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193
results.
Updated on
21/10/2025 [06:50:00]
Absstract of: CN120789018A
本发明属于医用配置品技术领域，公开了一种负载抗生素纳米血小板囊泡及其制备方法和应用。通过差速离心从静脉外周血中分离并富集得到血小板，与抗生素药物混合孵育后，通过非接触式超声进行纳米化，并经膜挤出后，得到负载抗生素纳米血小板囊泡。在保留了血小板内部与抗炎相关的细胞因子的同时，还在囊泡表面富集了靶向细菌相关的蛋白以及免疫调节相关蛋白，能够高效实现细菌靶向与炎症、免疫调节功能。将所述负载抗生素纳米血小板囊泡与纤维蛋白原、凝血酶混合制备为凝胶后，能够作为炎症调节、抗菌、促进内皮成管以及加速糖尿病感染性伤口愈合的药物，为复杂感染性伤口的治疗提供了一个范例，并克服了生物感染治疗难以进入临床研究的难题。
Absstract of: CN120789020A
本发明公开了一种视黄醇/酵母菌蛋白多肽共聚物及其制备方法和应用，涉及生物领域。本发明创建了一种采用酵母多肽包载视黄醇的制剂，酵母多肽提取自酵母自溶上清液，酵母自溶上清液采用动物源蛋白作为氮源进行发酵，显著提高了酵母多肽包载视黄醇含量，在稳定性、温和性和功效性等方面显著优于视黄醇。
Absstract of: CN120789179A
本发明属于生物医药领域，具体公开了一种治疗周围性面瘫的中药穴位贴及其制备方法。所述中药组合物由白芍、全蝎、木瓜等14味原料按特定配比制成，其创新在于：①采用超临界CO2萃取雪莲花脂溶性成分(40℃/25MPa)，酶解提取白芍(白芍苷≥90.3％)，PLGA包裹海马超微粉(包封率≥85％)，最大限度保留活性成分；②穴位贴设计三层结构，中层载药水凝胶嵌入可溶性微针阵列(长800μm)及pH响应壳聚糖微球，并添加复合促渗剂(氮酮+薄荷脑)，实现温/pH双重智能释药(35℃释速↑2.8倍，pH 5.5释速↑3.1倍)；③通过β‑环糊精包合纳米珍珠粉与白芍提取物(包合率≥91％)，提升稳定性。临床验证显示，联合西药治疗总有效率92％，显著优于单用西药组(76％，P<0.05)，且无新增不良反应。
Absstract of: MX2025007204A
Aspects of the present disclosure provides for improved mycobacterium tuberculosis vaccine compositions of ionizable lipid nanoparticles for the delivery of immunogenic nucleic acids to cells. Anionic phospholipids, including phosphatidyl serine and phosphatidylglycerol are included in the lipid nanoparticles to increase the transfection efficiency in dendritic cells. In some embodiments, the incorporation of mono-unsaturated alkyl chain analogs in dimethylaminopropyl - dioxolane or heterocyclic ketal ionizable lipids in the formulation provided high levels of transfection in human dendritic cells, compared to other ionizable lipids in the same family, and demonstrated good stability to oxidative damage. Other aspects of the present disclosure provide mRNA that encodes for concatenated peptides encoding for multiple MHC-II tuberculosis epitopes, and optionally includes a second mRNA encoding for concatenated MHC-I tuberculosis epitopes.
Absstract of: CN120789019A
本发明公开了一种多特异性肽纳米颗粒及其制备方法和应用，属于医药技术领域。所述多特异性肽纳米颗粒为由肿瘤细胞靶向肽修饰的两亲性聚合物、T细胞靶向肽修饰的两亲性聚合物与未作修饰的两亲性聚合物或/和两亲性磷脂分子混合后共组装形成的纳米颗粒，所述肿瘤细胞靶向肽、T细胞靶向肽均修饰于两亲性聚合物的亲水端。本发明提供的多特异性肽纳米颗粒促进肿瘤细胞和T细胞的结合，并增强T细胞对肿瘤细胞的杀伤，且无明显毒副作用，具有良好的临床转化前景和实际意义。
Absstract of: CN120794873A
本发明属于生物医药技术领域，公开了一种可电离阳离子脂质的制备方法：将7‑氧庚基癸酸酯与羟胺或其盐在碱存在下，于还原剂和催化剂钴钌合金催化剂存在下进行反应；向反应产物中加入(9Z,12Z)‑十八碳‑9,12‑二烯醛，并在还原剂存在下继续反应，得到羟胺衍生物中间体；再与4‑二甲基氨基丁酸或其盐酸盐在缩合剂和催化剂存在下进行酰胺化反应，得到可电离阳离子脂质。本发明还公开了上述制备方法得到的可电离阳离子脂质或脂质纳米颗粒组合物或载有mRNA的脂质纳米颗粒在制备用于mRNA递送的药物组合物或试剂盒中的应用。本发明提供的LNP具有良好的物理化学性质、生物相容性以及高效的mRNA包封和细胞内递送能力，可应用于制备用于mRNA递送的药物组合物或试剂盒中。
Absstract of: CN120789022A
