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プログラムされた死のリガンド－１（ＰＤ－ＬＩ）発現の画像化および標的化

Absstract of: WO2022032100A2

The presently disclosed subject matter provides compositions, kits, and methods comprising imaging agents that can detect Programmed Cell Death Ligand 1 (PD-L1). The presently disclosed imaging agents can be used to detect diseases and disorders, such as cancer, infection, and inflammation, in a subject.

一种基于细菌的肿瘤原位疫苗及其制备方法和应用

Absstract of: CN122582271A

本发明公开一种基于细菌的肿瘤原位疫苗，包括灭活细菌和腺苷脱氨酶，所述灭活细菌为大肠杆菌(Escherichia coli) Nissle 1917或减毒鼠伤寒沙门氏菌(VNP 20009)中的任意一种或两种。本发明的肿瘤原位疫苗对宿主脏器无明显毒副作用，具有良好的安全性，生产制备工艺简单、成本低；可通过瘤内注射方式刺激机体先天性和适应性免疫系统，增强抗肿瘤免疫，抑制肿瘤细胞生长，有效预防肿瘤的发生发展和复发转移。

一种兼具光热灭菌功能的适配体介导比率型光电化学传感器的构建方法和应用

Absstract of: CN122591946A

0001 本发明公开了一种兼具光热灭菌功能的适配体介导比率型光电化学传感器的构建方法和应用，涉及光电化学检测技术领域。本发明融合原位光热灭菌与信号放大技术，利用光热作用使捕获菌体裂解释放脂多糖，通过脂多糖与传感界面的特异性相互作用增强光电流响应，实现高效信号放大，完成目标菌精准定量检测。本发明实现灭菌与检测一体化，构建安全传感检测体系，从源头杜绝活菌外泄引发的感染隐患，保障操作生物安全，方法实用性强、抗干扰能力优，可高效完成样本中待测菌快速精准检测，适用范围广。

Phage Yrd1 capable of cracking salmonella pullorum, biological preparation containing same and application of bacteriophage Yrd1

Absstract of: CN122588018A

The invention belongs to the technical field of biological prevention and control and food safety, and discloses a bacteriophage Yrd1 capable of cracking salmonella pullorum, a biological preparation containing the bacteriophage Yrd1 and application of the bacteriophage Yrd1. The bacteriophage Yrd1 is obtained by taking salmonella pullorum as host bacteria through separation, is named as Salmonella pullorum Yrd1, is preserved in the China Center for Type Culture Collection on April 22, 2026, has the preservation number of CCTCC NO: M 2026766, and has good lysis activity and biological stability. The biological preparation containing the bacteriophage can be prepared into a liquid preparation, a freeze-dried powder preparation, a spray preparation, a preparation for drinking water addition, a preparation for feed addition or a food surface treatment preparation, is used for biological prevention and control of salmonella pullorum, and is especially suitable for inhibiting or reducing salmonella pullorum pollution in chicken juice, chicken and other chicken related matrixes.

一种检测血流感染病原体的试剂盒

Absstract of: CN122591955A

0001 本发明提供了一种检测血流感染病原体的试剂盒，属于免疫检测技术领域。本发明所述试剂盒包括优化后的样品处理液和包被液，所述样品处理液以PBS缓冲液为基底，包含Triton X‑100、皂苷、聚乙二醇6000、PC300、EDTA‑Na<2>、BSA和柠檬酸钠；所述包被液以碳酸盐缓冲液为基底，包含海藻糖、SDS、甲醇、BSA、PC300和脯氨酸。本发明提供的试剂盒可以实现血流感染病原体高灵敏度、高特异性、快速检测，且储存稳定、适用范围广、兼容性强，适用于临床血流感染中常见细菌、真菌等病原体的快速检测。

Method for carrying out cross-genus conjugational transfer from salmonella pSLT plasmid to escherichia coli

Absstract of: CN122588122A

The invention relates to a method for carrying out cross-genus conjugational transfer from salmonella pSLT plasmids to escherichia coli, and belongs to the technical field of microbial genetic engineering and horizontal gene transfer. According to the method, recombinant pSLT plasmids containing selection markers are constructed, and the problem that the pSLT plasmids are difficult to identify is solved; by researching conjugation transfer conditions, a trans-genus conjugation transfer method of the pSLT plasmid from salmonella to escherichia coli is established, and the host limitation is broken through; a dual verification system for successful transfer of recombinant plasmids: phenotype verification and molecular verification is established, so that the accuracy of a transfer result is ensured.

Method and system for rapidly detecting salmonella in food based on machine learning

Absstract of: CN122598171A

The invention provides a method and a system for rapidly detecting salmonella in food based on machine learning, and relates to the field of computer vision. The method specifically comprises the following steps: acquiring a food microscopic image, and constructing a microscopic input image; a microscopic input image is input into a self-adaptive preprocessing module, and preprocessing features are obtained after background separation, contrast and edge enhancement and denoising; extracting prior information of the preprocessing features through candidate connected domains, adding the prior information with the preprocessing features, performing coding, and performing alignment, multi-branch convolution and enhancement function joint analysis to obtain multi-scale features; constructing a thallus-impurity decoupling discrimination module to realize differential decoupling discrimination of the target and the impurities to obtain discrimination characteristics; and constructing an evidence accumulation module to jointly count multi-scale features, and performing threshold segmentation after multi-evidence fusion enhancement to output a result. According to the method, complex food matrix background interference can be effectively inhibited, the morphological expression of salmonella is enhanced, and the accuracy and stability of detection in a complex scene are improved.

TolC CK139 A novel Salmonella enterica typhimurium CK139 strain lacking the TolC gene and its use

Nº publicación: KR20260124251A 18/08/2026

Applicant:

PUSAN NATIONAL UNIV INDUSTRY UNIV COOPERATION FOUNDATION [KR]
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