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189
resultados
Última actualización
09/03/2025 [07:04:00]
Resumen de: WO2025049305A1
The invention relates to methods and kits for determining a SARS-CoV-2 strain in a sample. The invention also provides methods and kits for detecting a single nucleotide polymorphism (SNP) in a target nucleic acid, wherein the target nucleic acid is a SARS-CoV-2 nucleic acid. The invention further provides methods and kits for detecting one or more antibody biomarkers in a sample.
Resumen de: WO2025046130A2
The present invention relates to polypeptides, polynucleotides, compositions, microorganisms, vectors and vaccine compositions optimised for the treatment or prophylaxis of a disease or infection caused by Betacoronaviruses, including but not limited to: Embecovirus, Hibecovirus, Merbecovirus, Nobecovirus, Sarbecovirus, MERS-CoV, SARS-CoV-1 and SARS-CoV-2. In particular, the invention provides a vaccine composition comprising a polypeptide, wherein the polypeptide comprises one or more epitope sequences, wherein the one or more epitope sequences have the amino acid sequences of any one or more of the sequences of Table 1, or a variant thereof having at least 70% sequence identity thereto, and wherein the polypeptide sequence is no more than 1400 amino acids in length.
Resumen de: US2025079025A1
A pathogen test device, including a center body to facilitate gripping thereof, a swab connected to at least a portion of a first end of the center body to absorb at least one fluid therein in response to contact with the at least one fluid, a testing container detachably connected to at least a portion of a second end of the center body to store a testing liquid therein, and a test display disposed on at least a portion of the center body to display a test result identifying a presence of at least one of COVID-19, strep, and control in response to inserting the swab with the at least one fluid into the testing container.
Resumen de: AU2023313034A1
The disclosure provides compositions and methods comprising selective inhibitors of Rho-associated coiled-coil kinase 2 (ROCK2) for use in the treatment of viral infections, particularly coronavirus infections such as SARS-CoV-2, and in the treatment of sequelae resulting from the viral infection, including sequelae resulting from coronavirus infection.
Resumen de: US2025076294A1
A rapid test device for the detection of SARS-CoV-2 viruses and for the relative antibody production including a substrate of the lateral flow immunochromatographic assay divided into 5 regions: a first reception area to receive the biological sample (“Sample Deposition”); a second area where the first reaction takes place between an analyte and the molecule used for its specific identification (“Conjugation pad”); a third area where the signal amplification uses the addition of the gold nanoparticles (“Signal amplification”); a fourth test area (“Test line”) and a fifth control area (“Control Line”) in which a second and third immunoreaction takes place, providing a visual reading of the test result by a window and two results visible by a colored strip. The sample deposition area comprises a filter having porosity of about 200 nm-1 μm.
Resumen de: US2025074907A1
Described herein are compounds, and methods for the treatment of coronavirus infection.
Resumen de: US2025074938A1
Provided are protease inhibitor compounds that find use in treating or preventing coronavirus disease. In some embodiments, the coronavirus disease is COVID-19. Also provided are compositions and kits comprising the compounds, as well methods of using the compounds to treat or prevent coronavirus disease. Also provided are methods for reporting coronaviral protease inhibition.
Resumen de: WO2025049355A1
Disclosed herein are compositions comprising nanoparticles designed for CRISPR/Cas13 RNA targeting systems, specifically aimed at targeting poorly druggable, disease-driving genes in prostate cancer and COVID-19, and methods of use thereof.
Resumen de: WO2025049225A2
Diagnostic assay devices for detecting the presence of an analyte in a sample solution may comprise a microreactor configured to form a sample solution containing the analyte, flow the sample solution therethrough in a first direction to form an analyte-capture molecule complex, and transfer the sample solution to an absorbent strip pad configured to flow therethrough, in a second direction crossing the first direction, the sample solution including the analyte-capture molecule complex and indicate a presence of the analyte-capture molecule complex. In some embodiments the devices are configured to process a bioaerosol sample. In some embodiments the diagnostic assay devices may be multiplexed and may be used for detecting the presence of two or more analytes in a sample solution. The diagnostic devices may be used, for example, to identify the presence of one or more of SARS-Cov2, RSV, influenza A, influenza B or other pathogens in samples from patients.
Resumen de: WO2025046629A1
The present disclosure relates to in vitro identification of neutralizing antibody against Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Specifically, the present disclosure relates a kit and an in vitro assay for analyzing the presence of neutralizing antibody/inhibitors which could block or inactivate receptor binding domain of the spike protein of SARS-CoV-2.