本发明属于生物技术领域，公开了一种SMB纳米颗粒及其用于制备HCC免疫治疗药物的应用；通过靶向焦亡和训练免疫的工程化嗜粘蛋白细菌囊泡，将靶向PD‑L1的siRNA和金属有机框架封装在益生菌嗜粘蛋白细菌膜囊泡中来获得SMB纳米颗粒。SMB纳米颗粒通过GalNAc介导的细胞靶向表现出肿瘤细胞、尤其是HCC的特异性积累，激活诱导细胞焦亡，促进肿瘤相关抗原释放；同时，SMB纳米颗粒诱导肿瘤相关巨噬细胞重新编程为CXCL9+表型，表现出增强的抗原呈递和趋化能力，引发细胞毒性CD8+T细胞浸润，减少耗竭的T细胞群，重塑HCC中的TIME。与临床ICI相比，SMB纳米颗粒表现出更好的肿瘤抑制能力。
Absstract of: AU2024218499A1
Novel ionizable lipid compounds of Formula I are provided. The use of the compounds in forming lipid nanoparticles is described. The lipid nanoparticles may encapsulate a therapeutic, such as a nucleic acid, and these may be used in the delivery of the therapeutic and in methods of treating certain conditions or for inducing an immune response.
Absstract of: AU2024211148A1
Provided herein is a method of making circular RNA, a method of isolating circular RNA and compositions comprising circular RNA.
Absstract of: CN120789097A
本发明提供了一种金雀异黄素‑介孔氧化硅基纳米复合酶，由负载金雀异黄素的介孔二氧化硅纳米颗粒核芯、聚乙二醇改性的二氧化锰包覆层组成的核壳复合结构组合物。其制备方法包括在介孔二氧化硅纳米颗粒内负载金雀异黄素，然后在介孔二氧化硅纳米颗粒表面形成二氧化锰包覆层，最后通过聚乙二醇改性获得。本发明具有良好的生物相容性和生物安全性，克服金雀异黄素的水溶性差等缺点，提高肿瘤治疗的靶向性，减少对正常组织的破坏，利用化学‑化学动力学联合治疗，提高胰腺肿瘤治疗疗效。
Absstract of: WO2024181917A1
There is provided a compound represented by general formula (1) or ionized forms thereof for preparing lipid nanoparticles encapsulating a therapeutic, prophylactic and/or biological agent: wherein NR1R2 is a group that is ionizable at a pH range of from 3 to physiological pH; A comprises a linear aliphatic, branched aliphatic and/or cyclic hydrocarbons optionally comprising one or more groups selected from -OH, -NR-, -O-, -O-CxH2x-O-, where x ≥ 1; and where R is H, optionally substituted alkyl, optionally substituted alkenyl or optionally substituted alkynyl; R3, R4, R5, R6 and R7 are each independently H, optionally substituted alkyl, optionally substituted alkenyl or optionally substituted alkynyl; and R8 and R9 are each independently hydrophobic group.
Absstract of: AU2023330867A1
The present disclosure relates to the field of vaccines and binding molecules, as well as preparations and methods of their use in the treatment and/or prevention of disease. Described are vaccines and binding molecules, compositions containing the same, and uses thereof for treating or preventing coronavirus infections, including multivalent mRNA and nanoparticle vaccines.
Absstract of: CN120789021A
本发明提供了一种芹菜素纳米粒制剂及其制备方法和应用。该制备方法包括：称取芹菜素，将芹菜素溶于含有聚乳酸‑羟基乙酸共聚物的丙酮溶液中，或者，将芹菜素溶于含有聚乳酸‑羟基乙酸共聚物和Eudragit S100的丙酮溶液中，室温搅拌混匀，得混合溶液；将所述混合溶液滴加入聚乙烯醇溶液中，超声处理，去除溶剂，制得PANPs或者PEANPs。该制备方法简单，制得的PANPs和PEANPs的粒径小、包封率高，能有效穿透肠上皮屏障，促进芹菜素内化进入细胞，具有良好的缓释特性，能显著提高芹菜素的生物利用度，对炎症性肠病有良好的治疗效果。且PANPs对溃疡性结肠炎具有更佳的治疗效果，PEANPs对弥漫性结肠炎具有更好的治疗效果。
Absstract of: US2022000791A1
Multi-layered particles and compositions comprising a compound are disclosed. Processes of preparing the particles and compositions and uses thereof are also disclosed.
