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181
resultados
Última actualización
19/10/2024 [07:14:00]
Resumen de: US2024344226A1
In one embodiment, a method for manufacturing an aperture plate includes depositing a releasable seed layer above a substrate, applying a first patterned photolithography mask above the releasable seed layer, the first patterned photolithography mask having a negative pattern to a desired aperture pattern, electroplating a first material above the exposed portions of the releasable seed layer and defined by the first mask, applying a second photolithography mask above the first material, the second photolithography mask having a negative pattern to a first cavity, electroplating a second material above the exposed portions of the first material and defined by the second mask, removing both masks, and etching the releasable seed layer to release the first material and the second material. The first and second material form an aperture plate for use in aerosolizing a liquid. Other aperture plates and methods of producing aperture plates are described according to other embodiments.
Resumen de: US2024344245A1
A method of forming a substrate includes mapping a three dimensional spatial distribution of at least one structural protein fiber of extracellular matrix of biological material of interest, designing a fiber assembly pattern based on an intrinsic pattern of the at least one structural protein fiber of the extracellular matrix of the biological material, and assembling fibers based on the fiber assembly pattern to form the substrate.
Resumen de: US2024344016A1
A system and method for growing and maintaining biological material including producing a protein associated with the tissue, selecting cells associated with the tissue, expanding the cells, creating at least one tissue bio-ink including the expanded cells, printing the at least one tissue bio-ink in at least one tissue growth medium mixture, growing the tissue from the printed at least one tissue bio-ink, and maintaining viability of the tissue.
Resumen de: US2024344034A1
A method is provided for simultaneously producing both nephron progenitor cells and ureteric epithelial progenitor cells including the step of contacting intermediate mesoderm cells with: fibroblast growth factor 9 and/or fibroblast growth factor 20 and optionally, one or more selected from the group consisting of: bone morphogenic protein 7; heparin; a Wnt agonist; retinoic acid; and an RA antagonist. The concentrations of Wnt agonist, retinoic acid and/or RA antagonist may be manipulated to favour the relative production of nephron progenitor cells and ureteric epithelial progenitor cells. The intermediate mesoderm cells are ultimately derived from human pluripotent stem cells via a posterior primitive streak stage. The nephron progenitor cells and ureteric epithelial progenitor cells may have end uses such as for kidney repair and regeneration, bioprinting of kidneys and screening compounds for nephrotoxicity.
Resumen de: US2024343868A1
A composition including a particle including a crosslinked matrix, prepared from a liquid droplet including a formulation including a polymer, the gelled particle having an average diameter of less than 250 pm, is provided herein. A method of printing the composition including releasing the liquid droplet into a fluid including an aerosol including a crosslinking agent and contacting the liquid droplet with the fluid is further provided. A device configured to introduce an aerosol including a crosslinking agent to a droplet of a formulation including a polymer as the droplet passes through the aerosol including the crosslinking agent is further provided.
Resumen de: US2024346788A1
Disclosed is a computer-implemented method for adjusting an arrangement of a plurality of three-dimensional digital tooth models for a dental restoration. A three-dimensional digital teeth model comprising the plurality of the three-dimensional digital tooth models is received. A first input is received selecting one or more of the three-dimensional digital tooth models. A second input is received defining a modification of the selected one or more three-dimensional digital tooth models. The selected one or more three-dimensional digital tooth models are modified according to the second input. While the selected one or more three-dimensional digital tooth models are modified according to the second input, adjustments of a geometric form of the selected one or more three-dimensional digital tooth models are automatically calculated and applying. Furthermore, adjustments of a set of remaining three-dimensional digital tooth models of the three-dimensional digital teeth model depending on the modification of the selected one or more three-dimensional digital tooth models are automatically calculated and applied. The resulting adjusted three-dimensional digital teeth model is provided for manufacturing the dental restoration.
Resumen de: DE102023118473B3
Die Erfindung betrifft ein Verfahren und eine Vorrichtung zum Dispensieren vereinzelter biologischer Zellen (20). Das Verfahren umfasst das Bereitstellen einer Zellsuspension und das Bereitstellen einer Dispensiervorrichtung (10) mit einem Träger (12), in dem ein Kanal (14) zum Durchleiten der Zellsuspension ausgebildet ist, wobei der Kanal (14) sich in eine Längsrichtung (L) erstreckt und eine umfängliche Kanalwand (16) mit wenigstens einer lateralen Öffnung (18) und eine Zellfalle (22) in Nachbarschaft zu der Öffnung (18) aufweist. Das Verfahren umfasst ferner das Erzeugen einer Strömung der Zellsuspension in dem Kanal (14), das Einfangen einer einzelnen Zelle (20) in der Zellfalle (22), wobei der Aufenthaltsort der eingefangenen Zelle (20) bezogen auf die Längsrichtung (L) sich auf gleicher Höhe mit der lateralen Öffnung (18) befindet, und das Erzeugen eines Druckstoßes in der Umgebung der lateralen Öffnung (18), der eine in Richtung der Öffnung (18) wirkende Kraft auf die eingefangene Zelle (20) zur Folge hat.
