Alerta

一种3D打印卷绕式骨修复支架的批量制备方法

Absstract of: CN122353908A

本发明属于生物医用材料与骨组织工程技术领域，特别提供了一种3D打印卷绕式骨修复支架的批量制备方法，包括如下步骤，S1：复合材料的制备；S2：制备适用于三维打印的丝材、颗粒料、浆料;S3:多孔片材三维打印；S4：热软化卷绕定型；S5:切段；S6:支架后处理。本发明适用于多种可降解高分子/生物活性无机复合材料体系，在相关材料及流程共同作用下，通过三维打印精确控制支架孔径、孔隙率与空间结构，兼容丝材挤出、颗粒直挤及浆料直写等多种打印供料形式，经“长条多孔片材→卷绕定型→轴向切段”的工艺实现了小型骨支架标准化批量生产，具有孔隙结构可控性好、适合多种打印供料形式、批量化生产效率高、支架结构有利于骨再生、材料体系灵活的优点。

一种即时混合调色喷墨3D打印方法及在义齿制备中的应用

Absstract of: CN122353909A

本发明公开了一种即时混合调色喷墨3D打印方法及在义齿制备中的应用，属于3D打印技术领域。该方法包括：制备添加有磁性颗粒的多种颜色墨水；构建颜色色值‑墨水比例数据库；根据目标颜色检索数据库，确定所需墨水的比例配方；按配方将不同颜色墨水喷射至对应单元；通过磁场驱动磁性颗粒运动，使各颜色墨水即时充分混合，实现精确调色；最后固化成型。本发明通过在墨水中引入磁性颗粒并结合外部动态磁场，解决了喷墨3D打印中多色墨水难以在微米级空间内即时、均匀混合的技术难题。该方法尤其适用于制备具有空间全向、连续自然颜色梯度的义齿，显著提升美学效果。

一种脊柱矫形测量装置

Absstract of: CN122350686A

本发明涉及脊柱矫形技术领域，特别是涉及一种脊柱矫形测量装置。该装置包括支撑立板、电机丝杆导轨、支撑臂、电动线性模组、靠背板及测力组件，支撑立板上设限位开关，电动线性模组驱动靠背板升降，配合可调扶手实现患者姿态限位；电机丝杆导轨、手动丝杆导轨及螺纹丝杆协同调节测力传感器位置，精准对位脊柱待测点；装置可精准采集矫形力数据并传输至外部系统，为个性化脊柱矫形器设计生产提供实测依据。本装置定位精准、测力可靠，适配不同体型患者，操作便捷，有效提升青少年特发性脊柱侧凸矫形测力精度与效率。

带过滤的液滴输送装置

Absstract of: WO2025122635A1

An aerosol delivery device including a liquid supply, an electronically actuated droplet ejector in fluid communication with the liquid supply, and filter media or inertial filter points between the ejector and a droplets outlet to reduce the droplet size distribution of ejected droplets to smaller droplets exiting the droplets outlet.

一种选区激光熔化的镁合金输尿管支架及制备方法

Absstract of: CN122351603A

本发明涉及医疗器械技术领域，公开了一种选区激光熔化的镁合金输尿管支架及制备方法，包括多孔网状结构，支架表面生成有一层均匀致密的磷酸镁转化膜。支架由选区激光熔化专用镁合金复合粉末制成，粉末由钇、钆、钕、锌、锰、锆和高纯镁原料制成。制备方法包括建立患者三维模型并切片处理；采用复合粉末逐层铺粉并熔化得到毛坯；将毛坯分离并进行打磨；打磨后置于热处理炉中依次进行固溶处理和时效处理；浸没于磷酸水溶液中发生钝化反应原位生成转化膜，最后灭菌包装。通过基体成分设计配合选区激光熔化成型技术与表面钝化膜处理，获得了降解速率可控、抗结壳且具备初期力学支撑能力的镁合金输尿管支架。

具有多层级梯度氮化钛耐磨陶瓷层的钛合金关节植入体及其制备方法

Absstract of: CN122351574A

本发明公开了一种具有多层级梯度氮化钛耐磨陶瓷层的钛合金关节植入体及其制备方法，方法包括对植入体表面进行清洁打磨，并采用三维光学扫描轮廓生成路径；在氮气‑氩气混合气氛箱内，通过分阶段调控激光功率、扫描速度、光斑尺寸及氮气体积分数等工艺参数，利用激光重熔扫描依次构建成分梯度过渡层、深度重熔强化层、浅度重熔强化层及表面致密耐磨层，实现从钛合金基体到表层氮化钛陶瓷的成分、组织与性能连续梯度分布的一体化原位合成。本发明可在保留骨接触面仿生多孔结构的同时，在关节摩擦面形成厚度约200μm、显微硬度≥25GPa、表面粗糙度Ra＜0.2μm的高结合强度梯度氮化钛陶瓷层，显著提升植入体的耐磨性、生物相容性与长期服役稳定性。

