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59
results.
Updated on
15/07/2026 [08:33:00]
Absstract of: EP4772522A2
Disclosed herein are methods and compositions for detecting one or more pathogens that cause atypical pneumonia. Detectable pathogens include Mycoplasma pneumoniae, Chlamydophila pneumoniae, and Legionella pneumophila.
Absstract of: US20260168026A1
The present invention relates to a CRISPR-Cas-based composition for detection of Listeria monocytogenes and a Listeria monocytogenes detection method using same and, more specifically, to a composition for detection of Listeria monocytogenes, comprising a primer pair capable of specifically amplifying Listeria monocytogenes by isothermal amplification, a guide RNA, and a CRISPR-Cas protein, and a detection method using same.
Absstract of: WO2026121311A1
The present invention provides: a method for detecting an antibody against colibactin-producing bacteria in a subject; and a reagent or kit for detecting an antibody against colibactin-producing bacteria in a subject. Provided is a method for detecting an anti-colibactin-producing bacteria antibody in a sample, said method including a step for bringing the sample into contact with at least one of the lipopolysaccharides from among O2, O4, O6, O18, and O50 serotypes of Escherichia coli. Provided is a reagent or kit for detecting an anti-colibactin-producing bacteria antibody, said reagent or kit containing a sample and at least one of the lipopolysaccharides from among O2, O4, O6, O18, and O50 serotypes of Escherichia coli.
Absstract of: US20260146994A1
A system and method for detecting, enumerating, or extracting microorganisms in a sample is disclosed. Target microorganisms, such as Salmonella bacteria, may be of interest. Magnetic beads may be bound to the target microorganisms. After which, the bead-bound cells may be isolated. For example, a magnetic field may be applied in order to separate the target cells (with the magnetic beads attached thereto) and move then to a predetermined section of the well. Agar, or other immobilizing agent, may be added to the wells in order to immobilize the target cells. After which, the target cells are incubated and periodically analyzed to determine whether the target cells are growing, thereby indicating that the microorganisms are contained within the well.
Absstract of: US20260133191A1
Disclosed herein are compositions, devices, systems, and methods for detection of an amphiphile using visual inspection of a ligand-modified substrate. For example, disclosed herein are assays for detection of an amphiphile via visual inspection, the assay comprising a ligand-modified substrate and a film of lubricant disposed on the ligand-modified substrate. Also disclosed herein are methods of use of any of the assays disclosed herein. In some examples, the methods comprise contacting any of the assays disclosed herein with a liquid sample; tilting the assay; and visually inspecting the liquid sample disposed on the assay to determine a property of the liquid sample. In some examples, the amphiphile comprises a biological amphiphile, such as an endotoxin. In some examples, the biological amphiphile comprises an endotoxin secreted by a gram-negative bacteria, such as Escherichia coli.
Absstract of: EP4488391A1
The invention relates to methods for determining whether a sample comprises Legionella pneumophila, the method comprising performing an isothermal nucleic acid amplification (iNAAT) reaction, preferably loop-mediated isothermal amplification (LAMP), with said sample with a primer set specific for the Legionella pneumophila DotB or MIP gene and determining whether the sample comprises an amplification product of the amplification reaction. The invention further relates to primer sets specific for the Legionella pneumophila DotB or MIP gene that are useful in such method, and kits of part comprising such primer set.
Absstract of: EP4741805A1
0001 The current invention comprises systems and methods for the detection of food related bacteria, such as listeria, e. coli and s. aureus in a mobile and modular design. The combination of a dissolvable flexible cloth as sampling means, a multiple target sensor, smart readout optics and spectral processing enables to instantly ascertain, verify and validate the presence of specific microbes. The main application is the monitoring of the food and food production in order to prevent the coming to the market of bacteria invested products, such as fish, chicken or other food products destined for human consumption.
Absstract of: WO2025003117A1
The present invention relates to a gelled reaction medium for detecting, identifying, and/or isolating at least one Shiga toxin-producing strain of E. coli, the reaction medium comprising: - at least one toxin inducer, - at least one agglutinating conjugate comprising at least one specific binding partner of STX1 and/or at least one specific binding partner of STX2, coupled to a nanoparticle; - a concentration gradient of a compound for inhibiting non-target bacteria. The present invention also relates to the associated method for detecting and/or isolating Shiga toxin-producing E. coli which is likely to be present in a sample comprising enterobacteria.