Resumen de: US2024343915A1
The invention provides a method for producing a 3D item (1) by means of fused deposition modelling, the method comprising a 3D printing stage, wherein the 3D printing stage comprises a reflective material deposition stage, wherein the reflective material deposition stage comprises: (A) providing 3D printable material (201) comprising (i) a polymeric matrix material (211) that is transmissive for UV radiation, especially wherein the polymeric matrix material (211) comprises thermoplastic material, and (ii) a reflective material (212) that is reflective for the UV radiation and that is at least partly enclosed by the polymeric matrix material (211); wherein the reflective material (212) comprises a first fluoropolymer; and (B) depositing the 3D printable material (201), to provide the 3D item (1) comprising 3D printed material (202) comprising the matrix material (211) and the reflective material (212).
Resumen de: CN118401652A
The present invention relates to a method for producing a biocompatible structure for joining and culturing biological materials, a method for culturing aggregates of biological materials, and the use of a biocompatible structure for joining and culturing biological materials.
Resumen de: EP4445923A1
The invention relates to a Gelatin-based composition suitable for use in the treatment of a bone defect site. The composition contains hydroxyapatite particles, preferably hydroxyapatite nanoparticles and has the advantage of being pourable, e.g. injectable and/or extrudable and/or printable, e.g. for use in a 3D-printing process or injection-moulding process, at elevated temperatures, e.g. at 37 to 42 °C, and to be dimensionally stable upon cooling, e.g. to 5 °C or below to 0 °C or 1 °C, wherein the solidification upon cooling is sufficiently fast for generating dimensionally stable structures, e.g. upon cooling by depositing the pourable composition on a cooling carrier or platform.
Resumen de: EP4446348A1
A composition for forming oral appliances, a method for manufacturing oral appliances, and oral appliances manufactured by the method are disclosed. The disclosed composition for forming oral appliances includes photo-polymerizable compounds and an incomplete polymerization indicator, wherein the incomplete polymerization indicator has both photopolymerization initiation function and incomplete polymerization indication function.
Resumen de: EP4446093A1
