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Solicitudes publicadas en los últimos 60 días / Last 60 days publications
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Compounds and methods for reducing snca expression

Publication No.:  NZ763247A 29/08/2025
Applicant: 
IONIS PHARMACEUTICALS INC
IONIS PHARMACEUTICALS INC
MX_2025006917_A

Absstract of: NZ763247A

Provided are compounds, methods, and pharmaceutical compositions for reducing the amount or activity of SNCA mRNA in a cell or animal, and in certain instances reducing the amount of alpha-synuclein protein in a cell or animal. Such compounds, methods, and pharmaceutical compositions are useful to ameliorate at least one symptom or hallmark of a neurodegenerative disease. Such symptoms and hallmarks include motor dysfunction, aggregation of alpha-synuclein, neurodegeneration, cognitive decline and dementia. Such neurodegenerative diseases include Parkinson’s disease, dementia withLewy bodies, diffuse Lewy body disease, pure autonomic failure, multiple system atrophy, neuronopathic Gaucher’s disease and Alzheimer’s disease.

Treatment of neurological diseases

Publication No.:  NZ753881A 29/08/2025
Applicant: 
UNIV OF LANCASTER
University of Lancaster
US_2022033457_A1

Absstract of: NZ753881A

Aspects and embodiments of the present invention relate to the treatment of neurological disorders such as for example, Alzheimer’s disease and Parkinson’s disease. Particularly, certain embodiments relate to GIP/GLP-1 co-agonist peptides for use in the treatment of these two neurological disorders. Also included in the present invention are inter alia pharmaceutical compositions comprising the GIP/GLP-1 co-agonist peptides, together with methods of treating such disorders as well as other subject matter.

Composition for preventing improving or treating Alzheimer's dementia comprising freshwater fish hydrolysates

Publication No.:  KR20250129577A 29/08/2025
Applicant: 
국립강릉원주대학교산학협력단
KR_20250129577_PA

Absstract of: KR20250129577A

본 발명은 담수어 가수분해물을 포함하는 알츠하이머성 치매의 예방, 개선 또는 치료용 조성물에 관한 것으로, 보다 상세하게는, 본 발명의 가물치, 동자개, 메기, 무지개송어, 붕어, 쏘가리, 잉어, 향어, 미꾸라지, 또는 빙어 등의 담수어의 효소 가수분해물, 상기 가수분해물로부터 얻은 분획물, 상기 분획물로부터 분리한 펩타이드는 우수한 β-세크레타제 저해 활성을 가지므로, 이들을 알츠하이머성 치매의 예방, 개선 또는 치료를 위한 의약, 식품 등에 활용할 수 있다.

TAU BINDING MOLECULES

Publication No.:  US2025270301A1 28/08/2025
Applicant: 
GEN2 NEUROSCIENCE LTD [GB]
Gen2 Neuroscience Limited
US_2025270301_PA

Absstract of: US2025270301A1

The invention relates to isolated recombinant peptides comprising an epitope from human tau 2N4R. The invention also relates to antibodies, specific for isolated recombinant peptides comprising an epitope from human tau 2N4R and to such antibodies for use in investigation, diagnosis and treatment of tauopathies, such as Alzheimer's disease.

METHODS OF TREATING NEUROLOGICAL, METABOLIC, AND OTHER DISORDERS USING ENANTIOPURE DEUTERIUM-ENRICHED PIOGLITAZONE

Publication No.:  US2025268879A1 28/08/2025
Applicant: 
POXEL SA [FR]
Poxel SA
US_2025268879_A1

Absstract of: US2025268879A1

The invention provides enantiopure deuterium-enriched pioglitazone, pharmaceutical compositions, and methods of treating neurological disorders, cancer, respiratory disorders, metabolic disorders, and other disorders using enantiopure deuterium-enriched pioglitazone. A preferred aspect of the invention provides methods of treating Alzheimer's disease, non-small cell lung cancer, hepatocellular carcinoma, and chronic obstructive pulmonary disease using enantiopure deuterium-enriched pioglitazone.

