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166
results.
Updated on
14/09/2026 [06:57:00]
Results 125 to 150 of 166
Absstract of: US20260209815A1
0000 Embodiments of the invention provide amperometric analyte sensors having elements selected to optimize enzymatic activities associated with such sensors including polymers functionalized with enzymatic mediators as well as methods for making and using such sensors. While embodiments of the invention can be used in a variety of contexts, typical embodiments of the invention include glucose or ketone sensors used in the management of diabetes.
Absstract of: US20260207136A1
0000 A system includes a wearable device and a charger case. The wearable device is configured to be positioned on an ear of a wearer, and includes first and second body portions and a connection member mechanically coupled to each of the first body portion and the second body portion. The first body portion and/or the second body portion includes a processor, a memory, and a sensor set including at least one of a pulse oximeter, a photoplethysmogram (PPG) sensor, an accelerometer, a temperature sensor, a proximity sensor, an ambient light sensor, or a gyroscopic sensor. The memory stores instructions to cause the processor to calculate at least one of a blood oxygen saturation level, a pulse rate, a blood pressure level, a blood flow rate, a cardiac output/rhythm, a blood sugar level, a blood carbon monoxide level, a blood nitrous oxide level, or an electrocardiogram of the wearer.
Absstract of: US20260207087A1
0000 Disclosed herein is a wearable device for continuous glucose monitoring including a housing having a top surface opposite a bottom surface. A portion of the top surface is moveable relative to the bottom surface. The bottom surface has an opening and is configured to secure directly to skin. A puck assembly has a sensor, a wire coupled to the sensor, and a plurality of contacts. A rigid member is configured to move relative to the bottom surface. An engagement member is configured to rotate about an axis. A cutting element is coupled to the engagement member. Displacement of the movable portion of the top surface moves the rigid member into contact with the engagement member. The cutting element rotates through the opening to form an incision in the skin then to a locked position within the housing. The sensor and the wire advance through the opening and into the incision.
Absstract of: US20260207096A1
Analyte sensors featuring an enzyme system comprising diaphorase and a NAD-dependent dehydrogenase may be utilized to detect inhibitors of diaphorase, provided that the transfer of electrons to a working electrode is rate-limiting with respect to the diaphorase. Such analyte sensors may comprise a sensor tail comprising at least a first working electrode, a first active area disposed upon a surface of the first working electrode, and an analyte-permeable membrane overcoating at least the first active area. The enzyme system comprises NAD, reduced NAD, or any combination thereof; a NAD-dependent dehydrogenase, such as NAD-dependent glucose dehydrogenase; and diaphorase. Inhibitors of diaphorase that may be detected include, for example, warfarin, dicoumarol, and similar compounds. A second active area may be present to facilitate detection of an analyte differing from the inhibitor of diaphorase.
Absstract of: WO2026154038A1
A computer implemented method of training a machine learning model configured for predicting a hypoglycemic event for a subject is proposed, comprising: i. (126) receiving at least two time series of glucose sensor data, wherein each time series of glucose sensor data comprises a plurality of glucose measurements measured by a glucose monitoring device (112) configured for detecting glucose in a bodily fluid of the subject, wherein a first time series of the two time series of glucose sensor data is measured at least during and/or after being exposed to a first predefined program of glycemic stimuli, and wherein a second time series of the two time series of glucose sensor data is measured at least during and/or after being exposed to a second predefined program of glycemic stimuli, wherein the second predefined program of glycemic stimuli is different from the first predefined program of glycemic stimuli; ii. (128) forming a first training dataset using the first time series and forming a second training dataset using the second time series; iii. (130) training the machine learning model with the first training dataset and the second training dataset.