Absstract of: WO2025003119A1
The invention relates to a method for detecting and confirming at least one Shiga toxin-producing Escherichia Coli (STEC) which may be present in a sample comprising enterobacteria, comprising the following steps: - performing lysis of the sample, enabling lysis of the STECs in order to obtain a solution comprising the nucleic acids thereof; - bringing the solution of nucleic acids into contact with primers, making it possible to amplify at least the stx1 and/or stx2 gene or gene fragment; - if at least one of the stx1 and/or stx2 genes or gene fragments is amplified, part of the sample is deposited on an agar reaction medium comprising ■ at least one toxin inducer, ■ at least one agglutinating conjugate formed by at least one binding partner specific to the STX1 protein and/or at least one binding partner specific to the STX2 protein, which binding partner(s) is (are) coupled to a nanoparticle; - detecting and confirming the presence of at least one STEC by the appearance of a halo on the agar around the STEC.
Absstract of: CN121975962A
The invention discloses a primer group for simultaneously detecting four equine digestive tract bacteria and application thereof, the primer group comprises primer sequences as shown in SEQ ID NO: 1-8, and the four equine digestive tract bacteria are salmonella enteritidis, salmonella typhimurium, clostridium difficile and lawsonia intracellular. Extracting total DNA (deoxyribonucleic acid) of a sample to be detected by using the excrement sample nucleic acid extraction kit; the total DNA is used as a template, and the primer group is used for multiple PCR reaction to obtain an amplification curve. According to the invention, a primer sequence with high sensitivity and specificity is adopted, so that the quality of a detection result is ensured; the detection method is simple to operate, time-saving and labor-saving; the detection flux is high, and the reagent consumable cost is low.
Absstract of: CN121975957A
The invention relates to a flora prediction model for detecting premature delivery risk and a kit and application thereof. Through early-stage mNGS data collection and analysis, premature related strains are obtained, and through a large number of experimental screening and optimization, a set of optimal primer probe group is finally determined. The invention relates to a premature delivery risk calculation method, which comprises the following steps of: selecting 12 floras, namely lactobacillus crispatus, lactobacillus gasseri, lactobacillus inertus, lactobacillus jensenii, escherichia coli, enterococcus faecalis, enterobacter aerogenes, group B hemolytic streptococcus, ureaplasma parvum, chlamydia trachomatis, diplococcus gonorrhoeae and gardnerella vaginalis, and establishing a fluorescent quantitative PCR (Polymerase Chain Reaction) method and a premature delivery risk calculation model aiming at the detection of the 12 floras. Compared with an existing detection method, the method is simple, convenient, rapid, high in sensitivity and high in specificity, the false positive and false negative risk is reduced, and the purpose of batch detection is achieved. Clinically, the change of microbial flora in the reproductive system of a pregnant woman can be rapidly detected, corresponding treatment measures are taken, the risk of PTB occurrence is reduced, and the kit has a good application prospect.
Absstract of: CN121975958A
The invention discloses a pseudomonas aeruginosa drug resistance gene detection primer group based on multiple PCR-time-of-flight mass spectrometry, a kit and a use method of the kit. The pseudomonas aeruginosa drug-resistant gene comprises armA, rmtB, rmtC, mexA, blaVIM, blaNDM, blaIMP, blaKPC, blaOXA and blaGES, and the pseudomonas aeruginosa drug-resistant gene is a drug-resistant gene of pseudomonas aeruginosa. The detection primer group comprises upstream and downstream amplification primers of each gene and a single-base extension primer; the nucleotide sequences of upstream and downstream amplification primers of each gene are respectively as shown in SEQ ID NO.1-NO.20; nucleotide sequences of single base extension primers of all the genes are shown as SEQ ID NO. 21 to NO. 30 respectively. By adopting the kit comprising the primer group, whether pseudomonas aeruginosa infection exists or not can be known within 40 minutes, and if the pseudomonas aeruginosa infection exists, the drug resistance condition of the pseudomonas aeruginosa can be known. The detection method has high sensitivity and specificity in the detection process, the sample detection accuracy rate can reach 92-97%, and the method can be used for rapid, accurate, high-sensitivity and high-throughput detection of the pseudomonas aeruginosa antibiotic-resistant strains and is beneficial to application and popularization in laboratories of hospitals and grass-roots departments.