Methods of Using RHO Kinase Inhibitors to Treat Alzheimer's Disease

Publication No.:  US2025268911A1 28/08/2025
Applicant: 
WOOLSEY PHARMACEUTICALS INC [US]
Woolsey Pharmaceuticals, Inc
US_2025268911_A1

Absstract of: US2025268911A1

Disclosed are methods of treating patients with AD using a rho kinase inhibitor. A preferred rho kinase inhibitor used according to the invention is fasudil, which is typically administered orally in a total daily dose of 70-140 mg. A preferred dosing regimen involves administering the daily dose in three equal portions throughout the day. Preferred methods continue for more than one month and typically at least 2 or 3 months. Some preferred methods do not treat mild cognitive impairment and patients have and MMSE score of ≤23 and/or a CDR-SOB score of ≥4.5.

OXAFURAMINE, (1R)-N-ETHYL-1-(2R)-OXOLAN-2-YL-2-PHENYLETHANAMINE, HYDROCHLORIDE AND DERIVATIVES THEREOF FOR TREATING ALZHEIMER'S DISEASE (AD), VASCULAR DEMENTIA, DEMENTIA WITH LEWY BODIES (DLB), MIXED DEMENTIA, FRONTOTEMPORAL LOBAR DEGENERATION (FTLD), AND PARKINSON'S DISEASE (PD)

Publication No.:  US2025268859A1 28/08/2025
Applicant: 
NLS PHARMACEUTICS AG [CH]
NLS Pharmaceutics AG
US_2025268859_PA

Absstract of: US2025268859A1

The invention concerns a compound of formula (I) (I) R1═H, —CH3 or acyl group, preferably R1═—CH3R2═H or halogen atom selected in the group consisting of: F, Cl, Br, I, preferably R2═H or a pharmaceutically acceptable isomer, salt and/or solvate thereof, for use in preventing and/or treating neurodegenerative diseases when central muscarinic neurotransmission is compromised, wherein said neurodegenerative disease is selected in the group consisting of Alzheimer's Disease (AD), vascular dementia, Dementia with Lewy bodies (DLB), mixed dementia, frontotemporal lobar degeneration (FTLD), and Parkinson's disease (PD).

METHODS, APPARATUSES AND SYSTEMS FOR INSTILLING STEM CELLS AND PHARMACEUTICALS INTO THE HUMAN VENTRICULAR SYSTEM

Publication No.:  US2025268822A1 28/08/2025
Applicant: 
REGENERATION BIOMEDICAL INC [US]
Regeneration Biomedical, Inc
US_2025268822_PA

Absstract of: US2025268822A1

The METHODS, APPARATUSES AND SYSTEMS FOR INSTILLING STEM CELLS AND PHARMACEUTICALS INTO THE HUMAN VENTRICULAR SYSTEM (hereinafter “Ventricular Stem Cell System” or “VSCS”) disclosed herein provide safe and effective techniques for obtaining stem cells and instilling any type of stem cell or pharmaceutical agents into the human ventricular system for treatment of various diseases, including neurodegenerative diseases such as Parkinson's, Alzheimer's, Multiple Sclerosis, and others.

COMPOSITIONS AND METHODS FOR TREATMENT AND/OR PROPHYLAXIS OF PROTEINOPATHIES

Publication No.:  US2025268982A1 28/08/2025
Applicant: 
REGAIN THERAPEUTICS SWEDEN AB [SE]
REGAIN THERAPEUTICS SWEDEN AB
US_2025268982_PA

Absstract of: US2025268982A1

Non-aggregating protein analogues of proteins involved in a proteinopathy, for example Alzheimer's disease, are provided. The protein has a beta-sheet aggregation domain, and the non-aggregating protein analogue has a beta-sheet destabilizing modification in the beta-sheet aggregation domain but substantially retains wild type protein function. The beta-sheet destabilizing modification can be a substitution of a naturally occurring amino acid for a non-naturally occurring amino acid. Methods of treating a proteinopathy using the non-aggregating protein analogues and methods of designing a non-aggregating protein analogue are provided.