Absstract of: WO2026152526A1
Provided is a refrigeration cup for an insulin pen in which an insulin cartridge is arranged. The refrigeration cup comprises a refrigeration assembly, a cold conduction cylinder (500), a cup lid (100), and a cup body (200). The refrigeration assembly comprises a semiconductor refrigeration sheet (401), a heat conduction member (402), and a heat dissipation fan (403). The semiconductor refrigeration sheet (401) comprises a cold end and a hot end, and the hot end is attached to the heat conduction member (402). The cold conduction cylinder (500) comprises a sealed end (501) and an open end (502), and the cold end is attached to the sealed end (501). The cup lid (100) is suitable for accommodating the refrigeration assembly. The sealed end (501) is relatively fixedly connected to the semiconductor refrigeration sheet (401) and/or the cup lid (100). The cup body (200) comprises a cup wall (201) and a heat preservation cavity (202) defined by the cup wall (201). The open end (502) extends into the heat preservation cavity (202), and the cup lid (100) detachably seals the heat preservation cavity (202). The cold conduction cylinder (500) or the heat preservation cavity (202) defines an accommodating space capable of accommodating at most one or two insulin pens. The accommodating space is also suitable for accommodating the insulin cartridge. The diameter of the accommodating space ranges from 20 mm to 50 mm. By means of limiting the size of the cold conduction cylinder (500), por
Absstract of: US20260211903A1
Integrated glucose monitoring systems, comprising a memory configured to store data relating to at least two glucose measurements of a user, a glucose safe range, and exogenous data. Wherein the at least two glucose measurements of the user are at different time points t1 and t2; a user interface comprising a display; and a processor comprising computer-executable instructions. Wherein the computer-executable instructions determine a rate of change based on the at least two glucose measurements of the user; determine, based on the at least two glucose measurements of the user and the determined rate of change, a projected glucose level at a future time t3; and provide an alarm at the user interface if, based on at least one point of exogenous data, the projected glucose level at future time t3 is outside of the glucose safe range.
Absstract of: WO2024250121A2
Provided are computer-implemented methods, systems and devices for generating a type-II (T2DM) diabetic status prediction, including: extracting voice biomarker feature values from the voice sample for predetermined voice biomarker features; determining the T2DM diabetic status prediction for the subject based on the biomarker feature values and the diabetic status prediction model; and outputting the T2DM diabetic status prediction for the subject. Provided are computer-implemented methods, systems and devices for generating a diabetic status model for predicting a T2DM diabetic status, including: diabetic status labels identifying a corresponding diabetic status for training subjects; and voice samples collected from the training subjects at different time points, each of the voice samples associated with a corresponding diabetic status label; determining voice feature values for corresponding voice features for each of the voice samples in the voice samples; and generating the diabetic status model based on the voice samples and the voice feature values.
Absstract of: CN224523104U
The utility model provides a diabetes detection analyzer which comprises a detector main body, a blood taking needle is inserted into the detector main body, a cleaning part is inserted into the detector main body, one end of the cleaning part is sleeved with a sanitary cotton sleeve, the cleaning part comprises a protective shell, and a liquid storage rod is inserted into the protective shell. An extrusion rod is inserted into a cavity of the liquid storage rod in a penetrating mode, one end of the extrusion rod is attached to the inner side wall of the protective shell, and a driving assembly for driving the extrusion rod to extrude liquid in an inner cavity of the liquid storage rod is inserted into the side wall of the detector body in a penetrating mode. At the moment, the extrusion rod pushes disinfection alcohol in the liquid storage rod into the protection shell and wets the sanitary cotton sleeve, disinfection treatment can be conducted on a patient, then blood sampling operation can be conducted, the operation process is simplified, the process is simpler and more convenient, the cleaning component and the detector body are integrally arranged, and the device is more portable.
