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电场辅助3D打印制备含电气石颗粒的同轴骨支架的方法

Resumen de: CN121668399A

本发明公开了一种电场辅助3D打印制备含电气石颗粒的同轴骨支架的方法，包括：步骤1、制备外壳浆料和内芯浆料；步骤2、搭建电场辅助的同轴3D打印设备；步骤3、打印同轴骨支架。本发明将同轴3D打印技术与静电场技术相结合，通过同轴加料口和环形电极的设计，制备了具有粘度梯度的同轴支架，内芯为高粘度浆料容易凝固成型，提供良好的力学支撑；外壳为含电气石颗粒的低粘度浆料，能在环形电极形成的静电场的作用下使电气石颗粒在支架表面定向排列。

一种用于3D打印的高内相双峰乳液及其制备方法和应用

Resumen de: CN121673466A

本发明涉及一种用于3D打印的高内相双峰乳液及其制备方法和应用，所述制备方法包括如下步骤：将第一高内相乳液和第二高内相乳液进行剪切搅拌混合，得到所述用于3D打印的高内相双峰乳液；所述第一高内相乳液的众数粒径大于第二高内相乳液的众数粒径。本发明提供的用于3D打印的高内相双峰乳液具有自稳定性，进行3D打印的结构稳定好，精度高，不易出现结构坍塌、变形、分层和脱落等问题。

一种用于治疗口呼吸的个性化3D打印水凝胶贴片及其制备方法

Resumen de: CN121668051A

本发明公开了一种用于治疗口呼吸的个性化3D打印水凝胶贴片及其制备方法，涉及3D打印水凝胶贴制备技术领域，包括获取使用者唇部区域的三维表面形貌数据，并基于该数据构建个性化水凝胶贴片的数字模型；根据数字模型设计具有唇周贴合轮廓的三维结构文件；配制包含明胶甲基丙烯酰化、多巴胺甲基丙烯酰胺、丙烯酰胺、聚乙二醇二丙烯酸酯、光引发剂及护肤型功能性添加剂的预聚物溶液；将预聚物溶液注入光固化3D打印设备，并调用三维结构文件进行逐层曝光打印，形成湿态水凝胶贴片；将湿态水凝胶贴片置于缓冲溶液中清洗，以去除未反应组分；对清洗后的水凝胶贴片进行后固化处理，使交联网络充分形成，获得具备适中黏附力与高韧性的成品贴片。

一种抑菌水凝胶人造皮肤及其制备方法

Resumen de: CN121668395A

本申请提供了提供了一种抑菌水凝胶人造皮肤及其制备方法，属于3D打印生物材料技术领域，按重量份数计，包括以下原料制备得到：六水合氯化铝1～3份、水30～45份、接枝改性壳聚糖15～22份、丙烯酰胺8～15份、N,N'‑亚甲基双丙烯酰胺0.2～0.8份、光引发剂0.5～1.5份、季铵化壳聚糖6～12份和纳米羟基磷灰石4～8份。其中，接枝改性壳聚糖包括以下原料制备而成：壳聚糖5～10份，浓度2%乙酸溶液80～120份、甲基丙烯酸缩水甘油酯0.8～2.5份和偶氮二异丁腈0.05～0.2份。本申请通过采用以接枝改性壳聚糖为核心的配方，形成多尺度交联和个性化3D打印的协同设计，实现水凝胶的高力学强度、广谱长效抑菌、精准形态适配与优异生物相容性，满足临床复杂创面修复需求。

一种医用纤维增强复合材料的制备方法

Resumen de: CN121668390A

本发明提供了一种医用纤维增强复合材料的制备方法，属于医用材料技术领域。本发明提供一种兼具高屈服强度和弹性模量，且孔隙率大的医用纤维增强复合线材的制备方法，进一步可通过3D打印得到医用材料，提高力学性能的同时，提高材料的孔隙率，孔道结构也有利于营养液输送，显著提高支架结构的生物活性，且制备方法简便，满足多种医疗器械应用需求。

一种陶瓷内窥镜抓钳钳头及其一体化成型方法

Resumen de: CN121673045A

本发明公开了一种陶瓷内窥镜抓钳钳头的一体化成型方法。方法以氧化锆模型墨水与水溶性支撑墨水为原料，通过材料喷射成型逐层构建含上钳口、下钳口、旋转轴、连接管及螺纹鞘头的整体生坯；在齿形咬合区、镂空键槽及活动间隙按特定比例混合填充支撑，并在每2‑5层后采用螺旋滚刀在线铣削，保证尺寸精度。生坯经水洗、干燥、1550℃烧结后，制得致密度≥99.9%、Ra 3‑4μm、抗弯强度≥800MPa的陶瓷钳头，无需后续机加工或铆接。产品闭合宽度≤10mm，总长≤50mm，鳄鱼形弧面与32齿R0.1mm倒角协同镂空键槽、椭圆排液孔，实现轻量化、低损伤、高夹持力，可顺利通过φ2.0mm内镜通道，满足一次性使用需求，解决不锈钢钳头加工难、易过敏、易疲劳及成本高的问题。

一种硅胶阻鼾器制造系统及方法

Resumen de: CN121671003A

本发明涉及一种硅胶阻鼾器制造方法，属于医疗产品技术领域。该方法包括以下步骤：S1、数据获取与建模；S2、配准：将三维牙颌模型与头颅侧位片配准，实现牙颌模型与气道软组织的空间对齐；S3、测量分析：测量气道间隙、舌体形态及颌骨位置参数；S4、个性化矫正：根据测量结果自动设定下颌骨的前伸量与垂直打开量，依据WALA嵴与FA点设计牙弓扩弓宽度，设计舌诱导屏斜面角度以引导舌体向前向上移动；S5、制造。本发明突破传统阻鼾器仅能单一前移下颌的局限，通过协同调控下颌骨三维位姿、牙弓宽度及舌体姿态，实现对气道长度、宽度和高度的立体化综合扩展，有效增大气道容积，改善通气效率，显著提升对OSAHS的矫治效果。

一种模拟天然软骨四层结构的组织工程关节软骨及其原位3D打印方法

Resumen de: CN121668406A

本发明涉及一种模拟天然软骨四层结构的组织工程关节软骨及其原位3D打印方法，通过精准的分层建模与层特异性生物墨水，复刻天然软骨“表层‑移行层‑辐射层‑钙化层”的结构与成分特征，依托优化的原位3D打印工艺，在关节腔内直接构建与缺损区解剖匹配、与天然软骨力学及生理功能一致的组织工程软骨。另外，本发明减少了BMSCs体外诱导分化步骤，降低细胞突变风险，同时提升修复组织与宿主软骨的长期整合性，解决了临床修复长期有效性不足的问题。

儿童咬合垫、基于适应性咬合的儿童咬合矫治系统及其设计方法

Resumen de: CN121647835A

本发明公开了儿童咬合垫、基于适应性咬合的儿童咬合矫治系统及其设计方法，儿童咬合垫包括两个本体，两个本体被配置为覆盖佩戴者上颌/下颌左侧后牙区和右侧后牙区，两个本体之间通过连接部连接；本体包括朝向对颌牙列的咬合面、以及朝向其所覆盖牙列的组织面；组织面形成有用于容纳目标牙齿的萌出窝；萌出窝由侧壁和与目标牙齿咬合面相适配的窝底壁限定而成，侧壁围绕一引导轴线延伸；其中，本体被配置为在佩戴状态下，引导轴线相对于佩戴者的腭平面垂线具有预设偏转角度，以通过引导轴线的方向引导目标牙齿的萌出；萌出窝的窝底壁具有沿引导轴线方向测量的预设厚度。本发明提供的儿童咬合矫治系统既能提高固位力，又能根据错��类型主动引导牙齿定向萌出、重塑功能咬合平面，从而通过消除下颌内旋/外旋机制来矫治颌骨畸形。

一种3D打印掺镁矿化胶原复合骨支架及其制备方法

Resumen de: CN121648350A

本发明化学技术领域，具体涉及一种3D打印掺镁矿化胶原复合骨支架及其制备方法，复合骨支架主要由掺镁矿化胶原、羟基磷灰石和左旋聚乳酸制成，左旋聚乳酸、镁矿化胶原和羟基磷灰石质量比为3~5∶2~4∶1。制备方法，其步骤为：胶原蛋白溶解在酸性缓冲溶液中，滴加含PO43‑溶液后，再依次滴加含Ca2+与Mg2+的混合盐溶液，制得混合溶液；S13在混合溶液中加入碱溶液调节混合溶液pH至8.0~9.0，生成掺镁矿化胶原；将掺镁矿化胶原、左旋聚乳酸和羟基磷灰石混合后通过3D打印制成复合骨支架。本发明的制备方法，克服胶原不稳定的技术偏见，可以实现一步共沉淀法钙镁磷共沉积。

壳状牙科器械制作方法

Resumen de: WO2021147336A1

A method for fabricating a shell-shaped dental instrument, comprising: obtaining a three-dimensional digital model of a shell-shaped dental instrument (101); inspecting the three-dimensional digital model of the shell-shaped dental instrument (103); according to the result of inspection, directly modifying the three-dimensional digital model of the shell-shaped dental instrument (105); and using 3D printing technology to make the shell-shaped dental instrument on the basis of the modified three-dimensional digital model of the shell-shaped dental instrument (107). The present method can overcome the limitations on various aspects of a shell-shaped dental instrument caused by the limitedness of the traditional hot pressing film forming process.

一种用于深部脑神经定向再生的微型蠕动器及其制备方法

Resumen de: CN121647847A

本发明涉及蠕动器技术领域，且公开了一种用于深部脑神经定向再生的微型蠕动器，包括微型蠕动器，所述微型蠕动器的表面设置有褶皱结构，所述微型蠕动器的内部设置有驱动结构，所述驱动结构为记忆合金丝，通过电流控制记忆合金丝，实现收缩与断电恢复形变，进而驱动微型蠕动器产生蠕动运动。本发明中，微型蠕动器整体呈蠕虫状且由两个C形结构组成，配合表面连续环状褶皱结构，可模拟自然界生物在狭窄空间的高效蠕动模式，既能适配深部脑神经区域复杂的管腔与组织间隙，又能避免蠕动过程中对周围软组织的刮擦损伤，同时褶皱结构为运动提供稳定波形动力，确保在精细神经环境中灵活前行。

用于通过3D喷墨打印制备由氧化锆制成的陶瓷成形体的方法和料浆

Resumen de: US2025018599A1

Process and slip for the production of ceramic shaped parts made of zirconium oxide ceramic by a 3D inkjet printing process. The slip contains zirconium oxide which is suspended in a liquid medium, wherein the slip has a zirconium oxide content of from 68 to 88 wt.-% and contains not more than 5 wt.-% organic components. The process for the production of ceramic components comprises the layered shaping and subsequent sintering of the desired component from the slip.

一种功能化骨软骨修复材料及其制备方法

Resumen de: CN121648349A

本发明公开了一种功能化骨软骨修复材料，包括依次连接的软骨层、过渡层和骨层，所述软骨层以透明质酸、I型胶原蛋白和壳聚糖为基材，所述过渡层以羟基磷灰石和聚乳酸‑羟基乙酸共聚物为基材，所述骨层以β‑磷酸三钙、羟基磷灰石和聚乳酸‑羟基乙酸共聚物为基材，本发明涉及医用生物材料技术领域，通过设计有机‑无机复合过渡层，梯度衔接软骨层和骨层，界面剪切强度≥0.5MPa，有效解决了传统分层材料层间剥离的问题，能承受关节运动时的剪切应力和压缩应力，制备工艺采用冷冻干燥、模压成型、烧结等成熟医用材料生产设备，可实现规模化批量生产，同时支持选择性激光烧结3D打印的个性化制备，适配不同临床场景需求。

用于经由3D打印生产药物对象的系统和方法

Resumen de: AU2025205378A1

21894047_1 (GHMatters) P119307.AU.2 The invention relates to a system for producing pharmaceutical objects, such as tablets, granules and capsules, via 3D print- ing. The system comprises a 3D printing machine (2) with a me-5 chanical system (3) movable in one or more directions, at least one print head (5) with a nozzle (37) being movable by the me- chanical system (3) and a base system (4) carrying a print base (6) for receiving a prepared mixture (27) applied by the print head (5). The system comprises at least one carrier (35) for 10 holding a cartridge (28).Printing can be done on formatted print locations (49) on the base (6). The invention further relates to a method for producing pharmaceutical objects, comprising the steps of providing at least one pharmaceutical substance in at least one cartridge, placing the cartridge in a carrier, estab-15 lishing a fluid connection between a cartridge and a print head, such that the pharmaceutical substance may leave the print head through the print head nozzle, moving the print head nozzle ac- cording to a 3D print program and dispensing the pharmaceutical substance to a print base. 20 (Fig. 24) The invention relates to a system for producing pharmaceutical objects, such as tablets, granules and capsules, via 3D print- 5 ing. The system comprises a 3D printing machine (2) with a me- chanical system (3) movable in one or more directions, at least one print head (5) with a nozzle (37) being movable by the me- chanical system (3)

SYSTEM AND METHOD FOR PLANNING AND SIMULATING A SURGICAL OPERATION TO CREATE A PATIENT-SPECIFIC SPINAL IMPLANT

Resumen de: WO2026054808A1

A system and method for planning and simulating a surgical operation to create a patient-specific spinal implant are disclosed. The system comprises a remote server configured to receive patient-specific medical image data and generate a 3D mesh model of the patient's spine using algorithms that separate vertebral bodies, remove artifacts, and smooth surfaces. A doctor's computer receives the 3D mesh model and allows real-time manipulation of intervertebral spaces to achieve a desired spinal curvature. The server generates a spinal implant design with surface-mapped endplates matching the patient's vertebral anatomy, which is transmitted to a 3D printer for manufacturing. The method includes steps of receiving image data, generating and updating the 3D mesh model based on doctor input, generating the final implant design, and transmitting it for production. The invention enables the creation of patient-specific spinal implants with improved conformity and surgical outcomes.

MEMBRANE, MEMBRANE CONTACTOR, AND METHOD FOR PRODUCING A MEMBRANE

Resumen de: WO2026052280A1

The invention relates to a membrane (1) for a membrane contactor (2), which membrane is in the form of a hollow three-dimensional tube structure located on both sides of a plane/central plane (ME), in particular a hollow tube structure which is mirror-symmetrical to the plane/central plane and consists of branched tubes (3, 3 ́, 3 ́ ́, 3 ́ ́ ́, 3 ́ ́ ́ ́), preferably not exclusively planar branched tubes (3, 3 ́, 3 ́ ́, 3 ́ ́ ́, 3 ́ ́ ́ ́) having a plurality of branching planes (VE) in parallel with the plane/central plane (ME) on both sides of the plane/central plane (ME), wherein the walls of the tube structure are permeable to substances and/or permeable to energy, and wherein, in the region (B) of each branching plane (VE), each tube (3, 3 ́, 3 ́ ́, 3 ́ ́ ́) extending towards the plane/central plane (ME) branches into a plurality of tubes (3 ́, 3 ́ ́, 3 ́ ́ ́, 3 ́ ́ ́ ́) extending with respect to the plane/central plane (ME), and the tubes (3 ́ ́ ́ ́) extending from both sides of the plane/central plane (ME) from the corresponding last branching plane (VE) with respect to the plane/central plane (ME) merge into one another in the region (ÜB) of the plane/central plane (ME). The invention also relates to a membrane contactor (2) having a membrane of this type, and to a method for producing a hollow membrane (1).

ANATOMICAL BELOW-KNEE PROSTHETIC LEG THAT CAN BE FABRICATED WITH A 3D PRINTER

Resumen de: WO2026054745A1

The invention relates to an anatomical below-knee prosthetic leg that can be fabricated with a 3D printer, which has a complex geometry optimised according to stress regions by means of structural analyses considering engineering calculations and various loading conditions in daily life with a topology optimization method, for below-knee amputee patients.

