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COMPOUNDS FOR USE IN THE TREATMENT AND PREVENTION OF COVID- 19

Publication No.:  PL4313010T3 02/06/2025
Applicant: 
SZEKERES THOMAS [AT]
JAEGER WALTER [AT]
Szekeres, Thomas,
J\u00E4ger, Walter
US_2024166587_PA

Absstract of: US2024166587A1

The invention discloses a compound with the general formula (I) wherein R1 to R6 are identical or not and are H, OH—, or OR7, wherein R7 is a C1 to C3 alkyl group or a C1 to C4 acyl group, with the proviso that at least four of R1 to R6 are different than H, for use in the treatment and prevention of COVID-19 in a human subject, especially for inhibiting SARS-CoV-2.

FORMULATION OF AN INHALABLE QUERCETIN SOLUTION FOR THE MANAGEMENT OF RESPIRATORY DISEASES

Publication No.:  WO2025108530A1 30/05/2025
Applicant: 
SARL LABORATOIRE BEKER [DZ]
SARL LABORATOIRE BEKER

Absstract of: WO2025108530A1

The present invention describes the formulation of a phytotherapy product, namely an inhalable solution developed from a natural extract of quercetin, either alone or in combination with resveratrol, rigorously selected for their synergistic effects on the respiratory system and their potential in alleviating symptoms associated with respiratory diseases such as asthma, COPD, lung cancer, COVID-19, and long COVID. The solution is intended to be inhaled using a nebuliser or other inhalation device intended to transform the solution into an aerosol in order to have a direct effect on the bronchi and minimise side effects. Quercetin has anti-inflammatory, antioxidant, immunomodulatory, and antiviral properties. This document describes, through various examples, the manufacturing process developed to obtain a solution for inhalation.

SMALL PEPTIDES FOR INHIBITING SARS-COV-2 SPIKE PROTEIN-AND LPS-INDUCED INFLAMMATION AND CYTOKINE PRODUCTION

Publication No.:  WO2025111412A1 30/05/2025
Applicant: 
THE CURATORS OF THE UNIV OF MISSOURI [US]
THE CURATORS OF THE UNIVERSITY OF MISSOURI

Absstract of: WO2025111412A1

Small anti-inflammatory peptide for blocking NF-κB are disclosed herein. The peptides as well as compositions including the peptides can be administered to inhibit cytokine production and/or inhibit pulmonary inflammation in a subject in need. Particularly embodiments include administration to a subject suffering from coronavirus disease 2019 (COVID-19).

VZV ANTIGEN VARIANT, NUCLEIC ACID, PHARMACEUTICAL COMPOSITION AND USE THEREOF

Publication No.:  WO2025108306A1 30/05/2025
Applicant: 
SHANGHAI RNACURE BIOPHARMA CO LTD [CN]
\u4E0A\u6D77\u84DD\u9E4A\u751F\u7269\u533B\u836F\u6709\u9650\u516C\u53F8
CN_120020142_A

Absstract of: WO2025108306A1

Disclosed are a VZV antigen variant, a nucleic acid, a pharmaceutical composition and the use thereof. The VZV antigen variant has a difference of Y582G compared to an amino acid sequence as set forth in SEQ ID NO: 1; and/or the VZV antigen variant has deletions at positions 561-623, 569-623 or 574-623 compared to an amino acid sequence as set forth in SEQ ID NO: 1; and/or the VZV antigen variant has a modification of a transmembrane region and intracellular region of a protein compared to an amino acid sequence as set forth in SEQ ID NO: 1, wherein the modification of the transmembrane region and intracellular region of the protein involves the replacement of a transmembrane region and intracellular region of an original VZV antigen with a transmembrane region of a SARS-CoV-2Spike protein or a transmembrane region of an influenza H protein. The VZV antigen variant has a stronger immunogenicity than the VZV antigen in the prior art, can achieve a higher titer of binding antibodies, and has a higher protection efficacy.