Resumen de: US2025073259A1
A therapeutic material active against SARS-COV 2 and other microbial pathogens and method of administering the same.
Resumen de: AU2023334060A1
The present disclosure is directed to antibodies and antigen binding fragments thereof, or combinations of antibodies and antigen binding fragments thereof, having binding specificity for the S protein of coronaviruses (CoV-S), such as the S protein of the SARS coronavirus 2 (SARS-CoV-2-S), including neutralizing antibodies. The antibodies and antigen binding fragments thereof comprise the sequences of the VH, VL, and CDR polypeptides described herein, and the polynucleotides encoding them. The disclosure contemplates conjugates of anti-CoV-S antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. Methods of making said anti-CoV-S antibodies and antigen binding fragments thereof are also contemplated. Other embodiments of the disclosure contemplate using anti-CoV-S antibodies, and binding fragments thereof, for the diagnosis, assessment, and treatment of diseases and disorders associated with coronaviruses or the S protein thereof and conditions where neutralization or inhibition of coronaviruses or the S protein thereof would be therapeutically beneficial.
Resumen de: AU2023336178A1
The invention relates to a polynucleotide encoding a) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein; and/or b) at least one non-structural SARS-CoV-2 protein selected from the group consisting of non-structural protein 7, non-structural protein 8, non-structural protein 9, non-structural protein 10, non-structural protein 11, non-structural protein 12, an endoribonuclease, and a 2'-O-methyltransferase, wherein the polynucleotide comprises or consists of at least one sequence part comprising codon-pair deoptimizations in comparison to the SARS-CoV-2 genome, and wherein the polynucleotide further comprises a furin cleavage site modification resulting in a loss of a furin cleavage site being naturally present in the SARS-CoV-2 genome. The invention further relates to a live attenuated SARS- CoV-2 comprising this polynucleotide, to a vaccine comprising this live attenuated SARS-CoV-2, as well as to associated methods.
Resumen de: US2025073163A1
The present invention provides a method of treating an infectious disease. The method comprises the step of administering to a subject in need thereof an effective amount of (i) a polymer-flavonoid conjugate, (ii) a flavonoid oligomer, or (iii) micelles having a shell formed by one or more polymer-flavonoid conjugates or one or more flavonoid oligomers, or the combination thereof, and having an agent encapsulated within the shell. The present method is effective to treat viral infection, e.g., severe acute respiratory syndrome coronavirus (SARS-CoV), enterovirus virus, HIV, hepatitis B virus, MERS-CoV, influenza virus, Dengue virus, respiratory syncytial virus, hepatitis C virus, monkeypox virus, human papillomavirus, methicillin-resistant Staphylococcus aureus, Pseudomonas, tuberculosis, Bacillus anthracis, Tetani bacterium, Streptococcus pneumoniae, meningococcus, Escherichia coli, Legionella, Neisseria gonorrhea, Neisseria meningitidis, and Salmonella.
Resumen de: US2023355738A1
A bacteriophage T4-based, multivalent/multicomponent, needle and adjuvant-free, mucosal vaccine by engineering spike trimers on capsid exterior and nucleocapsid protein in the interior is disclosed herein. Intranasal administration of this T4-COVID vaccine induces higher virus neutralization antibody titers against multiple variants, balanced Th1/Th2 antibody and cytokine responses, stronger CD4+ and CD8+ T cell immunity, and higher secretory IgA titers in sera and bronchoalveolar lavage with no effect on the gut microbiota, compared to vaccination of mice intramuscularly. The vaccine is stable at ambient temperature, induce apparent sterilizing immunity, and provide complete protection against original SARS-CoV-2 strain and its Delta variant with minimal lung histopathology. This mucosal vaccine is an excellent candidate for boosting immunity of immunized and/or as a second-generation vaccine for the unimmunized population. This needle-free platform could be used to develop effective vaccines against many other respiratory infectious pathogens including Flu and any future emerging epidemic and pandemic pathogens.
Resumen de: EP4516931A1
The present disclosure relates to a composition for preventing or treating coronavirus infection, including a hotspot-derived peptide-nucleic acid hybrid molecule. It was confirmed that in vitro evolution-based hotspot-derived peptide-nucleic acid hybrid molecule prepared using the method of the present invention has high binding affinity for the RBDs of SARS-CoV-2 VOCs (alpha, beta, gamma, delta, and omicron). In particular, it was found that the greatest binding tolerance was exhibited in the most highly mutated omicron. Furthermore, the hybrid molecule showed high RBD binding affinity in competition with RBD-binding nucleic acid aptamers, macrocyclic peptides, and monoclonal antibodies. The hybrid molecule also exhibited excellent nuclease resistance and serum stability, indicating potential as virus neutralizer in addition to SARS-CoV-2.