Absstract of: MX2025013800A
Disclosed herein are methods and systems for rapid detection of microorganisms in a sample. A genetically modified bacteriophage is also disclosed which comprises an indicator gene in the late gene region. The specificity of the bacteriophage, such as Salmonella-specific bacteriophage, allows detection of a specific microorganism, such as Salmonella spp. and an indicator signal may be amplified to optimize assay sensitivity.
Absstract of: CN121950996A
The invention discloses a bacterium visual detection and in-situ quantitative sterilization method and application, and relates to the field of bacterium detection and sterilization. According to the method, liquid crystal double-emulsion (LCDE) is taken as a carrier, hCG, alpha-amylase and kanamycin are loaded, and bacterium visual detection and in-situ quantitative sterilization are realized by combining a host-guest competition effect and a pregnancy test strip (PTS). The pyrene-modified single strand and the LPS aptamer are hybridized to form double strands, when a target (LPS or bacteria) exists, the aptamer is specifically bound with the double strands to release the pyrene-modified single strand, the pyrene-modified single strand competes to occupy a beta-CD cavity and release CTAB, and the stability of an LCDE interface is destroyed to release an internal drug carrier; exo I shears single-stranded DNA, alpha-amylase hydrolyzes beta-CD, and the Exo I and the alpha-amylase synergistically amplify signals. The technology is excellent in detection performance, the LPS detection limit reaches 0.8 ng/mL, and the escherichia coli detection limit is 1.2 CFU/mL; the kanamycin is released according to needs, the sterilization rate exceeds 80%, the problems of environmental pollution and drug resistance caused by excessive drugs can be avoided, operation is easy and convenient, stability is good, and the method has great application value in multiple fields.
Absstract of: CN121955376A
The invention discloses a preparation method of a ratio type electrochemical luminescence biosensor, the sensor and application of the sensor in detection of escherichia coli O157: H7, and relates to the technical field of nano materials and biological detection. The sensor provided by the invention comprises an Aptamer-Templet double-strand body, a phi29 polymerase, a Nb.BbvCI nicking enzyme, a probe 1 and a probe 2, wherein the probe 1 and the probe 2 are connected with each other; the method comprises the following steps: specifically recognizing surface protein of escherichia coli O157: H7, releasing a Templet chain, releasing a Trigger chain and opening a hairpin structure of a probe 1 under the assistance of polymerase and cutting enzyme, and opening a hairpin structure of a probe 2 by the opened probe 1, so that self-assembly of the probe 1 and the probe 2 is realized, and a detectable object is obtained; the detection limit of the sensor to escherichia coli O157: H7 is as low as 1 CFU/mL, and the sensor is wide in linear range, high in stability, suitable for multiple samples, high in specificity and easy and convenient to use and operate.
Absstract of: CN121951013A
The invention discloses a method for detecting food-borne pathogenic bacteria based on Argonaute protein in combination with loop-mediated isothermal amplification and electrochemical biosensing, and belongs to the technical field of microbiological detection and biosensing. The integrated detection method based on Argonaute protein, loop-mediated isothermal amplification and electrochemical biosensing, which is high in sensitivity, strong in specificity, simple and convenient to operate and suitable for on-site rapid detection, is provided aiming at the problems that an existing food-borne pathogenic bacterium detection method is insufficient in sensitivity, depends on complex instruments, is difficult to apply on site and the like. Target nucleic acid is subjected to exponential amplification through LAMP (loop-mediated isothermal amplification), then Argonaute-mediated two-stage specific recognition and signal transduction are performed, and finally reading is performed through a high-sensitivity electrochemical platform, so that the detection limit of salmonella typhimurium as high as 1 CFU/mL is realized, and the detection range can cover 100-108 CFU/mL.