METHODS AND COMPOSITIONS FOR MODULATION OF TAU PROTEINS

Publication No.:  US2025268981A1 28/08/2025
Applicant: 
SANGAMO THERAPEUTICS INC [US]
Sangamo Therapeutics, Inc
US_2025268981_PA

Absstract of: US2025268981A1

The present disclosure is in the field of diagnostics and therapeutics for Alzheimer's Disease.

COMPOSITION FOR PREVENTING OR TREATING DETERIORATION IN BRAIN FUNCTION OR MAINTAINING OR IMPROVING BRAIN FUNCTION

Publication No.:  US2025268952A1 28/08/2025
Applicant: 
OTSUKA PHARMACEUTICAL CO LTD [JP]
TOKYO INSTITUTE OF TECH [JP]
OTSUKA PHARMACEUTICAL CO.,LTD,
TOKYO INSTITUTE OF TECHNOLOGY
US_2025268952_PA

Absstract of: US2025268952A1

The present invention aims to provide a method for evaluating dementia and a composition for preventing or treating deterioration in brain function, or for maintaining or improving brain function, and compared the gut microbiota of healthy individuals, individuals with mild cognitive impairment, and individuals with Alzheimer's disease. As a result, gut microorganisms were selected, such as microorganisms belonging to the genus Faecalibacterium, that are associated with cognitive function. Furthermore it was revealed that Faecalibacterium prausnitzii, possessing specific DNA, exhibited an improvement effect against brain function deterioration, such as learning and memory disorders.

USE OF EXTRACT FROM RABBIT SKIN INFLAMED BY VACCINIA VIRUS IN TREATMENT OF ALZHEIMER'S DISEASE

Publication No.:  US2025268946A1 28/08/2025
Applicant: 
ZODIAC BIO TECH LTD [CN]
ZODIAC BIO-TECH LIMITED
US_2025268946_PA

Absstract of: US2025268946A1

The present invention relates to the therapeutic use of extract from rabbit skin inflamed by vaccinia virus. More specifically, the present invention relates to the use of extract from rabbit skin inflamed by vaccinia virus for treating Alzheimer's disease. In addition, the present invention relates to the use of extract from rabbit skin inflamed by vaccinia virus for protecting neurological function of the brain or alleviating damage to neurological function of the brain in a patient suffering from Alzheimer's disease. In addition, the extract from rabbit skin inflamed by vaccinia virus can be Lepalvir.

METHODS FOR DIAGNOSIS AND TREATMENT OF ALZHEIMER'S DISEASE

Publication No.:  US2025270618A1 28/08/2025
Applicant: 
THE CHILDRENS MEDICAL CENTER CORP [US]
The Children's Medical Center Corporation
WO_2022192019_PA

Absstract of: US2025270618A1

Provided herein are methods for diagnosing and treating Alzheimer's disease in a subject comprising determining the expression level of three, four or five members of a panel of proteins in a biological sample obtained from the subject.

SYNAPTOSOMAL MICRO RNAS AND SYNAPSE FUNCTIONS IN ALZHEIMER'S DISEASE

Publication No.:  US2025270565A1 28/08/2025
Applicant: 
TEXAS TECH UNIV SYSTEM [US]
Texas Tech University System
WO_2023205354_PA

Absstract of: US2025270565A1

Embodiments of the present disclosure pertain to methods of treating or preventing a neurological disorder in a subject by administering to the subject at least one microRNA (miR-NA), at least one inhibitor of the miRNA, or combinations thereof. Additional embodiments of the present disclosure pertain to compositions that include at least one miRNA of the present disclosure, at least one inhibitor of the miRNAs of the present disclosure, or combinations thereof. In some embodiments, the composition is suitable for use in treating or preventing a neurological disorder in a subject.

1-(CYCLOBUTANEMETHYLIDENE)-2, 4, 5-TRIMETHOXYBENZENE COMPOUND AND PREPARATION METHOD AND USE THEREOF

Publication No.:  US2025270159A1 28/08/2025
Applicant: 
CHENGDU XINRUI TAIKANG TECH CO LTD [CN]
CHENGDU XINRUI TAIKANG TECHNOLOGY CO., LTD
CN_118851892_PA

Absstract of: US2025270159A1

A 1-(cyclobutylidenemethyl)-2,4,5-trimethoxybenzene compound and a preparation method and use thereof are provided, belonging to the field of drug development technology. The prepared 1-(cyclobutylidenemethyl)-2,4,5-trimethoxybenzene compound may be used for the preparation of an antiepileptic drug and drugs for treatment and/or prevention of traumatic craniocerebral injury disorders, ischemic stroke, hemorrhagic stroke, and Parkinson's disease.

