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200
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Results 75 to 100 of 200
Absstract of: CN122701876A
本申请公开了一种靶向modABC调控铁代谢的联合抗菌剂及其制备方法，属于抗感染药物技术领域。该联合抗菌剂中铁螯合剂与modABC通路抑制剂的质量比为1:0.5‑2，通过铁螯合剂与modABC通路抑制剂的协同作用，双重阻断细菌铁摄取途径，避免细菌产生代偿性铁摄取机制，实现高效杀菌；同时本申请提供联合抗菌剂的制备方法包括原料预处理、分散体系制备、乳化反应、载体成型、纯化处理、制剂后处理六个核心步骤，可根据实际制备需求，选择合适的分散介质、乳化参数、载体成型方法及功能辅料，实现联合抗菌剂的高效制备。
Absstract of: CN117986153A
The invention provides an ionizable cationic lipid compound as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The ionizable cationic lipid compound provided by the invention is a compound with a formula (1), or a salt, a stereoisomer and a tautomer thereof, can be used as a surfactant in various fields, and especially can be used as a lipid composition for delivering a therapeutic agent. The prepared lipid nanoparticles can show good effectiveness and safety in cells and in animal bodies. # imgabs0 #
Absstract of: CN122701682A
本发明公开了一种白藜芦醇‑单形拟杆菌共封装微胶囊组合物、制备方法及其应用。属于微胶囊技术领域。针对疏水性多酚白藜芦醇稳定性差、单形拟杆菌在加工和消化道中易失活，以及现有技术难以将二者同步保护与递送的问题，本发明提供了一种以乳清分离蛋白、壳聚糖和果胶为壁材的多层复合微胶囊。该微胶囊利用乳清分离蛋白的疏水结构域包埋白藜芦醇形成蛋白核心，再依次包覆壳聚糖阳离子层和果胶外壳层，并将单形拟杆菌包埋于外层多糖屏障中。通过选择不同酯化度的果胶可调控外壳致密程度，实现胃液保护与肠液释放的平衡。本发明能够显著提高白藜芦醇的稳定性以及单形拟杆菌在包埋、贮藏、热处理和模拟胃液中的存活率。
Absstract of: CN122706715A
本发明提供了一种兔出血症病毒的mRNA、疫苗及其制备方法与应用，属于基因工程技术领域。本发明提供的兔出血症病毒的mRNA，在抗原编码区的5'端添加N7mGpppAm帽结构和5'UTR，在抗原编码区的3'端添加3'UTR与poly(A)尾；所述抗原编码区包括核苷酸序列如SEQ ID NO.1所示的RHDV1抗原编码区或核苷酸序列如SEQ ID NO.2所示的RHDV2抗原编码区。本发明提供的兔出血症病毒的mRNA疫苗，能够在机体内有效地翻译成抗原蛋白，可诱导产生针对RHDV1、RHDV2的高水平抗体，对RHDV1、RHDV2的流行分离毒株具有良好的保护性，为RHDV的防控提供了新型技术和产品支撑。
Absstract of: CN122706582A
本发明属于植物提取技术领域，具体公开了一种植物纳米囊泡提取物的制备方法及应用，将植物原料清洗后进行反复冻融处理；冻融后的原料加入预冷提取缓冲液低温匀浆；匀浆液先低速离心、再高速离心取上清；上清用切向流过滤系统浓缩并洗滤，收截留液；截留液超速离心后取沉淀，用提取缓冲液重悬即得。本发明方法提取的植物纳米囊泡的产率高，植物纳米囊泡提取物纯度高、粒径均一、结构完整，纳米囊泡的平均粒径为80~150 nm，多分散系数小于0.25，囊泡呈典型的茶托状或球状形态，磷脂双分子层结构完整，可用于药物载体、化妆品及功能性食品。
Absstract of: CN122701685A
本发明公开了一种细胞膜包覆氧缺陷氧化铜纳米声敏剂及其制备方法和应用，属于纳米生物医药与肿瘤声动力治疗技术领域。该纳米声敏剂为核壳结构，内核为富含氧空位缺陷的氧化铜（CuO1‑X）纳米颗粒，作为超声响应声敏单元；外壳为肿瘤细胞膜融合层，赋予制剂同源靶向与生物相容性。通过氧空位缺陷工程调控氧化铜电子结构，显著提升超声辐照下活性氧生成效率；在超声刺激下，该制剂可同步实现三重协同抗肿瘤效应：一是活性氧介导的声动力直接杀伤肿瘤细胞，二是下调 CXCR4‑CXCL12 信号轴抑制肿瘤转移，三是诱导免疫原性细胞死亡激活全身性抗肿瘤免疫。体内外实验证实，该制剂对三阴性乳腺癌原位生长及肺转移具有显著抑制效果。
Absstract of: CN120732817A