Absstract of: CN121950481A
The invention relates to the technical field of biomedicine detection, and discloses a biomedicine-based salmonella detection instrument and method for livestock and poultry breeding, the biomedicine-based salmonella detection instrument comprises a detection table and an electron microscope mounted at the upper end of the middle part of the detection table, a conveying assembly is arranged at the upper end of the detection table, and the conveying assembly is used for continuously feeding a culture dish; and the conveying assembly comprises two groups of rotating rods connected with the detection table. According to the salmonella detection instrument and method for livestock and poultry breeding based on biomedicine, stable power is provided for the conveying assembly through the first motor, and continuous and automatic conveying of culture dishes is achieved in cooperation with transmission of a synchronous belt wheel and a feeding belt; the feeding assembly synchronously completes accurate feeding of single culture dishes through the power of the conveying assembly by means of linkage of a driving belt wheel, a driven belt wheel and a transmission belt, a power source does not need to be additionally arranged, the structure is simplified, and meanwhile cooperation and consistency of the feeding rhythm and the conveying rhythm are achieved; and the detection requirements of large-batch salmonella in large-scale livestock and poultry breeding are effectively met.
Absstract of: CN121955375A
The invention discloses a preparation method of an SERS (Surface Enhanced Raman Scattering) sensor based on oversized annular DNAzyme, a product and application of the SERS sensor in escherichia coli O157: H7 detection, and relates to the technical field of nano materials and biological detection. The SERS sensor disclosed by the invention comprises an aptamer, namely a Key chain-Link chain three-chain body, an LDNAzyme-Block chain double-chain body, an rA Hairpin, an Au-H1 Hairpin probe, an H2 Hairpin probe and an AuNPs-H3 Hairpin probe, and the SERS sensor disclosed by the invention is characterized in that the SERS sensor comprises an aptamer, namely a Key chain-Link chain three-chain body, an LDNAzyme-Block chain double-chain body, an rA Hairpin probe and an AuNPs-H3 Hairpin probe; in the presence of escherichia coli O157: H7, a bimorphic gold nano assembly probe can be formed; the preparation method of the SERS sensor is simple and easy to control, the bimorphic gold nano assembly probe formed after target recognition has a Y-shaped structure with 3D space constraint, the stability is high, the detection operation on escherichia coli O157: H7 is simple and convenient, the sensitivity is high, the detection limit is low, and the specificity is high.
Absstract of: CN121951097A
The invention relates to a primer and probe combination for simultaneously detecting urinary tract klebsiella pneumoniae, escherichia coli and drug-resistant genes through nested PCR (Polymerase Chain Reaction) and a kit of the primer and probe combination, which are characterized in that a phoE target gene is selected for primer and probe design to ensure that cross amplification of related bacteria is not caused, so that the detection specificity requirement of actual klebsiella pneumoniae is met; the Klebsiella pneumoniae and the escherichia coli can be identified at the same time, the source of the drug-resistant gene KPC can be judged, and the method is very important for clinical precise diagnosis and treatment.
Absstract of: CN121951093A
The invention relates to the technical field of biology, in particular to a rapid detection kit for bacterial food-borne pathogenic microorganisms and application of the rapid detection kit. The invention develops a primer probe combination kit for detecting food-borne bacteria salmonella, staphylococcus aureus, vibrio parahaemolyticus, listeria monocytogenes, escherichia coli O157 and clostridium perfringens through optimization of primers, optimization of hydrogel components and a system and the like. The primer probe combination kit is used for detecting food-borne bacteria salmonella, staphylococcus aureus, vibrio parahaemolyticus, listeria monocytogenes, escherichia coli O157 and clostridium perfringens. The kit is used for detecting salmonella, staphylococcus aureus, vibrio parahaemolyticus, listeria monocytogenes, Escherichia coli O157 and clostridium perfringens. The kit is high in sensitivity and specificity, strong in anti-interference capability, excellent in stability and portability, rapid and efficient in detection, simple and convenient to operate and low in cost, and can realize result visualization and relative quantification, so that the kit has wide application prospects and values.
