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59
resultados
Última actualización
03/08/2025 [07:15:00]
Resultados 25 a 50 de 59
Resumen de: AU2025204068A1
Abstract Provided herein are sulfopropanoic acid derivatives or pharmaceutically acceptable salts thereof, for treating a disease characterized by amyloid and amyloid-like aggregates, e.g., Alzheimer's disease.
Resumen de: US2025208135A1
The present invention provides a method for early detection or diagnosis of a neurodegenerative disease, disorder, or condition in a subject at risk of developing or suspected of having the neurodegenerative disease, disorder, or condition, the method comprising measuring in a blood sample obtained from the subject or a fraction thereof the levels of at least one biomarker selected from CD38+ peripheral blood mononuclear cells (PBMCs), trigonelline, GLUT1 expression in CD4+ T cells, Th2, Th2/Th1 ratio, naïve T cells, adenosine, allose, and HLA-DR T cells, as well as related methods and kits.
Resumen de: US2025208143A1
Disclosed are fragments of p53 peptide (P1) and their use in the diagnosis and/or prognosis of Alzheimer's disease (AD) in a biological sample. The invention provides a method based on mass spectrometry analysis for the diagnosis of Alzheimer's disease at the pre-clinical and prodromal stages of the disease and for the prognosis of cognitive decline in a subject, by quantitating the levels of one or more p53 peptide fragments in a biological sample of a subject.
Resumen de: WO2025137077A1
Compositions and methods are disclosed herein for the treatment of Alzheimer's disease with allogeneic mesenchymal stem cells. The methods of treatment involve the administration of a composition of allogeneic mesenchymal stem cells to a subject in need thereof, wherein the efficacy of the treatment methods can be determined through the measurement of specific biomarkers and improved cognitive function and/or quality of life.
Resumen de: WO2025137532A1
Disclosed herein are methods of measuring amyloid β protofibril levels in biological samples. Methods disclosed herein may detect amyloid β protofibril at femtomolar concentrations and selectively measure protofibril as compared to amyloid β monomers.
Resumen de: WO2025137359A1
Among the various aspects of the present disclosure is the provision of assay methods to identify diseases associated with orexin levels. The present teachings include methods to quantify an orexin concentration in a fluid sample, such as a cerebrospinal fluid sample, and identifying and treating diseases, including but not limited to narcolepsy and Alzheimer's disease, from the orexin concentration.
Resumen de: KR20250094348A
본 발명은 혈뇌장벽(blood-brain barrier)의 손상으로 인한 뇌질환을 진단할 수 있는 새로운 엑소좀 유래 바이오마커를 제공하는 것으로, MRI 영상 기반으로 뇌 국소영역을 정밀하게 구분하여 해당 국소 영역에서만 혈뇌장벽의 변성된 동물 모델을 제작하고, BBB 손상 동물 모델에서 분리된 혈청(serum)으로부터 엑소좀 단백질의 발현 수준을 비교 분석하여, BBB 손상 동물 모델에서 갈렉틴-7(Galectin-7) 단백질의 발현 수준이 11배 높게 나타나는 것을 확인함에 따라 갈렉틴-7(Galectin-7) 단백질 또는 이의 mRNA를 혈뇌장벽(blood-brain barrier)의 손상으로 인한 뇌질환의 진단용 바이오마커로 제공한다.
Resumen de: KR20250094349A
본 발명은 혈뇌장벽(blood-brain barrier)의 손상으로 인한 뇌질환을 진단할 수 있는 새로운 엑소좀 유래 바이오마커를 제공하는 것으로, MRI 영상 기반으로 뇌 국소영역을 정밀하게 구분하여 해당 국소 영역에서만 혈뇌장벽의 변성된 동물 모델을 제작하고, BBB 손상 동물 모델에서 분리된 혈청(serum)으로부터 엑소좀 단백질의 발현 수준을 비교 분석하여, BBB 손상 동물 모델에서 TMEM266(Transmembrane protein 266) 단백질의 발현 수준이 11배 높게 나타나는 것을 확인함에 따라 TMEM266(Transmembrane protein 266) 단백질 또는 이의 mRNA를 혈뇌장벽(blood-brain barrier)의 손상으로 인한 뇌질환의 진단용 바이오마커로 제공한다.
Resumen de: KR20250094345A
본 발명은 혈뇌장벽(blood-brain barrier)의 손상으로 인한 뇌질환을 진단할 수 있는 새로운 엑소좀 유래 바이오마커를 제공하는 것으로, MRI 영상 기반으로 뇌 국소영역을 정밀하게 구분하여 해당 국소 영역에서만 혈뇌장벽의 변성된 동물 모델을 제작하고, BBB 손상 동물 모델에서 분리된 혈청(serum)으로부터 엑소좀 단백질의 발현 수준을 비교 분석하여, BBB 손상 동물 모델에서 판테테이나제(Pantetheinase) 단백질의 발현 수준이 48배 높게 나타나는 것을 확인함에 따라 판테테이나제(Pantetheinase) 또는 이의 mRNA를 혈뇌장벽(blood-brain barrier)의 손상으로 인한 뇌질환의 진단용 바이오마커로 제공한다.