OPTIMIZED SARBECOVIRUS SPIKE S2 SUBUNIT BINDERS AND COMPOSITIONS COMPRISING THE SAME

Publication No.:  WO2025109176A1 30/05/2025
Applicant: 
EXEVIR BIO BV [BE]
VIB VZW [BE]
UNIV GENT [BE]
EXEVIR BIO BV,
VIB VZW,
UNIVERSITEIT GENT

Absstract of: WO2025109176A1

This invention relates to Sarbecovirus binding agents, in particular antibodies and antigen-binding fragments thereof, which are capable of potently neutralizing a Sarbecovirus, in particular capable of neutralizing any one or both of SARS-CoV-2, including SARS-CoV-2 variants, and SARS-CoV- 1, and affinity matured variants thereof. The binding agents, in particular the antibodies and antibody fragments, have one or more favourable antibody development characteristics. The invention also relates to methods using these binding agents and uses thereof.

DEVICE TO CLOSE TOILET LID BEFORE FLUSHING

Publication No.:  US2025169661A1 29/05/2025
Applicant: 
WILEWSKI ADAM PHILIP [SE]
PENZO JESSICA MARIA [SE]
Wilewski Adam Philip,
Penzo Jessica Maria
US_2025169661_PA

Absstract of: US2025169661A1

Device to close a toilet lid before flushing contains a base part (2) in which a drive device in form of an electrical motor (7) is situated. On top of the base part (2) a motion detector (5) is located that controls a movable arm (3). Within the base part a motherboard (6) is situated. With help from the movement that emerge when flushing the motion detector (5) is activated, that in turn activates the electrical motor (7) that is connected with the movable arm (3) on the front side of the base part (2). The arm (3) opens up 45 degrees, pushes the toilet lid and returns to the origin mode. The detector (4) senses that the lid is no longer resting against the base part (2) and shuts of the device (1). In this way the source of the power consumption, which is a rechargeable battery (3), is limited. The lid is closed completely before flushing and bacteria, virus and the spread of Covid 19 is reduced.

RAPID METHOD FOR ROOM TEMPERATURE REVERSE TRANSCRIPTION LOOP-MEDIATED ISOTHERMAL AMPLIFICATION (RT-LAMP) AND REAGENT KIT

Publication No.:  US2025171864A1 29/05/2025
Applicant: 
D NOME PRIVATE LTD [IN]
D NOME [IN]
D-NOME PRIVATE LIMITED,
D-NOME
US_2025171864_PA

Absstract of: US2025171864A1

The present invention relates to a rapid method to perform reverse transcription loop-mediated isothermal amplification (RT-LAMP) and LAMP at room temperature between 25-42° C., more specifically at 25-37° C., to detect RNA/DNA in a sample and a reagent kit thereof. Further, the invention relates to an in vitro method to detect SARS-CoV2 using RT-LAMP at room temperature between 25-42° C., more specifically at 37° C. The reagent kit comprises of enzymes/proteins—Klenow exo−/−, ApaI, High fidelity Taq Pol, Rpa32, StpA, AMV-RT for reverse transcriptase; buffer composition of—Tris-HCl, MgSO4, KCl, DTT, PEG, DMSO, 1 mM dNTPs each, at least 4 primers, and fluorescent or colorimetric dye.

CDP-CHOLINE A HOST-DIRECTED THERAPEUTIC FOR DISEASE CAUSED BY SARS COV-2 INFECTION

Publication No.:  US2025170246A1 29/05/2025
Applicant: 
OHIO STATE INNOVATION FOUND [US]
Ohio State Innovation Foundation
US_2025170246_PA

Absstract of: US2025170246A1

Compositions and methods are disclosed for treating coronavirus infections, such as SARS CoV-2 coronavirus infections. For example, a composition is disclosed that contains one, two, or more cytidine diphosphate (CDP)-conjugated phospholipid precursors selected from the group consisting of CDP-choline (CDP-CHO), CDP-ethanolamine (CDP-ETH), and CDPdiacylglycerol (CDP-DAG) in combination with one or more agents for treating COVID-19, such as corticosteroids, antibodies, or antivirals, in a pharmaceutically acceptable carrier. Also disclosed is a method of treating coronavirus (e.g. SARS CoV-2) infection in a subject that involves administering to the subject one, two, or more cytidine diphosphate (CDP)-conjugated phospholipid precursors selected from the group consisting of CDP-choline (CDP-CHO), CDPethanolamine (CDP-ETH), and CDP-diacylglycerol (CDP-DAG) in combination with agents for treating COVID-19, such as corticosteroids, antibodies, or antivirals.