SYSTEMS AND METHODS FOR CELL QUANTIFICATION IN BIOPRINTING

Resumen de: WO2026053002A2

In a bioprinting system and method, a bioprinter may include one or more reservoirs, a printhead, and a print surface on which the bioprinting is dispensed. An optical system may collect imaging data of a plurality of cells within a cross-linkable material during and/or after passage of the plurality of cells through the bioprinting system. A computing system may generate, via a machine learning algorithm executing on the image data, a plurality of segmented regions in the image data, wherein each segmented region in the plurality of segmented region defines a boundary around a different set of cell aggregates in the plurality of cells, identify a first segmented region in the plurality of segmented regions that defines a boundary around at least a visible portion of a first cell aggregate, wherein the first cell aggregate includes an occluded portion, determine, based on an estimated shape of the first cell aggregate, an extrapolated boundary around at least some of the visible portion of the first cell aggregate and at least some of the occluded portion of the first cell aggregate, compute a quantity of cells within the first cell aggregate based on an area surrounded by the extrapolated boundary, and determine one or more parameters associated with the plurality of cells, the material flow, or the bioprinting system based on the quantity of cells.

SYSTEMS AND METHODS FOR STITCHING FRAMES IN A VIDEO CAPTURED IN BIOPRINTING

Resumen de: WO2026053003A2

In a bioprinting system and method, a bioprinter may include one or more reservoirs, a printhead, and a print surface on which the bioprinting is dispensed. An optical system may collect imaging data of a plurality of cells within a material flow while passing through and/or exiting from the bioprinting system, wherein the passage of the plurality of cells through the bioprinting system creates a printed fiberduring and/or after. A computing system may identify a first frame in the imaging data captured at time t-n and a second frame in the imaging data captured at time t, generating, via a machine learning algorithm executing on the imaging data, a plurality of segmented regions in the imaging data, wherein each segmented region in the plurality of segmented region defines a boundary around a different set of cell aggregates or cells in the plurality of cells, determining, for combining with the first frame and based on the plurality of segmented regions, a portion of the second frame that is substantially non-overlapping with the first frame, determining, based on the plurality of segmented regions, one or more cells or cell aggregates in the plurality of cells that are located along an edge of the first frame or an edge of the portion of the second frame, identifying a seam where the first frame and the portion of the second frame are to be combined based at least on locations of the one or more cells or cell aggregates, combining the first frame and the portion of the sec

ANCHOR FOR USE WITH ORTHODONTIC APPLIANCE

Resumen de: WO2026053080A1

An anchor for use with an orthodontic appliance is provided. The anchor is configured to be coupled to an anchor surface defining a reference plane. The anchor includes a base configured to be coupled to the anchor surface, such that the reference plane interfaces with the base. The anchor further includes a hook portion extending from the base and curving towards the reference plane. The hook portion includes a tip distal to the base. The hook portion defines a pocket having a minimum width relative to the reference plane. A maximum distance between the tip and the reference plane is less than the minimum width of the pocket.

STERNAL IMPLANT

Resumen de: WO2026055711A1

A sternal implant for implant into a body is provided. The implant includes an outer frame forming a structurally rigid portion. The outer frame includes a plurality of openings configured to accommodate sutures for affixing the outer frame to the body. The implant includes a central structure connected within the outer frame. The central structure includes a in the form of a layer having a construction including multiple channels. The filling portion is configured to allow for fluid drainage and tissue ingrowth of tissue generated by the body.

Tibia-Implantat

Resumen de: DE102024126035A1

Die Erfindung betrifft ein Tibia-Implantat (2) für Gelenkersatz, welches aus Metalllegierung in einem additiven Fertigungsverfahrenhergestellt ist, mit einem Plateauabschnitt (4) und mit einem auf der tibiazugewandten Seite (8) des Plateauabschnitts (4) vorspringenden und sich davon in einer axialen Richtung (10) wegerstreckenden zapfen- oder kielförmigen Ankerabschnitt (6),; erfindungsgemäß wird vorgeschlagen, dass der Plateauabschnitt (4) auf seiner tibiazugewandten und mit Tibiaknochengewebe in Kontakt gelangenden Seite (8) eine dreidimensional poröse offenporige Oberflächenstruktur (14) mit in der axialen Richtung (10) hintergreifbaren Brücken, Stegen oder Wandbereichen aufweist, wobei die offenporige Oberflächenstruktur (14) eine erste Rauigkeit aufweist, und dass der Ankerabschnitt (6) anschließend an den Plateauabschnitt (4) in einem ersten axialen Ankerbereich (20) umfangsseitig eine in einer radialen Richtung (12) hinterschnittfreie, das heißt von hintergreifbaren Brücken und brückenbildenden Stegen freie Oberflächenstruktur (28) mit einer zweiten Rauigkeit aufweist, die geringer ist als die erste Rauigkeit, und dass der Ankerabschnitt (6) in der axialen Richtung (10) anschließend an den ersten axialen Ankerbereich (20) einen zweiten axial frei endenden axialen Ankerbereich (22) mit einer glatten Oberfläche aufweist.

ARTICLES INCLUDING A MICROSTRUCTURED CURVED SURFACE, TOOLING ARTICLES, AND METHODS

Resumen de: US20260070777A1

The present disclosure provides a microstructured article including a thermoplastic polymer shaped to have a curve. At least a portion of the curve includes a microstructured surface of utilitarian discontinuities and the microstructured surface includes peak structures and adjacent valleys. The peak structures and the curve are formed of a single piece of the thermoplastic polymer. A method of making the microstructured articles is also provided including a) obtaining a tool shaped to include at least one of a protrusion or a concavity; b) disposing a microstructured film on at least a portion of the tool including the protrusion and/or the concavity; and c) thermoforming a single piece of thermoplastic polymer onto the tool to form a microstructured article shaped to include a curve. The curve is an inverse of the protrusion or the concavity of the tool.

PATIENT INTERFACE

Resumen de: AU2026201217A1

A patient interface comprises a support structure and a seal-forming structure. The support structure is arranged to support the sealing portion and is configured to connect to the frame. The sealing portion comprises textile and is attached to the support structure along an outer perimeter of the sealing portion such that in use the sealing portion may be in tension due to reactive stress of the support structure and/or a resilient stretch characteristic of the textile such that the sealing portion exerts a force against the patient’s face. eb e b

MOLECULARLY CLEAVABLE BIOINK FORMULATION

Resumen de: US20260071187A1

A bioink formulation for digital light processing bioprinting comprising a mixture of a biocompatible cleavable polymer precursor, a biocompatible non-cleavable polymer precursor, and a photoinitiator is described. Three-dimensional (3D) objects prepared using these bioink formulations are also described. In addition, a method of 3D bioprinting is described. The method includes providing a bioink formulation in a 3D bioprinter vat; repeatedly photoactivating the biocompatible photoactive polymer precursors in the 3D bioprinter vat on a build plate immersed in the vat to form a 3D bioprinted object comprising polymers having a series of predefined shapes across the vertical direction based on a set of sliced images; and treating the 3D bioprinted object with an agent that cleaves chemical bonds within the cleavable polymer.

AUGMENTED REALITY SCANNING INTERFACE FOR GENERATING PERSONALIZED 3D PRINTED CASTS

Resumen de: US20260069145A1

A method of generating a 3D model of a body part includes scanning the body part with a 3D scanner; during the scanning step, generating, with an augmented reality user interface, an augmented reality view of said body part, wherein the augmented reality view differentiates between portions of the body part that have already been scanned and portions that have not yet been scanned; with guidance from the augmented reality view, completing the scan; and generating the 3D model based on data received from the scan. The augmented reality view is displayed on a practitioner-facing screen incorporated into the scanning device. The method may further include imaging the body part with a thermal imager and overlaying thermal scanning data onto the 3D model to thereby generate a distribution map of thermal sensitivity on the 3D model. The design is then generated with holes situated to maximize thermal comfort.

MEDICAL DEVICES AND RELATED METHODS

Resumen de: US20260069260A1

A medical device includes an operating member, a hub, and an end effector. The operating member includes an actuation portion. The hub includes a channel receiving the actuation portion of the operating member. The actuation portion of the operating member moves within the channel. The end effector is movable between a closed configuration and an open configuration. Distal extension of the operating member transitions the end effector to the open configuration, and proximal retraction of the operating member transitions the end effector to the closed configuration. The medical device is formed through an additive manufacturing process.

MULTI-MODAL PATIENT-SPECIFIC SURGICAL GUIDES

Resumen de: US20260069290A1

A surgical device includes a first body component including at least one insert embedded therein and a second body component including a patient-specific surface. The first body component includes a first material and the at least one insert includes a second material. The first body component defines at least one first hole and the second body component defines at least one second hole. The second body component is configured to be coupled to the first body component such that the at least one first hole and the at least one second hole are aligned when the first body component is coupled to the second body component to define at least one continuous fixation hole sized and configured to receive an elongate fixation device at a predetermined location.

DENTAL APPLIANCES WITH INTERPROXIMAL ENGAGEMENT STRUCTURES

Resumen de: US20260069385A1

Dental appliances and associated systems are provided. In some embodiments, a dental appliance includes a shell configured to receive a plurality of teeth, the shell having a sidewall and an interproximal engagement structure extending from the sidewall into a space of an interproximal region between a first tooth and a second tooth of the plurality of teeth. The interproximal engagement structure can be configured to contact the first tooth and the second tooth concurrently. The interproximal engagement structure can be larger than the space of the interproximal region, such that the contact causes deformation of one or more of the interproximal engagement structure or the sidewall.

SYSTEM AND METHOD FOR PERFORMING QUALITY ANALYSIS FOR MULTIDIMENSIONAL PRINTING

Resumen de: US20260070279A1

A system for performing quality analysis for multidimensional printing. The system includes a multidimensional printer, wherein the multidimensional printer comprises a printing head, a printing surface, an axis system and a scale, wherein the scale is arranged to measure weight applied on the printing surface; and a control unit operatively coupled to the multidimensional printer. The control unit is configured to control the printing head to extrude a printing material, to produce a printed object on the printing surface, obtain, from the scale, a weight of the printed object, and store the weight of the printed object in a memory associated with the control unit, compare the weight with a reference weight of the printed object, and control the printing head to stop extrusion of the printing material when the weight is equal to or exceeds the reference weight.

METHODS OF FABRICATING LASER-SINTERED CARBOHYDRATE MATERIALS AND COMPOSITIONS AND USES THEREOF

Resumen de: US20260070282A1

A composition useful in forming a structure in the form of a substantially interconnected vascular network. The composition includes a powder including a carbohydrate powder and an anti-caking agent, where the powder: has a granular form, and has a specific energy of less than 6 millijoules per milliliter (mJ/mL).

TWO-PHASE 3D PRINTING OF BIOCOMPATIBLE STRUCTURES

Resumen de: US20260069744A1

A method of printing a hydrogel scaffold is provided which includes providing a container containing an ink and a liquid that is immiscible with the ink; applying light from a light source to the ink to form a portion of the hydrogel scaffold; and applying light from a light source one or more additional times to produce one or more additional portions of the hydrogel scaffold.

SYNTHETIC BONE GRAFTS AND METHODS FOR THEIR PREPARATION

Resumen de: US20260069746A1

The present invention provides methods for the preparation of synthetic bone grafts which are made of a composition comprising two matrixes, one ceramic including interlocked CDHA crystals, and another of one or more binder(s), the two matrixes being admixture. The method comprises the preparing of an ink composition, the 3D-printing, and the hardening of the binder and ceramic components, in this order.The resulting bone grafts, which are characterized by including the two matrixes in admixture, shows improved mechanical properties as well as excellent biological properties.

SUCTION TOOTHBRUSH AND RELATED METHODS

Resumen de: US20260069028A1

A suction toothbrush includes a handle defining an opening, a toothbrush head including internal channels, a seal with a distal end received within the toothbrush head and a proximal end coupled to the handle through the opening thereof, and a connector extending through the annular body of the seal. The connector includes a main body having a distal end disposed within the internal conduit of the toothbrush head and a proximal end extending into the handle through the top opening thereof, and a vibration motor housing offset from the proximal end of the main body. A waste reservoir for a suction toothbrush includes a lid, a basin defining a sump for waste material, and a gas-permeable membrane disposed between the lid and the basin that defines central inlet opening. A 3-D printing method for suction toothbrush heads.

SYSTEM AND METHOD FOR PRODUCING PHARMACEUTICAL OBJECTS VIA 3D PRINTING

Resumen de: US20260069503A1

Method for 3D printing, comprising the following steps: providing a packaging (2′) having at least one recess (3′) for receiving a product (1′), wherein the shape of the recess (3′) corresponds at least in part to the shape of the product (1′) and wherein the recess (3′) forms a protuberance at the other side of the packaging (2′); providing a 3D printer with a print base (5′) having at least one recess (6′) for receiving the protuberance formed by the recess (3′) of the packaging (2′); inserting the packaging (2′) in the print base (5′) such that the protuberance formed by the recess (3′) of the packaging (2′) is received by the recess (6′) of the print base (5′); filling a print head (7′) of the 3D printer with at least one material for printing the product (1′); 3D printing the product (1′) inside the recess (3′) of the packaging (2′), wherein the part of the recess (3′) corresponding to the shape of the product (1′) serves as the mold and print support, resp., for those layers of the product (1′) which are 3D printed first. The method is performed with a system for 3D printing, comprising a packaging (2′) having at least one recess (3′) for receiving a product (1′), wherein the shape of the recess (3′) corresponds at least in part to the shape of the product (1′) and wherein the recess (3′) forms a protuberance at the other side of the packaging (2′); and a 3D printer with a print head (7′) and a print base

TIBIA IMPLANT

Resumen de: US20260069422A1

A tibia implant for joint replacement has a plateau section and an anchor section projecting from a tibia-facing side of the plateau section. The anchor section is insertable into a channel in a tibia bone. The plateau section has a first surface structure that is a porous open-pore surface structure with bridges, webs or wall regions that can be gripped from behind in the axial direction on the tibia-facing side that comes into contact with tibia bone tissue. The open-pore surface structure has a first roughness. The anchor section is connected to the plateau section in a first axial anchor region on the circumferential side has a surface structure with a second roughness that is lower than the first roughness. The anchor section has a second axially free-ending axial anchor region with a smooth surface in the axial direction adjacent to the first axial anchor region.

SEMICRYSTALLINE SULFUR CONTAINING POLYMERS FOR ORTHODONTIC APPLICATIONS

Resumen de: US2025009476A1

The present disclosure provides polymeric materials comprising semicrystalline sulfur-containing polymers, methods and curable compositions for making the same, and orthodontic appliances made from said polymeric materials.

RADICALLY POLYMERISABLE COMPOUND AND COMPOSITION

Resumen de: WO2024227533A1

The invention relates to a radically polymerisable compound represented by a structure of formula 1: PG-Sp-PCA-Sp- OG (O) NH-K-NHC (O) O-Sp-PCA-Spn-PG (formula 1), wherein PG = in each case independently selected from a radically polymerisable group, R1 = selected from hydrogen, a C1-C8 alkyl group, an aryl group and an araliphatic group having C6-C8 carbon atoms, R2 = selected from hydrogen, a C1-C4 alkyl group; Sp = in each case independently of one another a spacer group selected from unbranched and branched alkylene with C1-C19 carbon atoms, which may additionally contain oxygen, sulfur and/or -OOC- in the carbon chain, or Sp is absent; PCA = in each case independently of one another a polycyclic group; K = an aliphatic acyclic, saturated or unsaturated unit having C1-C15 carbon atoms, an aliphatic cyclic, saturated or unsaturated unit having C3-C15 carbon atoms, or an aromatic or araliphatic unit having C6-C14 carbon atoms; n = 1 to 9. The invention also relates to a process for preparing such a compound, a radically polymerisable composition containing such a compound, the use thereof and a cured dental material.

分解性ポリ乳酸ポリマーブレンドを含む方法及び組成物

Resumen de: US2023139077A1

Disclosed herein polylactide polymer blend compositions, and methods of making and using such compositions.

DESIGN METHOD OF TRANSPARENT ORTHODONTIC DEVICE AND ATTACHMENT FOR ORTHODONTICS

Resumen de: EP4706587A1

The method for designing a transparent orthodontic appliance and attachment for tooth alignment according to the present invention has been devised to solve the above technical problems. It is a method for designing an orthodontic appliance using a computer, comprising: a step (S01) of designing the shape of an attachment to be affixed to the surface of a tooth model; a step (S02) of designing the inner surface shape of the transparent orthodontic appliance corresponding to the attachment designed in step S01; and a step (S03) of outputting the transparent orthodontic appliance by means of a 3D printer. The attachment comprises: two pressure surfaces (101) formed to face each other; two inclined surfaces (201) formed to be inclined toward each other while contacting the two pressure surfaces (101); a top surface (301) contacting the edges of the two pressure surfaces (101) and the two inclined surfaces (201); and an attachment surface (401) affixed to the surface of a tooth. This configuration serves as the technical means for solving the problem.

