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218
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Updated on
23/12/2025 [06:52:00]
Results 200 to 218 of 218
Absstract of: WO2025214340A1
A lipid nanoparticle formulation having remarkably improved stability and a preparation method therefor. The lipid nanoparticle formulation comprises a pharmaceutically acceptable buffer solution, lipid nanoparticles and a nucleic acid encapsulated in the lipid nanoparticles.
Absstract of: WO2024235034A1
Provided is a method for characterizing delivery vehicles for in vivo delivery of an agent. The methods can be used to characterize various properties of a wide variety of delivery vehicles.
Absstract of: CN121081415A
本发明公开了预活化小胶质细胞膜包被负载人参皂苷的纳米颗粒和制备方法及其在抑郁症中的应用，包括如下步骤：将预活化的小胶质细胞膜包被于人参皂苷Rb1的纳米颗粒表面制备得到预活化小胶质细胞膜包被负载人参皂苷的纳米颗粒。本发明能将GRb1@PLGA和GRb1@PLGA@AM招募至抑郁小鼠的脑部，从而增加GRb1@PLGA@AM在炎性病变部位的积蓄，实现高效抑郁症炎症部位的靶向功能，不但能够有效抑制抑郁的进展，且具有良好的生物安全性。
Absstract of: CN121081411A
本发明公开了一种微环境响应型释放硫化氢的多功能靶向纳米粒子及其制备方法和应用，步骤：(1)制备Poly‑Lys‑Cbz；(2)制备α‑PLL；(3)制备PB‑TCD；(4)取α‑PLL、SPDP‑PEG‑NHS、DMSO和三乙醇胺反应；加入PB‑TCD和4‑二甲氨基吡啶反应；反应液透析，干燥，获得聚合物1；(5)将聚合物1和CGRGDS多肽溶于DMSO中，透析，获得聚合物2；(6)将聚合物2溶解在DMSO中，得到溶液1，透析，得到一种微环境响应型释放硫化氢的多功能靶向纳米粒子；本发明的纳米粒子具有良好的生物相容性，有效靶向到气体爆炸造成的急性肺损伤处，并有效下调ROS，清除细胞外游离DNA。
Absstract of: MX2025009590A
The present disclosure relates to compositions and methods for treating phenylketonuria (PKU). In particular, the present disclosure relates to AAV â¿¿ piggyBac transposon polynucleotide vectors and LNP compositions comprising a nucleic acid encoding a transposase, and methods of using the compositions for treating PKU.
Absstract of: MX2025009878A
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Absstract of: CN121081414A
本发明涉及一种仿生纳米CO发生器及其制备和应用，属于医药技术领域，解决目前迫切需要开发能够协同促进神经保护与神经发生、并具备脑靶向与控释能力的CO递送系统的问题。提供了一种仿生纳米CO发生器，包括载药颗粒内核和覆膜，其中，所述载药颗粒内核包括中空介孔CeO2纳米颗粒，及负载于所述中空介孔CeO2纳米颗粒上的MnCO，所述覆膜为巨噬细胞膜，包覆于所述载药颗粒内核外部。用于通过整合神经保护与增强内源性神经生长的创新双通道进行卒中治疗给药，有望显著减少脑卒中后的脑损伤并恢复神经功能，以缓解关于脑缺血再灌注损伤后高死亡率和长期残疾的担忧。
Absstract of: CN121081409A
本发明涉及生物医药领域，特别是一种可用于核酸递送的阳离子脂质及其在TLR9激动剂组合物中的应用，以及所述组合物的制备方法和应用。通过本发明的阳离子脂质所制备的TLR9激动剂LNP佐剂配伍疫苗与单独疫苗相比有较为显著的免疫增强效果，且与市售的疫苗佐剂以及由市售的LNP产品中所用的磷脂制备的佐剂相比，有着更强的免疫效力、更长的持续时间，以及对毒性及其分布控制上的优势。
Absstract of: CN121081466A
本发明公开了一种用于治疗多囊卵巢综合征的组合药物及其应用。所述组合药物含有Ins（肌醇、手性肌醇）和BBR（小檗碱）。本发明证明了肌醇、手性肌醇和小檗碱组合在改善激素水平、减轻肥胖症状、提高生育质量和增加线粒体质量方面均优于使用NAC（N‑乙酰半胱氨酸），Ins和BBR。而且各项技术指标与PCOS组均存在显著差异。本发明从激素调节、代谢能力、线粒体质量以及生育力几个方面来阐明药物作用，并且都取得显著治疗效果，结果更加可信。
Absstract of: CN121081618A
本发明涉及一种递送细胞因子且响应释放的肿瘤免疫治疗系统及其制备方法和应用，包括由锰纳米佐剂和通过静电、氢键等相互作用负载于锰纳米佐剂外表面的细胞因子组成的复合物、以及通过静电、氢键等相互作用包裹所述复合物的肿瘤响应性高分子材料；所述锰纳米佐剂包括四氧化三锰纳米颗粒和包裹于四氧化三锰纳米颗粒表面的阳离子化模板分子，所述阳离子化模板分子为经过阳离子化修饰处理的蛋白、或其蛋白片段、或其多肽片段。本发明提供了一种全新的肿瘤免疫治疗策略，突破了传统细胞因子递送和免疫激活的局限。
Absstract of: US2024277625A1
A method of producing lipid-encapsulated RNA nanoparticles includes flowing an aqueous solution comprising an RNA through a 1st tube having a first inner diameter (ID); the RNA comprises from about 6,000 to about 13,000 nucleotides; flowing an ethanol solution comprising lipids through a 2nd tube having a second inner diameter (ID), at a flow rate of about 0.2 to about 1 times relative to the aqueous solution through the 1st tube, the lipids comprise a cationic lipid; and mixing the ethanol solution with the aqueous solution; the first ID and second ID and flow rates through the 1st tube and 2nd tube are selected to produce a shear force sufficiently low to preserve the integrity of the RNA; the mixing produces an output solution flowing in the 1st tube comprising a turbulent flow of the RNA and the lipids in between about ethanol, the lipid-encapsulated RNA nanoparticles having a bilayer structure.