TRYPTANTHRIN DERIVATIVES WITH THIOSEMICARBAZONE SUBSTITUTION AND USE THEREOF

Publication No.:  US2025171449A1 29/05/2025
Applicant: 
UNIVERZITA KARLOVA [CZ]
UNIVERZITA KARLOVA
US_2025171449_PA

Absstract of: US2025171449A1

The invention relates to tryptanthrin derivatives with thiosemicarbazone substitution of the general formulae I and II, where R1-R8 are independently H, OH, alkyl with 1 to 6 carbon atoms, C(CH3)3, allyl, propargyl, ben-zyl, phenyl, F, Cl, Br, I, CH2OH, O (alkyl), CF3, OCF3, CN, COOH, COO(alkyl), CONH2, CONH(alkyl), NO2, N(alkyl)2, NH(alkyl), NHCO(alkyl), where the alkyl has 1 to 6 carbon atoms, or R1-R2 or R2-R3 or R3-R4 or R5-R6 or R6-R7 or R7-R8 is —CH═CH—CH═CH—, i.e., a fused benzene ring, X and Z are independently H, alkyl of 1 to 6 carbon atoms, benzyl or phenyl. The compounds combine a structural motif suitable for PLpro targeting, have strong affinity and selectivity for RNA over DNA, and at the same time effectively chelate ferric and ferrous ions. Thus, these compounds have the desired properties for potential use as inhibitors of the production of SARS-COV-2 viral particles and can thus be used for the preparation drugs for the treatment of coronavirus diseases, especially COVID-19.

N4-ISOBUTYRYLOXYCYTIDINE ANALOG SYNTHESIS AND COMPOSITION FOR TREATING VIRAL INFECTION COMPRISING ANTI-VIRAL USE THEREOF

Publication No.:  US2025171486A1 29/05/2025
Applicant: 
DONG A UNIV RESEARCH FOUNDATION FOR INDUSTRY ACADEMY COOPERATION [KR]
Dong-A University Research Foundation for Industry-Academy Cooperation
US_2025171486_A1

Absstract of: US2025171486A1

The present disclosure relates to N4-isobutyryloxycytidine analog synthesis and to the anti-viral use thereof against dengue virus, influenza virus, and SARS-COV-2 virus.

COMPOSITIONS AND METHODS FOR DETECTING SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-COV-2), INFLUENZA A AND INFLUENZA B

Publication No.:  US2025171862A1 29/05/2025
Applicant: 
ROCHE MOLECULAR SYSTEMS INC [US]
Roche Molecular Systems, Inc
US_2025171862_PA

Absstract of: US2025171862A1

Methods for the rapid detection of the presence or absence of SARS-CoV-2, influenza A and influenza B in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers and probes targeting SARS-CoV-2, influenza A, and influenza B and kits are provided that are designed for the detection of SARS-CoV-2, influenza A and influenza B.

ANTIVIRAL PEPTIDES AND METHODS OF USE THEREOF

Publication No.:  US2025171511A1 29/05/2025
Applicant: 
VERSITECH LTD [CN]
CENTRE FOR VIROLOGY VACCINOLOGY AND THERAPEUTICS LTD [CN]
Versitech Limited,
Centre for Virology, Vaccinology and Therapeutics Limited
US_2025171511_PA

Absstract of: US2025171511A1

Antiviral peptides and formulations thereof are described for use in treating or preventing one or more symptoms of coronavirus infections. Peptides derived from human beta defensin 2 have been shown to have antiviral properties against different variants of coronavirus including cross-linking viral particles, blocking cell-to-cell fusion, and/or inhibiting viral release. Pharmaceutical compositions and methods of using one or more antiviral peptides are also provided. Preferably, the antiviral peptides are administered via intranasal route to prevent or alleviate one or more symptoms of coronavirus infections such as reducing the syncytial formation and lung damage.

