Ministerio de Industria, Turismo y Comercio LogoMinisterior
 

Alerta

Resultados 214 results.
LastUpdate Updated on 16/02/2026 [06:51:00]
pdfxls
Solicitudes publicadas en los últimos 15 días / Applications published in the last 15 days
previousPage Results 200 to 214 of 214  

NANOEMULSION COMPRISING CANNABINOID AND/OR CANNABIMIMETIC

Publication No.:  MX2024001081A 03/02/2026
Applicant: 
NICOVENTURES TRADING LTD [GB]
NICOVENTURES TRADING LIMITED
JP_2024528847_A

Absstract of: MX2024001081A

The present disclosure provides nanoemulsions comprising one or more active ingredients (e.g., one or more cannabinoid and/or cannabimimetics), formulated for use as tinctures or shots. Such nanoemulsions, tinctures, and shots can exhibit high physical stability, e.g., exhibiting no observable phase separation over a period of 6 months or more or 12 months or more.

一种含有阳离子脂质的药物组合物及其用途

Publication No.:  CN121463960A 03/02/2026
Applicant: 
上海瑞宏迪医药有限公司
CN_121463960_A

Absstract of: AU2024307171A1

A pharmaceutical composition containing a cationic lipid and the use thereof. Specifically, provided are a pharmaceutical composition comprising a carrier, the carrier comprising a cationic lipid, and the molar percentage of the cationic lipid to the carrier being greater than or equal to 10% and less than 50%.

Lípidos ionizables a base de dianhidrohexitol para el suministro de ácidos nucleicos

Publication No.:  CO2026000577A2 02/02/2026
Applicant: 
SANOFI PASTEUR INC [US]
SANOFI PASTEUR INC
CN_121419982_PA

Absstract of: TW202517243A

The present invention provides, in part, dianhydrohexitol-based cationic lipids of Formula (I), and sub-formulas thereof:, or a pharmaceutically acceptable salt thereof. The present invention also provides, in part, dianhydrohexitol-based cationic lipids of Formula (II), and sub-formulas thereof:, or a pharmaceutically acceptable salt thereof. The compounds provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.

Compositions and methods for treating non-age-associated hearing impairment in a human subject

Publication No.:  IL325122A 01/02/2026
Applicant: 
AKOUOS INC [US]
SIMONS EMMANUEL J
NG ROBERT
REISINGER ELLEN
AL MOYED HANAN
KUGLER SEBASTIAN
AKOUOS INC,
SIMONS Emmanuel J,
NG Robert,
REISINGER Ellen,
AL-MOYED Hanan,
KUGLER Sebastian
AU_2025263792_A1

Absstract of: AU2025263792A1

COMPOSITIONS AND METHODS FOR TREATING NON-AGE- ASSOCIATED HEARING IMPAIRMENT IN A HUMAN SUBJECT Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing loss in a subject. COMPOSITIONS AND METHODS FOR TREATING NON-AGE- ASSOCIATED HEARING IMPAIRMENT IN A HUMAN SUBJECT Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing loss in a subject. ov - - o v

Cytokine compositions and methods of use thereof

Publication No.:  IL325654A 01/02/2026
Applicant: 
ZAHAV BIOSCIENCE LLC [US]
PACIOTTI GIULIO FRANCO [US]
ZAHAV BIOSCIENCE LLC,
PACIOTTI Giulio Franco
AU_2023455215_PA

Absstract of: AU2023455215A1

Provided herein are novel constructs comprising gold nanoparticles bound to two types of cytokines, wherein the two types of cytokines comprise Tumor Necrosis Factor alpha (TNF ) and a cytokine selected from the group consisting of Interferon gamma (IFN ) and lnterleukin-12. Further provided is a method for treating cancer in a subject in need thereof.

Sterol analogs in lipid nanoparticle formulations

Publication No.:  IL325527A 01/02/2026
Applicant: 
SANOFI PASTEUR INC [US]
SANOFI PASTEUR INC
WO_2025003760_A1

Absstract of: WO2025003760A1

Provided are lipid nanoparticles for delivering nucleic acids molecules such as mRNA. Also provided are methods of making and using thereof.

Dianhydrohexitol based ionizable lipids for nucleic acid delivery

Publication No.:  IL325550A 01/02/2026
Applicant: 
SANOFI PASTEUR INC [US]
SANOFI PASTEUR INC
CN_121419982_PA

Absstract of: TW202517243A

The present invention provides, in part, dianhydrohexitol-based cationic lipids of Formula (I), and sub-formulas thereof:, or a pharmaceutically acceptable salt thereof. The present invention also provides, in part, dianhydrohexitol-based cationic lipids of Formula (II), and sub-formulas thereof:, or a pharmaceutically acceptable salt thereof. The compounds provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.

Use of glycerides for lnp formulations

Publication No.:  IL325528A 01/02/2026
Applicant: 
SANOFI PASTEUR INC [US]
SANOFI PASTEUR INC
CN_121398801_A

Absstract of: TW202515513A

Provided are lipid nanoparticles for delivering nucleic acids molecules such as mRNA. Also provided are methods of making and using thereof.