Disclosed in the present application are: a pen-type structure for mixing and discharging a bio-ink or a hydrogel: and a bio-ink or hydrogel printing method using same. The pen-type structure comprises: a cylindrical first barrel for housing a first screw; a cylindrical second barrel for housing a second screw, which is longer than the first screw and has a structure parallel with the first screw; a controller connected to a gear of the first screw and a gear of the second screw so as to drive the first screw and the second screw; two or more supply units formed in the first barrier and supplying a bio-ink or hydrogel material into the first barrel; and a bio-ink or hydrogel discharge unit which extends from the end portion of the second barrel on the opposite side of the controller, and which discharges bio-ink or hydrogel.
Resumen de: CN118773470A
本发明提供一种三元锌合金多孔结构材料及其制备方法和应用，1.包括以下步骤：S1.准备三元锌合金粉末，按质量百分比计包括以下元素成分：Mg：0.01‑1.00％，X：0.01‑1.00％，余量为Zn和不可避免的杂质；所述杂质中O≤0.02％，C≤0.01％；所述X为Cu、Al、Li、Ca中的一种；S2.进行三维数字建模，设计多孔单元按Gyroid周期排列的多孔结构，孔径尺寸为30‑300μm，孔隙度为30‑70％；S3.使用激光选区熔化将三元锌合金粉末制备得到建模目标，即得所述三元锌合金多孔结构材料。具有高抗拉强度、屈服强度、延伸率，生物安全性良好，可用于骨植入器械医疗领域，制备生物医用植入器械、支架、骨填充块等。
Resumen de: CN118781360A
本发明涉及多孔梯度骨骼支架技术领域，具体涉及一种用3D打印可再生功能梯度骨骼支架的制备方法，包括通过CT扫描设备对骨缺损处进行三维扫描，获取图像数据；对所述图像数据进行去床操作，得到去床图像；对所述去床图像进行特征提取，得到扫描特征；基于所述扫描特征利用三维制图软件设计梯度模型；基于所述梯度模型以钛合金材料作为多孔骨骼支架材料，利用3D打印SLM成形出环状的梯度多孔支架；将所述梯度多孔支架置于混合溶液中，得到功能梯度多孔仿生复合支架，解决了通过CT扫描设备对骨缺损处进行三维扫描的过程中，会将CT床，以及床上残留的干扰物一并扫描进去，从而影响后续的梯度模型的生成效果的问题。
Resumen de: CN118767334A
本发明涉及动物医疗技术领域，具体为一种3D打印的动物头盔，包括头盔本体、刺激块、紧固衣，头盔本体采用3D打印制作，头盔本体底端开设有嘴槽，嘴槽槽边安装挡板，挡板为弧形板，嘴槽上端开设有第一定位槽，第一定位槽四周开设有用于装配刺激块的安装块，安装块上安装有刺激块，刺激块包括但不限于磁、超声、CT等治疗手段，头盔本体一端设有用于稳定头盔本体的紧固衣，头盔本体底端两侧安装有束缚机构，束缚机构顶端都安装有四个子扣A，束缚机构末端都安装有皮带扣A，头盔本体两侧底端内部开设有母扣A，母扣A与头盔本体内部固定连接，子扣A与母扣A相配合。
Resumen de: CN118767346A
本发明提供一种点阵式核素敷贴装置及其制备方法，属于放射性敷贴技术领域。所述点阵式核素敷贴装置包括：与目标瘢痕组织面积大小相匹配的敷贴基片及盖合于敷贴基片表面的密封盖片；敷贴基片内设有放射凹槽；放射凹槽内填充有与放射凹槽的形状和大小相匹配且用于治疗目标瘢痕组织的水凝胶放射性物质。本发明通过在敷贴基片内设置放射凹槽，并注入用于治疗的水凝胶放射性物质，从而使水凝胶放射性物质通过密封盖片包埋在敷贴基片中，减少了点阵式核素敷贴装置整体厚度，即减少了点阵式核素敷贴装置整体对辐射的吸收衰减，提高了辐射照射效率，并且固定了放射凹槽的形状即固定了水凝胶放射性物质的形状，避免注入打印基材后流动、溢出造成变形。
Resumen de: CN118751922A
本发明提供一种球形医用钽合金粉末及其制备方法和应用，其制备方法包括以下步骤：S1.将纯钽粉末初步等离子球化，得到球形纯钽粉末；S2.将S1所得球形纯钽粉末与纯铜颗粒、纯银颗粒混合，行星球磨，得到混合金属粉末；S3.将S2所得混合金属粉末等离子球化，筛分过滤，即得所述球形医用钽合金粉末。本发明通过二级等离子球化技术结合行星球磨技术的制备方法，有效减少了铜和银的烧损，并进一步提升钽合金粉末的球化率，并将铜和银包覆在钽粉末的外面，得到元素烧损量少和致密度高、适于增材制造的球形医用钽合金粉末，球形度高，异形颗粒或卫星粉等非合格球体少，生物相容性优良，可用于医疗领域，具有重要的经济价值和推广意义。
Resumen de: CN118750642A
本发明公开了一种自组装多肽纳米纤维水凝胶复合的3D打印组织再生支架材料，其特征在于，包括抗血管化的多肽，所述多肽的氨基酸链段为SLSLSLSLSLSLTSLDASIIWAMMQN，即丝氨酸‑亮氨酸‑丝氨酸‑亮氨酸‑丝氨酸‑亮氨酸‑丝氨酸‑亮氨酸‑丝氨酸‑亮氨酸‑丝氨酸‑亮氨酸‑苏氨酸‑丝氨酸‑亮氨酸‑天冬氨酸‑丙氨酸‑丝氨酸‑异亮氨酸‑异亮氨酸‑色氨酸‑丙氨酸‑蛋氨酸‑蛋氨酸‑谷氨酰胺‑天冬酰胺。本发明核心成分为抗血管化的多肽，具有自组装形成纳米纤维并且在体内抑制血管再生的作用，将其与光敏高分子复合通过3D打印技术制备出一种抗血管化组织再生支架材料，针对瘢痕体质或者血管化过度的病人提供一种抑制血管化的组织再生修复材料，有利于病人的康复。
Resumen de: CN118750245A
本申请公开了基于3D打印的脊柱侧弯矫形设备，涉及脊柱矫正技术领域，技术要点是：脊柱侧弯矫形设备包括：矫形器本体，包括基于3D打印制备形成，所述矫形器本体背部具有两个可活动部分，其中一部分连接有收缩带；驱动机构，连接在所述矫形器本体背部另外一部分上，收缩带与所述驱动机构驱动连接，使得所述矫形器本体背部的两个分离部分可相对移动，收缩所述矫形器本体；压力传感器；控制设备，与所述驱动机构和所述压力传感器连接，用于接收所述压力传感器的第一压力数值，在每t个时间段中，对接收到的第一压力数值进行处理，判断第一压力数值是否超过阈值。
Resumen de: CN118750143A