Absstract of: CN224523718U
The utility model provides a squeezing and shaking structure for high-capacity insulin nutrient solution infusion, which comprises a hanging part used for hanging a three-liter bag, fixing a mounting part on an infusion support and hanging the three-liter bag on the hanging part, so that the mounting part pushes two rotating rollers to clamp the three-liter bag; according to the invention, the driving part drives the two rotating rollers to rotate and descend along the three-liter bag, so that the three-liter bag can be extruded, liquid in the three-liter bag can be fused, the hanging part is driven to rotate through the mounting part, and the hanging part can drive the three-liter bag to shake up and down; and meanwhile, the mounting part can push the rotating roller to move towards the three-liter bag in a reciprocating manner and can also shake the three-liter bag, so that liquid in the three-liter bag can be fully fused as much as possible, the situation that the liquid in the three-liter bag is not uniformly mixed and the concentration is not uniform is avoided as much as possible, and manpower is greatly saved.
Absstract of: CN122427864A
The invention discloses a serum-free medium for 3D culture of human mesenchymal stromal cells by using a bioreactor and a culture method. Firstly, a serum-free culture medium is disclosed and comprises a basic culture medium and an additive; the additives comprise human platelet lysate, bFGF (basic fibroblast growth factor), PDGF-BB (platelet derived growth factor-BB), N-acetylcysteine, L-ascorbic acid, human serum albumin, insulin, lysophosphatidic acid, human fibronectin, heparin sodium, DNA (deoxyribonucleic acid) enzyme and PF-68. The invention further discloses a method for culturing human mesenchymal stromal cells by using the serum-free culture medium. The serum-free culture medium is matched with a culture method, so that the amplification level and the cell viability of the hMSC can be greatly improved, meanwhile, the risks of cell shedding, agglomeration, viability reduction and insufficient dryness maintenance in the culture process can be reduced, high-viability, high-density, high-uniformity and amplifiable hMSC preparation is realized, and the production requirements of clinical-grade cell therapy products are met.
Absstract of: WO2018039642A1
Compounds of formula I, (I) or enantiomers thereof, metabolites thereof, derivatives thereof, deuterated derivatives thereof, halogenated derivatives thereof, prodrugs thereof, pharmaceutically acceptable salts thereof, N- oxides thereof, or a combination thereof, processes and intermediates for preparation thereof, compositions thereof, and uses thereof, are provided. Pharmaceutical compositions comprising a compound of formula I and a compound of Formula II: (IIa) (IIb) or enantiomers thereof, metabolites thereof, derivatives thereof, deuterated derivatives thereof, prodrugs thereof, pharmaceutically acceptable salts thereof, N-oxides thereof, or a combination thereof. Compositions and methods for improving the efficacy of DEX, or providing beneficial pharmacokinetic effects to DEX, comprising co-administering a compound of formula I or SARPO, and a compound of Formula II or DEX to a subject in need thereof, and dosage forms, drug delivery systems, methods of treatment thereof.
Absstract of: CN122405790A
The invention relates to the technical field of biomedical sensing and flexible electronics, in particular to a proteolytic enzyme response type sensor, a battery-free multiplexing wound monitoring patch and a preparation method and application of the battery-free multiplexing wound monitoring patch. The sensor is a proteolytic enzyme response type photonic crystal hydrogel, and comprises silicon dioxide nanoparticles and methacrylated gelatin in a mass ratio of (500-600): (30-90). The invention further discloses a battery-free multiplexing wound monitoring patch which comprises the proteolytic enzyme response type sensor. According to the proteolytic enzyme response type sensor disclosed by the invention, the PCH is used for carrying out specific response on the proteolytic enzyme, and the PCH is prepared by adopting a colloid self-assembly-in-situ photocuring one-step method; the monitoring patch can synchronously monitor four indexes of proteolytic enzyme activity, pH, glucose and D-lactic acid in the same patch, joint evaluation of wounds can be achieved without electrodes, and the accuracy of infection judgment is improved.