The invention discloses macrophage targeting nanoparticles as well as a preparation method and application thereof, belongs to the technical field of biomedicine, and solves the technical problems of poor macrophage targeting, short joint residence time, poor inflammation regulation effect and the like in current osteoarthritis treatment in the prior art. The nano-particles of the targeted macrophage are nano-particles of which the surfaces are modified with PGlu, the general formula is P1-b-PGlu, P1 is a hydrophobic segment polymer, or the nano-particles which can enter a living body and are non-toxic, specifically, by introducing a glucosamine functional group, the combination of the nano-particles and a saccharide recognition receptor on the surface of a macrophage cell membrane is enhanced, and the macrophage recognition efficiency is improved. Therefore, the active targeting on the macrophages is realized. The constructed nano-particles have excellent physical stability and appropriate particle size distribution, the residence time of the nano-particles in an articular cavity is remarkably prolonged, and continuous slow release is achieved. The targeted nano system effectively realizes polarization conversion from M1 to M2, improves a synovial immune microenvironment, and plays a synergistic treatment role of immune regulation and tissue repair.
Absstract of: CN122701686A
本发明提供了一种负载雷公藤甲素的氮氧自由基聚合物纳米颗粒及其制备方法和在小细胞肺癌中的应用，属于纳米医药技术领域。本发明提供的纳米颗粒采用氮氧自由基聚合物作为载体，其氮氧自由基结构不仅赋予了纳米颗粒良好的稳定性和生物相容性，还能让雷公藤甲素（TP）在体内进行长循环，主要蓄积在肿瘤部位，从而主动降低TP引起的氧化应激损伤，纳米颗粒在体外能有效抑制人源或鼠源小细胞肺癌细胞活力，在皮下移植瘤和原位瘤模型中表现出优于游离TP的抗肿瘤效果，而且能显著减轻TP引起的全身毒性，特别是对睾丸组织的损伤，保护雄性生育能力。
Absstract of: CN122701684A
本发明提供了一种透明质酸包覆铜掺杂普鲁士蓝纳米酶CuPB@HA的制备方法及应用。所述制备方法包括以下步骤：首先合成普鲁士蓝纳米颗粒，再掺杂铜得到铜掺杂普鲁士蓝纳米颗粒CuPB，并对其表面进行透明质酸修饰，获得CuPB@HA纳米酶。所述CuPB@HA纳米酶可靶向识别并富集于动脉粥样硬化病灶中CD44高表达的巨噬细胞，从而提高病灶部位摄取效率。该纳米酶兼具脂质代谢调控功能，可降低脂质摄取受体CD36表达，并上调胆固醇外排相关蛋白ABCA1和ABCG1表达，进而减少泡沫细胞形成，促进巨噬细胞向有利于炎症消退的表型转化。与此同时，所述CuPB@HA纳米酶亦具备活性氧清除能力，能够有效缓解斑块微环境中的氧化应激，从而进一步抑制炎症反应，提升斑块稳定性。动物实验表明，所述CuPB@HA纳米酶可显著降低动脉粥样硬化斑块负荷并提高斑块稳定性，具有良好的应用前景。
Absstract of: CN122701880A
本发明涉及生物医药技术领域，公开了一种用于子宫内膜癌靶向递送siRNA的铜基仿生纳米药物及其制备方法和应用，纳米药物为子宫内膜癌细胞膜包裹的Cu/siRNA复合纳米颗粒，Cu/siRNA复合纳米颗粒由铜离子和siRNA组装而成，同时具备靶向肿瘤递送siRNA和免疫治疗增敏能力，以解决现有子宫内膜癌免疫治疗对肿瘤抗原呈递不足改善程度有限，难以激活充分且持久的抗肿瘤免疫应答，进而导致临床获益受限的问题。
Absstract of: CN122701750A
本发明公开了一种富含MFGE8的鹿茸干细胞外泌体抗肝纤维化药物制剂，该药物制剂以鹿茸干细胞外泌体为活性成分，所述鹿茸干细胞外泌体中MFGE8（乳脂球表皮生长因子8）的含量不低于100ng/mg总蛋白。本发明通过特定的培养条件和分离纯化方法，显著提高了鹿茸干细胞（ASCs）外泌体中MFGE8的表达水平，使其能够通过抑制肝星状细胞活化、促进肝细胞修复再生以及调节肝脏免疫微环境等多种途径，有效逆转肝纤维化进程。本发明的药物制剂具有生物相容性好、靶向性强、副作用小等优点，为肝纤维化的临床治疗提供了一种新的有效手段。