DUPILUMAB FOR TREATMENT OF COVID-19

Publication No.:  US2025171546A1 29/05/2025
Applicant: 
UNIV OF VIRGINIA PATENT FOUNDATION [US]
UNIVERSITY OF VIRGINIA PATENT FOUNDATION
US_2025171546_PA

Absstract of: US2025171546A1

Methods for treating coronavirus disease 2019 (COVID-19), the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, are described. The methods include administration of combinations of agents, including combinations that include dupilumab. The methods can be used to treat subjects diagnosed with a SARS-CoV-2 infection, including those already hospitalized to treat COVID-19 and/or those also having lymphopenia, to reduce the severity of outcomes related to COVID-19, such as admittance to the intensive care unit (ICU), mechanical ventilation, and/or death, particularly over periods of time longer than a month or two months following the initial administration of the agents. Compositions for use in the treatment of COVID-19 are also described.

ACTION OF L-CITRULLINE TO PREVENT OR TREAT ENDOTHELIAL DYSFUNCTION

Publication No.:  US2025170084A1 29/05/2025
Applicant: 
ASKLEPION PHARMACEUTICALS LLC [US]
VANDERBILT UNIV [US]
Asklepion Pharmaceuticals, LLC,
Vanderbilt University
US_2025170084_PA

Absstract of: US2025170084A1

This invention provides methods for treating endothelial dysfunction by administering an effective amount of citrulline to a patient. The patients may be suffering from acute respiratory distress syndrome (ARDS), sepsis, or infection by COVID-19 (Coronavirus Disease 2019); COVID-19 patients may be at risk of developing endothelial dysfunction, or they may be experiencing endothelial dysfunction. The effective amount of citrulline is sufficient to reduce the uncoupling of endothelial nitric oxide synthase (eNOS) or to reduce the formation of free radicals. Citrulline may be administered orally; intravenously; or both orally and intravenously in a sequential manner. Sequential administration of citrulline may be in three phases, such as (a) an initial phase in which citrulline is administered orally, (b) an intermediate phase wherein citrulline is administered intravenously, and (c) a final phase wherein citrulline is administered orally. The intermediate phase may be while the patient's breathing is being assisted mechanically.

COVID-19 AND RESPIRATORY DISEASE VIRUS INFECTION MODELS USING LUNG ORGANOIDS

Publication No.:  EP4560010A1 28/05/2025
Applicant: 
CATHOLIC UNIV KOREA IND ACADEMIC COOPERATION FOUNDATION [KR]
The Catholic University Of Korea Industry-Academic Cooperation Foundation
EP_4560010_PA

Absstract of: EP4560010A1

The present invention relates to a COVID-19 infection model using alveolar organoids. Respiratory virus-infected alveolar organoids produced according to the present invention are expected to be usefully used in preclinical or clinical drug screening and the like for the development of therapeutic agents for SARS-CoV-2 infection.

ENVELOPED VIRUS LIKE PARTICLES COMPRISING SARS-COV-2 S PROTEIN

Publication No.:  EP4558623A1 28/05/2025
Applicant: 
NAT RES COUNCIL CANADA [CA]
National Research Council of Canada
WO_2024018364_PA

Absstract of: WO2024018364A1

Provided is an enveloped virus-like particle (eVLP) comprising a substantially full-length recombinant SARS-CoV-2 spike (S) protein. The eVLP may further comprise an additional recombinant SARS-CoV-2 S protein having a different sequence, another recombinant viral antigen, or a recombinant non-viral protein. The eVLP is derived from an animal cell, such as a CHO cell, expressing the recombinant SARS-CoV-2 spike protein. Also provided are methods of producing such eVLPs, compositions including such eVLPs, and methods and uses for the induction of an immune response against a SARS-CoV-2 spike protein and/or prevention of COVID-19 or SARS-CoV-2 infection, employing such eVLPs.