METHOD FOR MANUFACTURING ORTHODONTIC DEVICE BY USING INSERTION PATH

Resumen de: EP4706586A1

The present invention relates to a program for designing an orthodontic appliance. The method comprises: displaying, on a screen, the insertion path for determining the insertion direction of the appliance (S01); designating a tooth targeted for the insertion path setting (S02); setting the insertion path for the designated tooth in an arbitrary direction (S03); displaying, on the screen, undercuts of each tooth caused by the set insertion path (S04); calculating and storing depth values of the undercuts for each tooth (S05); and calculating and storing the total sum of undercut volumes for each tooth according to the insertion path (S06).

Scanning and printing calibration tool

Resumen de: JP2024160362A

To provide a dentition phantom model capable of precisely evaluating scanning accuracy of a scanner.SOLUTION: A dentition phantom model 100 includes a base layer composed of a first base layer 110 and a second base layer 120, and a dentition layer 130 disposed on the base layer and including a tooth model, where the tooth model is configured so that a shape observed from one direction is different respectively from shapes observed from the remaining other directions.SELECTED DRAWING: Figure 1aa

一种用于制作后巩膜加固术垫片材料的取材模板及其制作装置

Resumen de: CN223979895U

本实用新型公开了一种用于制作后巩膜加固术垫片材料的取材模板及其制作装置，立体状态时，取材模板包括由中间的第一加固区和两侧的第一连接带构成的垫片立体模板，平面状态时，包括由所述垫片立体模板展开形成平板式结构的垫片平面模板，垫片平面模板包括中间的第二加固区和两侧的第二连接带，第二加固区上端轮廓为若干弧线光滑过渡连接并向上凸起的曲线，第二加固区下端轮廓为若干弧线光滑过渡连接组成并向上凸起曲线；第二连接带轮廓为若干曲线光滑过渡连接组成的长条形。本实用新型中3D打印系统根据不同患者的实际情况，准确制造出适合每一位患者的垫片模板，再根据该垫片模板制出垫片，提高了手术的效率，而且提高了垫片精度，保证手术质量。

一种3D打印颌骨生物支架

Resumen de: CN121622995A

本发明提供了一种3D打印颌骨生物支架，利用3D打印技术成功构建了负载颌骨BMSCs与牙髓dECM生物支架，同步满足颌骨缺损修复对机械支撑强度、生物活性微环境、成骨仿生诱导特性及免疫调控能力的核心需求。

心电图机及心电图机的打印控制方法

Resumen de: CN121622054A

本申请实施例提供了一种心电图机及心电图机的打印控制方法，包括：打印机构，包括包含第一加热点和第二加热点在内的多个加热点；驱动机构，用于驱动目标纸张和打印机构相对移动；控制器，用于：根据第一心电波形数据控制打印机构在第一目标纸张打印至少部分以第一预定布局排布的第一心电图报告，第一加热点用以生成其中的第一基线；根据第二心电波形数据控制打印机构在第二目标纸张打印至少部分以第二预定布局排布的第二心电图报告，第二加热点用于以生成其中的第二基线；第一心电波形和第二心电波形分别位于第一预定布局和第二预定布局二者布局相同的区域，以显著减少部分加热点的加热次数，进而提升心电图机中打印功能模块的使用寿命。

一种三维水凝胶支架及其制备方法和骨修复应用

Resumen de: CN121623010A

本发明涉及医用生物材料技术领域，尤其涉及一种三维水凝胶支架及其制备方法和骨修复应用。所述三维水凝胶支架为通过若干水凝胶管搭建的层叠的、三维有序结构，每层包括平行间隔排列的多根水凝胶管，相邻两层的水凝胶管之间呈夹角，所述三维水凝胶支架的组分包括海藻酸钠；在三维水凝胶支架中，每根水凝胶管之间具有大孔，每根水凝胶管内部具有全连通微通道，每根水凝胶管的外表面和内表面都具有表面取向性纳米纤维结构。本发明的三维水凝胶支架能很好的应用于骨修复方面，并且本发明利用3D打印、不均匀的交联和拉伸干燥联合技术成功构建了三维水凝胶支架，制备工艺简单准确，易于操作，有利于工业推广和应用。

一种医疗设备

Resumen de: CN121622053A

本发明提供了一种医疗设备，涉及具有纸张打印功能的医疗设备领域，包括主机和纸仓；纸仓包括纸仓壳体和纸辊，纸仓壳体上设有纸张放置空间，纸辊转动装配在纸仓壳体上；主机包括主机壳体、打印模块和限位部件；主机壳体上设有纸仓安装腔，在纸仓完全装入纸仓安装腔后，纸仓安装腔具有对应于顶部仓口的顶侧和与顶侧相对的底侧；打印模块具有打印部，限位部件设置在纸仓安装腔的顶侧，限位部件包括凸起部位，凸起部位朝向纸张放置空间凸出以限制打印纸的活动空间，在垂直于纸仓底面的方向上，凸起部位相对于打印部更靠近纸仓的底面。本发明能够降低医疗设备在打印过程中卡纸问题发生的概率。

一种防移位锁定加压接骨板及其制备方法

Resumen de: CN121622217A

本发明公开了一种防移位锁定加压接骨板及其制备方法，属于医疗器械技术领域。所述接骨板包括：具有解剖曲度的主体；设置在主体骨干对应区的梯度多孔结构区域，其孔隙率自中轴向两侧梯度降低，以优化力学匹配、促进骨长入；沿板体排列的多功能复合孔组，每组包含一个锁定孔和一个带倾斜加压滑道的动态加压孔；以及设于板体两端的T形定位槽与遍布骨接触面的微观防滑纹理构成的防移位锚定结构，确保术中瞬时定位与术后抗微动稳定。其制备方法基于患者医学影像进行参数化设计与有限元优化，并采用选区激光熔化技术一体成型。本发明有效解决了传统接骨板应力遮挡、术后移位与骨整合不足的临床问题，显著提升了固定效果与愈合质量。

一种具有结肠靶向功能的淀粉-鱼油复合3D打印凝胶糖果及其制备方法

Resumen de: CN121621425A

本发明公开了一种具有结肠靶向功能的淀粉‑鱼油复合3D打印凝胶糖果及其制备方法。通过脉冲电场‑微波协同预处理技术优化淀粉分子结构，结合微射流纳米化与动态超高压均质实现鱼油在淀粉基质中的高效复合与稳态化包埋，再经喷雾冷冻‑真空冷冻干燥技术构建多孔微球载体。最后，将所得微球粉末与特定亲水胶体复配成打印墨水，通过超声多段式辅助3D打印技术精准成型。本发明所制备的凝胶糖果兼具优异的抗氧化性与抗消化特性其鱼油释放率与淀粉水解率低。该产品具有结肠靶向释放功能，在结肠中发挥良好的肠道菌群调节功能，体外发酵总短链脂肪酸含量高，并能显著提升双歧杆菌与乳酸杆菌的相对丰度。

一种基于丝素蛋白的生物3D智能响应支架及其制备方法和应用

Resumen de: CN121622997A

本发明涉及生物支架技术领域，具体涉及一种基于丝素蛋白的生物3D智能响应支架及其制备方法和应用，本发明的生物3D智能响应支架采用定向纤维膜、多孔海绵层和界面层三层仿生梯度结构，模拟天然组织，分别提供力学引导、细胞栖息与生物活性界面，协同促进血管、神经、皮肤的高质量再生。本发明具有pH/酶/温度三重响应单元，能感知病变微环境并触发靶向释放，可解决了传统物理载药突释率高的问题，实现按需精准给药。本发明采用SF/HPMC凝胶进行3D打印，打印精度高，使得本发明孔隙率差异<2%，产品性能稳定，孔隙结构可以根据不同组织（如血管、神经、皮肤）的再生需求进行精确设计和定制。

基于喷墨打印的柔性流体传感系统及其制备方法

Resumen de: CN121633193A

本申请涉及传感器技术领域，本申请提供一种基于喷墨打印的柔性流体传感系统及其制备方法，其传感系统包括柔性基板以及设置于所述柔性基板上的能量采集天线、能量管理单元、微流控传感器、微泵和信号调制单元，通过设置能量采集天线和能量管理单元，系统能够从环境中自主采集射频能量并转换为电能，为整个系统进行供电，并且能够将采集到的分散能量存储起来，并在需要时提供瞬时高功率输出，摆脱了对传统电池或外接电源的依赖。

一种牙科活动修复体及其制备方法、以及钴铬钼合金粉末

Resumen de: CN121624457A

本申请涉及生物医疗材料领域，具体公开了一种牙科活动修复体及其制备方法、以及钴铬钼合金粉末。该牙科活动修复体是以钴铬钼合金为原料，由激光选区熔化技术成形；钴铬钼合金按重量百分比计由以下元素组成：Cr 26~30%，Mo 4~7%，Si 0.5~1.5%，B 0.01%~0.05%，余量为Co及不可避免的杂质；其中，所述钴铬钼合金中不包含W和Ta，且不可避免的杂质总量低于0.5%。其制备方法包括合金熔炼与雾化制粉、筛分干燥、激光选区熔化（SLM）成形及去应力退火。本发明的核心在于通过添加微量硼元素并优化合金组分，使3D打印成形的牙科活动修复体（如支架、卡环）在950~1000℃的常规去应力退火后，即可获得断后伸长率不低于20%、抗拉强度不低于1000 MPa的高塑性及高强度结合。

一种基于人工智能的人工关节假体制造系统

Resumen de: CN121638130A

本发明涉及骨科植入医疗器械制造技术领域，公开了一种基于人工智能的人工关节假体制造系统，包括流体动力学逆向解析单元及拓扑结构逻辑生成单元，构建与多相流瞬态压力场映射的变刚度过滤晶格，在高压冲击核心区生成由截面惯性矩逆向配置的弹性微梁单元，并建立压强响应形变机制，最终输出一体化成型的增材制造指令，本发明利用金属弹性模量与微观拓扑的力学耦合，实现低压下微孔拦截微粒与高压下弹性扩孔瞬态泄压的自适应切换，提升静态植入物原位流体调节功能，避免植入过程中的脂肪栓塞风险。

一种可控光热-酶促降解多孔材料及其制备方法和应用

Resumen de: CN121628208A

本发明提供一种可控光热‑酶促降解多孔材料及其制备方法和应用，所述可控光热‑酶促降解多孔材料的制备原料包括油相混合物和水相混合物；所述油相混合物包括酶敏感聚合物基材、无规杂聚物（RHP）‑酶复合物、Janus光热纳米颗粒、内相分散剂和溶剂；所述水相混合物包括水、电解质和海藻酸盐。本发明提供的多孔材料，通过将Janus光热纳米颗粒与RHP‑酶复合物耦合，在近红外光下，会触发RHP构象变化释放BC脂肪酶，在37℃的温和条件下即可触发多孔材料的降解，48h降解率可达到98%。

一种用于多细胞互作和神经化骨再生的多级结构生物活性三维支架及其制备方法和应用

Resumen de: CN121622980A

本发明涉及一种用于多细胞互作和神经化骨再生的多级结构生物活性三维支架及其制备方法和应用。所述多级结构生物活性三维支架包括：具有宏观通道结构的生物活性支架基体，以及填充在所述基体内部的微观定向拓扑结构；所述宏观通道结构具有三维可控的多样结构，所述微观定向拓扑结构为填充在内部的定向微米级通道；本发明提供的多级结构生物活性三维支架可作为协调多细胞时空相互作用的“空间桥梁”，对于多种细胞在三维空间上的相互迁移、能量代谢水平和特异性分化行为具有有益促进作用；本发明构建多级结构生物活性三维支架是一种兼具多级结构和生物活性的新型的骨修复生物材料，为大段骨修复及其他复杂组织重建提供了一种新策略。

基于锥体束CT预测与3D打印的PAOO术后唇挡和方法

Resumen de: CN121622300A

基于锥体束CT预测与3D打印的PAOO术后唇挡和方法，聚焦于通过锥体束CT数据精准定制、数字化设计与制作的个性化PAOO术后唇挡，可实现对PAOO手术术区的高效防护，填补当前临床中术后手术区域个性化保护器具的技术空白，其特征在于，包括以下步骤：步骤1，锥体束CT扫描；步骤2，数据重建与植骨量计算；步骤3，唇档三维建模；步骤4，光敏树脂阴性模具打印；步骤5，PETG膜片热压成型（PETG，聚对苯二甲酸乙二醇酯‑1,4‑环己烷二甲醇酯）；步骤6，后处理（打磨、清洗、非高温高压消毒（75%酒精浸泡））。

一种超弹低模量抗菌骨植入体的制备方法

Resumen de: CN121624446A

本发明涉及生物医用材料技术领域，具体涉及一种超弹低模量抗菌骨植入体的制备方法，首先基于三周期极小曲面（Gyroid）设计特定孔隙参数的多孔结构模型，然后将NiTi合金粉末与少量Ag粉末均匀混合，最后在保护气氛下采用优化的激光粉末床熔融工艺参数一体化成形。所制备的骨植入体具有1.5‑3.5GPa的低弹性模量，能与人体骨骼良好匹配，显著降低应力屏蔽效应；同时保留了NiTi合金的超弹性，并在4%应变下具有可恢复变形能力。此外，Ag元素的添加使植入体对金黄色葡萄球菌和大肠杆菌的抗菌率均超过90%，在不过度改变基体组织的前提下赋予了材料优异的抗菌性能，有效提升了植入体的临床安全性与服役可靠性。

载药血管支架及其制备方法

Resumen de: CN121623023A

本申请提供了一种载药血管支架及其制备方法，其中，所述载药血管支架的制备方法，包括：制备载药微球；其中，所述载药微球包括负载消炎药物的壳聚糖纳米粒、包覆所述壳聚糖纳米粒的抗菌药物层，以及包覆所述抗菌药物层的PLGA壳层；将所述载药微球与PLGA微球混合制备为共混线材；根据数字模型将所述共混线材经3D打印成型为载药血管支架。

一种医用3D打印材料

Resumen de: CN121623007A

本申请提供一种3D骨骼打印材料，包括具有生物活性的生物骨粉和骨水泥，其中生物骨粉由自体骨、异体骨或动物骨骼中的一种或几种制成，骨水泥包括粉剂和液剂，生物骨粉和骨水泥的质量比为1:1～1:12，骨水泥粉剂和骨水泥液剂的质量比为0.5:1～1.5:1。

颅骨修复体及其制备方法

Resumen de: CN121622322A

一种颅骨修复体及其制备方法，所述颅骨修复体包括：由内侧至外侧依次设置的第一诱导层、第一支撑层、隔离层、第二支撑层以及第二诱导层；第一诱导层、第二诱导层均由至少包括矿化胶原的材料形成，第一、第二支撑层均由高分子材料以及纳米生物陶瓷颗粒复合形成，隔离层由可降解聚合物材料形成，适于在可降解聚合物材料降解前实现对于第一、第二支撑层之间的物理分隔，并在可降解聚合物材料完成降解后形成三维连通孔道；三维连通孔道的平均孔径小于第一诱导层、第一支撑层、第二支撑层以及第二诱导层的平均孔径。本发明技术方案兼顾支撑性能与促进骨组织再生功能，并且使两侧骨组织在中央区域形成有效融合以及避免在植入初期导致发生感染的风险。

一种丝素蛋白4D智能水凝胶生物支架及其制备方法

Resumen de: CN121622996A

本发明涉及生物支架技术领域，具体涉及一种丝素蛋白4D智能水凝胶生物支架及其制备方法，本发明以丝素蛋白为主要成分，结合京尼平作为交联剂，通过打印技术制备而成，京尼平与丝素蛋白形成温敏物理交联网络，使得本发明所制备的生物支架具有4D智能特性，在低温平台上被固化为一种临时形状，当植入体内（37℃）时，在体温的刺激下，水凝胶生物支架会自发地发生变化，以适应并紧密贴合特定的组织缺损部位，解决了传统静态支架与缺损部位匹配度不佳的技术难题，可为不同患者受损组织进行个性化定制，本发明具有良好的生物相容性、优异机械强度、生物可降解和智能响应特性，能够促进细胞粘附、增殖和组织再生，特别适用于软组织修复。