Resumen de: KR20250094344A
본 발명은 혈뇌장벽(blood-brain barrier)의 손상으로 인한 뇌질환을 진단할 수 있는 새로운 엑소좀 유래 바이오마커를 제공하는 것으로, MRI 영상 기반으로 뇌 국소영역을 정밀하게 구분하여 해당 국소 영역에서만 혈뇌장벽의 변성된 동물 모델을 제작하고, BBB 손상 동물 모델에서 분리된 혈청(serum)으로부터 엑소좀 단백질의 발현 수준을 비교 분석하여, BBB 손상 동물 모델에서 호르네린(Hornerin) 단백질의 발현 수준이 98배 높게 나타나는 것을 확인함에 따라 호르네린(Hornerin) 또는 이의 mRNA를 혈뇌장벽(blood-brain barrier)의 손상으로 인한 뇌질환의 진단용 바이오마커로 제공한다.
Resumen de: KR20250094347A
본 발명은 혈뇌장벽(blood-brain barrier)의 손상으로 인한 뇌질환을 진단할 수 있는 새로운 엑소좀 유래 바이오마커를 제공하는 것으로, MRI 영상 기반으로 뇌 국소영역을 정밀하게 구분하여 해당 국소 영역에서만 혈뇌장벽의 변성된 동물 모델을 제작하고, BBB 손상 동물 모델에서 분리된 혈청(serum)으로부터 엑소좀 단백질의 발현 수준을 비교 분석하여, BBB 손상 동물 모델에서 BCAM(Basal cell adhesion molecule) 단백질의 발현 수준이 13배 높게 나타나는 것을 확인함에 따라 BCAM(Basal cell adhesion molecule) 단백질 또는 이의 mRNA를 혈뇌장벽(blood-brain barrier)의 손상으로 인한 뇌질환의 진단용 바이오마커로 제공한다.
Resumen de: KR20250094346A
본 발명은 혈뇌장벽(blood-brain barrier)의 손상으로 인한 뇌질환을 진단할 수 있는 새로운 엑소좀 유래 바이오마커를 제공하는 것으로, MRI 영상 기반으로 뇌 국소영역을 정밀하게 구분하여 해당 국소 영역에서만 혈뇌장벽의 변성된 동물 모델을 제작하고, BBB 손상 동물 모델에서 분리된 혈청(serum)으로부터 엑소좀 단백질의 발현 수준을 비교 분석하여, BBB 손상 동물 모델에서 Rab2A(Ras-related protein Rab-2A) 단백질의 발현 수준이 15배 높게 나타나는 것을 확인함에 따라 Rab2A(Ras-related protein Rab-2A) 단백질 또는 이의 mRNA를 혈뇌장벽(blood-brain barrier)의 손상으로 인한 뇌질환의 진단용 바이오마커로 제공한다.
Resumen de: PH12021552938A1
The present invention is in the field of transactive response DNA binding protein with a molecular weight of 43 kDa (TARDB or also TDP-43). The invention relates to TDP-43 specific binding molecules, in particular to anti-TDP-43 antibodies or an antigen-binding fragment or a derivative thereof and uses thereof. The present invention provides means and methods to diagnose, prevent, alleviate and/or treat a disease, disorder and/or abnormality associated with TDP-43 aggregates including but not limited to Frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), Parkinson's disease (PD), Chronic Traumatic Encelopathy (CTE), and limbic-predominant age-related TDP-43 encephalopathy (LATE).
Resumen de: AU2023406056A1
Disclosed herein are methods of diagnosing, selecting, monitoring, and treating subjects with Alzheimer's disease (AD) or suspected of having AD or another disorder associated with amyloid accumulation in the brain using a tau PET level.
Resumen de: WO2024052650A1
The invention relates to neurodegenerative disorders, and the diagnosis and/or prognosis of neurodegenerative disorders in a test subject using a lateral flow test, or the like. The invention also relates to detecting diagnostic and prognostic biomarkers in a range of various patient sample types for diagnosing and/or prognosing neurodegenerative disorders, such as Alzheimer's disease. The invention further provides biomarker detection methods, and apparatus and apparatuses for diagnosing and prognosing neurodegenerative disorders, and methods of treating patients diagnosed or prognosed with a neurodegenerative disorder. The invention also extends to detection of biomarkers and/or screening in pre-symptomatic subjects, for early diagnosis, to enable disease prevention or intervention.
Resumen de: WO2025128726A1
Disclosed herein are methods for analyzing oligomeric protein structures by mass spectrometry. The method includes providing a sample having one or more oligomers; producing, with an ion source, ions of the sample, each of the ions having a mass-to-charge (m z) ratio; detecting a multiplicity of ions generated with a current detector; determining ion masses for each of the multiplicity of ions detected with the current detector with a mass analyzer; generating a mass-domain spectrum from the ion masses with the mass-analyzer, the mass-domain spectrum having one or more mass-domain peaks; and determining one or more metrics capturing the mass heterogeneity and/or mass abundance of oligomers. Methods for diagnosing a subject, assessing treatment efficacy, and assessing treatment efficacy are also provided.