一种磷酸钙-聚己内酯复合材料支架及其制备方法与应用

Absstract of: CN122351600A

本发明提供了一种磷酸钙‑聚己内酯复合材料支架及其制备方法与应用，其中磷酸钙‑聚己内酯复合材料的制备原料包括聚己内酯、β‑磷酸三钙和羟基磷灰石，所得到的复合支架具有促免疫和调控骨再生的功能。本发明的磷酸钙‑聚己内酯复合材料支架的制备方法是先形成羟基磷灰石/聚己内酯复合薄膜，经破碎后与β‑磷酸三钙再度形成复合溶液的方式，所得到的3D打印复合支架不仅具有良好的机械强度和生物相容性，还同时具有诱导干细胞增殖和成骨分化、诱导巨噬细胞的再生分型极化的功能，可用于调控免疫细胞反应，诱导产生有利于骨生成的骨免疫微环境，进而提升骨再生效果，可用于组织缺损的修复和再生。

一种基于冷冻3D打印的多孔聚醚醚酮/陶瓷复合材料及其制备方法

Absstract of: CN122356557A

本发明提供了一种基于冷冻3D打印的多孔聚醚醚酮/陶瓷复合材料及其制备方法，将PEEK粉末与陶瓷粉末均匀分散于溶剂中，形成复合浆料；将复合浆料在低温冷冻平台上逐层打印，形成以冰晶为模板的预制体；随后经冷冻干燥移除冰晶，再通过程序化的热处理使PEEK颗粒固结，最终获得具有预设三维多孔结构的复合支架。本发明利用冷冻打印过程中冰晶的定向生长与升华，一步成型高精度、高连通性的仿生多孔结构，并实现了陶瓷材料在PEEK基体中的均匀、稳固复合，使支架同时具备较大的孔隙率和良好的力学性能，解决了传统高温发泡加工无法兼容热敏感陶瓷、以及多孔结构调控精度不足的问题。该制备工艺灵活，适用于制造个性化多孔结构与材料。

SYSTEMS AND METHODS FOR TRAINING MACHINE LEARNING MODELS FOR USE IN A PLURALITY OF SENSORY MONITORING DEVICES

Absstract of: US20260191463A1

0000 Methods and systems for receiving, by at least one processor, for each of a plurality of subjects at defined time intervals during a medical procedure, a subject-specific sensory metric output and a subject-specific sensor dataset. The subject-specific sensory metric output is outputted by a first sensory-monitoring device (SMD) of a first SMD type. The subject-specific sensor dataset is outputted by sensors monitoring a body of each subject from the plurality of subjects, and to be utilized by a second SMD of a second SMD type. The at least one processor executes code to correct for data collection deficiencies, to generate a training dataset for training a machine learning model (MLM) based on the subject-specific sensory metric output and a corrected subject-specific sensor dataset, to train the MLM, and to provide the trained MLM to the second SMD to facilitate medical actions during subsequent medical procedures.

ALIGNER MANUFACTURING SYSTEMS

Absstract of: US20260192507A1

A system is configured to manufacture multiple aligners simultaneously. The system includes a plate configured to secure first and second molds that are based on first and second digital models associated with a dental arch of a patient corresponding to first and second stages of an orthodontic treatment. The system further includes a heater configured to heat a sheet of plastic to generate a heated sheet and a mask configured to surround the sheet of plastic during heating of the sheet of plastic to minimize heat transfer to other sheets of plastic and to substantially provide a thermal seal between the heater and the sheet of plastic. The system further includes a thermoforming chamber configured to simultaneously thermoform the heated sheet over the first and second molds to form first and second aligners shaped to fit the dental arch at the first and second stages of the orthodontic treatment.

SUPPORT MATERIAL FORMULATIONS USABLE IN ADDITIVE MANUFACTURING AND METHODS EMPLOYING SAME

Absstract of: WO2026146504A2

A curable formulation usable as a support material formulation in additive manufacturing of a three-dimensional object such as a denture structure, which forms a hardened mixed layer with a modeling material formulation and provides an object that features improved toughness (e.g., fracture toughness), and additive manufacturing methods employing same are provided. The curable formulation comprises at least one non-curable material which comprises at least one polymeric material featuring water solubility (e.g., ECAH) lower than 200 grams/liter, at least one mono-functional (meth)acrylate featuring low Tg and miscibility in the non-curable material, at least one multi-functional (meth) acrylate featuring at least 10 ethoxylated groups and/or Tg lower than 0 °C, and at least one mono-functional (meth)acrylate. Additive manufacturing of a three- dimensional assembly which comprises a hardened object and a hardened sacrificial structure, and systems employing same are also provided.