MRNA FOR SARS-COV-2 S PROTEIN AND USE THEREOF

Publication No.:  EP4560021A1 28/05/2025
Applicant: 
SHENZHEN SHENXIN BIOTECHNOLOGY CO LTD [CN]
Shenzhen Shenxin Biotechnology Co., Ltd
EP_4560021_A1

Absstract of: EP4560021A1

The present invention relates to an RNA encoding the S protein of SARS-COV-2, a vaccine comprising the RNA, and uses thereof. The present invention also relates to a universal polynucleotide molecule comprising a 5'-UTR and/or a 3'- UTR, and a nucleic acid sequence encoding a protein and/or polypeptide of interest, and optionally comprising a polyA.

METHOD FOR SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-COV-2) DETECTION ON BASIS OF RECEPTOR BINDING

Publication No.:  ZA202407723B 28/05/2025
Applicant: 
CENTRAL HOSPITAL OF MINHANG DISTR SHANGHAI [CN]
CENTRAL HOSPITAL OF MINHANG DISTRICT SHANGHAI
WO_2024055843_PA

Absstract of: ZA202407723B

The present disclosure provides a method for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection on the basis of receptor binding, including: subjecting crosslinked agarose as a matrix to surface carboxyl modification to obtain a magnetic agarose microsphere, and covalently coupling the magnetic agarose microsphere with a receptor protein to obtain a receptor protein-coupled magnetic agarose microsphere; allowing the receptor protein covalently binding to a surface of the receptor protein-coupled magnetic agarose microsphere to recognize and bind to a receptor-binding domain (RBD) of an outer membrane protein S of a SARS-CoV-2 sample, which simulates a binding process of the SARS-CoV-2 to a host cell to capture the SARS-CoV-2; subjecting the magnetic microsphere to washing, purification, and elution successively to obtain the SARS-CoV-2 with a cell binding ability; and detecting by an immunobinding-fluorescence quantitative polymerase chain reaction (PCR) combination, and evaluating infectivity and transmissibility of the SARS-CoV-2. The method is suitable for evaluating the replication and transmission of the SARS-CoV-2 in a patient infected with the SARS-CoV-2 during a treatment process and the infectivity of the SARS-CoV-2 carried by a patient with relapse symptoms after recovery.

ANTIBODIES CAPABLE OF BINDING TO THE SPIKE PROTEIN OF CORONAVIRUS SARS-COV-2

Publication No.:  HUE070285T2 28/05/2025
Applicant: 
RQBIO COVID LTD [GB]
RQBio Covid Limited
MA_61946_B1

Absstract of: MA61946B1

The disclosure relates to antibodies useful for the prevention, treatment and/or diagnosis of coronavirus infections, and diseases and/or complications associated with coronavirus infections, including COVID-19. In particular, the disclosure relates to antibodies capable of binding to the spike protein of coronavirus SARS-CoV-2 and uses thereof.

HOP DERIVED COMPOUNDS FOR USE IN THE TREATMENT OF DISEASES CAUSED BY CORONAVIRUSES

Publication No.:  WO2025104281A1 22/05/2025
Applicant: 
CENTRE NAT RECH SCIENT [FR]
INST NAT SANTE RECH MED [FR]
PASTEUR INSTITUT [FR]
UNIV STRASBOURG [FR]
UNIV LILLE [FR]
CENTRE HOSPITALIER UNIV DE LILLE [FR]
UNIV HAUTE ALSACE [FR]
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE,
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE,
INSTITUT PASTEUR DE LILLE,
UNIVERSITE DE STRASBOURG,
UNIVERSITE DE LILLE,
CENTRE HOSPITALIER UNIVERSITAIRE DE LILLE,
UNIVERSITE DE HAUTE-ALSACE
WO_2025104281_A1

Absstract of: WO2025104281A1

The present invention belongs to the field of compounds for use in therapeutic treatment, and more particularly hop derived compounds for use in the treatment of diseases caused by coronaviruses. The main field of application is human health, through the development of new active beta-acid-type antivirals against SARS-CoV-2. The present invention relates to hop derived compounds according to the invention for use in the treatment of diseases caused by a virus chosen from coronaviruses belonging to the Coronaviridae family.