Resumen de: EP4516301A2
The invention relates to specific compounds which are useful in treating coronavirus infections such as COVID-19.
Resumen de: AU2023262192A1
The present disclosure provides antibodies and antigen-binding fragments thereof that specifically bind to the spike protein of SARS-CoV-2 and methods of making and using the same. The antibodies can be used, for example, in prophylaxis, post-exposure prophylaxis, or treatment of SARS-CoV-2 infection. The antibodies can also be used to detect SARS-CoV-2, e.g., an infection in subject.
Resumen de: PL446010A1
Niniejsze zgłoszenie dotyczy sposobu wykrywania w warunkach laboratoryjnych materiału genetycznego wirusa SARS-CoV-2 w próbce materiału biologicznego, sposobu diagnozowania in vitro zakażenia wirusem SARS-CoV-2 z wykorzystaniem takiego sposobu wykrywania materiału genetycznego wirusa SARS-CoV-2 oraz zestawu do wykrywania materiału genetycznego wirusa SARS-CoV-2 lub diagnozowania zakażenia wirusem SARS-CoV-2 w próbce materiału biologicznego w warunkach laboratoryjnych.
Resumen de: PL446009A1
Niniejsze zgłoszenie dotyczy sposobu wykrywania w warunkach nie-laboratoryjnych materiału genetycznego wirusa SARS-CoV-2 w próbce materiału biologicznego, sposobu diagnozowania in vitro zakażenia wirusem SARS-CoV-2 z wykorzystaniem takiego sposobu wykrywania materiału genetycznego wirusa SARS-CoV-2 oraz zestawu do wykrywania materiału genetycznego wirusa SARS-CoV-2 lub diagnozowania zakażenia wirusem SARS-CoV-2 w próbce materiału biologicznego w warunkach nie-laboratoryjnych.
Resumen de: US2025064950A1
The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which bind to P-selectin. The invention also relates to multimeric binding complexes of polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold that are binders of P-selectin. The invention also includes drug conjugates comprising said peptides and complexes, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands, complexes and drug conjugates and the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by a cell adhesion molecule, such as P-selectin, including vaso-occlusive crisis and sickle cell disease-related conditions, cancer, or COVID-19.
Resumen de: US2025064919A1
The disclosure is directed to a new human parainfluenza virus (HPIV)/SARS-CoV-2 vaccine or vaccine construct/polynucleotide. Specifically, the HPIV is a Human parainfluenza virus type 3 (HIPV3), and the vaccine construct encoding a SARS-CoV-2 spike protein (S protein), that is a SARS-CoV-2 S protein S1 subunit and/or a SARS-CoV-2 S protein receptor binding domain (RBD), in certain aspects the vaccine or vaccine construct is administered via intranasal administration.
Resumen de: WO2025040122A1
A beta-coronavirus (β-CoV) recombinant chimeric antigen, a preparation method therefor and a use thereof. The β-CoV recombinant chimeric antigen is a chimeric dimer antigen formed by linking an RBD fragment of S protein of a SARS-CoV-2 Omicron variant BA.1 subtype or BA.2 subtype and an RBD fragment of S protein of SARS-CoV in series, which can not only stimulate an organism to generate high-level neutralizing antibodies against a SARS-CoV-2 prototype strain and various variants and against SARS-CoV, but also stimulate the organism to generate high-level neutralizing antibodies against other SARS-related coronaviruses, so that the β-CoV recombinant chimeric antigen is expected to become an immunogen for broad-spectrum vaccines against β-CoVs, and has great clinical application prospects and industrial values.
Resumen de: US2025064795A1
Topotecan for use in the treatment of COVID-19 and/or its associated symptoms. Also disclosed is a method of treating an individual infected with a coronavirus, wherein said method comprises the steps of: providing Topotecan: and administering said Topotecan to said individual in a dosage amount sufficient to prevent/stabilize/reduce the risks and/or symptoms associated with a coronavirus infection.
Nº publicación: US2025064888A1 27/02/2025
Solicitante:
SHENZHEN HIGHTIDE BIOPHARMACEUTICAL LTD [CN]
SHENZHEN HIGHTIDE BIOPHARMACEUTICAL LTD
Resumen de: US2025064888A1
The invention provides compositions and methods for treating, reducing or preventing cytokine storm, for example, in connection with a viral infection (e.g., by SARS-CoV-2), drug treatment or therapy, trauma or an inflammatory disease, or a related disease and disorder.
BOPI
Sede Electrónica