PROBIOTIC FORMULATION FOR PREVENTING OR TREATING ALZHEIMER'S DISEASE AND USE THEREOF

Publication No.:  WO2025175626A1 28/08/2025
Applicant: 
SHENZHEN INSTITUTES OF ADVANCED TECH CHINESE ACADEMY OF SCIENCES [CN]
\u4E2D\u56FD\u79D1\u5B66\u9662\u6DF1\u5733\u5148\u8FDB\u6280\u672F\u7814\u7A76\u9662
WO_2025175626_PA

Absstract of: WO2025175626A1

Provided are a probiotic formulation for preventing or treating Alzheimer's disease and use thereof. The microorganisms in the probiotic formulation consist of Akkermansia muciniphila and Bifidobacterium breve. Akkermansia muciniphila and Bifidobacterium breve can coordinate with each other after being compounded, so as to provide a synergistic effect on alleviating Alzheimer's disease and thereby a new strategy for preventing or treating Alzheimer's disease. Since Akkermania muciniphila and Bifidobacterium breve are both probiotics, a related functional product prepared from Akkermania muciniphila and Bifidobacterium breve may feature good safety and less likelihood of inducing resistance.

DUAL VECTOR SELF-INACTIVATING CRISPR/CAS9 SYSTEM

Publication No.:  WO2025179044A1 28/08/2025
Applicant: 
LI CHENJIAN [US]
ZHENG SUSHUANG [US]
LI, Chenjian,
ZHENG, Sushuang
WO_2025179044_PA

Absstract of: WO2025179044A1

A self-inactivating CRISPR/Cas9 delivery system utilizing a dual vector system may be provided. A first viral vector includes an expression unit for expression of a Cas9 nuclease and a nucleotide sequence encoding an sgRNA targeting a specific genomic locus. The second viral vector includes a nucleotide sequence encoding an sgRNA targeting expression of the Cas9 nuclease by the expression unit. The self-inactivating CRISPR/Cas9 dual vector delivery system can be used for treating a genetic gene-associated disease/disorder and/or a sporadic gene-associated disease/disorder. In embodiments, the disease and/or disorder may be a neurological disease and/or disorder. In embodiments, neurological disease and/or disorder may be Huntington's disease. Methods of treatment, medicaments, and pharmaceutical compositions may be provided.

BIOMARKERS, COMPOSITIONS, KITS, AND METHODS DISTINGUISHING ACUTE GERIATRIC TBI FROM PRE-EXISTING DEMENTIA OR COGNITIVE IMPAIRMENT

Publication No.:  WO2025179300A1 28/08/2025
Applicant: 
BRAINBOX SOLUTIONS INC [US]
BRAINBOX SOLUTIONS, INC
WO_2025179300_PA

Absstract of: WO2025179300A1

Methods, compositions, and kits are capable of detecting, identifying, diagnosing, prognosing, assessing, monitoring, and/or treating a neurological injury such as acute TBI and distinguishing geriatric TBI from conditions such as dementia, Alzheimer's Disease, Parkinson's disease and the like. Also disclosed are methods of testing elderly patients who have or are suspected of having traumatic brain injury using panels of biomarkers that distinguish TBI from dementia, and, optionally, treating such patients for TBI or dementia based upon the results of the biomarker tests.

3TC TABLETS FOR TREATING ALZHEIMER'S DISEASE AND RELATED TAUOPATHIES

Publication No.:  WO2025179301A1 28/08/2025
Applicant: 
BOARD OF REGENTS THE UNIV OF TEXAS SYSTEM [US]
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
WO_2025179301_PA

Absstract of: WO2025179301A1

Embodiments are directed to methods for treating neurodegenerative disease by administering anti-viral compounds to subjects having or at risk of developing neurodegenerative diseases such as Alzheimer's disease.