Absstract of: CN121085994A
组织蛋白酶B‑还原双响应型生物自降解阳离子脂质及其脂质纳米粒的制备与应用，本发明属于药物制剂新辅料和新剂型技术领域，涉及组织蛋白酶B和还原双响应型自降解阳离子脂质的制备方法及其siRNA脂质纳米粒的构建，结肠靶向递送可定植化菊粉‑螺旋藻复合凝胶以及其在核酸药物递送中的应用。本发明通过整合微藻生物技术和纳米药物，设计了一种结肠特异性模块化水凝胶平台，为解决脂质纳米粒的毒副作用和口服递送RNA提供了新的策略和选择。
Absstract of: CN121081614A
本发明公开了一种基因Ⅱ型草鱼呼肠孤病毒mRNA疫苗及其制备方法和应用，涉及水产疫苗领域，该疫苗包含一条修饰后的mRNA链，依次由非翻译区（UTR）序列、Kozak序列、GCRV‑II型外衣壳蛋白VP35编码序列、终止密码子、非翻译区（UTR）序列以及poly(A)尾序列组成。通过转染和脂质纳米颗粒（LNP）包装的形式递送至稀有鮈鲫下颌细胞（GRLJ）和人胚胎肾细胞（HEK293T）细胞内，该疫苗在以上两种细胞中均能够有效表达VP35蛋白。进一步注射稀有鮈鲫后，可诱导鱼体产生特异性免疫应答，从而提高鱼体抗病毒能力并显著降低感染死亡率，具有广阔应用前景。
Absstract of: CN121081413A
本发明属于生物医药技术领域，具体涉及一种肝外靶向的脂质纳米颗粒组合物及其应用。所述脂质纳米颗粒组合物的原料包括SM1012、DSPC、β‑谷甾醇和DMG‑PEG；所述DSPC占所述脂质纳米颗粒组合物的摩尔百分比为20‑30％。本发明所述脂质纳米颗粒在不同注射方式下可显著改变体内分布行为。与传统脂质纳米颗粒经肌肉注射等不同方式注射后均大量富集于肝脏的特性不同，本发明所述脂质纳米颗粒在通过相同途径注射后，能够有效减少向肝脏的靶向聚集，从而实现在注射局部区域的高浓度滞留与富集，有助于提高药物在靶部位的生物利用度，降低全身暴露及潜在肝毒性，为局部精准给药提供了更优的递送策略。
Absstract of: CN121081647A
本发明涉及生物制药领域，尤其涉及DC疫苗、载药纳米颗粒及其制备方法和应用。本发明提供了组合物，包括：0.1~50 mM的细胞通路抑制剂、负载mOVA含有肿瘤抗原的LNPs和0.01~50 μg/mL的细胞通路激动剂。本发明构建了一种DC疫苗和载药PLGA纳米颗粒共递送体系的构建及制备方法，该DC疫苗通过与负载激动剂PLGA纳米颗粒连用，从而有效特异性激活T细胞，实现高效抗肿瘤效果。以上组合方式明显提高了对肿瘤的抑制效果，其效果优于分别单独使用。
Absstract of: US2025360202A1
The present disclosure belongs to the technical field of mRNA vaccines, and specifically relates to a herpes zoster mRNA vaccine, a preparation method therefor, and a use thereof. The herpes zoster mRNA vaccine provided by the present disclosure comprises an RNA encoding a varicella-zoster virus gE glycoprotein or a variant thereof. The vaccine can prevent herpes zoster infection and its complications.
Absstract of: EP4628070A1
One aspect according to the present invention relates to: a gold nanozyme including glycol chitosan and gold particles; and a pharmaceutical composition for preventing or treating inflammatory bowel disease, the composition comprising the gold nanozyme. The gold nanozyme and the pharmaceutical composition comprising same according to one aspect of the present invention was found to inhibit the expression of inflammatory factors, inhibit the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) inside cells, and reduce the production of nitric oxide (NO) inside cells. In addition, the gold nanozyme was found to inhibit the secretion of Hight Mobility Group Box 1 (HMGB1) when further including glycyrrhizin. In addition, the gold nanozyme and the composition comprising same were found to enable the recovery of the length, weight, etc., of damaged intestines, and thus can be used in the inflammatory bowel disease prevention and/or treatment industry/market.
Nº publicación: CN121081412A 09/12/2025
Applicant:
成都市第三人民医院
Absstract of: CN121081412A
本发明提供了一种钴基纳米马达及其制备方法和在制备放疗损伤的空间分布异质性药物中的应用，属于纳米药物技术领域。本发明构建的钴基纳米马达在低剂量X射线辐照下，可放大ROS对于肿瘤细胞的杀伤效果，显著增强肿瘤放射治疗效果。此外，由于钴基纳米马达中含有碳酸氢铵，能够响应肿瘤酸性微环境，在肿瘤微酸环境下释放二氧化碳，推动其深入肿瘤组织并在肿瘤内部积聚，并通过催化治疗作用消耗肿瘤细胞内抗氧化谷胱甘肽，放大ROS损伤。本发明初步证明了钴基纳米马达凭借其在肿瘤组织中的优异穿透能力，实现不均匀放射动力学治疗，达到放疗损伤的空间分布异质性的效果，从而激活免疫反应，实现增效肿瘤放疗疗效的作用。
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