Absstract of: CN122701849A
本发明提供了一种铜绿假单胞菌抗原PA0833与载体蛋白mi3通过Linker连接可自组装形成纳米颗粒化的PA0833‑mi3重组蛋白。本发明提供了表达载体和重组工程菌，以及在作为铜绿假单胞菌疫苗抗原的应用。本发明还提供了PA0833‑mi3重组蛋白作为抗原时本身具有自佐剂效应。本发明公开了PA0833‑mi3自佐剂纳米颗粒黏膜疫苗的制备及用于诊断、防治或治疗铜绿假单胞菌感染在药物中的应用。采用本发明提供的重组蛋白可有效刺激机体产生较高的体液免疫、细胞免疫和黏膜免疫应答。
Absstract of: WO2025160594A1
A method for immunizing a subject against a pathogen, comprising the steps of: (1) administering to the subject an effective amount of a prime vaccine, wherein the prime vaccine comprises one or more mRNA constructs encoding one or more immunogens from the pathogen; and (2) administering to the subject an effective amount of a boost vaccine, wherein the booster vaccine comprises a non-mRNA vaccine modality, such as a recombinant protein, against the pathogen, wherein the boost vaccine comprises the immunogen or immunogens encoded in one or more mRNA constructs in the prime vaccine, or wherein the boost vaccine comprises the immunogen or immunogens that are not the same as encoded in one or more mRNA constructs in the prime vaccine, wherein the boost vaccine is administered after the administration of the prime vaccine.
Absstract of: WO2025134071A1
Provided herein are ionizable or cationic lipids of Formula (I): (I), or pharmaceutically acceptable salts thereof. The ionizable or cationic lipids provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.
Absstract of: CN122701681A
本发明公开一种用于治疗缺血性脑卒中的纳米载药系统及其制备方法；所述纳米载药系统包括脂质纳米颗粒载体、负载的治疗活性物质以及表面修饰的第一靶向分子和第二靶向分子；治疗活性物质包括Zn2+依赖型脱氧核酶和疏水性抗炎药物姜黄素；第一靶向分子介导跨越血脑屏障，第二靶向分子引导靶向至脑缺血病灶；该载药系统利用缺血病灶区域Zn2+浓度显著升高的病理微环境特异性激活脱氧核酶，沉默NLRP3炎症小体基因表达，同时联合姜黄素清除活性氧，实现从早期氧化应激到后期神经炎症的阶段性协同治疗，有效提高脑卒中治疗效果并降低毒副作用。
Absstract of: CN122701651A
本发明涉及生物医用材料技术领域和骨关节炎治疗技术领域，具体涉及一种靶向软骨细胞的代谢重编程水凝胶系统及其制备方法与应用；制备步骤如下：（1）提取软骨细胞膜与FGF21共挤出制备靶向纳米颗粒；（2）合成普鲁士蓝纳米酶；（3）制备苯硼酸修饰透明质酸，与聚乙烯醇构建ROS响应型水凝胶基质；（4）将两种功能纳米颗粒负载于水凝胶前驱液中，交联得到复合水凝胶系统。本发明构建的水凝胶系统兼具软骨细胞同源靶向、ROS响应按需释放、炎症微环境重塑与细胞代谢重编程多重功能，可显著延长FGF21关节腔滞留时间、提升靶向富集效率，协同恢复软骨细胞精氨酸代谢稳态、修复软骨损伤、改善关节功能，生物相容性优异。
Absstract of: CN122701847A
本发明属于生物医药技术领域，具体涉及一种纳米融合膜疫苗在抗结核分枝杆菌感染中的应用，为含有纳米融合膜疫苗的药物或药物组合物在抗结核分枝杆菌感染中的应用，纳米融合膜疫苗的制备步骤为：制备结核分枝杆菌菌膜组分；制备大肠杆菌菌膜组分；制备PLGA聚合物纳米颗粒；制备结核病纳米融合疫苗。本发明基于严格的控制变量方法利用溶菌酶去除MTB细胞壁，并提取菌膜组分，将其以设定的比例与大肠杆菌菌膜融合后，通过纳米技术制备出的新型结核病纳米融合膜疫苗开展细胞和动物实验，发现该疫苗体外能够显著提高树突状细胞的成熟并刺激其产生细胞因子。
Absstract of: CN122705483A
本发明涉及一种ATP响应性脂质、核酸纳米制剂和制备方法。该ATP响应性脂质的结构式如下式(I)所示。本发明的ATP响应性脂质以及核酸纳米制剂在细胞内高水平ATP条件下，能够与ATP结合，增加膜的流动性，促进脂质纳米粒与内体膜的融合，破坏内体膜的完整性，增加溶酶体逃逸效率，进而提高核酸递送和表达效率。
