising an antigen, or a fragment or variant thereof. The invention also extends to nucleic acids encoding such fusion polypeptides and proteins, and to recombinant vectors expressing such nucleic acids. The invention is especially useful for the rapid development of protein-based vaccines, and to their use in methods of treating infectious diseases or cancer, and also to pharmaceutical compositions comprising the fusion proteins.
Resumen de: CN118326061A
The invention belongs to the technical field of biology, and particularly relates to a kit for rapidly detecting intestinal infection pathogenic bacteria and a detection method thereof. The multiple fluorescent LAMP kit for simultaneously detecting the four pathogenic bacteria of vibrio cholerae, diarrheogenic escherichia coli, staphylococcus aureus and salmonella and the detection method of the multiple fluorescent LAMP kit are established for the first time, and the method has the advantages of high efficiency, rapidness, high sensitivity, high specificity and the like, can be used for rapidly identifying the intestinal infection pathogenic bacteria, and has a relatively great application prospect.
Resumen de: CN118325762A
The present invention discloses a pathogenic bacterium inhibition and tumor resistance lentinobacillus lentini and application thereof, and relates to the technical field of microorganisms, and the technical key points are as follows: the lentinobacillus lentini belongs to bacillus laotingensis NGMCC 1.200927, the preservation unit is China General Microbiological Culture Collection Center, the preservation number is CGMCC (China General Microbiological Culture Collection Center), the preservation number is CGMCC 1.200927, the preservation number is CGMCC 1.200927, the preservation number is CGMCC 1.200927, the preservation number is CGMCC 1.200927, and the preservation number is CGMCC 1.200927. The preservation address is No.3, Yard 1, Beichen West Road, Chaoyang District, Beijing; the preservation number is CGMCC No: 27646; the preservation date is June 15, 2023. According to the invention, after fermentation culture, the eulenium lerenkii can generate relatively strong bacteriostatic active substances, has a relatively obvious bacteriostatic effect on pathogenic bacteria such as staphylococcus aureus, salmonella typhimurium and pseudomonas aeruginosa, and also has a very good effect of inhibiting the activity of tumor cells; the compound has a wide development space in prevention and treatment of pathogenic bacteria such as staphylococcus aureus, salmonella typhimurium and pseudomonas aeruginosa and diseases caused by tumors, and has a good development and application pros
Resumen de: CN118325770A
The invention discloses a strain of Enterococcus faecium C7, the preservation number of which is CGMCC (China General Microbiological Culture Collection Center) No.29914. The strain has a good probiotic effect on regulating intestinal flora of chicks and preventing diarrhea of the chicks. The strain has an obvious inhibition effect on escherichia coli and salmonella, has the characteristics of acid resistance, cholate resistance and strong adhesive force, and does not have obvious drug resistance.
Resumen de: CN118338909A
The present invention relates to a pharmaceutical composition for preventing or treating cancer, comprising salmonella and an immune checkpoint inhibitor as active ingredients. The present invention can be advantageously used as a prophylactic or therapeutic composition for significantly reducing tumor size by co-administration of bacterial and immune checkpoint inhibitors in cancer, particularly in cancer types that are drug-resistant and difficult to treat by a single anti-cancer therapy, thereby improving survival.
Resumen de: US2024226190A1
The present invention relates to the field of cancer therapy. In particular, the present invention relates to a first composition comprising a live attenuated bacterium for use in the treatment, prevention, reduction, inhibition, prevention of recurrence, or control of a neoplastic disease in a subject being or intended to be administered a second composition comprising a live attenuated bacterium, said bacterium being the same or different to that of the first composition and methods thereof.
Resumen de: US2024228910A1
Methods and antimicrobial compositions are provided for surface cleaning. The antimicrobial compositions which include very low concentrations of an organic acid and one or more anionic surfactants can, unexpectedly, provide effective and broad spectrum antimicrobial activity within two minutes of contact with a surface and in some instances within one minute of contact time. Contacting the antimicrobial compositions with a surface can result in greater than or equal to about 4.0 log kill or 5.0 log kill for one or more of Staphylococcus aureus, Pseudomonas aeruginosa, and Salmonella enterica on the surface in two minutes or less. The compositions can have antimicrobial activity against at least one gram-positive bacterium, gram-negative bacterium, virus, and fungus in two minutes or less of contacting the composition with a surface.