基于3D打印的股骨滑车成形方法

Resumen de: CN121622253A

本发明公开了基于3D打印的股骨滑车成形方法，本发明涉及三维重建技术领域。包括步骤：数据采集、数据预处理、三维模型构建、参数测量、个体化重建、截骨导板设计、术中成形：通过螺旋CT数据采集、多步骤图像处理及三维建模，精准获取膝关节骨骼解剖细节，实现基于患者个体解剖的滑车沟个体化重建，使重建后的滑车沟在曲率半径、宽度、深度和关节面角度上与髌骨高度匹配，提升手术精准性，解决滑车沟发育不良引发的髌骨不稳定问题；截骨导板的设计实现虚拟截骨到实际手术的精准转化，其贴合面与股骨外表面紧密贴合，截骨通道与截骨工具精准匹配，缩短手术时间，固定孔设计确保导板稳定，降低截骨偏差风险，提升手术安全性。

一种医用高强度高抗菌性承重骨植入体的制备方法

Resumen de: CN121624447A

本发明涉及生物医用材料技术领域，具体涉及一种医用高强度高抗菌性承重骨植入体的制备方法，通过激光粉末床融合技术，将1‑5 wt.%的银粉与95‑99 wt.%的镍钛合金粉末混合，在低氧环境下进行3D打印成形。通过优化激光功率、扫描速度等关键工艺参数，实现了银元素的均匀分布和第二相的弥散强化，显著提升了材料的综合性能。所得植入体具有高致密度、高强度和高抗菌性，其抗压强度可达3400‑3800 MPa，弹性模量接近人骨，对金黄色葡萄球菌和大肠杆菌的抗菌率超过95%，同时保持了镍钛合金固有的超弹性和形状记忆效应，特别适用于椎间融合器、人工关节等高载荷部位的骨科植入。

一种用于组织工程半月板支架的生长因子可控释放载体及其制备方法

Resumen de: CN121622998A

本发明属于半月板损伤修复材料技术领域，具体涉及一种用于组织工程半月板再生修复的生长因子可控释放载体及其制备方法。本发明公开了一种用于组织工程半月板再生修复的生长因子可控释放载体及其制备方法，提出壳‑芯结构同轴静电纺丝载体，具体为通过同轴静电纺丝在壳芯层负载不同的生长因子，并且通过壳芯层使用不同降解速率载体（芯层降解速率大于壳层）实现生长因子的时序性释放，随着时间推移实现空心纤维结构。将静电纺丝纤维打碎形成短棒状纤维与生物墨水结合，通过3D打印实现精确的异质性结构以及成分仿生。本申请通过微观尺度的降解速率调控与结构设计，突破时序释放与血管引导的技术瓶颈。

一种具有镁含量和模量双梯度的骨组织工程支架及其制备方法与应用

Resumen de: CN121606737A

本发明提供一种具有镁含量和模量双梯度的骨组织工程支架及其制备方法与应用。该支架由磷酸三钙/白磷钙石(TCP/WH)构成的3D打印无机支架与活性纤维增强基质金属蛋白酶(MMP)响应水凝胶复合而成，将水凝胶灌注到无机支架中可形成具有镁含量和刚度双梯度。该复合支架特别适用于通过软骨内成骨机制的骨再生修复，细胞可在镁离子浓度和基质刚度的牵引下，逐步由水凝胶迁移到活性纤维，再迁移到无机支架，从而促进细胞的增殖、成软骨分化、成血管和新骨形成。本发明的制备方法包括无机支架的3D打印、活性纤维增强MMP响应水凝胶的制备及其灌注复合等步骤，该复合支架材料体系在骨再生修复领域具有潜在的应用价值。

一种可控降解镁合金骨支架的制备方法

Resumen de: CN121606736A

一种可控降解镁合金骨支架及其制备方法，属于生物材料领域。该方法包括：通过激光选区熔融3D打印技术制备WE43镁合金支架，并进行电解抛光；随后采用原子层沉积工艺在支架表面构建多级TiN/TiO₂纳米复合防护膜，通过控制膜级数调控降解速率。本发明制得的支架具有与人体皮质骨相匹配的压缩强度（≥130 MPa），降解均匀可控，当膜层数N≥2时，其平均降解速率≤0.5 mm/year，满足骨愈合期内力学支撑要求。该支架生物相容性良好，能促进骨整合，且无需二次手术取出，适用于各类骨缺损修复。

一种生物降解的3D打印骨修复材料及其制备方法

Resumen de: CN121606739A

本发明属于生物医用工程材料领域，旨在提供一种可3D打印的生物降解骨修复材料及制备方法。生物3D打印是增材制造和生物医学交叉融合的新兴学科，通过生物3D打印得到的组织工程支架具有良好的生物相容性和优秀的生物活性。本发明将可降解骨修复材料和3D打印结合。本发明将可降解的聚乳酸和无机生物材料相融合，将聚己内酯‑ZnO静电纺丝增强材料的支撑强度，同时添加骨组织生长需要的羟基磷灰石和微量金属元素。在临床应用时，骨修复材料在细胞分裂，新组织生成期间起到支撑作用。在临床应用时，骨修复材料在细胞分裂，新组织生成期间起到支撑作用。随着修复材料在生物体内逐渐降解，其降解产物对生物体不会产生宿主反应，同时降低了患者在骨修复后需要进行二次手术取出植入材料的再次创伤和医疗费用。

面向偏头痛的耳模3D打印与电刺激一体化治疗系统

Resumen de: CN121606824A

本发明涉及医疗设备技术领域，具体为面向偏头痛的耳模3D打印与电刺激一体化治疗系统，包括：耳廓数据采集模块采集患者耳廓的三维几何数据、耳穴定位数据及皮肤阻抗分布数据；个性化耳模生成模块通过自适应分层3D打印算法构建内置仿生弧度电极通道的个性化耳模，进行电极通道与目标耳穴的对位；智能电刺激调控模块结合改进的靶向Attention‑LSTM模型，动态调整电刺激频率、脉冲宽度及刺激强度，生成个性化电刺激方案；执行与安全监控模块将个性化电刺激方案转化为靶向电刺激物理治疗过程，并在治疗全程实施动态监控与自适应调整。由此，解决现有技术中耳廓数据采集维度单一、个性化耳模打印与适配性缺陷明显等问题。

光開始剤を有する歯科用の複合材料

Resumen de: WO2024170529A1

The invention relates to a polymerizable, light-radiation curable dental composite material comprising (i) 30 to 90 wt.% of at least one inorganic filler component comprising at least one dental glass and optionally at least one amorphous metal oxide, (ii) 5 to 60 wt.% of at least one urethane acrylate, urethanemethacrylate or mixtures thereof, (iii) 0.01 to 30 wt.% of at least one di-, tri-, tetra- or multifunctional monomer which is not urethane acrylate and/or urethane alkylacrylate, and (iv) 0.01 to 10 wt.% comprising hexaarylbisimidazol (HABI) and/or substituted hexaarylbisimidazol and comprising at least one mercaptotetrazol as the initiator system, and optionally at least one pigment, wherein the total composition of the composite material is 100 wt.%. The invention also relates to a polymerized composite material for producing direct dentures or indirect dentures.

METHOD FOR PRODUCING A JAW MODEL INTENDED FOR MOUNTING IN AN ARTICULATOR

Resumen de: WO2022049078A1

The present invention relates to a method for producing a jaw model of a patient intended for mounting in an articulator (10), said method comprising the production of at least one jaw model (11, 12), at least one model plate (17) assigned to this jaw model and at least one articulation plate (19), which is detachably connectable to the model plate, is to be arranged approximately parallel to the model plate (17), can be inserted into an articulator (10) and is connectable to the latter, the model plate (17) and articulation plate (19) being fixable with respect to one another by an interlocking connection, and, according to the invention, the data for the jaw model being obtained digitally and the jaw model (11, 12) then being produced by means of 3D printing on the basis of these digital data. The jaw model (11, 12) is preferably produced from plastic in one piece together with the model plate (17) by means of 3D printing. The method according to the invention is simple, reliable and accurate and, as necessary, also allows for easier removal of individual tooth stumps (27, 28) from the model.

Resektionsschablone und Verfahren zum Rekonstruieren einer knöchernen Anatomie mit einer solchen Resektionsschablone

Resumen de: DE102024125227A1

Resektionsschablone (1) zum Rekonstruieren einer knöchernen Anatomie aus einem Transplantat (2), mit zumindest einem Segment (10), und mit zumindest einem Einsatz (12), welcher jeweils mindestens eine Bohrhülse (13) zum Vorgeben einer Position einer Bohrung im Transplantat (2) aufweisen; das zumindest eine Segment (10) einen Hauptkörper (HK), mindestens zwei im Hauptkörper (HK) angeordnete Löcher (14), und im Hauptkörper (HK) ausgebildete erste und zweite Aussparungen (15) aufweist, wobei die Aussparungen (15) zum Einsetzen von dem zumindest einem Einsatz (12) an einer vorgegebenen Position im Segment (10) vorgesehen sind, sowie Verfahren zum Rekonstruieren einer knöchernen Anatomiemit einer solchen Resektionsschablone (1).

Membran und Membrankontaktor

Resumen de: DE102024125325A1

1. Die Erfindung betrifft eine Membran (1) für einen Membrankontaktor (2), die als eine zu einer Mittelebene (ME) spiegelsymmetrische hohle Röhrenstruktur aus verzweigten Röhren (3, 3', 3", 3''', 3'''') mit beidseits der Mittelebene (ME) mehreren zur Mittelebene (ME) parallelen Verzweigungsebenen (VE) ausgebildet ist, wobei die Wandungen der Röhrenstruktur stoffpermeabel und/oder energiepermeabel sind und wobei im Bereich (B) jeder Verzweigungsebene (VE) jede in Richtung zur Mittelebene (ME) erstreckte Röhre (3, 3', 3'', 3''') in mehrere zur Mittelebene (ME) erstreckte Röhren (3', 3'', 3''', 3'''') verzweigt und die von beiden Seite der Mittelebene (ME) von der jeweils letzten Verzweigungsebene (VE) zur Mittelebene (ME) erstreckten Röhren (3'''') im Bereich (ÜB) der Mittelebene (ME) ineinander übergehen. Die Erfindung betrifft weiterhin einen Membrankontaktor (2) mit einer solchen Membran und ein Verfahren zur Herstellung einer hohlen Membran (1).

NON-BRAIDED BIODEGRABLE FLOW DIVERTING DEVICE FOR ENDOVASCULAR TREATMENT OF ANEURYSM AND ASSOCIATED FABRICATION METHOD

Resumen de: US20260060688A1

A biodegradable flow diverting device (BFDD) that will regulate blood flow into an aneurysmal sac, act as a scaffold for endothelization at the neck of an aneurysm, and degrade after successful dissolution of aneurysm and remodeling of blood vessel. This BFDD and associated fabrication method have the following features: (1) This is a non-braided FDD. The pore shapes, sizes, architectures (especially at the inlet and outlet of the pores), pore densities and porosities can be controlled for the optimum performance depending on the blood vessel and aneurysmal morphologies from patient MRI images, (2) BFDD is developed on a rotary arm with programmable variable speed and diameter in conjunction with a micromotion stage (3) Fabrication system can take any material including blended/composite biomaterials by adjusting temperature of the electro-melt extruder/needle and (4) Fabrication system is compatible with CAM (computer aided manufacturing) software and able to operate based on the adapted G-code.

System and Method for Planning and Simulating a Surgical Operation to Create a Patient-Specific Spinal Implant

Resumen de: US20260060750A1

A system and method for planning and simulating a surgical operation to create a patient-specific spinal implant are disclosed. The system comprises a remote server configured to receive patient-specific medical image data and generate a 3D mesh model of the patient's spine using algorithms that separate vertebral bodies, remove artifacts, and smooth surfaces. A doctor's computer receives the 3D mesh model and allows real-time manipulation of intervertebral spaces to achieve a desired spinal curvature. The server generates a spinal implant design with surface-mapped endplates matching the patient's vertebral anatomy, which is transmitted to a 3D printer for manufacturing. The method includes steps of receiving image data, generating and updating the 3D mesh model based on doctor input, generating the final implant design, and transmitting it for production. The invention enables the creation of patient-specific spinal implants with improved conformity and surgical outcomes.

SYSTEMS AND METHODS FOR ORTHODONTIC BRACKET DESIGN

Resumen de: US20260060783A1

In an embodiment, a method of manufacturing customized ceramic labial/lingual orthodontic brackets by additive manufacturing may comprise measuring dentition data of a profile of teeth of a patient, based on the dentition data, creating a three dimensional computer-assisted design (3D CAD) model of the patient's teeth, and saving the 3D CAD model, designing a virtual 3D CAD bracket structure model for a single labial or lingual bracket structure based upon said 3D CAD model, importing data related to the 3D CAD bracket structure model into an additive manufacturing machine, and directly producing the bracket with the additive manufacturing machine by layer manufacturing from an inorganic material including at least one of a ceramic, a polymer-derived ceramic, and a polymer-derived metal.

WIRELESS MICROFLUIDIC SMART BANDAGE FOR EFFICIENT WOUND EXUDATE MANAGEMENT AND ANALYSIS IN HUMAN SUBJECTS

Resumen de: US20260060845A1

A wearable wound management system integrating a flexible microfluidic assembly and real-time electrochemical sensing to autonomously sample, transport, and analyze wound exudate. A Janus membrane, formed by selective deposition of perfluoroalkyl-functionalized silica nanoparticles and O2 plasma etching on a PET film, may collect fluid via its superhydrophobic wound-facing side and deliver it to a curved, wedge-shaped microfluidic channel that enhances capillary flow. Downstream, a graded PDMS micropillar array refreshes a sensing region by unidirectional fluid movement. A drop-on-demand inkjet-printed, CO2 laser-patterned flexible sensor patch may measure nitric oxide, oxygen, hydrogen peroxide, pH, temperature, and other relevant metrics. An encapsulated wireless electronic module may transmit health data for wireless monitoring. This system, combined with machine-learning analytics, may enable continuous, in situ monitoring and predictive wound classification, supporting proactive and personalized chronic wound care.

PATIENT-SPECIFIC NEURAL IMPLANTS ENGINEERED VIA 3D PRINTING TECHNOLOGY

Resumen de: WO2026049910A1

Embodiments relate to bioelectrodes designed to accommodate patient specific gyral patterns, and to methods of making and using thereof. A bioelectrode may be manufactured by obtaining a three-dimensional scan of at least a portion of a brain; identifying a target region of the brain; designing a bioelectrode model configured to fit the target region; and printing the bioelectrode based on the bioelectrode model. The bioelectrode is printed to include a top layer, a bottom layer, and an electrode layer positioned between the top layer and the bottom layer such that the top layer and bottom layer encapsulate the electrode layer. The bioelectrode may have a Young's modulus between 0.1 and 10 kPa to better mechanically match brain tissue.

PROCESS FOR THE MANUFACTURING OF MICROSCALE HOLLOW METAL BODIES

Resumen de: US20260060925A1

A hollow body has a bottom, an upper end wall, and side walls extending between the bottom and the upper end wall. The upper end wall and side walls are made of metal. The cavity within the hollow body has a volume in the range between 1 picoliter to 1,000 picoliter. The upper end wall comprises at least one opening. The hollow body is suitable for encapsulating small amounts of liquid, or a small micro-electromechanical system, and may be used for the controlled release of pharmaceutical components.

METHOD FOR PRODUCING A DENTAL ARCH MODEL, DENTAL ARCH MODEL, AND ARRANGEMENT

Resumen de: WO2026046865A1

The invention relates to a method for producing a dental arch model (100) intended to be detachably arranged on an articulator plate (300) of an articulator (1), and to a corresponding dental arch model (100) and to an arrangement comprising such a dental arch model (100). The dental arch model (100) is manufactured by 3D printing and comprises a model base plate (200) formed in one piece therewith, wherein the model base plate (200) has a number of recesses (220) which each have a bearing surface (225) in the form of a concave spherical-segment surface and which correspond to a number of projections (320) that are provided on the upper side of the articulator plate (300) and each have a bearing surface (325) in the form of a convex spherical-segment surface, and the recesses (220) on the model base plate (200) are designed such that the produced dental arch model (100), when arranged on the articulator plate (300), rests exclusively with the bearing surfaces (225) in the form of a concave spherical segment surface on the bearing surfaces (325) in the form of a convex spherical segment surface at the articulator plate (300), and the model base plate (200) and the articulator plate (300) are otherwise spaced apart from one another.