Absstract of: CN120789023A
本发明提供了靶向CD24的纳米药物递送系统及其在制备抗肿瘤药物中的应用。本发明纳米药物递送系统包括(1)核心结构：介孔二氧化锰hMnO₂用于共负载葡萄糖氧化酶GOx和胱氨酸Cys；(2)靶向递送：用抗CD24单链可变片段scFv修饰的基因工程膜EM‑CD24包裹纳米颗粒。本发明可以改善肿瘤穿透，减少脱靶积累，并增强药代动力学，这在维持低系统性暴露的同时，达到了肿瘤中治疗性Gox和胱氨酸浓度，最大限度地减少了脱靶毒性。
Absstract of: CN120796166A
本发明涉及一种地不容来源的细胞外囊泡及其制备方法和应用。所述细胞外囊泡由地不容根提取纯化得到，流体动力学粒径为161.8±2.68 nm，平均粒径为124.9±2nm，带负表面电荷‑33.82±1.675 mV，含有脂质、蛋白质和活性小分子化合物。制备方法包括：地不容根预处理及提取、梯度离心，超速离心和滤膜过滤等步骤。所述细胞外囊泡可用于制备抗乳腺癌药物，具有良好的生物相容性，可抑制乳腺癌生长和转移、促进乳腺癌细胞凋亡、可靶向肿瘤部位且长时间滞留，所述细胞外囊泡还可作为药物载体用于乳腺癌靶向药物递送系统。
Absstract of: CN120788985A
本发明涉及水凝胶制剂技术领域，且公开了一种水凝胶制剂、制备方法和在修复精子损伤中的应用。所述方法包括以下步骤：步骤一、构建重组质粒；步骤二、质粒转化；步骤三、蛋白纯化；步骤四、制备mEXOs包裹SKAP2蛋白；步骤五、制备SKAP2水凝胶制剂；本发明中通过原核生物大肠杆菌表达SKAP2蛋白，提取牛奶外泌体，然后将SKAP2蛋白包裹进入牛奶外泌体中，之后将含SKAP2蛋白的外泌体融进水凝胶制剂，可通过皮肤涂抹方式显著提高弱精子症小鼠的精子活力，包括改善重金属铅、有机内分泌干扰物邻苯二甲酸酯、高温和衰老导致的弱精子症的精子活力下降作用，解决了现有技术中弱精子症没有有效修复制剂的问题。
Absstract of: WO2025217121A1
The present disclosure relates generally to novel lipids and lipid nanoparticles or their compositions for the delivery of nucleic acid therapeutics. Further, the present disclosure relates generally to methods of treating or preventing a disease comprising administering to a subject in need thereof the novel lipids and lipid nanoparticle compositions described herein.
Absstract of: WO2025214591A1
The present invention provides novel conjugates comprising a magnetic particle and a multitude of viral structures covalently bound to said particle and its manufacturing. These conjugates are suited for medical applications, both diagnostic and therapeutic.
Absstract of: WO2025217538A2
The invention relates to methods of using lung targeted amphiphilic Janus dendrimers that form nanoparticles for delivery of therapeutic agents to the lung parenchyma.
Absstract of: WO2025215637A1
Particles comprising a polysaccharide shell and encapsulating hydrophobic compounds are provided. Further provided is a composition and a kit comprising the particle and methods of preparation thereof. Methods of use, such as for enhancing the bioavailability of the hydrophobic compound, are also provided.
Absstract of: WO2025217299A1
The present disclosure provides ionizable lipids containing a diketopiperazine moiety, lipid nanoparticles formed using such ionizable lipids, as well as their use in delivering nucleic acids and other therapeutic agents to certain cell types.
Absstract of: WO2025217087A1
Lipid nanoparticle formulations for delivery of therapeutic agents can be used in the treatment of diseases or disorders.
Absstract of: WO2025217298A1
The present disclosure provides ionizable lipids containing a diketopiperazine moiety, lipid nanoparticles formed using such ionizable lipids, as well as their use in delivering nucleic acids and other therapeutic agents to certain cell types.
Nº publicación: WO2025216396A1 16/10/2025
Applicant:
RESEARCH \uFF06 BUSINESS FOUNDATION SUNGKYUNKWAN UNIV [KR]
COSMOCOS CO LTD [KR]
\uC131\uADE0\uAD00\uB300\uD559\uAD50\uC0B0\uD559\uD611\uB825\uB2E8,
\uC8FC\uC2DD\uD68C\uC0AC \uCF54\uC2A4\uBAA8\uCF54\uC2A4
Absstract of: WO2025216396A1
A method for preparing a cationic cellulose surfactant, according to the present invention, comprises the steps of: providing cellulose to a basic solution and dispersing same so as to prepare a base solution; and providing a cationic epoxy to the base solution and reacting same so as to prepare a cationic cellulose solution containing cellulose nanofibers, wherein, in the step of preparing the cationic cellulose solution, cationic functional groups can be provided on the surface of the cellulose nanofibers.
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