Resumen de: US2024229100A1
Disclosed herein are methods and systems for rapid detection of microorganisms in a sample. A genetically modified bacteriophage is also disclosed which comprises an indicator gene in the late gene region. The specificity of the bacteriophage, such as Salmonella-specific bacteriophage, allows detection of a specific microorganism, such as Salmonella spp. and an indicator signal may be amplified to optimize assay sensitivity.
Resumen de: WO2024148143A1
Methods and antimicrobial compositions are provided for surface cleaning. The antimicrobial compositions which include very low concentrations of an organic acid and one or more anionic surfactants can, unexpectedly, provide effective and broad spectrum antimicrobial activity within two minutes of contact with a surface and in some instances within one minute of contact time. Contacting the antimicrobial compositions with a surface can result in greater than or equal to about 4.0 log kill or 5.0 log kill for one or more of Staphylococcus aureus, Pseudomonas aeruginosa, and Salmonella enterica on the surface in two minutes or less. The compositions can have antimicrobial activity against at least one gram-positive bacterium, gram-negative bacterium, virus, and fungus in two minutes or less of contacting the composition with a surface.
Resumen de: WO2024146625A1
A duplex fluorescent PCR detection primer probe group of duck Salmonella enteritidis and Salmonella typhimurium, a kit, and the use thereof. Comparative analysis on the whole genomes of Salmonella enteritidis and Salmonella typhimurium is performed to screen out as identification targets a specific fragment Sdf I of lyg D gene of Salmonella enteritidis and a specific gene STM4497 of Salmonella typhimurium, and the present application designs specific primers and probes.
Resumen de: CN118308310A
The invention discloses a salmonella typhimurium bacteriophage ZK22, and relates to the technical field of bacteriophage viruses, the preservation number of the bacteriophage is GDMCC No: 64387-B1, the preservation unit name is Guangdong Microbial Culture Collection Center, the preservation address is Building 5, No. 59, No. 100 Courtyard, Xianlie Middle Road, Guangzhou City, and the preservation date is March 4, 2024. The invention also discloses application of the salmonella typhimurium bacteriophage ZK22 in inhibition of proliferation of salmonella typhimurium and preparation of salmonella typhimurium inhibition drugs. The bacteriophage ZK22 has high specificity on salmonella typhimurium, is good in stability, high in splitting efficiency and high in safety, and has a relatively great application value.
Nº publicación: KR20240107309A 09/07/2024
Solicitante:
CTC VAC CO LTD [KR]
\uC8FC\uC2DD\uD68C\uC0AC \uC528\uD2F0\uC528\uBC31
Resumen de: KR20240107309A
본 발명은 돼지 부종병 ELISA 키트 및 상기 키트를 이용한 돼지 부종병의 진단방법에 관한 것으로, 보다 상세하게는 시가 독소(shiga toxin) 재조합 항원 및/또는 상기 재조합 항원 특이적 항체를 포함하는 효소면역측정법 기반 돼지 부종병 진단 키트에 관한 것이다. 본 발명에서는 시가 독소(shiga toxin) 유래 재조합 항원(HJP2 항원) 및 상기 항원 특이적인 재조합 항체를 제조하였으며, 이를 이용하여 간접면역효소면역측정법(indirect ELISA) 기반 및 샌드위치 효소면역측정법(sandwich ELISA) 기반 돼지 부종병 진단 키트를 제조하였다. 본 발명에서 제조한 진단 키트는 돼지 혈청 속에 포함된 시가 독소에 대한 항체를 효과적으로 인식하는 것을 확인하였으므로, 돼지 부종병 진단에 유용하게 활용할 수 있다.