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109
resultados
Última actualización
20/10/2024 [06:50:00]
Resultados 100 a 109 de 109
Resumen de: WO2023036814A1
The present invention relates to a fusion protein comprising fragments of the spike (S) protein and of the nucleoprotein (N) of a coronavirus. The present invention further relates to a vaccine, a composition, a pharmaceutical composition, or a diagnostic kit comprising the fusion protein, to a method for diagnosing an infection by a coronavirus and to a method for preventing or treating a coronavirus infection based on the use of the fusion protein.
Resumen de: US2024269317A1
Compositions useful for delivery of active pharmaceutical ingredients (APIs) and active nutraceutical ingredients (ANIs) to a targeted tissue or a targeted cell of a mammalian body, comprising a complex of at least one nanoparticle; at least one API; the API is contained by the nanoparticle; at least one nutraceutical ligand, the nutraceutical ligand is configured to specifically bind to the targeted tissue or a targeted cell; wherein the API or the ANI is activated at the targeted tissue or at a targeted cell by the mediation of the nutraceutical ligand.
Resumen de: CN118743753A
本发明属于纳米医药技术领域，具体涉及一种多组元纳米探针、制备方法和应用，包括Au@Cu2‑xSe@Pt和修饰在Au@Cu2‑xSe@Pt表面的PEG，所述Au@Cu2‑xSe@Pt为Au纳米球，包裹在Au纳米球上的Cu2‑xSe，以及岛状生长在Cu2‑xSe表面的Pt，本发明具有深层组织穿透能力、高空间分辨率和灵敏度、高最大允许曝光强度以及多种治疗和成像模式等肿瘤诊疗一体化。
Resumen de: US2021259969A1
An extracellular vesicle includes an exogenous therapeutic component. The exogenous therapeutic component can include a therapeutic polypeptide, a polynucleotide that encodes a therapeutic polypeptide, a therapeutic nucleic acid, or a therapeutic agent. In some embodiments, the extracellular vesicle includes an exosome or purified exosome product (PEP).
Resumen de: CN118743687A
本发明属于生物医药技术领域，涉及一种共载氯硝柳胺和黏菌素的聚合物纳米粒及其制备方法和应用。该聚合物纳米粒由内核、中间层和外壳组成，内核由两亲性聚合物的亲水端和负载在亲水端的黏菌素组成，中间层由两亲性聚合物疏水端和负载在疏水端的氯硝柳胺组成，外壳由两亲性聚合物的亲水端组成。其制备方法为：1）将黏菌素溶于水，得到内水相；2）将两亲性聚合物和氯硝柳胺溶于有机溶剂，得到油相；3）将内水相加入到油相中，得到初乳；4）将初乳加入外水相中，得到复乳；5）将复乳进行稀释，得到混悬液，去除混悬液中的有机溶剂，得到聚合物纳米粒悬液。本发明聚合物纳米粒同时包载有黏菌素和氯硝硫胺，氯硝柳胺能够逆转多重耐药革兰氏阴性菌对黏菌素的耐药性，对黏菌素耐药革兰氏阴性菌具有优异的抗菌活性。
Resumen de: MX2024003688A
The invention relates to fusion proteins of apolipoprotein with an immunomodulatory biomolecule and/or a rerouting molecule. The fusion proteins can be used as a carrier for an immunomodulatory biomolecule as such or incorporated in a lipid nanoparticle. The fusion protein finds use in the treatment of immune related disorders, or targeting a payload to a specific target site.
Resumen de: CN118176207A
The present invention relates to artificial T cell receptors wherein the antigen binding domain of the artificial T cell receptor specifically binds to complement pathway proteins, nucleic acids encoding such artificial T cell receptors and cells genetically engineered to express such nucleic acids. The present invention also relates to targeting polypeptides comprising an extracellular ligand binding domain and an intracellular domain comprising a transcription factor, and wherein the transcription factor is configured to be released when the ligand binding domain is bound by a ligand. The invention also relates to cells genetically engineered to express the artificial T cell receptor and the targeting polypeptide, in particular where the expression of the artificial T cell receptor is operably linked to the binding of the ligand binding domain. The cells of the invention are useful in medicine, in particular in the treatment of inflammatory conditions.
Resumen de: US2024287146A1
The present invention relates to a polypeptide comprising a silk polypeptide and an antigen. Further, the present invention relates to an article comprising the polypeptide. Furthermore, the present invention relates to a pharmaceutical composition comprising the article. In addition, the present invention relates to the article or pharmaceutical composition for use as a pharmaceutical, for inducing an immune response and/or for use in a prophylactic and/or therapeutic treatment of a disease.
Nº publicación: CN118743690A 08/10/2024
Solicitante:
河北水熊基因科技有限公司
Resumen de: CN118743690A
本发明公开了一种载药细胞外泌体胶囊及制备方法，包括以下原料：载体材料60%‑80%、细胞外泌体10%‑20%、药物8%‑12%和3%‑7%辅助成分；包括以下步骤：S1：生物工程处理；S2：三维细胞培养；S3：细胞外泌体的收集；S4：载药；S5：筛选和纯化；S6：制备立体蜂窝状载体；S7：包埋成胶囊；S8：胶囊性质鉴定。本发明使细胞外泌体培养成和载体材料制作成立体蜂窝状结构，从而最终制成可多层立体蜂窝状释放的载药细胞外泌体胶囊，其具有控制释放、药物保护、药效持久、降低毒副作用和提高生物利用度的多重优点，有望成为未来靶向治疗和药物输送领域的重要发展方向。
BOPI
Sede Electrónica