Resumen de: WO2025123398A1
An Alzheimer's disease biomarker based on a brain metabolite and a use thereof. The biomarker comprises any one or a combination of at least two of palmitic acid, DHA, gallic acid, 11Z,14Z,17Z-eicosatrienoic acid, glycodeoxycholic acid, palmitoleic acid, linoleic acid, erucic acid, petroselinic acid, and arachidonic acid. The level of a metabolite is detected to assist in early diagnosis of the Alzheimer's disease, thus facilitating rapid detection; in addition, the present invention has the characteristics of timeliness, convenience, high specificity and high sensitivity.
Resumen de: WO2025123283A1
The use of a reagent, which detects changes in the concentration or number of immune cells and immune factors in the peripheral circulatory system and cerebrospinal fluid, in the preparation of a diagnostic tool or a therapeutic tool for diagnosing or monitoring Alzheimer's disease. A method for diagnosing or monitoring Alzheimer's disease, in which a reagent for detecting immune cells and immune factors in the peripheral circulatory system and cerebrospinal fluid is used to detect changes in the concentration or number of the immune cells and immune factors in the peripheral circulatory system and cerebrospinal fluid. A method for treating Alzheimer's disease, in which immune cells and immune factors in the peripheral circulatory system and cerebrospinal fluid are taken as targets for administration so as to reduce or decrease the concentration or number of the immune cells and immune factors.
Resumen de: WO2025125705A1
An in vitro procedure for diagnosing or determining the risk of a person developing Alzheimer's disease (AD), said procedure detecting and quantifying the expression products of the LMNA gene (SEQ. ID: No. 3): lamin A protein (SEQ. ID: No. 1) and its precursor prelamin A (SEQ. ID: No. 2), in a sample of peripheral nerve or smooth muscle.
Resumen de: EP4571315A1
A use of a new highly toxic amyloid oligomer Apo*3F as a target for diagnosing Alzheimer's disease (AD) in the early stage and the middle-late stage and mild cognitive impairment (MCI) caused by AD. The Aβo*3F specifically binds to an antibody 3F and is present in cerebrospinal fluid (CSF), blood and/or brain tissue of AD patients and patients with MCI caused by AD, and the levels show highly significant differences in CSF, blood and/or brain tissue of AD patients, MCI patients and healthy elderly persons. In addition, the Apo*3F is an ultra-highly toxic oligomer, is the most important toxic component in an Aβ oligomer mixture, has a strong pathogenic effect, and plays a key role in the occurrence and development of AD.
Resumen de: EP4570823A1
The present invention relates to an improved antibody specifically binding to amyloid-β oligomers (AβOs). Specifically, the present invention relates to an improved form of the antibody W20. Compared with the antibody W20, the improved form of the antibody W20 has a significantly improved affinity to AβOs, and can more significantly inhibit the aggregation of Aβ and the AβOs-induced toxicity of nerve cells, more effectively improve the cognition and memory functions of an Alzheimer's disease model mouse, and reduce pathological changes in the brain of the mouse. The improved form of the antibody can specifically bind to oligomers of an amyloid-β, α-synuclein, mHTT and SOD 1, can inhibit the aggregation and cytotoxicity of various amyloids, and has a better potential for treating various amyloid diseases, such as Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis, than the antibody W20. The improved form of the antibody can specifically bind to a highly toxic amyloid protein oligomer Aβo*3F, and has a better AD diagnosis value. The amino acid sequence of the antibody W20 is as shown in SEQ ID NO: 1.
Resumen de: AU2023357033A1
The present disclosure generally relates to the surprising discovery that subjects likely to respond to treatment with an 11β-HSD1 inhibitor can be selected for treatment based on a comparison between a baseline level of a tau protein in the subject, and a reference level of the tau protein.
Resumen de: US2025189536A1
The present application provides methods, compositions and kits for determining SHD catabody levels in a biological sample, and for treating or preventing a protein aggregation disease (PAD) in an individual. Also provided are catabodies specifically recognizing amyloid beta (Aβ) peptides and methods of use thereof.
Resumen de: US2025191903A1
Provided are methods for determining the apolipoprotein E (ApoE) phenotype in a sample by mass spectrometry; wherein the ApoE allele(s) present in the sample is determined from the identity of the ions detected by mass spectrometry. In another aspect, provided herein are methods for diagnosis or prognosis of Alzheimer's disease or dementia.
Nº publicación: US2025189517A1 12/06/2025
Solicitante:
DNA GENOTEK INC [CA]
DNA Genotek, Inc
Resumen de: US2025189517A1
A solution is described for preserving cells and/or extra cellular components in naturally expressed bodily fluids (e.g. saliva, sputum, urine) for further downstream analysis and/or for diagnosis of a medical condition. The solution may be hypertonic with respect to blood. Techniques are described for enriching cells from a sample of a naturally expressed bodily fluid, and/or for analysis, e.g. to diagnose medical conditions such as cancer, obesity, infections, autism, Alzheimer disease, hetotological disorders, cardiovascular disease or disorders, diabetes, vulnerable plack, LTBI, HIV infection, COPD, ACQS.
BOPI
Sede Electrónica