SARS-COV-2 IMMUNOGENIC COMPOSITIONS

Publication No.:  WO2025106738A1 22/05/2025
Applicant: 
BIONTECH SE [DE]
BIONTECH SE
WO_2025106738_A1

Absstract of: WO2025106738A1

Disclosed herein are compositions comprising protein antigens and RNA encoding the same (e.g., compositions comprising protein antigens and RNA encoding antigens) that can be used to induce an immune response against SARS-CoV-2. Also disclosed herein are immunogenic compositions and medical preparations comprising the same, and methods of making and using the same. In some embodiments, the technologies provided herein can result in an improved immune response as compared to current SARS-COV-2 vaccines.

USE OF GAMMA PRIME FIBRINOGEN AS A BIOMARKER IN THE ASSESSMENT OF COVID-19 INFECTIONS AND PROGNOSIS OF SEVERE DISEASE

Publication No.:  US2025164510A1 22/05/2025
Applicant: 
GAMMA DIAGNOSTICS INC [US]
Gamma Diagnostics Inc
WO_2023163797_PA

Absstract of: US2025164510A1

A method of assessing a COVID-19 infection in a person, the method comprising analysing the concentration or levels of one or more biomarkers in a biological sample from a person, wherein the one or more biomarkers comprises γ′ fibrinogen, and wherein concentration or levels of γ′ fibrinogen are elevated in a biological sample from a person infected with COVID-19 and can be used for predicting COVID-19 disease severity and/or for making a prognosis of severe COVID-19 disease in a person infected with COVID-19.

Methods of Treating Covid-Related Disorders

Publication No.:  US2025161308A1 22/05/2025
Applicant: 
ATHIRA PHARMA INC [US]
Athira Pharma, Inc
JP_2025508768_A

Absstract of: US2025161308A1

The present disclosure relates to a method of treating long-term sequelae of infection with SARS-CoV-2, also known as long COVID. More particularly, it discloses the method of treating long COVID, the method comprising administering to a patient in need thereof a therapeutically effective amount of a HGF/MET positive modulating agent.

Pharmaceutical Compositions and Methods for Treating Covid

Publication No.:  US2025161262A1 22/05/2025
Applicant: 
BARANOWITZ STEVEN [US]
BARANOWITZ Steven
WO_2023150067_A1

Absstract of: US2025161262A1

Pharmaceutical compositions and methods for preventing, treating, relieving, or ameliorating symptoms of coronavirus infection, including COVID-19 and variants thereof, including treating or preventing severe illness from corona vims infection, comprising the administration of IMPDH inhibitors and/or restricted diets of guanosine-containing nucleosides or nucleotides.

MICROWAVE DISINFECTION PROTOCOL OPTIMISED FOR THE DESTRUCTION/ INACTIVATION OF SARS-COV-2 AND H1N1 VIRUSES

Nº publicación: US2025161518A1 22/05/2025

Applicant:

ELETTR S P A [IT]
ELETTRONICA S.P.A

JP_2025506276_PA

Absstract of: US2025161518A1

The invention concerns a microwave disinfection device (2) configured to destroy/inactivate the SARS-COV-2 and H1N1 viruses and comprising a microwave irradiation section (22) configured to: irradiate microwave signals that have an incident electric field amplitude not higher than 6 V/m and frequencies that are included in the 8-10 GHz band and are spaced from each other by a step comprised between 10 MHZ and 100 MHz; irradiate the microwave signals at each individual frequency for a time interval comprised between 50 ms and 1 s; and irradiate the microwave signals with duty cycles comprised between 5% and 50%.

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