Absstract of: CN122404636A
The invention discloses a wearable hydrogel sensor and method for rapid detection of glucose concentration in sweat, the wearable hydrogel sensor is obtained by performing cold crosslinking and photo-crosslinking operation on a pre-gel solution, and the pre-gel solution contains a glucose response material adopting 3-acrylamido phenylboronic acid; the ion conductive material adopts sodium alginate; methacrylamide amidated gelatin is adopted as the temperature-sensitive material; the photo-crosslinking monomer material adopts acrylic acid; a photocrosslinking agent; and a photoinitiator. The cold cross-linking comprises the following steps: spraying the pre-gel solution to induce the pre-gel solution to instantly lose the temperature to form porous hydrogel with a porous skeleton, then carrying out photo-cross-linking through irradiation of an ultraviolet lamp to enable the porous hydrogel to generate a loose polymer network, and finally, removing a gelatin molecular skeleton and silicon dioxide particles through ablation to obtain the porous hydrogel. The porous network hydrogel with a submicron-micron composite pore structure and a loose polymer network is obtained. And soaking the porous network hydrogel in an ethylene glycol aqueous solution to obtain the wearable hydrogel sensor.
Absstract of: CN122399161A
Provided herein are devices, systems, and methods for removing preservatives/excipients/stabilizers from pharmaceutical preparations/medicaments. The devices and systems include a resin for filtering preservative from a pharmaceutical preparation. The method allows a pharmaceutical preparation to be incubated in a resin that effectively removes the preservative while maintaining a desired amount or concentration of the active compound in the preparation for a period of time. Also provided herein are devices, systems, and methods for controlled release of anti-inflammatory agents in insulin infusion devices.
Absstract of: CN122399156A
The invention discloses an automatic drug delivery device and system for diabetes double-stem cell treatment. The device comprises a drug delivery module and a control module, the drug delivery module comprises a first drug delivery unit and a second drug delivery unit; wherein the first administration unit is used for accommodating a first medicament; the first medicament comprises hematopoietic stem cells and a histone deacetylase inhibitor; the second drug delivery unit is used for containing a second drug; the second medicament comprises mesenchymal stem cells or a mesenchymal stem cell culture; the control module is used for acquiring first blood glucose data and first basic data of a target subject; determining a first administration scheme according to the first blood glucose data and the first basic data; according to the first administration scheme, controlling an administration module to carry out administration on the target subject; acquiring second blood sugar data of the target subject; and adjusting the first administration scheme according to the second blood glucose data to obtain a second administration scheme. By adopting the embodiment of the invention, the efficiency of sequential administration of diabetes mellitus is improved.
Absstract of: CN122398288A
The invention relates to the technical field of blood glucose monitoring, in particular to a non-invasive blood glucose monitoring device, circuit board and method based on a multi-modal sensor. The device comprises a sensing module, a power supply module, a control module and an upper computer, the sensing module comprises a photoelectric sensor, a light emitting unit, a metabolic heat sensor and a microneedle sensor; the metabolic heat sensor comprises a thermal radiation sensor, a temperature and humidity sensor and a cardiovascular photoelectric sensor; the power supply module comprises a 3.7 V lithium battery power supply circuit, a USB-5V power supply circuit, a 1.8 V power supply circuit and a 3.3 V power supply circuit; the control module comprises an integrated circuit bus, a serial peripheral interface, a system management bus, an asynchronous transceiving transmitter, Bluetooth and a microcontroller, and the control module is connected with the power supply module and the sensing module; the upper computer is in wireless communication connection with the control module, the device can avoid trauma, infection and pain during use, the long-term use cost is reduced, and a more comfortable and efficient new monitoring path is provided for daily management of diabetes.