本发明公开了一种多自由度体内原位生物制造系统，包括输送导管、打印部和控制部，输送导管内置输送通道和驱动导丝，通过驱动结构将操作结构的动作通过驱动导丝传递并最终引导打印部动作，输送导管利用体内修复材料前体输送通道将体内修复材料前体输送至打印部，打印部将体内修复材料前体打印在体内待修复区域，体内修复材料前体在体内待修复区域通过光照射或多种体内修复材料前体混合生成修复材料，并作用于体内待修复区域。本发明系统整体结构小型化，可用于微创手术中进行体内原位修复，系统设计驱动导丝结合柔性管且集成了体内修复材料前体和固化光组件，通过多自由度控制，实现在手术穿孔直径很小情况下直观性的运转以及自由操作。
Resumen de: JP2022048617A
To provide a tablet printing device capable of suppressing printing failure to a tablet; and to provide a tablet manufacturing method.SOLUTION: A tablet printing device has conveyance devices 21, 31 for conveying tablets T, a plasma generator 100 for irradiating a product by atmospheric pressure plasma from a supply opening 101 to a printing object surface of the tablets T, and a print head 24a arranged on the furthermore downstream in the conveyance direction of the tablets T than the supply opening 101, for printing on the printing object surface to which the product is irradiated.SELECTED DRAWING: Figure 1
Resumen de: EP4254429A2
Orthodontic systems and related methods are disclosed for designing and providing improved or more effective tooth moving systems for eliciting a desired tooth movement and/or repositioning teeth into a desired arrangement. Methods and orthodontic systems include the generation of an overcorrection in the tooth-receiving cavities of an appliance worn in the dentition. The overcorrection may provide an improved and more accurately applied force or moment applied to a tooth. The overcorrected force or moment can move a tooth closer to a desired position than if not overcorrected as sufficient force can still applied to the tooth as it gets closer to the desired position. The overcorrected force or moment may also better target the root of the tooth where the biological response to tooth movement occurs. The overcorrection may be calculated in various ways as described herein.
Resumen de: CN118750378A
本发明涉及一种多材料药片3D打印装置，属于医疗器械技术领域，包括：机架、成型系统、供粉系统及喷液系统，机架的内部固定有固定板且固定板上设有长条孔；成型系统沿X轴滑动在长条孔内；供粉系统包括支撑架和多个供粉斗，支撑架固定在固定板上；多个供粉斗沿X轴方向间隔固定在支撑架上且其漏粉孔可分别与多个容粉孔相对布置；喷射系统包括Y轴驱动机构和多个喷射器，Y轴驱动机构固定在机架上且其驱动端沿Y轴方向往复移动；多个喷射器间隔固定在Y轴驱动机构的驱动端。本发明突破传统3D打印机单一配比打印药物的设计束缚，匹配全新的药物喷射粘结技术，可以灵活配比多种材料，提高药片的成型效率和成型效果。
Resumen de: CN118750242A
本发明提供一种颅骨智能矫正装置，它包括矫正头盔、感知反馈模块、主动驱动模块、温湿度调节模块和总控制模块。温湿度调节模块和总控制模块内置在矫正头盔内；主动驱动模块贴附在头盔内壳的内壁上；感知反馈模块贴附在主动驱动模块的外表面上，与佩戴者头皮接触，感知佩戴者头部所承受的力、温度、湿度和佩戴者的心率、血压、头部偏移角度及方向。本发明还提供了一种颅骨智能矫正系统，它包括颅骨智能矫正装置和智能监测分析系统。智能监测分析系统通过自适应算法不断地调整优化矫正轨迹，通过颅骨智能矫正装置对佩戴者畸形头部施加压力，再由感知反馈模块实时监测佩戴者的感受，调整施加压力。
Nº publicación: CN118752777A 11/10/2024
Solicitante:
中国人民解放军空军军医大学
Resumen de: CN118752777A
本发明提供一种3D打印设计制作一体中空封闭式阻塞器的方法，涉及牙科技术领域。制作方法包括：通过口内扫描仪获取患者牙列及颌骨缺损区域的数字化模型；通过第一数字化设计软件在数字化模型的基础上进行阻塞器设计，得到初始阻塞器数字化模型；通过第二数字化设计软件对初始阻塞器数字化模型的位置进行调整，以使初始阻塞器数字化模型的咬合平面与XY平面平行，并使初始阻塞器数字化模型的组织面朝向Z轴正方向。通过层间暂停方法与自下而上的3D打印方式相结合，避免了中空阻塞器腔内的液态树脂残留，能够实现一体中空封闭式阻塞器的直接3D打印制作，为中空结构的直接3D打印制作提供了一种有效的解决方案。
BOPI
Sede Electrónica