Absstract of: CN122705435A
本申请公开了一种化合物，结构式如式(Ⅰ)所示，以及其药学上可接受的盐或其立体异构体，本申请还公开了一种包含上述化合物或其药学上可接受的盐或其立体异构体的纳米颗粒药物制剂，本申请的纳米颗粒对于粘膜组织有特异性靶向作用，可以高效递送药物、疫苗至细胞内，发挥药物、疫苗的治疗或预防目的。
Absstract of: CN122701683A
本申请公开了一种脂质纳米颗粒，其包含式(I)所示化合物、阳离子脂质、磷脂、结构脂质和PEG脂质。本申请脂质纳米颗粒相较于传统的四组分脂质纳米颗粒可以更高效地将活性成分递送至细胞内，发挥治疗或预防目的。(I)
Absstract of: WO2025046121A1
Disclosed is a lipid nanoparticle (LNP) encapsulating a nucleic acid cargo preferably comprising messenger ribonucleic acid (mRNA). The LNP comprises at least an ionizable lipid fraction, and a stabilizer fraction. The stabilizer fraction preferably comprises at least one polyethylenglycol (PEG) lipid. Furthermore, the ionizable lipid fraction comprises at least one ionizable glycerol dialkyl glycerol tetraether (GDGT) lipid. Also disclosed is a pharmaceutical composition comprising the LNP, such as an mRNA vaccine. In a further aspect, the invention relates to the ionizable GDGT lipids and methods for producing them.
Absstract of: WO2025040887A1
Described is a nanopore that is selectively convertible between an open form and a closed form using light, a method for producing such a nanopore, a method of modulating the flow of one or more substances through the nanopore, the use of the nanopore in modulating ionic flow across an amphiphilic membrane, a device comprising the nanopore, use of the nanopore as an ionotronic component, use of the nanopore in bio-computation and/or bioionotronics, a method of transmitting information using the nanopore, and method of receiving information comprising the nanopore, and an ionotronic component comprising the nanopore.
Absstract of: CN122701648A
本发明公开了一种用于治疗和改善日光性皮炎的汉黄芩素立方液晶纳米粒水凝胶的制备及其应用。本发明制备方法是先将汉黄芩素与GMO和F127制备成汉黄芩素立方液晶纳米粒，再加入羟苯甲酯、甘油、壳聚糖和乳酸制备成汉黄芩素立方液晶纳米粒水凝胶。该汉黄芩素立方液晶纳米粒水凝胶可用于治疗和改善日光性皮炎，且起效更快，外透皮能力强，能提供更久的药物渗透能力。
Absstract of: WO2025171237A1
Compositions comprising lipidoid compounds, methods of preparing such compositions, and the use of these compositions in gene delivery applications are disclosed.
Nº publicación: CN122681820A 04/09/2026
Applicant:
青岛大学迈赛凯尔（山东）生命科学有限公司
Absstract of: CN122681820A
本发明公开了工程化外泌体模拟脂质纳米颗粒及其制备方法和在制备促进老年肝脏再生的药物方面的应用。所述的工程化外泌体模拟脂质纳米颗粒包含作为载体的脂质体及其负载的蛋白质和miRNA；所述的miRNA包含hsa‑miR‑222‑3p、hsa‑miR‑221‑3p和hsa‑miR‑7‑5p，所述的蛋白质包含PGD、C3、COL1A1、AHCY、A2M、APOB和GLUL。其专门用于逆转肝脏衰老并恢复老年肝脏组织的结构与功能完整性。
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