Absstract of: CN122398303A
The invention relates to the technical field of diabetes mellitus detection, and discloses a diabetes mellitus rapid detection dodging device, which comprises a finger clip type noninvasive blood glucose detector, a locking assembly and a shading assembly, the locking assembly is arranged at the detection port of the finger clip type noninvasive blood glucose detector, and the shading assembly is arranged at the detection port of the finger clip type noninvasive blood glucose detector. The locking assembly comprises a fixing ring, a power rod, a rotating ring, multiple sets of clamping plates, multiple sets of connecting plates and a driving motor, the driving motor is in transmission connection with the power rod, the power rod is in meshing transmission with the rotating ring, the rotating ring is in transmission connection with the clamping plates through the connecting plates, and the shading assemblies are arranged on the two sides of the finger clamping type noninvasive blood glucose detector. The shading assembly comprises a first baffle and a second baffle, the second baffle is embedded in the first baffle in a sliding mode, the first baffle is connected with the lower portion of the finger clip type noninvasive blood glucose detector, and the second baffle is connected with the upper portion of the finger clip type noninvasive blood glucose detector.
Absstract of: CN122399167A
The invention discloses a portable insulin injection device, belongs to the technical field of medical instruments, and solves the problems that an existing insulin injection device lacks intelligent reminding and is poor in contact stability during injection. The portable insulin injection device comprises an insulin pen body push rod sliding part and a dose adjusting part, and a push rod is driven to move axially through rotation; the contact ring is detachably arranged on the periphery of the front end of the pen body in a sleeving mode, can axially slide and comprises an outer-layer silica gel anti-skid ring, a middle-layer memory metal elastic ring and an inner-layer plastic mounting ring, and a needle tube of the needle head assembly penetrates through a center hole of the contact ring and extends outwards; the pressure sensing layer is arranged on the surface of the silica gel anti-slip ring, a reminding module is arranged in the pen body or on the surface of the pen body and comprises a storage subunit for storing a preset injection time table, a timing subunit and a reminding subunit, and the reminding subunit sends out an injection reminding signal when timing reaches a preset time point. The device can intelligently remind a patient to inject on time, and the comfort degree and the positioning stability during injection are improved through the multi-layer structure contact ring.
Absstract of: CN224506014U
The utility model discloses a needle stick injury prevention type insulin pen and needle head which comprises a needle head, the needle head comprises a cover cap and a needle body, the needle body penetrates through the cover cap, and clamping grooves are symmetrically formed in the outer side of the cover cap; the insulin pen is provided with a rod piece, a clamping block is formed on the rod piece corresponding to the front end of the insulin pen and used for being clamped with the clamping groove so that the needle head can be fixed to the front end of the insulin pen, and a driving end is formed at the end, away from the clamping block, of the rod piece and used for driving the rod piece to move so as to control the clamping block to be separated from the clamping groove. The needle head can be quickly disassembled and assembled through clamping connection of the clamping groove and the clamping block, so that contact between a human body and the needle body is reduced, and the puncture risk is reduced.
Absstract of: CN224506025U
The utility model discloses an injection sounding structure and an injection structure of an insulin injection pen, and belongs to the technical field of medical instruments. Comprising an injection pen body; the driving tube is arranged in the injection pen body, the screw rod is arranged in the driving tube, and the driving tube rotates to drive the screw rod to rotate and forwards push the medicament bottle inner plug to perform injection action; elastic teeth protruding outwards are arranged on the outer wall of the driving tube, an annular thorn face is arranged on the inner wall of the injection pen body, and the elastic teeth and the annular thorn face are matched to form an injection sound production structure; in the injection process, the driving tube rotates and drives the elastic teeth to rotate along the annular thorn face, and the elastic teeth make contact with the annular thorn face to produce sound. Through cooperation of the elastic teeth and the annular thorn face, sound feedback is provided in the injection process, a user is helped to confirm the injection process, and the elastic teeth are integrated on the outer wall of the driving pipe, so that a clear visual field is achieved during assembly, and the problem that the elastic teeth are damaged due to the fact that the visual field is blocked during assembly is solved.