METHOD FOR OBTAINING A POROUS INJECTABLE SCAFFOLD BASED ON SIMILAR BIOPOLYMERS, BUT WITH DIFFERENT MELTING TEMPERATURES

Resumen de: US20260061094A1

Method for generating a porous injectable scaffold that includes providing a liquid composition of 2 phases at a temperature below 25° C., of Newtonian behavior, where the composition comprises: a liquid dispersant phase at room temperature formed by a gelatin with a low melting point, less than 15° C., functionalized with methacryloyl or methacrylamide groups; and a photoinitiator;and a dispersed phase, of microdroplets or beads in solid state, of a gelatin solution with a melting point greater than 25° C.; initiating the polymerization of the dispersing phase by light radiation; raising the temperature to 35-40° C. and allowing melting of the dispersed phase; and obtaining a porous scaffold. The formed porous scaffold and its use as a biological support for tissue regeneration/generation; as a biological matrix as a support for cells, for cell invasion; as an acellular biological matrix, a biological matrix as a mechanical support and/or a biological matrix for active components.

METHOD FOR PRODUCING A COLLAGEN AND SILK POLYPEPTIDE COMPOSITE STRUCTURE

Resumen de: WO2024223794A1

The present invention relates to a method for producing a collagen and silk polypeptide composite structure. In addition, the present invention relates to a collagen and silk polypeptide composite structure and uses thereof.

BAND WRAPPING DEVICE

Resumen de: WO2024226028A1

A band wrapping device forms a length of band material into a loop for automatically applying the band to a limb (e.g., wrist) of a user. The band wrapping device may receive the length of band material from a cassette receivable in the band wrapping device and can include a band transport mechanism for transporting the band material, a sealer module for sealing the band material to itself and cutting the band material to a length, and/or a ring module for reception of the limb of the user for band application. The device and its constituent components can help reduce the contact between the individual requiring a band and those applying the band, can help reduce waste by using a more precise amount of band material sized to the limb, and can help reduce the staffing requirements in areas in which the bands are to be applied.

METHOD OF DESIGNING AND MANUFACTURING A CUSTOMIZED HAND PROSTHESIS

Resumen de: WO2024224174A1

A method for designing a functional prosthesis of customized hand, for patients amputated at trans-radial level, implemented with additive manufacturing technology. The method flow for designing and developing the devices consists of the following steps: i) kinematic analysis and 3D scan of the limb contralateral to the amputated one; ii) kinematic synthesis of the planar mechanism at one active degree of freedom (GdL), modular for each finger, and optimization of the same through a global performance index (GPI); iii) prototyping of the assembly of five fingers.

包括整体式模具主体的牙体修复模具

Resumen de: WO2025027496A1

A custom tool for forming a dental restoration in a mouth of a patient includes a one-piece mold body providing for a customized fit with at least one tooth of the patient, the one-piece mold body including an occlusal portion forming an occlusal surface corresponding with an occlusal surface of the tooth, a mesial proximal portion forming a mesial proximal surface corresponding with a mesial proximal surface of the tooth, and a distal proximal portion forming a distal proximal surface corresponding with a distal proximal surface of the tooth. The mold body is configured to combine with the tooth of the patient to form a mold cavity encompassing missing tooth structure of the tooth. The occlusal portion, the mesial proximal portion, and the distal proximal portion are based on three-dimensional scan data of the mouth of the patient.

一种降低裂瓷率的齿科用钴铬合金修复体3D打印工艺

Resumen de: CN121589301A

本发明的目的在于提供一种降低裂瓷率的齿科用钴铬合金修复体3D打印工艺，其中，钴铬合金粉末按重量百分比包括如下成分：Co：58‑64wt%；Cr：25‑31 wt %；Mo：5‑6 wt %；W：2‑3 wt %；Si：0.8‑1.2 wt %；Mn：0.5‑1.0 wt %；稀土氧化物：0.1‑0.3 wt %。打印工艺包括：采用如本发明所述的钴铬合金粉末预热、进行3D打印，打印过程中通过动态能量密度调制分别打印核心区、过渡区和表面区后获得修复体打印件，将钴铬合金打印件进行后处理获得钴铬合金修复体。本发明突破性结合粉末材料，3D打印工艺和后处理元素掺杂技术，显著提高金瓷结合力、实现金属与陶瓷的渐进式连接，从本质上解决界面失配问题。

一种3D打印用的医用级PEEK复合材料及其制备方法

Resumen de: CN121592153A

本发明公开了一种3D打印用的医用级PEEK复合材料及其制备方法，涉及3D打印技术领域，解决了现有PEEK材料存在的生物活性低的问题。该医用级PEEK复合材料由以下重量份的原料制成：聚醚醚酮基体80～95份、生物活性填料5～15份、界面改性剂0.5～5份、导热与成核增强剂0.1～3份；所述生物活性填料包括重量比为（1～5）:（5～1）的纳米羟基磷灰石和生物活性玻璃。能够有效模拟天然骨环境，提高复合材料的生物活性，促进细胞黏附与增值，从而提高细胞增值率，还能有效提高了复合材料的抑菌效果和力学性能。

一种用于挤出3D打印的光-酸协同增强生物墨水及其制备方法

Resumen de: CN121592122A

本发明公开了一种用于挤出3D打印的光‑酸协同增强生物墨水及其制备方法。该墨水由N‑乙烯基吡咯烷酮（NVP）、聚乙烯醇（PVA）、光引发剂及具有“单羟基‑双羧基”特异结构的苹果酸组成。打印时，墨水经挤出并结合紫外光照射实现初步定型，随后在加热油性支撑浴中同步触发酸催化NVP深度聚合及PVA微晶化，一步完成光固化定型与热处理增强。本发明利用苹果酸独特的分子结构构建了高效的光‑酸协同增强机制，不仅显著提升了单体转化率，更通过物理‑化学双网络大幅增强了打印体的力学强度与形状保真度，有效解决了生物墨水可打印性与强度的矛盾，在组织工程、柔性电子等领域具有广阔应用前景。

一种人工血管打印方法及设备

Resumen de: CN121590022A

本发明涉及人工血管制造的技术领域，具体而言，公开了一种人工血管打印方法及设备包括：第一储液部件，用于储存芯相材料；第二储液部件，用于储存外相材料；同轴打印组件，具备同轴设置的内料管和外料管，内料管连接第一储液部件，外料管连接第二储液部件；压力源，连通第一储液部件和第二储液部件，用于提供压力；接收部件，设置于同轴打印组件下方，用于接收人工血管；光固化组件，设置于接收部件的一侧，用于固化人工血管；通过使用本发明，能够复现天然管状组织复杂的解剖学特征，能够防止微小血栓的产生；且能够有效避免造成微通道堵塞，避免影响制备精度和效率，能够兼顾血管结构的生物相容性和高机械强度。

临时修复体穿龈三维形态塑形工具盒及其制造方法

Resumen de: CN121587868A

本发明公开了临时修复体穿龈三维形态塑形工具盒及其制造方法。包括本体和塑形凹槽，塑形凹槽开设于所述本体上，塑形凹槽用于提供种植替代体的放置空间并模拟天然牙穿龈三维形态的结构；其中，本体包括上本体和下本体；上本体和下本体可拆卸连接；塑形凹槽包括种植替代体放置结构和穿龈轮廓成型结构，种植替代体放置结构与穿龈轮廓成型结构周边连接，种植替代体放置结构用于放置与种植体匹配的种植替代体，穿龈轮廓成型结构用于容纳与种植替代体相连接的临时修复基台，并模拟天然牙穿龈三维形态。

一种基于甲基丙烯酰化明胶的微球、其制备方法及其在生物墨水中的应用

Resumen de: CN121588283A

本发明公开了一种基于甲基丙烯酰化明胶的微球、其制备方法及其在生物墨水中的应用，该微球以甲基丙烯酰化明胶为核心基材，可选择性复合糖胺聚糖‑甲基丙烯酰化明胶和/或脂质体，通过微流控技术制备而成，所得微球尺寸均一，且复合组分可赋予微球优异的自粘附特性；进一步采用微流控技术，以基材及复合组分作为微球壳相、细胞分散液作为微球核相，制备具有核壳结构的载细胞微球，该载细胞微球能良好维持包埋细胞的正常存活与生长。基于甲基丙烯酰化明胶的微球或载细胞的基于甲基丙烯酰化明胶的微球，可作为3D打印墨水用于制备支架材料、载细胞支架材料，适配细胞三维培养、细胞球培养、高密度细胞培养及组织工程植入材料领域。

包括整体式模具主体的牙体修复模具

Resumen de: WO2025027496A1

A custom tool for forming a dental restoration in a mouth of a patient includes a one-piece mold body providing for a customized fit with at least one tooth of the patient, the one-piece mold body including an occlusal portion forming an occlusal surface corresponding with an occlusal surface of the tooth, a mesial proximal portion forming a mesial proximal surface corresponding with a mesial proximal surface of the tooth, and a distal proximal portion forming a distal proximal surface corresponding with a distal proximal surface of the tooth. The mold body is configured to combine with the tooth of the patient to form a mold cavity encompassing missing tooth structure of the tooth. The occlusal portion, the mesial proximal portion, and the distal proximal portion are based on three-dimensional scan data of the mouth of the patient.

増強又は骨充填のための部分的な骨梁要素

Resumen de: AU2023303676A1

Element (100, 200, 300) for augment or bone filler, comprising at least one first outer-layer portion (101) having a trabecular lattice of metallic material, and further comprising at least one reinforcing inner layer (103) of metallic material having a plurality of channel structures (104) arrayed with respective channel openings (105) delimited by edges in structural contact with the at least one first outer-layer portion (101).

セラミックベニア及びセラミックベニアを作製する連続付加製造

Resumen de: CN120857914A

The present disclosure provides a method of making a ceramic article. The method comprises (a) obtaining a photopolymerizable slurry or sol comprising a plurality of ceramic particles distributed in the photopolymerizable slurry or sol, and (b) continuously moving a build substrate through the photopolymerizable slurry or sol using actinic radiation, and selectively polymerizing the photopolymerizable slurry or sol to form a gelled article. The method further includes (c) extracting a solvent from the gelled article to form an aerogel article or a xerogel article; (d) heat treating the aerogel article or the xerogel article to form a porous ceramic article; and (e) sintering the porous ceramic article to form a sintered ceramic article. The sintered ceramic article exhibits a specific density. In addition, additive manufactured ceramic articles exhibiting specific density, opacity, or both are provided.

一种种植模型3D打印树脂材料及其应用

Resumen de: CN121570635A

本发明公开了一种种植模型3D打印树脂材料，包含如下按重量份计的原料组分：聚氨酯丙烯酸酯低聚物30‑50份；单官能团活性稀释剂30‑40份；双官能团活性稀释剂20‑40份；光引发剂1‑3份；流平剂0.1‑3份；消泡剂0.1‑3份；填料0.5‑3份；耐刮蜡0.5‑3份；颜料0.2‑0.5份；聚氨酯丙烯酸酯低聚物与活性稀释剂的质量比为（0‑1）：1；所述单官能团活性稀释剂和双官能团活性稀释剂的质量比为（1‑1.5）：1。该树脂材料通过引入聚氨酯丙烯酸酯体系，改善后的光敏树脂通过3D打印制造的种植牙模，具有高下机精度、高逆扫尺寸稳定性、高性价比，应用于口腔医学领域。

一种蜂窝状刚性-柔性两相颗粒及其在光固化3d打印树脂中的应用

Resumen de: CN121574311A

本发明公开了一种蜂窝状刚性‑柔性两相颗粒及其在光固化3d打印树脂中的应用。该蜂窝状刚性‑柔性两相颗粒包括柔性聚氨酯相和刚性氧化硅相。制备步骤S1、制备包含聚氨酯颗粒的乳液作为种子乳液（乳液A）；S2、制备包含氧化硅前体和引发剂的乳液（乳液B）；S3、将乳液B加入到乳液A中，混合均匀得到混合液；S4、在施加动态作用和无氧条件下，将混合液升温至60‑80℃反应20～24h，得到含有蜂窝状刚性‑柔性两相颗粒的乳液。将含有蜂窝状刚性‑柔性两相颗粒的乳液加入到具有光固化性能的可降解聚合物材料中能同时提升聚合物材料的韧性和强度，且不影响聚合物的光固化性能和生物相容性；适用于作为填料添加到高精度光固化3d打印制备的各类成型制品。

数字化可无线传输的3D打印支具多参数监测系统及方法

Resumen de: CN121572596A

本申请涉及医疗器械与智能健康监测技术领域，公开了一种数字化可无线传输的3D打印支具多参数监测系统及方法，旨在解决刚性支具与柔性传感器因弹性模量差异大而导致的界面应力集中、传感器易脱落及信号精度差的问题。该系统通过3D打印在支具内表面构建梯度互锁界面结构，并原位成型柔性多参数传感阵列，实现刚柔一体化；还包括嵌入式数据采集处理单元、无线传输模块及微型能源模块。该方法包括三维建模分区、梯度界面路径生成、多材料协同打印、信号同步采集融合及无线传输。本发明显著提升界面结合强度与监测精度，简化制造流程，支持个性化定制。

辅助器打印方法、装置、电子设备、存储介质及计算机程序产品

Resumen de: CN120770988A

The invention discloses an artificial limb printing method and device, electronic equipment, a storage medium and a computer program product.The method comprises the steps that a first physiological data set of a first user is obtained; calling a first artificial intelligence model to process the first physiological data set to obtain a first constraint parameter set; the first artificial intelligence model is used for recommending a constraint parameter group based on an input physiological data group; the constraint parameter set represents constraints related to the mechanical performance requirements corresponding to the input physiological data set; taking the first constraint parameter group as a constraint, and calling a generative design algorithm to process the first physiological data group to obtain a first design parameter group; the generative design algorithm is used for generating a design parameter group meeting the corresponding comfort requirement on the basis of the input physiological data group, and the design parameter group comprises a plurality of design parameters of the artificial limb; and generating a first file based on the first design parameter group and the slice parameter group, and outputting the first file to the three-dimensional printing device.