TEXTILE SEAL-FORMING STRUCTURE WITH MULTIPLE CURVATURES

Absstract of: AU2026204772A1

A patient interface including a seal-forming structure with a textile membrane that has at least one hole such that the flow of air at a therapeutic pressure is delivered to at least an entrance to the patient’s nares and/or an entrance to the patient’s mouth. The seal-forming structure is constructed and arranged to maintain the therapeutic pressure in a cavity of a plenum chamber throughout the patient’s respiratory cycle, in use. The textile membrane includes a first portion that is held in a relaxed state and a second portion that is held in a taut state. The taut state of the second portion is configured to allow the seal-forming structure to include a three-dimensional shape that has multiple curvatures. un u n

METHODS AND SYSTEMS FOR DYNAMIC CORONARY ROADMAPPING

Absstract of: US20260191490A1

Methods and systems are provided for dynamically visualizing an object of interest that includes part of the vasculature of a patient, which employ a 3D model of the object to generate at least one roadmap that includes information that characterizes properties of the object (such as centerlines, contours, and an image mask. Reference location(s) corresponding to the roadmap(s) are determined for an interventional device used to treat the object. In an online phase, non-contrast-enhanced x-ray image data of the object are obtained and processed to determine location of the interventional device in the image data, and a particular roadmap is selected or accessed. The reference location corresponding to the particular roadmap and the determined location of interventional device are used to transform the particular roadmap. A visual representation of the transformed roadmap is overlaid on the image data for display.

PULMONARY HEALTH MANAGEMENT DEVICE

Absstract of: US20260192061A1

An inhalation device includes a housing defining an air flow channel, a pressure sensor configured to detect air flow within the air flow channel, and a piezoelectric driven ejector configured to eject droplets of a fluid into the air flow channel. A controller is electrically coupled to the pressure sensor and the piezoelectric driven ejector. During an initialization phase in which a user takes a set number of deep breaths, the controller determines a trigger point based on measured inhalation flow. The pressure sensor generates a peak inspiratory flow measurement based on a minimum pressure during inhalation and a pulmonary output based on a maximum flow achieved during exhalation. During a dosing inhalation, the controller actuates the piezoelectric driven ejector when the trigger point is reached to dispense a dose of the fluid. The device may further generate pulmonary health management information based on inspiratory and expiratory flow measurements.

SYSTEM AND METHOD FOR DECISION SUPPORT USING LIFESTYLE FACTORS

Absstract of: US20260192043A1

0000 Systems and methods are provided relating to open loop decision-making for management of diabetes. People with diabetes face many problems in controlling their glucose because of the complex interactions between food, insulin, exercise, stress, activity, and other physiological and environmental conditions. Established principles of management of glucose sometimes are not adequate because there is a significant amount of variability in how different conditions impact different individuals and what actions might be effective for them. Accordingly, systems and methods according to present principles minimize the impact of the vagaries of diabetes on individuals, i.e., by looking for patterns and tendencies of an individual and customizing the management to that individual. Consequently, the same reduces the uncertainty that diabetes typically is associated with and improves quality of life.

METHOD FOR MAKING IMPLANT HAVING A WEB STRUCTURE

Absstract of: US20260191659A1

Various methods for making an implant for interfacing with a bone structure are described. The implant includes a web structure having a space truss. The implant may be made according to a three-dimensional model of the implant. The implant may be made by applying multiple layers of a biocompatible material to a support (e.g., a support structure) in a layer-by-layer process. The web structure may have a plurality of struts joined at nodes where the web structure is configured to interface with human bone tissue.

Multi-State Engagement With Continuous Glucose Monitoring Systems

Absstract of: US20260191434A1

Multi-state engagement with continuous glucose monitoring (CGM) systems is described. Given the number of people that wear CGM systems and because CGM systems produce measurements continuously, a platform that provides a CGM system may have an enormous amount of data. This amount of data is practically, if not actually, impossible for humans to process. In implementations, a CGM platform includes a data analytics platform that obtains packages of glucose measurements provided by a CGM system and also obtains additional data associated with a user. The data analytics platform generates state information for the user by processing these CGM packages and the additional data, at least in part, by using one or more models. Based on this state information, the data analytics platform controls communication with the user, which may include generating intervention strategies to prevent users from transitioning to a negative state such as discontinuing use of the CGM system.

CONTRACEPTIVE MEDICAL DEVICES

Absstract of: US20260191771A1

Disclosed herein are contraceptive medical devices that include at least a polymeric ring, a porous barrier material and an injection molding guide, where the guide may be symmetrical and/or have one or a plurality of planar surfaces, where the device may optionally administer at least one active agent.