Compounds, nanoparticles, and pharmaceutical compositions for the treatment of drug addiction

Publication No.:  IL325075A 01/02/2026
Applicant: 
BOARD OF REGENTS OF THE UNIV OF NEBRASKA [US]
EDAGWA BENSON [US]
BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA,
EDAGWA Benson
AU_2024281932_PA

Absstract of: AU2024281932A1

Provided herein are compounds of Formula (I), or a pharmaceutically acceptable salt thereof. Further disclosed are nanoparticles comprising one of the compounds and methods of using the same for treating drug addiction, drug dependence, drug overdose, opioid use disorder, pain, chronic pain, fibromyalgia, arthritis, or obesity.

New method of producing an aqueous mesoparticle composition comprising a lipophilic compound

Publication No.:  IL325475A 01/02/2026
Applicant: 
BIOGNTX R& D B V [NL]
BIOGNTX R& D B.V
AU_2024309710_PA

Absstract of: AU2024309710A1

Described is a method for the preparation of an aqueous mesoparticle composition comprising a lipophilic compound, comprising the steps of: a. Providing an emulsifier or a blend of emulsifiers in powder form; b. Mixing one or more oils at a temperature above 40°C where all oils have become liquid, wherein said oils differ in melting temperature and which mixture comprises at least a sufficient amount of medium chain triglycerides to enable the composition formed in step g have a partly liquid oil phase at temperatures around about 4°C; c. Adding the hydrophobic or amphiphilic compound in any hydrophobic solvent to the oil mixture; d. Optionally letting the mixture cool down to room temperature; e. Adding the emulsifier powder and water to the oil mixture and letting the mixture emulsify, under optional agitation and heating to 30-40°C; f. Subjecting the emulsified mixture to a sonication and optionally mixing or fluidisation treatment until the average particle size of the mixture remains stable; g. Cooling down the sonicated mixture allowing sufficient time for crystallisation; and h. Optionally, a second sonication treatment while keeping the mixture cold and compositions produced by the above method.

Nanoparticle compositions associated with peptides

Publication No.:  IL325438A 01/02/2026
Applicant: 
THE REGENTS OF THE UNIV OF MICHIGAN [US]
MOON JAMES J [US]
SCHWENDEMAN ANNA [US]
XU CHENG [US]
SOLOMEVICH SERGEY [US]
NAM JUTAEK [US]
THE REGENTS OF THE UNIVERSITY OF MICHIGAN,
MOON James J,
SCHWENDEMAN Anna,
XU Cheng,
SOLOMEVICH Sergey,
NAM Jutaek
AU_2024314758_A1

Absstract of: AU2024314758A1

The present invention relates to compositions comprising sHDL nanoparticles. In particular, the present invention relates to sHDL nanoparticles comprising a phospholipid; an apoplipoprotein mimetic; a thiol-reactive lipid; and a peptide comprising a linker moiety connected with a payload moiety, wherein the linker comprises cysteine (C) and one to five amino acids independently selected from aspartic acid (D), glutamic acid (E), and serine (S), the payload comprises a polypeptide that is 5 to 35 amino acids in length and has a net positive charge at a pH of 7 to 12, and the peptide comprises a net negative charge at a pH of 7 and an isoelectric point of 0.4 to 12; and wherein the peptide is covalently attached to the thiol-reactive lipid by way of the cysteine (C).

Amide containing lipids

Publication No.:  IL325114A 01/02/2026
Applicant: 
ACUITAS THERAPEUTICS INC [CA]
ACUITAS THERAPEUTICS INC
US_2024423914_PA

Absstract of: US2024423914A1

Compounds are provided having the following Formula (I):or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein G1, R1, R2, R3, L1, and L2 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.

Mixed amide ester containing lipids for use in lipid nanoparticles

Publication No.:  IL325117A 01/02/2026
Applicant: 
ACUITAS THERAPEUTICS INC [CA]
ACUITAS THERAPEUTICS INC
US_2025025427_PA

Absstract of: US2025025427A1

Compounds are provided having the following Formula (I):or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein G1, G2, R1, R2, R3, L1a, L1b, and L2 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.

Ionizable lipids

Nº publicación: IL325487A 01/02/2026

Applicant:

ETHERNA IMMUNOTHERAPIES NV [BE]
KASMI SABAH [BE]
DE COEN RUBEN [BE]
DE KOKER STEFAAN [BE]
DUMBRE SHRINIVAS [BE]
ETHERNA IMMUNOTHERAPIES NV,
KASMI Sabah,
DE COEN Ruben,
DE KOKER Stefaan,
DUMBRE Shrinivas

TW_202517616_A

Absstract of: TW202517616A

The present invention generally relates to the field of ionizable (also termed cationic) lipids, and in particular provides a novel type of such lipids as represented by formula (I). The present invention further provides methods for making such lipids as well as uses thereof, in particular in the preparation of nanoparticle compositions, more in particular nanoparticle compositions comprising active agents. It further provides pharmaceutical formulations comprising nanoparticle compositions based on the ionizable lipids disclosed herein.

traducir