一种基于直接3D打印的无托槽隐形矫治器及其数字化设计与制造方法

Resumen de: CN121572585A

本发明公开了一种基于直接3D打印的无托槽隐形矫治器及其数字化设计与制造方法。该方法构建了一个数字化闭环流程：首先通过口内扫描与数字化排牙设定矫治目标；继而利用收缩包裹算法构建矫治器光滑包络空间；采用基于PointNet++的AI技术精准分割牙冠以界定力边界；通过厚度控制与边缘优化算法生成形态精确、力学稳定的矫治器数字模型；最后，基于DLP技术使用生物相容性树脂直接打印矫治器，并经过严格的二次固化等后处理确保其性能与安全。本发明省去了传统压膜工艺，从根本上消除了累积误差，并能通过工艺控制实现矫治器力学性能的个性化梯度设计，标志着隐形矫治技术从“形态匹配”迈向“功能适配”。

一种负泊松比结构多功能血管支架及其制备方法

Resumen de: CN121571655A

本发明公开了一种负泊松比结构多功能血管支架及其制备方法，涉及医疗器械技术领域，包括负泊松比结构的血管支架模型的构建、选区激光熔化增材制造、化学抛光处理以及表面仿生改性处理。该支架利用负泊松比特性能够更好地适应血管的变形，减少因变形不同步产生的不相容性，其结构圆润平滑，可有效避免传统支架锐利拐角处易产生的血流湍流与涡流，改善血流动力学性能，降低血小板激活与血栓形成的风险，通过制备表面梯度涂层，实现多机制协同，有利于支架表面内皮层的形成。

一种具有生物相容性的低粘度树脂组合物及其制备方法和应用

Resumen de: CN121574312A

本发明提供了一种具有生物相容性的低粘度树脂组合物及其制备方法和应用，涉及临时牙冠树脂材料的技术领域。所述具有生物相容性的低粘度树脂组合物按重量份数计包括：丙烯酸酯树脂10~40份、活性稀释剂30~60份、改性填料10~50份、光引发剂0.5~2.5份、助剂0.5~5份；所述改性填料为钛酸酯偶联剂改性纳米填料，且所述钛酸酯偶联剂改性纳米填料包括纳米填料内核、以及包覆于所述纳米填料内核的表面的单分子钛酸酯偶联剂包覆层。本发明提供的临时牙冠用树脂组合物的粘度较低，流动性优异，利于材料打印成型；同时，保证了所制备的材料具有较好的生物相容性以及力学强度。

一种基于3D打印的双层载药植入体及其制备方法与应用

Resumen de: CN121570412A

本发明属于药物共递送技术领域，具体涉及一种基于3D打印的双层载药植入体及其制备方法与应用。本发明通过合成明胶甲基丙烯酸酯GelMA；制备2‑氨基葡萄糖修饰的奥沙利铂Oxa‑2‑DG；MExo的提取与纯化；GelMA的3D打印与AI优化最终制备获得具有双层结构的载药植入体LEH@OG。本发明制备的共递送平台可在腹腔内降解，实现内外层药物的序贯释放，具有较高的生物安全性，对各组织脏器均无明显损伤。并表现出强大的抗肿瘤疗效和免疫激活作用。

一种颈椎单开门手术3D打印导板的制作方法

Resumen de: CN121572598A

本发明公开了一种颈椎单开门手术3D打印导板的制作方法，涉涉及医疗辅助器械与增材制造交叉技术领域，先获颈椎CT数据三维重建骨骼模型，虚拟规划手术方案，再参数化生成导航模板数字化原型，经有限元仿真优化，用光固化设备以生物相容性树脂打印，最后处理得终产品。本发明通过CT薄层扫描与三维重建生成高精度颈椎骨骼模型，经虚拟规划确定铰链区、开门槽线及钉道参数，解决传统手术依赖经验易致损伤或定位偏差问题；再以特定算法构导航模板贴附曲面并留软组织补偿间隙，配镂空窗凸起限磨钻深度，同时经有限元仿真与拓扑优化控导板变形，选特定树脂保稳定性，借虚拟配准与标准化制造保适配性，提升手术精准安全与效率。

ADDITIVE MANUFACTURING PART SUPPORT AND HANDLING FRAME

Resumen de: AU2025210859A1

A cutting instrument includes an insert and a frame having sidewalls that extend from a base and define a slot. The slot is configured to receive a portion of the insert such that an edge of the insert extends beyond the frame. The sidewalls are configured to shrink around a portion of the insert such that an edge of the insert extends beyond the frame. Additionally, a method for fabricating a cutting instrument includes depositing layers of metal powder onto a base and selectively binding the deposited layers of the metal powder onto the base to form a frame attached to the base. Next, placing an insert within the frame such that a portion of the insert extends beyond the frame and the combination of the base, the frame, and the insert forms an in-process assembly. A cutting instrument includes an insert and a frame having sidewalls that extend from a base and define a slot. The slot is configured to receive a portion of the insert such that an edge of the insert extends beyond the frame. The sidewalls are configured to shrink around a portion of the insert such that an edge of the insert extends beyond the frame. Additionally, a method for fabricating a cutting instrument includes depositing layers of metal powder onto a base and selectively binding the deposited layers of the metal powder onto the base to form a frame attached to the base. Next, placing an insert within the frame such that a portion of the insert extends beyond the frame and the combination of the base, th

CURABLE COMPOSITION FOR THREE-DIMENSIONAL STEREOLITHOGRAPHY, METHOD FOR PRODUCING OBJECT BY THREE-DIMENSIONAL STEREOLITHOGRAPHY, AND METHOD FOR PRODUCING DENTAL RESTORATION

Resumen de: WO2026042469A1

Provided is a curable composition for three-dimensional stereolithography, the curable composition containing 100 parts by mass of a radical polymerizable monomer (A), 5.0-400 parts by mass of an inorganic filler (B), 0.05-10.0 parts by mass of a photopolymerization initiator (C) containing an acylphosphine compound, 0.01-5.0 parts by mass of a polymerization inhibitor (D), and 0.01-10.0 parts by mass of a photosensitizer (E) including a thioxanthone compound represented by formula (1). The present invention also provides a method for producing an object by three-dimensional stereolithography and a method for producing a dental restoration, the methods using said curable composition for three-dimensional stereolithography. In the formula, Y1 to Y8 each independently represent a hydrogen atom, an alkyl group having 1-20 carbon atoms, or the like.

三次元成形の粘土製猫砂

Resumen de: CN120752087A

The present invention is a process for preparing shaped three-dimensional clay particles with improved absorbency suitable for use in cat litter. The method is three-dimensionally printing a clay slurry into a desired particulate shape, where the printed clay particles (when printed at low temperature and when dried) provide improved absorbency compared to extruded clay particles. The particles are not pulverized and are not sintered at high temperatures.

POROUS INTERBODIES

Resumen de: WO2026043576A1

In various aspects, an implant includes a body having a lattice structure, with the lattice structure extending continuously from a superior surface of the body to an inferior surface of the body. The lattice structure may define a gradient of pores, with each pore in the gradient having a plurality of vertices. Additionally, the implant may include a plurality of projections extending superiorly from each of the plurality of vertices of each pore of the gradient of pores at the superior surface of the body, with each projection of the plurality of projections having a directionality. The implant may also include one or more radiographic markers incorporated into the lattice structure, the one or more radiographic markers having a density greater than the density of the lattice structure immediately around the one or more radiographic markers and being comprised of the same material as the lattice structure.

MICRONEEDLE PARTICLES FOR ENHANCED TOPICAL TRANSDERMAL DRUG DELIVERY

Resumen de: US20260053731A1

A microneedle particle arranged to be rolled and massaged on a subject's skin to penetrate the stratum corneum is disclosed. The microparticle comprises a support body, and a plurality of microneedles protruding from the support body (20), each microneedle comprising a tip. The support body maintains the microneedles and tips in a predetermined conformation allowing the microneedle particle to be rolled on the skin. The microneedles have an average tip sharpness radius of less than 20 μm, an average microneedle length of less than 100 μm, and an average tip sharpness to microneedle length ratio of 1:5 to 1:200. Formulations and kits for said use are provided. A microneedle particle manufacturing method using a non-linear two-photon absorption process, a non-therapeutic cosmetic method of skin treatment, and a method of drug delivery through the skin for said microneedle particle are disclosed.

METHOD OF TREATING A WOUND AND METHOD OF MANUFACTURING A SKIN GRAFT

Resumen de: WO2026043980A1

Synthetic skin constructs are produced using 3D bioprinting and a cleaning process involving supercritical carbon dioxide (ScCO2). The ScCO2 process effectively removes all cellular materials, minimizing the risk of immune rejection and ensuring the skin constructs are safe and optimally effective.

3D BIOPRINTED LIVER

Resumen de: WO2026043615A1

The present disclosure provides 3D bio-printed livers and methods of making or using the same. Aspects of the disclosure relate to compositons of 3D bio-printed livers. In some embodiments, the 3D bio-printed livers comprise a mesh casing, a plurlaity of microporous organoid-infused microgel matrices, and a hetaptic vasculature. Other aspects of the disclosure relate to methods of making the 3D bio-printed livers dislcosed herein. In some embodiments, the methods relate to creating a mesh casing in the shape of a liver, or portion thereof, loading a plurality of microporous organoid-infused microgel matrices into the mesh casing, and using embedded bioprinting to create a hepatic artery, a portal vein, and biliary duct within the mesh casing.

DENTAL DEVICE WITH INTEGRATED FLUIDIC RESERVOIR AND MICROCHANNELS, AND METHOD FOR MANUFACTURING SAID DENTAL DEVICE

Resumen de: WO2026041252A1

The present invention is related to a dental device (1) intended to cover at least part of a teeth (2) and/or at least part of gums (3) or other surfaces of a mouth for repositioning or retaining said teeth (2) and optionally said gums (3) or other surfaces of the mouth, said dental device (1) comprising a channel (7) provided in a main body (31; 40, 42) of the dental device (1) and having at least one opening (4, 5) to the exterior. The present invention is also related to a method of manufacturing said dental device (1) by additive manufacturing and to methods for circulating a substance and/or saliva and oxygen through the dental device (1) in view of releasing said substance and/or saliva and oxygen inside the mouth.

ADDITIVE MANUFACTURING OF EMBEDDED MATERIALS

Resumen de: US20260053988A1

In one aspect, a method includes providing support material within which the structure is fabricated, depositing, into the support material, structure material to form the fabricated structure, and removing the support material to release the fabricated structure from the support material. The provided support material is stationary at an applied stress level below a threshold stress level and flows at an applied stress level at or above the threshold stress level during fabrication of the structure. The provided support material is configured to mechanically support at least a portion of the structure and to prevent deformation of the structure during the fabrication of the structure. The deposited structure material is suspended in the support material at a location where the structure material is deposited. The structure material comprises a fluid that transitions to a solid or semi-solid state after deposition of the structure material.

METHOD OF ASSEMBLING A BIOREACTOR HAVING A BIOLOGICAL MATERIAL DEPOSITING END THAT IS MOVABLE WITH THE TOP PORTION TO ALLOW BIOPRINTING

Resumen de: US20260055354A1

A bioreactor allowing bioprinting inside an interior volume thereof is assembled to form a side wall extending upwardly from a base provided with a target support for the bioprinting. Once an adapter has been coupled to a bioreactor top portion to plug a corresponding aperture O4, a biological material depositing end may be maintained in an inserted state, extending through and/or being adapted to be fed via the aperture. A sealed enclosure, including the side wall and ports, is formed by a sealing operation to interconnect the base and the top portion. Bioprinting is done by driving from outside the depositing end, using variation of said volume, for delivering the biological material on the support and then, a culture and/or maturation phase of the printed tissue may start inside the enclosure, without displacement of the printed tissue.

SOCKET FORMING TOOLS FOR AUTOTRANSPLANTATION

Resumen de: US20260053600A1

A socket preparation tool configured to facilitate autotransplantation of a donor tooth to a recipient site is provided. The socket preparation tool includes a tooth replica of the donor tooth. A coronal portion is optionally included for facilitating alignment of the tooth replica adjacent teeth during a simulated autotransplantation. A radicular portion includes a smooth surface configured to facilitate compression of soft bone or soft tissue of the tooth replica or a contoured surface adapted for filing or cutting bone of the tooth replica. A cylindrical attachment is configured to be coupled to the tooth replica, such as via a receiver. A method of guided autotransplantation of a donor tooth via the customized socket preparation tool includes at least fitting and adjusting the socket preparation tool coupled to the tooth replica in the recipient site, before extracting the donor tooth.

SYSTEM, METHOD AND APPARATUS FOR PERSONALIZED DENTAL PROSTHESES PLANNING

Resumen de: US20260053603A1

Methods, systems, and techniques for collecting data for use in designing a personalized dental prosthesis for a patient. At least one camera is used to obtain a series of two-dimensional photos or a three-dimensional model of a head and face of the patient. At least one machine learning model is used to determine facial or oral landmarks and a central incisal edge of the prosthesis from the photos or model. Dimensions for the dental prosthesis are determined form the landmarks and central incisal edge. The dimensions include a labial border of the prosthesis, distal borders of the prosthesis, a superior border of the prosthesis, an inferior border of the prosthesis, a lingual border of the prosthesis, and buccal borders of the prosthesis. The dimensions are output to an output file for use in manufacturing the prosthesis.

POROUS INTERBODIES

Resumen de: US20260053633A1

In various aspects, an implant includes a body having a lattice structure, with the lattice structure extending continuously from a superior surface of the body to an inferior surface of the body. The lattice structure may define a gradient of pores, with each pore in the gradient having a plurality of vertices. Additionally, the implant may include a plurality of projections extending superiorly from each of the plurality of vertices of each pore of the gradient of pores at the superior surface of the body, with each projection of the plurality of projections having a directionality. The implant may also include one or more radiographic markers incorporated into the lattice structure, the one or more radiographic markers having a density greater than the density of the lattice structure immediately around the one or more radiographic markers and being comprised of the same material as the lattice structure.

MANUFACTURE OF PATIENT-SPECIFIC ORTHODONTIC BRACKETS WITH TOOTH-SPECIFIC BREAKAWAY MECHANISM

Resumen de: US20260053596A1

Embodiments may provide improved techniques for creating custom lingual or labial ceramic orthodontic brackets, and which provides the capability for in-office fabrication of such brackets. For example, a method of manufacturing customized ceramic labial/lingual orthodontic brackets by ceramic slurry-based AM may comprise measuring dentition data of a profile of teeth of a patient, based on the dentition data, creating a three dimensional computer-assisted design (3D CAD) model of the patient's teeth using reverse engineering, and saving the 3D CAD model on a computer, designing a 3D CAD bracket structure model for a single labial or lingual bracket structure, importing data related to the 3D CAD bracket structure model into a ceramic slurry-based AM machine, directly producing the bracket (green part) in the ceramic slurry-based AM machine by layer manufacturing, and processing the brackets in a sintering and debinding oven prior to direct use.

ENZYME AND NANOZYME LOADED MICROPARTICLES

Resumen de: AU2023463148A1

This invention describes microcapsule compositions and methods to encapsulate gas modulating enzymes or nanozymes at unprecedented concentrations and stability, that can be used to regulate the local gas concentrations. Microcapsules can be comprised of gelatin with a polydopamine coating. This system can replace expensive incubators/chambers and is the first system that can create spatiotemporal gradients of gases within a finite volume. The microcapsules have a broad range of applications in tissue culture, bioprinting, in vivo, and industrial uses.

RECOMBINANT PROTEINS, RECOMBINANT DNA SEQUENCES, VECTORS, EUKARYOTIC AND PROKARYOTIC EXPRESSION SYSTEMS AND THEIR USE

Resumen de: AU2024288436A1

The invention relates to recombinant RE15mR and EJ17zipR hybrid proteins with the structure specified in the description, recombinant DNA sequences encoding recombinant hybrid proteins, vectors containing recombinant DNA sequences, as well as eukaryotic or prokaryotic expression systems transformed with recombinant DNA sequences. The invention also concerns the use of recombinant hybrid proteins as components of bioink intended for bioprinting, and also as components of biomaterials. Furthermore, the invention relates to the use of recombinant DNA sequences, vectors and eukaryotic or prokaryotic expression systems for the production of recombinant hybrid proteins.

DEVICE AND METHOD FOR FOOTWEAR CUSTOMIZATION

Resumen de: US20260020643A1

A device and method for the formation of customized footwear insoles and pads is provided. The system employs computers operatively engaged to scanning components to produce individual electronic footprints of a foot of a wearer. Software operating to the tasks of employing the digital data from one or a plurality of electronic footprints, correlating to scans of the feet of a footwear user, will customize an insole or pad for positioning in the footwear to more comfortably support the foot therein.

ROTATIONAL STEREOLITHOGRAPHY FOR ARCUATE 3D ARTICLES

Resumen de: CN120981335A

A three-dimensional (3D) printing system is configured to manufacture a plurality of arcuate 3D articles. The 3D printing system includes a build container, at least one build component, a light engine, and a controller. The at least one build assembly includes a shaft, a build plate, and a motorized gear assembly, respectively. A motorized gear assembly is coupled to the shaft and configured to rotationally position the shaft about an axis of rotation. The light engine is located above the build container. The controller is configured to operate the motorized gear assembly to progressively rotate the build plate between a plurality of stop positions about the axis of rotation. The controller is configured to operate the light engine at respective stop positions to selectively illuminate the photocurable liquid in a plurality of spatially separated build planes respectively above one of the plurality of build plates.

CALIBRATING A DISPENSING MEANS OF A 3D BIO-PRINTER

Resumen de: CN120957859A

The present disclosure relates to a method, a system, a 3D bio-printer including a control system, a computer program carrier, and a computer program product. A computer-implemented method comprises acquiring sensor data representative of a printhead (1) of a 3D bioprinter and the surroundings of the printhead, the acquired sensor data comprising one or more images of the printhead of the 3D bioprinter captured by means of an imaging sensor device (6). Further, the method includes providing the acquired sensor data to a trained neural network algorithm. The method further includes generating one or more predicted outputs representative of calibration conditions of the distribution device by means of a neural network algorithm.