Absstract of: CN224505898U
The utility model relates to the technical field of infusion bottles, and discloses a self-discharging glucose injection infusion bottle body which comprises a bottle body and a suspension clasp fixed on the bottle body, the bottle body is composed of a bottle body, a bottle neck section and a bottle opening section, a liquid lifting assembly is fixedly connected to the inner wall of the bottle neck section, a first sealing film is arranged at the position of the bottle opening section in a sleeved mode, and a second sealing film is arranged at the position of the bottle opening section. A supporting sleeve is fixedly connected to the side wall of the first sealing film, and the supporting sleeve and one end of the liquid lifting assembly are arranged in a penetrating and sliding mode. According to the glucose injection bottle, through the arrangement of the liquid lifting assembly, when only a small amount of glucose injection is left in the bottle body, the elastic force of the isolation sleeve enables the contraction sliding sleeve to slide upwards along the outer wall of the supporting sleeve, the liquid level of the glucose injection in the bottle body is lifted, and residues of the glucose injection in the bottle body are greatly reduced; the first sealing film is protected and further fixed, and the protective cover does not need to be detached when a needle of the infusion apparatus is inserted.
Absstract of: CN122398289A
The invention discloses a blood glucose detection method based on a detection device, the detection device and electronic equipment, the device comprises a detection probe and a spectrograph, a connecting end is connected with the spectrograph, one end of a plurality of signal transmission channels forms a plurality of annular channel groups arranged in the radial direction at the detection end, and the other end of the signal transmission channels forms a plurality of annular channel groups arranged in the radial direction at the detection end. Each annular channel group comprises a plurality of signal transmission channels arranged around the axis of the detection probe, the other ends of the signal transmission channels in each annular channel group converge at the connecting end to form a signal port, and the signal ports corresponding to different annular channel groups are mutually independent; the method comprises the following steps: determining one of a plurality of signal ports as a transmitting port, and determining the rest of the signal ports as receiving ports; and controlling the spectrometer to emit near-infrared light to a detected object through the emission port, receiving multiple groups of near-infrared diffuse reflection spectrum data reflected by the detected object through the receiving ports, extracting blood glucose characteristic peak signals from the data, and inputting the blood glucose characteristic peak signals into a pre-constructed blood gluc
Absstract of: CN122398300A
The invention relates to the technical field of noninvasive blood glucose detection, and provides a noninvasive blood glucose estimation method based on a dual-wavelength photoelectric volume pulse wave signal. Aiming at the problems of insufficient stability and insufficient engineering implementation of the existing noninvasive blood glucose estimation, dual-wavelength PPG signals corresponding to 660nm red light and 880nm infrared light are collected at the same detection part of a human body, the signals are subjected to pretreatment and quality evaluation, features at least comprising pulse wave period features and frequency spectrum features are extracted and fused, and the non-invasive blood glucose estimation result is obtained. And then inputting the joint feature vector into a blood glucose estimation model based on regression calculation, and outputting a blood glucose estimation value according to a preset parameter or weight. The method is suitable for family health monitoring and blood glucose risk screening scenes.
Nº publicación: CN224505443U 17/07/2026
Applicant:
LI JIALI
\u674E\u4F73\u5229
Absstract of: CN224505443U
The utility model relates to a blood sampling structure, belongs to the technical field of glucometers, and particularly relates to a rapid blood sampling structure of a glucometer, which comprises a shell, detection test paper is arranged outside the shell, a blood sampling component is arranged inside the shell, and an ejection component is arranged inside the shell. According to the utility model, the ejector rod is pushed towards the inside of the fixing block, the position of the ejector rod is clamped through the positioning sliding block, when blood sampling is needed, the positioning sliding block is lifted upwards to be staggered with the side wall of the puncture needle, and the ejector rod and the puncture needle are pushed to move outwards through the elasticity of the ejection spring, so that the skin of a patient is punctured by the puncture needle; due to the fact that the tip end of the puncture needle is soaked in blood, the blood enters the capillary through hole through the communicating hole according to the capillary principle and finally drips on the side wall of the detection test paper through the tail end of the puncture needle, and the effect of automatically detecting the blood sugar of a patient is achieved. The problem that an existing blood glucose detection operation process is tedious is solved.
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