Absstract of: CN121927707A
The invention relates to a micro-fluidic chip capable of simultaneously detecting multiple food-borne pathogenic bacteria as well as a preparation method and application of the micro-fluidic chip, in particular to detection of the food-borne pathogenic bacteria, and belongs to the technical field of analysis and detection. The device comprises a functionalized glass slide, a PDMS chip layer and a copper net, the functionalized glass slide is located at the bottommost layer, and a PDMS chip layer in plasma bonding connection is arranged on the functionalized glass slide; a plurality of through holes are formed in the PDMS chip layer, and a copper net is placed in each through hole; a plurality of round holes with the same diameter are formed in the copper net. The micro-fluidic chip is prepared through preparation of a functionalized glass slide, preparation of a PDMS chip layer, preparation of a detection unit and training of a deep learning model and is used for detecting various food-borne pathogenic bacteria at the same time. The liquid crystal biosensor provided by the invention has the advantages of simplicity, portability, rapidness, sensitivity, low cost, no mark, visualization and the like. The method has a good practical application prospect in the fields of rapid detection and the like.
Absstract of: CN121931266A
The invention provides a primer probe combination, a kit, a nucleic acid detection method and application, and relates to the technical field of biochemical detection. The primer probe combination comprises a first primer pair and a first probe, wherein the first primer pair and the first probe are used for specifically amplifying pseudomonas aeruginosa; the second primer pair and the second probe are used for specifically amplifying enterococcus; the third primer pair and the third probe are used for specifically amplifying staphylococcus aureus; the fourth primer pair and the fourth probe are used for specifically amplifying the salmonella enterica. According to the primer and probe combination, a specific nucleotide sequence is utilized, efficient and accurate recognition of pseudomonas aeruginosa, enterococcus, staphylococcus aureus and salmonella enterococcus is achieved in a complex intestinal environment, and non-specific interference is effectively avoided; meanwhile, synchronous quantitative detection of four pathogens is supported, the detection efficiency is remarkably improved, and an accurate and sensitive detection means is provided for rapid clinical evaluation of flora conditions.
Absstract of: CN121917621A
The invention discloses application of electrochemical active bacteria sensitive to organochlorine pollutants in detection of water quality biotoxicity, and belongs to the technical field of water quality biotoxicity detection.After a bacteria solution of the electrochemical active bacteria is exposed in toxic pollutants, the water quality biotoxicity is determined according to an electric signal inhibition rate; the toxic pollutants are organic chlorine pollutants; the electrochemical active bacterium is a pseudomonas genus, and specifically, the pseudomonas genus is Pseudomonas lopnurensis or Pseudomonas delhiensis. The invention further discloses a preparation method of the electrochemical active bacterium. The method provided by the invention is expected to improve the sensitivity of determining the biotoxicity of the organic chlorine pollutants, overcome the application bottleneck of low sensitivity, and provide technical support for biotoxicity monitoring work.
Absstract of: CN121917619A
The invention belongs to the technical field of harmful microorganism detection, and particularly provides an electrochemical sensor for detecting escherichia coli (escherichia coli O157: H7) in food and a preparation method of the electrochemical sensor. According to the electrochemical sensor, the surface of a substrate electrode is sequentially modified with an electron transduction layer and a recognition molecular layer; wherein the electron transduction layer is formed by an infinite coordination polymer composite material of gold nanoparticles; the recognition molecular layer is a nucleic acid aptamer. The electrochemical sensor is high in sensitivity, good in selectivity and low in detection limit; compared with other detection methods, the method does not need incubation and can be directly used for in-situ and rapid detection of bacteria.
Nº publicación: CN121915177A 24/04/2026
Applicant:
BEIJING HUAXIN NONGWEI BIOTECHNOLOGY CO LTD
BEIJING UNIV OF AGRICULTURE
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Absstract of: CN121915177A
The invention belongs to the technical field of microbiological detection, and particularly relates to a primer and a method for detecting salmonella and a drug-resistant gene thereof and application of the primer and the method. The gene of the salmonella is invA, and the drug resistance genes are blaCTX-M, blaNDM-1, blaTEM-1 and blaOXA; the gene of the salmonella is invA, and the drug resistance genes of the salmonella are blaCTX-M, blaNDM-1, blaTEM-1 and blaOXA; the primers comprise inner primers and outer primers of invA, blaCTX-M, blaNDM-1, blaTEM-1 and blaOXA, a primer group is designed according to conserved regions of a salmonella invA gene and part of beta-lactam drug-resistant genes blaNDM-1, blaTEM-1, blaOXA and blaCTX-M, a detection method of SYBR-LAMP and HNB-LAMP technologies is established, and screening of part of beta-lactam drug-resistant genes carried by animal-derived pathogenic strains is realized.
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