ホスフィンオキシド系光開始剤

Resumen de: CN120435392A

The present invention relates to phosphine oxide-based photoinitiators, to a method for producing said photoinitiators and to precursors which can be used for producing said photoinitiators. The invention also relates to a photoinitiator composition, a curable composition, a method of preparing a cured product, an inkjet printing method, a 3D printing method and a method of coating nails. The invention also relates to a photoinitiator composition or a precursor of a photoinitiator. The invention also relates to the use of a photoinitiator or a photoinitiator composition.

ベンゾイルギ酸アミド誘導体を含有する組成物

Resumen de: CN120379961A

The present invention addresses the problem of providing a benzoyl formamide derivative. The benzoyl formamide derivative has good photopolymerization initiation and photosensitive effect on long-wavelength ultraviolet rays, and a cured product obtained from the curable composition containing the benzoyl formamide derivative has extremely low content of low-molecular-weight components, yellowing resistance, high durability and high safety. Solution The present invention provides a benzoylformamide derivative.

一种光驱动水凝胶微纳操作机器人及其制备方法和应用

Resumen de: CN121554898A

本发明涉及一种光驱动水凝胶微纳操作机器人及其制备方法和应用。所述光驱动水凝胶微纳操作机器人依次包括光识别区域和变形执行区域；光识别区域由含有高浓度的光热纳米材料的第一水凝胶预聚液聚合形成；变形执行区域由含有高浓度的光热纳米材料的第一水凝胶预聚液与含有低浓度的光热纳米材料的第二水凝胶预聚液以不同配比共混后聚合形成，以使得所述变形执行区域中含有光热纳米材料的浓度从靠近所述光识别区域一侧向远离所述光识别区域一侧逐渐递减。本发明提供的是可精确光控、多模态运动、高度可控且可批量制备的水凝胶微纳机器人，能在复杂微环境中实现转向、扭曲、抓取、螺旋、爬行、避障及重构等操作。

一种3D打印踝关节ABS骨模型

Resumen de: CN121552683A

本发明公开了一种用于踝关节手术方案复现与术后形态预测的3D打印ABS骨模型，旨在解决现有三维骨模型仅能展示术前解剖结构、无法直观呈现手术方案及术后骨形态的问题。本发明基于患者术前三维影像学数据进行骨结构重建，在医生选定手术方案后，通过参数化模拟截骨、旋转和矫正过程，生成踝关节术后骨结构的三维模型，并采用光固化3D打印技术以ABS光敏树脂材料将其实体化。模型中可显示术后骨形态及相关手术调整信息，用于辅助术前诊断、手术规划、医患沟通及术中参考。本发明制作流程明确、成本可控，具有良好的临床应用前景和推广价值。

METHOD FOR THE REALIZATION OF A SUPPORT ELEMENT FOR THE HUMAN BODY AND A SUPPORT ELEMENT SO OBTAINED

Resumen de: US2024140035A1

A method for making a support element for the human body equipped with a first component or support component, a second component or padding component, wherein at least the second component or padding component is obtained by means of a three-dimensional printing technique; and an apparatus for implementing the method for obtaining the support element and support element thus obtained.

一种个性化踝上截骨3D打印导板

Resumen de: CN223930202U

一种个性化踝上截骨3D打印导板，包括3D打印的主体，使用时通过克氏针固定在手术部位，其特征在于：主体形成有贯穿主体的引导孔和多个定位孔，引导孔用于引导截骨切割方向，定位孔用于供克氏针穿过，通过计算机辅助设计3D打印的主体，使导板的主体的内侧面与手术部位的胫骨外周面相适配，这能够根据患者手术部位的胫骨外周面形状进行个性化定制，为患者提供了更贴合其自身情况且结构简单的手术辅助工具，而引导孔则可以更好地引导医生手术时的操作，定位孔使用克氏针将主体固定在胫骨外周面上，可以使主体更稳定地固定在手术部位上。

可吸收矿化胶原骨修复植入体的制备方法

Resumen de: CN121550490A

一种可吸收矿化胶原骨修复植入体的制备方法，包括：以生物可降解材料，通过增材制造工艺制备形成致密层及其上、下表面的多个凸起的呈螺旋状的倒刺，该倒刺穿过多孔层向外伸出；以配置的矿化胶原溶液为材料，在预设温度条件下通过增材制造工艺或者受控组装工艺制备形成多孔层；多孔层从靠近致密层上、下表面至远离致密层上、下表面的方向依次至少包括高孔隙率内层以及低孔隙率外层；将制备成型的所述致密层和所述多孔层进行组装，形成所述可吸收矿化胶原骨修复植入体。本发明技术方案通过形成梯度孔隙率结构的多孔层以及螺旋状倒刺设计，既能够兼顾成骨整合与初期力学支撑，又能够显著提高固定效果以及降低对骨组织的损伤程度。

一种基于机器学习的多孔支架SLM制备方法及装置

Resumen de: CN121561873A

本发明公开了一种基于机器学习的多孔支架SLM制备方法及装置，属于增材制造技术领域。该方法首先设计了一种由内层简单立方胞元和外层体心立方胞元组成的复合晶格多孔结构，两者通过节点直接连接；接着采用拉丁超立方抽样设计试验方案并获取选区激光熔化工艺初始小样本数据；随后引入回归合成少数类过采样技术对数据集进行增强处理；在此基础上，建立经群智能算法优化的核极限学习机预测模型；最后基于目标性能反求最优工艺参数并完成制备。通过复合结构设计有效缓解了应力屏蔽效应，解决了传统工艺优化中实验成本高、样本数据少及预测精度低的问题，实现了高性能医用CoCrMo植入物的高效、精准定制化制造。

一种表面改性3D打印人工骨的制备方法及其人工骨复合材料与应用

Resumen de: CN121550481A

本发明提供一种表面改性3D打印人工骨的制备方法及其人工骨复合材料与应用，涉及人工骨领域。本发明表面改性3D打印人工骨的制备方法，包括以下步骤：β‑TCP与光敏树脂混合，经DLP打印，烧结，清洗，得到β‑TCP支架；将β‑TCP支架浸入可降解高分子聚合物溶液中，浸泡，烘干，得到高分子聚合物包覆的支架；将高分子聚合物包覆的支架放入盐酸多巴胺的Tris‑HCl缓冲液中，反应，得到聚多巴胺改性的支架；聚多巴胺改性的支架置于胶原蛋白溶液中，在聚多巴胺改性的支架表面吸附上胶原蛋白，得到表面改性3D打印人工骨。本发明通过简单的改性方法显著提高3D打印人工骨的机械性能。本发明在不降低机械性能的情况下，进一步提高支架的生物相容性，更加利于骨缺损修复。

基于多智能体决策系统的骨软组织肿瘤修复假体打印方法

Resumen de: CN121549962A

本公开的实施例公开了基于多智能体决策系统的骨软组织肿瘤修复假体打印方法。该方法包括：根据预设肿瘤等级筛选信息、预设肿瘤分级标准信息、所获取的肿瘤相关材料信息和肿瘤相关材料信息，生成肿瘤知识图谱信息；对初始化后的预设肿瘤决策智能体进行变更处理，得到肿瘤决策智能体组；根据预设肿瘤记录信息和肿瘤决策智能体组，生成任务处理分配信息；根据肿瘤决策智能体组、任务处理分配信息和肿瘤知识图谱信息，生成假体打印参考信息；根据假体打印参考信息，生成肿瘤材料重建影像；根据肿瘤材料重建影像，控制打印设备打印出肿瘤修复假体。该实施方式可以提高生成的假体打印参考信息的准确性，减少浪费3D打印的生物相容性材料。

一种上投影用3D打印树脂材料及其应用

Resumen de: CN121554658A

本发明公开了一种上投影用3D打印树脂材料及其应用，上投影用3D打印树脂材料，包含如下按重量份计的原料组份：聚氨酯丙烯酸酯交联剂5‑40份；聚氨酯丙烯酸酯低聚物5‑40份；单官能团活性稀释剂25‑40份；多官能团活性稀释剂15‑40份；光引发剂1‑5份；流平剂0.1‑3份；消泡剂0.1‑3份；表面助剂1‑15份；填料0.5‑3份；耐刮蜡0.5‑3份；颜料0.2‑0.5份；其中，所述聚氨酯丙烯酸酯交联剂与聚氨酯丙烯酸酯低聚物的质量比为（0.01‑1）：1；所述单官能团活性稀释剂和多官能团活性稀释剂的质量比为（0.5‑2）：1。该树脂材料改善后粘度低，适用与上投影的3D打印技术，打印制造种植牙模，具有高下机精度、高逆扫尺寸稳定性，应用于口腔医学领域。

UNDERWATER 3D BIOPRINTER COMPRISING A MODULAR SYSTEM

Resumen de: CN120379821A

A modular system (1) insertable into a closed environment (20), such as a container containing a fluid, comprises: a base unit (2) comprising a working surface (3) movable along a working plane; an upright structure (9) restricted to one side of the base unit (2) and extending from the base unit (2); a support head (10) for supporting a tool or accessory; the upright structure (9) comprises, in sequence: guide means (11) for guiding the support head (10) in a direction (Z) transverse to the working plane; sliding means (14) for sliding the support head (10) along the guide means (11); at least one motor (M) for the sliding device (14); a box-like housing (15) provided with a sealing gasket for accommodating the motor (M), the modular system (1) further comprising at least one tubular body (21) for cables of the motor (M).

BONE IMPLANT WITH COATED POROUS STRUCTURE

Resumen de: US2022354651A1

The invention relates to a bone implant, comprising a main body, which has, in its outer region, an open-cell porous lattice structure, which is formed from a plurality of regularly arranged elementary cells, the elementary cells being in the form of an assembled structure and each being composed of an interior and of a plurality of interconnected bars surrounding the interior. The porous lattice structure is provided with a bone-growth-promoting coating comprising calcium phosphate, the calcium phosphate coating having a hydroxylapatite proportion forming a pore inner coating extending into the depth of the porous lattice structure.

3D 3D APPARATUS AND METHOD FOR CALIBRATING 3D MODEL OF THREE DIMENSIONAL PRINTER

Resumen de: KR20260024056A

본 개시의 몇몇 실시예에 따른, 적어도 하나의 프로세서를 포함하는 컴퓨팅 장치에 의해 수행되는 3D 모델을 보정하기 위한 방법이 개시된다. 상기 3D 모델을 보정하기 위한 방법은 치아와 관련되는 3D 모델인 제1 모델을 결정하는 단계; 상기 제1 모델을 구성하는 메시(mesh)에 대한 전처리를 수행하는 단계; 상기 제1 모델 및 전처리가 수행된 제2 모델에 대한 합집합 연산을 수행함으로써, 상기 제1 모델 및 상기 제2 모델이 병합된 제3 모델을 생성하는 단계; 및 상기 제3 모델을 구성하는 메시에 대한 후처리를 수행함으로써, 상기 제3 모델을 보정하는 단계를 포함할 수 있다.

탈착식 치과 보철물의 제조 방법, 및 그 방법에 따라 제조된 탈착식 치과 보철물

Resumen de: WO2024251724A1

The invention relates to a method for producing a first connection element of a removable dental prosthesis, said connection element being suitable for a sliding connection between a first fit surface of the first connection element and a second fit surface of a second connection element of the removable dental prosthesis. The invention is characterized in that the first connection element is produced by connecting a stability-granting material and a ductile material which forms the first fit surface in an additive multi-material manufacturing method.

NON-SWELLING COLD WATER SPECIES GELATIN HYDROGELS FOR 3D BIOPRINTING

Resumen de: WO2026037844A1

The invention relates to an aqueous composition comprising thiolated and norbornene-modified cold- water species-derived gelatine. A further aspect of the invention relates to a method to generate a three-dimensional hydrogel object, particularly an in vitro model for disease modelling/drug testing or an implant, comprising providing a composition according to the invention and forming the hydrogel object by bioprinting (extrusion-based or digital light-based (DLP)) or molding/casting to provide the three-dimensional hydrogel object. Also provided are a hydrogel implant obtained by a method according to the invention, and a kit comprising dried thiolated and norbornene-modified cold-water marine species gelatine.

THREE-DIMENSIONAL (3D)-PRINTABLE STRETCHABLE TRIBOELECTRIC NANOGENERATOR FIBERS

Resumen de: US20260051829A1

A fabrication process is disclosed for the production of flexible triboelectric nanogenerator (TENG) fiber, which can comprise a copper core surrounded by a silicone cladding. The TENG fibers are fabricated using a coaxial micro-extrusion process that enables 2D and 3D constructs to be fabricated with the fibers via 3D printing on both stationary and moving substrates to form mechanosensors as membranes, meshes, and hollow 3D structures. The mechanosensors can be integrated into wearable items for human activity monitoring, or can be formed on organs for organ monitoring, e.g., monitoring of perfused organs. The mechanosensors can be integrated into facemasks and uses for silent speech recognition, such as words mouthed in the absence of sound production by the speaker. The mechanosensors are self-powered and have high stretchability.

METHOD AND SYSTEM TO CREATE CUSTOM PRODUCTS

Resumen de: US20260050182A1

Systems and methods for creating fully custom products from scratch without exclusive use of off-the-shelf or pre-specified components. A system for creating custom products includes an image capture device for capturing image data and/or measurement data of a user. A computer is communicatively coupled with the image capture device and configured to construct an anatomic model of the user based on the captured image data and/or measurement data. The computer provides a configurable product model and enables preview and automatic or user-guided customization of the product model. A display is communicatively coupled with the computer and displays the custom product model superimposed on the anatomic model or image data of the user. The computer is further configured to provide the customized product model to a manufacturer for manufacturing eyewear for the user in accordance with the customized product model. The manufacturing system is configured to interpret the product model and prepare instructions and control equipment for the manufacturing of the customized product.

Multi-Layer-Multi-Turn Structure For High Efficiency Wireless Communication

Resumen de: US20260051766A1

A structure for wireless communication having a plurality of conductor layers, an insulator layer separating each of the conductor layers, and at least one connector connecting two of the conductor layers wherein an electrical resistance is reduced when an electrical signal is induced in the resonator at a predetermined frequency. The structure is capable of transmitting or receiving electrical energy and/or data at various near and far field magnetic coupling frequencies.

PROCESS FOR THE MANUFACTURE OF A SOLID PHARMACEUTICAL ADMINISTRATION FORM

Resumen de: US20260048018A1

The present invention relates to a process for the preparation of a solid pharmaceutical administration form comprising an amorphous solid dispersion using a 3D printing process. The process is a printing process that allows the production of a solid pharmaceutical solid administration form comprising an amorphous solid dispersion in an easy and flexible manner and the possibility to achieve fast disintegrating dosage forms with high drug loads.

THREE-DIMENSIONAL SCAFFOLD COMPOSITIONS AND METHODS FOR BONE REPAIR OR REGENERATION

Resumen de: US20260048175A1

Described herein are three-dimensional scaffold compositions and methods for bone repair or regeneration. In some embodiments, the disclosed scaffolds comprise a core portion mimicking a native trabecular bone structure that is surrounded by an exterior portion mimicking a native cortical bone structure. In some embodiments, the scaffolds may be functionalized by mineralization and/or pre-vascularization to promote bone and blood vessel formation.

MUSCLE ASSISTANCE MEMBRANE

Resumen de: US20260048176A1

The invention relates to a muscle membrane intended to be affixed to a muscle of a human or animal body, the membrane being capable of at least partially surrounding the muscle, the muscle comprising fibres covered with an outer tissue, the positioned membrane having a shape that is identical to that of the muscle. The membrane is characterised in that it exhibits anisotropic behaviour so as to reproduce the mechanical behaviour of the muscle, the membrane comprising: -a matrix designed in a biocompatible material having an elasticity similar to that of the outer tissue of the muscle, -one or more reinforcing strips rigidly attached to the matrix, each strip being designed in a biocompatible material having an elasticity similar to that of the fibres it covers and each strip being oriented according to membrane stiffening requirements and according to the expected muscle correction.

FIXATION DEVICE FOR TRANSVERSE BONE DISTRACTION

Resumen de: US20260047867A1

In a particular embodiment, a fixation device (1) for transverse bone distraction comprising an elongated base (3) having a bone-remote top surface (5), a bone-facing bottom surface (7), a central section (9), a first end (11) and a second end (13), a first outer Schanz screw (15) attached to the first end (11) on the bottom surface (7) of the base (3), and a second outer Schanz screw (17) attached to second end (13) on the bottom surface (7) of the base (3), at least one inner Schanz screw (19) attached to the central section (9) on the bottom surface (7) of the base (3), and at least one displacement device (21) configured to move the at least one inner Schanz screw (19) away from the bone relative to the outer Schanz screws (15, 17).