ANTI-ABETA ANTIBODY, ANTIGEN-BINDING FRAGMENT THEREOF AND APPLICATION THEREOF

Publication No.:  US2025270303A1 28/08/2025
Applicant: 
JIANGSU HENGRUI MEDICINE CO LTD [CN]
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD [CN]
Jiangsu Hengrui Medicine Co., Ltd,
Shanghai Hengrui Pharmaceutical Co., Ltd
MX_2025002838_A

Absstract of: US2025270303A1

Murine, chimeric or humanized anti-Abeta antibody having a specific CDR region, an antigen-binding fragment thereof, a pharmaceutical composition thereof, and usage thereof. Use of a humanized anti-Abeta antibody for the preparation of drugs for the treatment of a disease or disorder (such as Alzheimer's disease) caused by amyloid beta protein.

MULTICOMPARTMENT COMPOSITIONS IN THE TREATMENT OF PARKINSON'S DISEASE

Publication No.:  WO2025176317A1 28/08/2025
Applicant: 
LAXXON MEDICAL AG [CH]
LAXXON MEDICAL AG
WO_2025176317_A1

Absstract of: WO2025176317A1

The present invention relates to a solid composition for use in the treatment of Parkinson's disease comprising at least two compartments, a first active pharmaceutical ingredient (API) and a second API, preferably for increasing uptake of the second API and reducing side effects associated with the treatment of Parkinson's disease.

CONDENSED PYRAZINES OR PYRIMIDINES ALS TREM2 AGOONISTS

Publication No.:  WO2025176748A1 28/08/2025
Applicant: 
F HOFFMANN LA ROCHE AG [CH]
HOFFMANN LA ROCHE INC [US]
F. HOFFMANN-LA ROCHE AG,
HOFFMANN-LA ROCHE INC
WO_2025176748_PA

Absstract of: WO2025176748A1

The invention provides compounds having the general formula (I) or (II) (I) (II) wherein A, A1, X1, R1, R2, R3, R4, R5, and R6 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds in the treatment or prevention of diseases that are associated with TREM2.

CONDENSED PYRIMIDINE DERIVATES ALS TREM2 AGONISTS

Publication No.:  WO2025176753A1 28/08/2025
Applicant: 
F HOFFMANN LA ROCHE AG [CH]
HOFFMANN LA ROCHE INC [US]
F. HOFFMANN-LA ROCHE AG,
HOFFMANN-LA ROCHE INC
WO_2025176753_A1

Absstract of: WO2025176753A1

The invention provides compounds having the general formula (I) wherein A, X1, X2, R1, R2, R3, R4, and R5 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds in the treatment or prevention of diseases that are associated with TREM2.

MULTICOMPARTMENT COMPOSITIONS IN THE TREATMENT OF PARKINSON'S DISEASE

Publication No.:  WO2025176909A1 28/08/2025
Applicant: 
LAXXON MEDICAL AG [CH]
LAXXON MEDICAL AG
WO_2025176909_A1

Absstract of: WO2025176909A1

The present invention relates to a solid composition, and its use in the treatment of Parkinson's disease, comprising at least two compartments, a first active pharmaceutical ingredient (API) and a second API, preferably for increasing uptake of the second API thereby optimizing its use in the treatment of Parkinson's disease, in particular improving its clinical activity and reducing its side effects associated with the treatment of Parkinson's disease.

TRANS-SPLICING RIBOZYME SPECIFIC TO APOE4 RNA AND USE THEREOF

Nº publicación: US2025270547A1 28/08/2025

Applicant:

RZNOMICS INC [KR]
RZNOMICS INC

JP_2022543446_PA

Absstract of: US2025270547A1

The present invention relates to a trans-splicing ribozyme specific to Alzheimer's disease, and a use thereof. The trans-splicing ribozyme replaces RNA of genes that cause or increase the risk of Alzheimer's disease with RNA of genes that are beneficial for the treatment of the disease, thereby reducing the expression of the disease-causing genes and increasing the expression of the genes beneficial for the treatment of the disease, and thus can be usefully used to prevent or treat Alzheimer's disease.

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