SYSTEMS AND METHODS FOR RHYTHM RECOGNITION

Absstract of: US20260196350A1

The disclosed systems and methods provide systems and methods for rhythm recognition and the analysis of ECG signals.

METHODS AND SYSTEMS FOR PREVENTING CARDIOMETABOLIC DISEASES

Absstract of: US20260191896A1

Some embodiments provide for a method for identifying an intervention for a subject in furtherance of preventing development of cardiovascular disease in the subject, the method comprising: obtaining cardiometabolic health data for the subject; determining, using at least some of the cardiometabolic health data, a first trained machine learning (ML) model and for each of multiple time intervals, one or more measures of risk that the subject develops cardiovascular disease to obtain multiple measures of risk; determining, using the multiple measures of risk that the subject develops cardiovascular disease and at least one second trained ML model, benefit of administering to the subject one or more therapeutic interventions designed to reduce risk of cardiovascular disease by targeting one or more modifiable causes of the cardiovascular disease; and identifying, using the determined benefit of administering the therapeutic intervention(s), at least one therapeutic intervention to recommend being administered to the subject.

METHOD AND SYSTEM FOR CONFIRMATION OF MICRONEEDLE-BASED ANALYTE-SELECTIVE SENSOR INSERTION INTO VIABLE TISSUE VIA ELECTRICAL INTERROGATION

Absstract of: US20260191471A1

0000 A system and method to confirm the insertion of an analyte-selective sensor comprising an array of microneedles possessing vertical extent between 200 and 2000 μm into viable tissue is disclosed herein. Mechanical insertion of an analyte-selective sensor is firstly attempted by means of an application of external force. Either during or following this routine, an electrical stimulus is applied between at least two distinct electrodes located within the said analyte-selective sensor; a resultant response is measured. This response is compared with a reference value to determine if insertion was successful. If insertion was successful, no further effort is required and the sensor can operate as intended. However, if insertion was not successful, the user can be instructed to continue to apply additional force to said sensor to achieve successful insertion or otherwise re-apply the said sensor altogether.

3D PRINTING OF POROUS MICROFLUIDIC DRUG DELIVERY SYSTEMS

Absstract of: WO2026146019A1

The invention relates to 3D-printed controlled-release solid oral pharmaceutical compositions comprising a hydrophobic matrix comprising cavities filled with air, allowing flotation in the stomach, one or more regions within the matrix comprising a pharmaceutical, one or more regions within the matrix comprising a swellable material, wherein optionally the one or more regions within the matrix comprise a swellable material and a pharmaceutical one or more fracture zones within the matrix with weaker or less dense structure, one or more hydrophilic channels within the matrix fluidly connecting the outside of the composition with a region within the matrix comprising the swellable material or the pharmaceutical.

STRETCHABLE AND HIGHLY CONDUCTIVE CRUMPLED GRAPHENE-BASED FILMS FOR MULTIFUNCTIONAL APPLICATIONS

Absstract of: US20260193139A1

Embodiments relate to a nanocomposite material including a graphene-based 3D porous scaffold coated with active nanoparticles and to methods of making and using the material. The nanocomposite material exhibits high electrical conductivity, mechanical stretchability, and surface roughness, achieved through laser scribing, electrodeposition, and pre-strain transfer printing to induce crumpling. Embodiments further relate to a device including a crumpled nanocomposite material as an electrode and to methods of making and using the device.

SCALABLE FLUIDIC DEVICES FOR HIGH-THROUGHPUT ENRICHMENT AND SEPARATION OF CHARGED SPECIES AND METHODS OF USE

Absstract of: US20260192217A1

The present disclosure relates generally to fluidic devices for high-throughput removal of charged particles from a fluid, for example contaminants from drinking water or contaminants from spent dialysate. The fluidic devices comprise a flow-through 3D ion selective structure within a channel for focusing charged particles along an electric field gradient at the boundary of an ion depleted zone and/or in an ion enriched zone created by the 3D ion selective structure, thereby removing said charged particles from the fluid flowing through the 3D ion selective structure.

SYSTEM FOR CREATING HUMAN TISSUE SAMPLES THROUGH THREE-DIMENSIONAL BIOPRINTING AND CULTURING

Nº publicación: WO2026147958A1 09/07/2026

Applicant:

MAYO FOUNDATION FOR MEDICAL EDUCATION AND RES [US]
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH

Absstract of: WO2026147958A1

This document relates to devices, systems, and methods for fabricating a three-dimensional sample of human tissue. For example, this document relates to techniques for depositing cells according to a predefined pattern and treating the deposited cells to simulate a realistic human tissue sample.