BONE FIXATION DEVICE

Resumen de: US20260047875A1

A bone fixation device (1) is presented, comprising a wire (7) and a load distributor (9), the load distributor comprising: a contact side (2) having a contact region (11) which is pressed against the bone to be fixed upon tightening of the wire (7), and two opposite lateral sides (4) that are not in contact with the bone upon tightening of the wire (7). At least one of the lateral sides (4) is provided with a plurality of recesses (5) which do not extend into the contact sides (2). The contact side (2) of the load distributor (9) has a continuous smooth surface which is configured to slide across the bone without damaging the bone when the load distributor (9) is pulled longitudinally across the bone during application.

VARIABLE THICKNESS DENTAL APPLIANCES AND ASSOCIATED METHODS

Resumen de: US20260047910A1

Dental appliances and associated methods are provided herein. In some embodiments, a dental appliance includes an appliance shell formed from a plurality of 3D printed polymer layers. The appliance shell can include a plurality of tooth receiving cavities arranged to receive a dentition and to exert one or more forces on the dentition, and a plurality of variable thickness regions integrally formed with the appliance shell as a single monolithic component. The plurality of variable thickness regions can include an upper thickened region at a first side of a tooth receiving cavity and a lower thickened region at a second side of the tooth receiving cavity opposite the first side. The upper and lower thickened regions can be configured to control movement of a tooth received within the tooth receiving cavity.

DENTAL RETAINER AND METHOD FOR MANUFACTURING THE SAME

Resumen de: KR102928400B1

치아 유지장치가 개시된다. 상기 치아 유지장치는, 환자의 치아 구조에 대한 3D 스캔 데이터에 기초하여 3D 프린터로 제조되는 치아 유지장치에 있어서, 전치부의 적어도 하나의 치아 형상에 대응하여 설측 치아면에 부착되는 대면부와 상기 대면부 사이에 위치되고 치간에 대면하는 돌출부를 포함하는 형상부; 및 상기 형상부의 양측 단부에 위치되어 소구치의 교합면에 대면하여 부착되는 양단부;를 포함할 수 있다.

MANDIBULAR RECONSTRUCTION SYSTEMS AND METHODS

Resumen de: US20260047934A1

Systems and methods for mandibular reconstruction are provided. An example neo-mandible assembly may comprise: (1) a first bone graft section; (2) a second bone graft section; (3) a tensioning plate; (4) a first dental implant that secures the first bone graft section to the tensioning plate; and (5) a second dental implant that secures the second bone graft section to the tensioning plate. The tensioning plate may hold the first bone graft section and the second bone graft section in fixed positions relative to each other. The first dental implant may comprise: (a) a dental screw that extends through an aperture of the tensioning plate and into the first bone graft section to secure the tensioning plate to the first bone graft section; and (b) a snap abutment attached to a head of the dental screw, wherein the snap abutment is configured to receive a dental implant.

치과용 스플린트를 제조하기 위한 디바이스

Resumen de: WO2024254624A1

A device for producing a dental splint is described, comprising a computing unit (1), a thermoforming station (2) for a film on a denture model (3), and a laser cutting system (4) for cutting out the dental splint from the film. In order to configure a device of the type depicted at the outset in such a way as to enable a manufacturing process of dental splints which is as fully automated and rapid as possible, wherein, in particular, the space requirement of the required devices is minimized and complicated robotics systems for transporting the dental splints are intended to be dispensed with, it is proposed that a plurality of workstations are provided which comprise at least one 3D printer (5) for producing the denture model (3) on a workpiece carrier (10), the thermoforming station (2), a severing device (6) for severing the thermoformed film from the denture model (3), and the laser cutting system (4), wherein the workstations are arranged along a transport system (7) which comprises a guide (8) and a transport means (9) which is arranged movably along the guide (8) for loading and unloading the workstations with the workpiece carrier (10).

RUBBER KNEE REPLACEMENT APPARATUS AND METHOD FOR CUSTOMIZATION

Resumen de: US20260047936A1

A prosthetic knee replacement apparatus constructed of rubber avoids the disadvantages of metal prosthetics. The knee replacement apparatus includes a base member as a spacer between the upper and lower legs of a patient. A femoral portion extends upwardly from an upper surface of the base member and a tibial portion is coupled to a lower surface of the base member. The knee replacement apparatus may be constructed completely or substantially from a rubber material so as to reduce friction and degeneration. The knee replacement system may be constructed or even 3D printed after the leg bones of the patient are scanned.

MANDIBULAR RECONSTRUCTION SYSTEMS AND METHODS

Resumen de: US20260047933A1

Systems and methods for mandibular reconstruction are provided. An example system may comprise a drilling guide comprising: (1) a body configured to register against two adjacent surfaces of a native mandible when the body is temporarily secured to the native mandible; and (2) a tube extending from the body. The tube may be configured to constrain orientation of a drill bit when inserted through the tube and into the native mandible to reduce off-axis tilt of the drill bit when forming a void in the native mandible. Size and orientation of the void may correspond with size and orientation of a phalange of a neo-mandible assembly to be received within the void.

FABRICATION OF ADDITIVELY MANUFACTURED OBJECTS WITH MECHANICALLY INTERLOCKING ELEMENTS

Resumen de: US20260048566A1

Materials and additively manufactured objects including mechanically interlocking elements are provided. In some embodiments, a method includes forming a dental appliance at least partially out of a composite material. The composite material can include an interlocking structure having a plurality of interlocking elements. The interlocking structure can have a first mechanical property. The composite material can also include a matrix surrounding at least a portion of the interlocking structure. The matrix can have a second mechanical property different from the first mechanical property.

3D-PRINTED CERVICAL PLUG AND PREPARATION METHOD

Resumen de: WO2026037007A1

A 3D-printed cervical plug. A 3D-printed cervical plug support is filled with a nanocomposite hydrogel. The nanocomposite hydrogel is a supramolecular nanocomposite formed by self-assembly of (-)-epigallocatechin-3-gallate and metal ions in a hydrogel.

PAUSE-PRINT PARTS MEDICAL AND DENTAL PARTS LIBRARY FOR ROBOTIC ASSEMBLY

Resumen de: WO2026039619A1

A method of fabricating a dental or medical device, wherein the method comprises: (a) acquiring 3D digital image data of a body part of a patient; (b) creating a 3D digital model of a dental or medical device to be fabricated wherein the 3D digital model incorporates a model part selected from a digital library of virtual parts, each of the virtual parts corresponding to an associated physical part of a plurality of physical parts; (c) fabricating a first portion of the device from the 3D digital model using additive manufacturing or subtractive manufacturing; (d) selecting one physical part of the plurality of physical parts that corresponds to the model part; (e) inserting the one physical part into a location in the first portion of the device; and (f) fabricating a second portion of the device from the 3D digital model using additive manufacturing or subtractive manufacturing.

MICRONEEDLES AND METHODS OF MANUFACTURE THEREOF

Resumen de: EP4696508A2

A microneedle array (105) for administration of a substance of interest into a biological tissue is provided. The array comprises a base substrate (110) having a microneedle side (115) and an opposing back side (120); a primary funnel portion (925, 1125) extending from the microneedle side (115) of the base substrate; and two or more solid microneedles (130) extending from the at least one primary funnel portion. The solid microneedles (130) comprise a substance of interest. A microneedle patch (100) is also provided, which includes the microneedle array (105) as well as an adhesive layer (135) and a handle layer (140) affixed to the base substrate and comprises a tab portion (150). The tab portion extends away from the solid microneedles and permits a person to manually hold the tab portion to manipulate the patch without contacting the solid microneedles. Also provided is a method for making an array of microneedles.

３Ｄプリンティング用細胞外マトリックスベースのハイブリッドインクおよびその製造方法

Resumen de: US2025058017A1

One embodiment of the present disclosure provides an extracellular matrix-based hybrid ink for 3D printing, the hybrid ink including an extracellular matrix having an amine group and a modified hyaluronic acid introduced with an ethylenically unsaturated bond functional group, in which the extracellular matrix and the modified hyaluronic acid are in a crosslinked state by a chemical bond formed between at least some of amine groups present in the extracellular matrix and the ethylenically unsaturated bond functional group present in the modified hyaluronic acid. According to an embodiment of the present disclosure, the hybrid ink has mechanical properties suitable for 3D printing through chemical crosslinking between the extracellular matrix and modified hyaluronic acid as constituents, and can control the drug release rate by adjusting the chemical crosslinking density.

FISH GELATINE BASED HYDROGEL FORMULATION

Resumen de: EP4696337A1

The invention relates to an aqueous composition comprising thiolated and norbornene-modified cold-water species-derived gelatine. A further aspect of the invention relates to a method to generate a three-dimensional hydrogel object, particularly an in vitro model for disease modelling/drug testing or an implant, comprising providing a composition according to the invention and forming the hydrogel object by bioprinting (extrusion-based or digital light-based (DLP)) or molding/casting to provide the three-dimensional hydrogel object.Also provided are a hydrogel implant obtained by a method according to the invention, and a kit comprising dried thiolated and norbornene-modified cold-water marine species gelatine.

SUPPORT STRUCTURES FOR 3D PRINTED ORTHODONTIC DENTAL APPLIANCES AND MANUFACTURING METHODS THEREOF

Resumen de: US20260033918A1

The present disclosure provides a support of a 3D printed orthodontic dental appliance is provided. The orthodontic dental appliance includes a shell structure defined by an inner contour surface and an outer contour surface. The support comprises: a middle support including a middle support base mesh and a plurality of middle support struts and a main support configured to connect the middle support to a build platform of a 3D printing device used to print the orthodontic dental appliance. One end of each middle support strut of the plurality of middle support struts is connected to the orthodontic dental appliance at a junction of the inner contour surface and the outer contour surface, and the other end of the middle support strut is connected to a rim of the middle support base mesh.

PRINTHEAD AND SYSTEM FOR ELECTROPORATION, AND METHOD OF PRINTING PATTERNED TISSUE

Resumen de: WO2024228814A2

A method of printing patterned tissue includes flowing a bioink comprising cells and a biological cargo through a nozzle moving relative to a substrate and exposing selected voxels of the bioink to a pulsed electric field as the bioink flows through the nozzle. Consequently, a portion or all of the cells in each of the selected voxels undergoes electroporation and transfection with the biological cargo. A cell-laden filament comprising the bioink and including the selected voxels is continuously extruded from an outlet of the nozzle, and, as the nozzle moves relative to the substrate, the cell-laden filament is deposited in a predetermined pattern on the substrate. Thus, a tissue having spatial patterns of gene expression may be printed.

SYSTEMS AND METHODS FOR DESIGNING OBJECTS

Resumen de: US2024342995A1

Systems and methods for designing additively manufactured objects are provided. In some embodiments, a method includes receiving a treatment plan for a patient's teeth, and determining a set of appliance parameters for a dental appliance configured to implement the treatment plan. The method can also include determining a set of manufacturing parameters for a fabrication system to be used to additively manufacture the dental appliance. The method can further include generating a 3D digital representation of an appliance geometry for the dental appliance. The appliance geometry can be configured to mitigate loss of fidelity at a target region of the dental appliance due to at least one manufacturing parameter of the fabrication system.

为OSA症推荐治疗方案的系统、方法、设备及介质

Resumen de: CN121533835A

本发明提供了一种为OSA症推荐治疗方案的系统、方法、设备及介质，包括为初筛为OSA的患者进行口腔扫描，获取患者口腔数字印模；制取患者的牙齿印模；由所述口腔数字印模以及所述牙齿印模制作患者的预制口腔矫正器；采集患者在佩戴所述口腔矫正器时的第一睡眠监测数据，以及未佩戴所述口腔矫正器时的第二睡眠监测数据；对比所述第一睡眠监测数据以及所述第二睡眠监测数据，根据对比结果确定患者与口腔矫正器的适配性；根据患者与口腔矫正器的适配性为患者推荐合适的治疗方案。本发明能够解决OSA治疗成本高，治疗疗效不确切的技术问题。

一种生物仿生骨软骨生物电池及其制备方法和应用

Resumen de: CN121534223A

本发明提供了一种生物仿生骨软骨生物电池及其制备方法和应用，属于生物医用材料与组织工程技术领域。该生物电池包括阳极层、阴极层和隔膜层；所述阳极层由锌粉和水凝胶骨架组成，所述阴极层由二氧化锰粉和水凝胶骨架组成，所述隔膜层由聚偏氟乙烯粉和水凝胶骨架组成。本发明提供的生物电池能够模拟天然骨软骨组织电微环境与化学信号、具备仿生分层结构、并可实现程序化电刺激与离子释放。该电池不仅能提供稳定持久的内源性电刺激，还能引导内源性干细胞进行分区定向分化，从而实现骨软骨缺损的一体化、功能性再生。

TRANSALVEOLAR DENTAL IMPLANT AND METHOD OF MANUFACTURE

Resumen de: EP4659703A2

The present disclosure relates to single tooth or full arch dental restoration. In cases where patients have insufficient bone stock for conventional root-form dental implants, current solutions often fail to restore function. The present disclosure describes a transalveolar dental implant for single tooth or full arch dental restoration. The transalveolar dental implant is comprised of a post and a bone plate, the bone plate having a contoured portion fabricated to match the topography of a bony surface of the facial skeleton. Through primary fixation of the contoured portion of the bone plate, the transalveolar dental implant improves function and outcomes in affected patients.

Method for producing a multiphase polymer 3D gel dosimeter mimicking human tissues, soft, bone and lung, intended for radiotherapy treatment planning

Resumen de: PL449505A1

Przedmiotem zgłoszenia jest sposób wytwarzania wielofazowego polimerowego dozymetru żelowego 3D imitującego tkanki ludzkie, miękką, kostną i płucną, przeznaczonego do opracowania planu leczenia w radioterapii, z wykorzystaniem metody druku 3D polegającej na drukowaniu obiektu na podstawie jego modelu wirtualnego sporządzonego za pomocą programu komputerowego, poprzez wytwarzanie na podłożu bazowym za pomocą drukarki, której program sterujący jej pracą zawiera model wirtualny wytwarzanego obiektu, kolejnych warstw tego obiektu, jedna na drugiej z substratu do sporządzenia tego obiektu, aż do wytworzenia całego obiektu, który charakteryzuje się tym, że metodą druku 3D wytwarza się fazę dozymetru wielofazowego imitującą co najmniej jedną z tkanek tego wielofazowego dozymetru, na podstawie modelu wirtualnego drukowanej tkanki, który sporządza się na podstawie obrazów tkanki indywidualnego pacjenta, uzyskanych z tomografii komputerowej lub rezonansu magnetycznego, na podłożu bazowym ogrzanym do temperatury 50°C, z umieszczonego w dozowniku drukarki, zżelowanego roztworu dozymetrycznego do wytworzenia fazy wielofazowego polimerowego dozymetru 3D imitującej drukowaną tkankę. Roztwór dozymetryczny do wytworzenia fazy dozymetru wielofazowego imitującej tkankę kostną, roztwór dozymetryczny do wytworzenia fazy dozymetru wielofazowego imitującej tkankę miękką oraz roztwór dozymetryczny do wytworzenia fazy dozymetru wielofazowego imitują

多数の曲率を有するエラストマーシール形成構造

Nº publicación: JP2026026085A 16/02/2026

Solicitante:

レスメド・プロプライエタリー・リミテッド

Resumen de: JP2025100573A

To provide a textile seal-forming structure with multiple curvatures.SOLUTION: A patient interface includes a seal-forming structure with a textile membrane which has at least one hole so that the flow of air at a therapeutic pressure is delivered to at least an entrance to the patient's nares and or the patient's mouth. The seal-forming structure is constructed and arranged to maintain the therapeutic pressure in a cavity of a plenum chamber throughout the patient's respiratory cycle in use. The textile membrane includes a first portion that is held in a relaxed state and a second portion that is held in a taut state. The taut state of the second portion is configured to allow the seal-forming structure to include a three-dimensional shape that has multiple curvatures.SELECTED DRAWING: Figure 12